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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064014
Ensembl Protein ID ENSMUSP00000019443.8
UniProt Accession Q924T7; RNF31_MOUSE
Genbank Protein ID BAB47406.1; AAH57595.1
Protein Name E3 ubiquitin-protein ligase RNF31; HOIL-1-interacting protein; Putative Ariadne-like ubiquitin ligase; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31
Genbank Nucleotide ID AB053120; BC057595
Gene Name Rnf31; Paul
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000047098.17 ENSMUST00000019443.14 ENSMUSP00000019443.8
ENSMUSG00000047098.17 ENSMUST00000137296.7 ENSMUSP00000122955.1
ENSMUSG00000047098.17 ENSMUST00000140178.1 ENSMUSP00000118215.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/NZF NZF 20005846
Classification
Family E-value Score Start End
UBD/ZnF/NZF 4.50e-28 97.5 345 371
UBD/Alpha-Helix/UBA 0.0017 19.5 573 606
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/NZF
   S: 2    eaqWaCsaCTflNePeavkCemCsrpR 28
           + qWaC++CTf+Ne++av C++C+rpR
   Q: 345  RDQWACQSCTFENEAAAVLCAICERPR 371
           579***********************9 PP
   

   UBD/Alpha-Helix/UBA
   S: 6    kleqlveMGF.dreealqaLraannnleaAveyL 38
           k+ +l++ GF ++e  lqaL ++++++ +A++ L
   Q: 573  KVHELQSLGFgPKEGSLQALFQHGGDVARALTEL 606
           899***************************9987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
 E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
Protein Sequence
(Fasta)
MPGDEERGFL AAREELASAL RWDSAQVFPL EQLMPLLATS LPPAARYLQL DAGRLVRCNA 60
HGEPRNYLNT LSTALNILEK YGRNLLSPQR PRYWRSVKFN NPVFRSTVDA VQGGRDVLRL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064014|UBD,NZF;UBD,UBA|Mus musculus
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Nucleotide Sequence
(Fasta)
CTCTAAAGTG GCCCACAGTC CCGCCCTCTC TGCCAGGACT TCCTGTTCCC GGTAACCCTG 60
GCCGTGGATG GGGCTGAGCG GGGCGGTGGC TTAAGTGACC CGGGCTGCTG TGGCGCCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064014|UBD,NZF;UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR002867--IBR_dom
IPR018997--PUB_domain
IPR026254--RNF31
IPR032065--RNF31-UBA
IPR015940--UBA
IPR001876--Znf_RanBP2
IPR017907--Znf_RING_CS
PROSITE

PS50030--UBA
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
Pfam

PF16678--HOIP-UBA
PF01485--IBR
PF09409--PUB
SMART

SM00647--IBR
SM00547--ZnF_RBZ
Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0023035--P:CD40 signaling pathway
GO:0060546--P:negative regulation of necroptotic process
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0097039--P:protein linear polyubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0050852--P:T cell receptor signaling pathway
KEGG mmu:268749
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002017 Ailuropoda melanoleuca 83.89 0.00e+00 1622.00
IUUC-Aca-004719 Anolis carolinensis 55.19 0.00e+00 856.00
IUUC-Ame-011924 Astyanax mexicanus 36.82 4.00e-113 402.00
IUUC-Bta-012795 Bos taurus 81.23 0.00e+00 1571.00
IUUC-Cja-019168 Callithrix jacchus 84.06 0.00e+00 1673.00
IUUC-Cfa-020767 Canis familiaris 84.01 0.00e+00 1665.00
IUUC-Cpo-022291 Cavia porcellus 82.73 0.00e+00 1680.00
IUUC-Csa-024246 Chlorocebus sabaeus 83.09 0.00e+00 1431.00
IUUC-Cho-024866 Choloepus hoffmanni 57.16 0.00e+00 840.00
IUUC-Cin-025568 Ciona intestinalis 34.11 5.00e-95 342.00
IUUC-Dre-027426 Danio rerio 43.77 0.00e+00 750.00
IUUC-Dno-029925 Dasypus novemcinctus 82.00 0.00e+00 1580.00
IUUC-Dor-030389 Dipodomys ordii 81.77 0.00e+00 1320.00
IUUC-Dme-031816 Drosophila melanogaster 43.70 4.00e-87 318.00
IUUC-Ete-032383 Echinops telfairi 91.44 0.00e+00 698.00
IUUC-Eca-033807 Equus caballus 84.18 0.00e+00 1697.00
IUUC-Eeu-034745 Erinaceus europaeus 69.28 0.00e+00 726.00
IUUC-Fca-036464 Felis catus 85.39 0.00e+00 1687.00
IUUC-Gmo-039121 Gadus morhua 42.51 3.00e-175 609.00
IUUC-Gac-041766 Gasterosteus aculeatus 46.26 0.00e+00 831.00
IUUC-Ggo-045259 Gorilla gorilla 84.24 0.00e+00 1662.00
IUUC-Hsa-046269 Homo sapiens 84.14 0.00e+00 1660.00
IUUC-Itr-048764 Ictidomys tridecemlineatus 85.22 0.00e+00 1825.00
IUUC-Lch-049622 Latimeria chalumnae 51.27 0.00e+00 1063.00
IUUC-Laf-054027 Loxodonta africana 81.98 0.00e+00 1600.00
IUUC-Mcc-054906 Macaca mulatta 84.33 0.00e+00 1713.00
IUUC-Meu-056354 Macropus eugenii 67.22 0.00e+00 1294.00
IUUC-Mmr-060835 Microcebus murinus 82.95 0.00e+00 1614.00
IUUC-Mdo-061883 Monodelphis domestica 74.72 0.00e+00 1501.00
IUUC-Mlu-067075 Myotis lucifugus 82.65 0.00e+00 1622.00
IUUC-Nle-069954 Nomascus leucogenys 84.05 0.00e+00 1671.00
IUUC-Opr-070399 Ochotona princeps 79.29 0.00e+00 1578.00
IUUC-Ont-071593 Oreochromis niloticus 46.85 0.00e+00 845.00
IUUC-Oan-073591 Ornithorhynchus anatinus 91.21 9.00e-47 178.00
IUUC-Ocu-073785 Oryctolagus cuniculus 67.44 0.00e+00 1254.00
IUUC-Ogl-077291 Oryza glaberrima 27.96 2.00e-04 39.70
IUUC-Oin-079800 Oryza indica 29.03 2.00e-04 39.70
IUUC-Oni-082829 Oryza nivara 29.03 2.00e-04 39.70
IUUC-Ola-086357 Oryzias latipes 45.38 0.00e+00 813.00
IUUC-Oga-088724 Otolemur garnettii 85.34 0.00e+00 1654.00
IUUC-Oar-089318 Ovis aries 82.00 0.00e+00 1682.00
IUUC-Ptr-091249 Pan troglodytes 84.24 0.00e+00 1687.00
IUUC-Pan-092080 Papio anubis 84.16 0.00e+00 1733.00
IUUC-Pma-094655 Petromyzon marinus 50.63 1.00e-67 249.00
IUUC-Pfo-096097 Poecilia formosa 45.41 0.00e+00 832.00
IUUC-Pab-098380 Pongo abelii 81.92 0.00e+00 1619.00
IUUC-Pca-101024 Procavia capensis 81.88 0.00e+00 1306.00
IUUC-Pva-102289 Pteropus vampyrus 82.65 0.00e+00 1594.00
IUUC-Rno-105864 Rattus norvegicus 94.37 0.00e+00 1852.00
IUUC-Sha-107428 Sarcophilus harrisii 74.20 0.00e+00 1433.00
IUUC-Ssl-108588 Sclerotinia sclerotiorum 22.47 4.00e-03 36.20
IUUC-Sar-113745 Sorex araneus 78.80 0.00e+00 1573.00
IUUC-Ssc-116246 Sus scrofa 83.24 0.00e+00 1621.00
IUUC-Tru-118704 Takifugu rubripes 45.47 0.00e+00 801.00
IUUC-Tsy-119077 Tarsius syrichta 83.08 0.00e+00 1386.00
IUUC-Tni-120343 Tetraodon nigroviridis 45.74 0.00e+00 813.00
IUUC-Tbe-127822 Tupaia belangeri 85.97 0.00e+00 778.00
IUUC-Ttr-129179 Tursiops truncatus 79.89 0.00e+00 1571.00
IUUC-Xtr-132864 Xenopus tropicalis 50.24 0.00e+00 934.00
Created Date 25-Jun-2017

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