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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046150
Ensembl Protein ID ENSP00000315700.4
UniProt Accession Q13112; Q99548; CAF1B_HUMAN
Genbank Protein ID AAA76737.1; BAA89426.1; BAA95549.1; AAH21218.1; CAA66915.1
Protein Name Chromatin assembly factor 1 subunit B; Chromatin assembly factor I p60 subunit; M-phase phosphoprotein 7
Genbank Nucleotide ID U20980; AP000694; AP001725; BC021218; X98262
Gene Name CHAF1B; CAF1A; CAF1P60; MPHOSPH7; MPP7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000159259.7 ENST00000314103.5 ENSP00000315700.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-19 71.4 127 162
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH ++v+++++ +d +l++s+s D+t  +WD+++g 
   Q: 127  GHLEDVYDICWaTDgNLMASASVDNTAIIWDVSKGQ 162
           89**********999****************99886 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
 Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
Protein Sequence
(Fasta)
MKVITCEIAW HNKEPVYSLD FQHGTAGRIH RLASAGVDTN VRIWKVEKGP DGKAIVEFLS 60
NLARHTKAVN VVRFSPTGEI LASGGDDAVI LLWKVNDNKE PEQIAFQDED EAQLNKENWT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046150|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCTGCGGC GCGCGGGAAG CGGCGCGCGC TGCGCGGGAG GTGACGGTGC CTCTGACTGT 60
CCGGGTCCCT CCAGGTACGG CTTCCCTGGC CCGGGCAGCT CCGCGGCTCT TTTGGTCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046150|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR029129--CAF1_p60_C
IPR001632--Gprotein_B
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF15512--CAF-1_p60_C
PF00400--WD40
PRINTS

PR00319--GPROTEINB
SMART

SM00320--WD40
Gene Ontology

GO:0033186--C:CAF-1 complex
GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0051082--F:unfolded protein binding
GO:0007049--P:cell cycle
GO:0031497--P:chromatin assembly
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0006335--P:DNA replication-dependent nucleosome assembly
GO:0006461--P:protein complex assembly
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:8208
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000474 Aegilops tauschii 40.30 2.00e-82 300.00
IUUC-Aml-001755 Ailuropoda melanoleuca 84.91 0.00e+00 943.00
IUUC-Atr-002674 Amborella trichopoda 40.45 2.00e-86 312.00
IUUC-Apl-003701 Anas platyrhynchos 73.62 0.00e+00 818.00
IUUC-Aca-004692 Anolis carolinensis 73.20 0.00e+00 775.00
IUUC-Aly-006286 Arabidopsis lyrata 39.38 7.00e-86 311.00
IUUC-Ath-007683 Arabidopsis thaliana 39.56 3.00e-86 312.00
IUUC-Ago-007940 Ashbya gossypii 35.48 3.00e-65 243.00
IUUC-Acl-008070 Aspergillus clavatus 44.19 5.00e-45 176.00
IUUC-Afl-008414 Aspergillus flavus 42.52 3.00e-44 173.00
IUUC-Ani-009399 Aspergillus nidulans 44.65 2.00e-44 174.00
IUUC-Ang-009650 Aspergillus niger 40.91 1.00e-42 168.00
IUUC-Aor-009937 Aspergillus oryzae 42.52 3.00e-44 173.00
IUUC-Ate-010505 Aspergillus terreus 35.98 5.00e-28 119.00
IUUC-Bgr-012005 Blumeria graminis 40.19 1.00e-39 157.00
IUUC-Bta-013423 Bos taurus 84.15 0.00e+00 920.00
IUUC-Bci-013847 Botrytis cinerea 40.28 9.00e-41 162.00
IUUC-Bdi-014860 Brachypodium distachyon 40.70 8.00e-83 301.00
IUUC-Bol-016603 Brassica oleracea 37.00 2.00e-82 300.00
IUUC-Bra-017175 Brassica rapa 40.10 1.00e-79 290.00
IUUC-Cel-018272 Caenorhabditis elegans 35.24 3.00e-58 219.00
IUUC-Cja-019558 Callithrix jacchus 94.32 0.00e+00 1018.00
IUUC-Cfa-020900 Canis familiaris 84.22 0.00e+00 921.00
IUUC-Cpo-022054 Cavia porcellus 79.19 0.00e+00 835.00
IUUC-Csa-023850 Chlorocebus sabaeus 97.67 0.00e+00 1066.00
IUUC-Cho-024510 Choloepus hoffmanni 85.47 1.00e-144 506.00
IUUC-Cin-025178 Ciona intestinalis 47.58 7.00e-109 387.00
IUUC-Csv-025885 Ciona savignyi 48.30 2.00e-36 144.00
IUUC-Cgl-026572 Colletotrichum gloeosporioides 43.93 8.00e-38 152.00
IUUC-Cne-027015 Cryptococcus neoformans 32.03 3.00e-37 150.00
IUUC-Cme-027136 Cyanidioschyzon merolae 31.72 3.00e-57 216.00
IUUC-Dre-027879 Danio rerio 56.76 0.00e+00 669.00
IUUC-Dno-029335 Dasypus novemcinctus 88.71 0.00e+00 1014.00
IUUC-Dor-030520 Dipodomys ordii 71.91 0.00e+00 756.00
IUUC-Dse-031566 Dothistroma septosporum 41.31 2.00e-43 171.00
IUUC-Dme-031838 Drosophila melanogaster 47.83 2.00e-109 390.00
IUUC-Eca-033563 Equus caballus 89.80 0.00e+00 1042.00
IUUC-Fca-036052 Felis catus 84.10 0.00e+00 927.00
IUUC-Fal-037080 Ficedula albicollis 71.10 0.00e+00 795.00
IUUC-Fox-038022 Fusarium oxysporum 41.78 1.00e-41 164.00
IUUC-Fso-038115 Fusarium solani 42.25 1.00e-40 161.00
IUUC-Gmo-039461 Gadus morhua 72.12 6.00e-136 476.00
IUUC-Ggr-040100 Gaeumannomyces graminis 41.23 3.00e-42 167.00
IUUC-Gga-041133 Gallus gallus 73.31 0.00e+00 810.00
IUUC-Gac-041769 Gasterosteus aculeatus 64.36 0.00e+00 660.00
IUUC-Gma-043339 Glycine max 41.73 7.00e-95 341.00
IUUC-Ggo-044561 Gorilla gorilla 98.93 0.00e+00 1067.00
IUUC-Hvu-047792 Hordeum vulgare 38.97 2.00e-51 196.00
IUUC-Itr-048630 Ictidomys tridecemlineatus 90.49 0.00e+00 935.00
IUUC-Kpa-049397 Komagataella pastoris 40.10 7.00e-83 300.00
IUUC-Lch-050365 Latimeria chalumnae 53.94 1.00e-146 513.00
IUUC-Lpe-050875 Leersia perrieri 40.55 9.00e-83 301.00
IUUC-Loc-052770 Lepisosteus oculatus 69.12 0.00e+00 687.00
IUUC-Lma-053291 Leptosphaeria maculans 39.91 8.00e-43 169.00
IUUC-Laf-053505 Loxodonta africana 87.30 0.00e+00 1019.00
IUUC-Mcc-054803 Macaca mulatta 98.03 0.00e+00 1068.00
IUUC-Meu-056578 Macropus eugenii 71.96 0.00e+00 791.00
IUUC-Mor-057211 Magnaporthe oryzae 40.57 9.00e-41 162.00
IUUC-Mpo-057411 Magnaporthe poae 40.76 2.00e-41 164.00
IUUC-Mtr-058066 Medicago truncatula 42.82 5.00e-94 338.00
IUUC-Mga-059735 Meleagris gallopavo 73.31 0.00e+00 815.00
IUUC-Mvi-060288 Microbotryum violaceum 30.22 5.00e-32 133.00
IUUC-Mmr-061343 Microcebus murinus 93.01 0.00e+00 1079.00
IUUC-Mdo-062065 Monodelphis domestica 79.64 0.00e+00 884.00
IUUC-Mmu-063501 Mus musculus 85.69 0.00e+00 900.00
IUUC-Mac-064864 Musa acuminata 39.30 5.00e-82 298.00
IUUC-Mpu-066549 Mustela putorius furo 83.42 0.00e+00 909.00
IUUC-Mlu-067121 Myotis lucifugus 77.30 0.00e+00 839.00
IUUC-Nfi-068462 Neosartorya fischeri 44.65 2.00e-45 177.00
IUUC-Ncr-068838 Neurospora crassa 39.25 1.00e-41 164.00
IUUC-Nle-069854 Nomascus leucogenys 98.75 0.00e+00 1055.00
IUUC-Opr-070803 Ochotona princeps 80.82 0.00e+00 892.00
IUUC-Ont-071642 Oreochromis niloticus 65.53 0.00e+00 664.00
IUUC-Oan-073675 Ornithorhynchus anatinus 77.12 0.00e+00 850.00
IUUC-Ocu-073863 Oryctolagus cuniculus 96.07 0.00e+00 778.00
IUUC-Oba-075682 Oryza barthii 39.80 8.00e-78 284.00
IUUC-Obr-076039 Oryza brachyantha 41.81 3.00e-84 306.00
IUUC-Ogu-078021 Oryza glumaepatula 40.81 2.00e-82 299.00
IUUC-Oin-079908 Oryza indica 35.96 3.00e-62 233.00
IUUC-Olo-081063 Oryza longistaminata 40.81 2.00e-82 300.00
IUUC-Ome-081930 Oryza meridionalis 40.55 2.00e-81 296.00
IUUC-Oni-082547 Oryza nivara 40.81 2.00e-82 299.00
IUUC-Opu-084089 Oryza punctata 40.30 8.00e-80 291.00
IUUC-Oru-084844 Oryza rufipogon 40.81 2.00e-82 299.00
IUUC-Osa-085582 Oryza sativa 40.81 2.00e-82 299.00
IUUC-Ola-087187 Oryzias latipes 61.81 0.00e+00 671.00
IUUC-Olu-087792 Ostreococcus lucimarinus 39.55 3.00e-77 282.00
IUUC-Oga-088390 Otolemur garnettii 89.07 0.00e+00 1036.00
IUUC-Oar-089740 Ovis aries 83.22 0.00e+00 887.00
IUUC-Ptr-091581 Pan troglodytes 99.64 0.00e+00 1082.00
IUUC-Pan-092258 Papio anubis 90.30 0.00e+00 974.00
IUUC-Psi-093761 Pelodiscus sinensis 75.49 0.00e+00 848.00
IUUC-Ppa-095428 Physcomitrella patens 42.31 1.00e-92 333.00
IUUC-Pfo-097357 Poecilia formosa 75.93 0.00e+00 662.00
IUUC-Pab-098520 Pongo abelii 98.39 0.00e+00 1068.00
IUUC-Pop-099331 Populus trichocarpa 37.03 2.00e-86 313.00
IUUC-Ppe-101548 Prunus persica 40.69 7.00e-88 318.00
IUUC-Pva-103243 Pteropus vampyrus 87.64 0.00e+00 901.00
IUUC-Pgr-103591 Puccinia graminis 33.71 3.00e-36 147.00
IUUC-Pte-104247 Pyrenophora teres 40.85 8.00e-43 169.00
IUUC-Pyt-104641 Pyrenophora triticirepentis 40.85 1.00e-42 168.00
IUUC-Rno-105202 Rattus norvegicus 85.69 0.00e+00 907.00
IUUC-Sce-106250 Saccharomyces cerevisiae 34.27 1.00e-73 270.00
IUUC-Sha-107036 Sarcophilus harrisii 81.98 0.00e+00 926.00
IUUC-Sja-107912 Schizosaccharomyces japonicus 37.47 6.00e-77 281.00
IUUC-Spo-108050 Schizosaccharomyces pombe 33.91 1.00e-71 263.00
IUUC-Ssl-108607 Sclerotinia sclerotiorum 38.27 4.00e-41 163.00
IUUC-Sit-109838 Setaria italica 42.64 3.00e-85 309.00
IUUC-Sly-110872 Solanum lycopersicum 39.75 6.00e-84 304.00
IUUC-Stu-111933 Solanum tuberosum 39.15 1.00e-80 293.00
IUUC-Sbi-114587 Sorghum bicolor 41.33 4.00e-86 312.00
IUUC-Ssc-115462 Sus scrofa 87.88 0.00e+00 994.00
IUUC-Tgu-117186 Taeniopygia guttata 71.28 0.00e+00 778.00
IUUC-Tru-118310 Takifugu rubripes 65.47 0.00e+00 664.00
IUUC-Tsy-118927 Tarsius syrichta 86.23 0.00e+00 768.00
IUUC-Tni-120832 Tetraodon nigroviridis 59.45 0.00e+00 653.00
IUUC-Tca-121584 Theobroma cacao 42.96 7.00e-88 317.00
IUUC-Tre-122140 Trichoderma reesei 40.65 7.00e-41 162.00
IUUC-Tvi-122663 Trichoderma virens 42.06 4.00e-41 163.00
IUUC-Tae-123476 Triticum aestivum 40.30 2.00e-82 300.00
IUUC-Tur-126239 Triticum urartu 40.30 1.00e-82 301.00
IUUC-Tme-127108 Tuber melanosporum 40.24 1.00e-81 297.00
IUUC-Ttr-129010 Tursiops truncatus 88.91 0.00e+00 986.00
IUUC-Vda-129825 Verticillium dahliae 43.40 5.00e-43 169.00
IUUC-Vpa-130374 Vicugna pacos 81.00 3.00e-102 365.00
IUUC-Vvi-131136 Vitis vinifera 40.85 2.00e-84 306.00
IUUC-Xtr-132141 Xenopus tropicalis 74.89 0.00e+00 707.00
IUUC-Xma-133980 Xiphophorus maculatus 76.43 0.00e+00 664.00
IUUC-Yli-134457 Yarrowia lipolytica 40.18 3.00e-39 157.00
IUUC-Zma-135321 Zea mays 42.71 6.00e-86 311.00
Created Date 25-Jun-2017

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