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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-136374
UUCD1 version UUC-HoS-01099
Ensembl Protein ID ENSP00000395487.2
UniProt Accession Q01804; B4DYS4; Q147U2; Q1ZYK1; Q6PG39; Q96MQ5; Q9NT94; Q9UPV6; OTUD4_HUMAN
Genbank Protein ID AK056597; AK302581; AC096757; CH471056; X68242; DQ427109; BC057242; BC118572; BC118653; AB028969; AL137460
Protein Name OTU domain-containing protein 4;HIV-1-induced protein HIN-1
Genbank Nucleotide ID BAB71229.1; BAG63836.1; EAX05045.1; EAX05046.1; CAA48313.1; ABD72605.1; AAH57242.2; AAI18573.1; AAI18654.1; BAA82998.2; CAB70748.1
Gene Name OTUD4;HIN1;KIAA1046
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164164.15 ENST00000454497.6 ENSP00000409279.2
ENSG00000164164.15 ENST00000447906.6 ENSP00000395487.2
ENSG00000164164.15 ENST00000514973.5 ENSP00000425972.1
ENSG00000164164.15 ENST00000509620.6 ENSP00000424192.2
ENSG00000164164.15 ENST00000504501.1 ENSP00000423453.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpressTCGAICGCCOSMIC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/OTU OTU 22298430; 23827681
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin.
Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin.
Protein Sequence
(Fasta)
MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV AEQVLHSQSR 60
HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW VGQVEISALS LMYRKDFIIY 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-136374|DUB,OTU|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCAGGGCTT CCCTATGCGC CCGGAGAGCG CGGACCGCTG CCTCGGGCCG CCGCCGCCTG 60
CCGCCGCTCG CGGAGCCCGA GCCCCAGCCC GAGCCGCCGC CTGCCCCAGG CCGGGGCGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-136374|DUB,OTU|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

KEGG hsa:54726
Orthology
iUUCD ID Species Identity E-value Score
Created Date 25-Jun-2017

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