iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.00e-69	232.2	241	548

Active Site

Position(s)	Description	Evidence
250	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
490	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           +GlkN+g+tCYmNS+LQ+L+++++lr  + +  + +      +++++++  slq++f+el +  ++ v +++l+k++++e   +++++q+D+qEfl++
   Q: 241  VGLKNQGATCYMNSLLQTLYFTNSLRLSVYR-IPTEA-----DDSSKSVGLSLQRVFHEL-QFGDRPVGTKKLTKSFGWET--LDSFMQHDVQEFLRV 329
           6******************************.44444.....46788*************.99999************887..67************* PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftk 196
           lld+le+++                          k +  + +i  lF+g+++s ikc++ d +s+r+e+f+d++l++++k+     ++ ++++++++
   Q: 330  LLDKLESKM--------------------------KGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKK-----NIYESFQDYVA 396
           *********..........................789999*****************************************.....9********** PP
   S: 197  eeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsGslssGH 294
           +e+leg+nky     +++qea+k + ++++P+vL+lhL+Rf+++  ++s++k n+++ef ++++l+++++++e++      Y L+av+vHsG  ++GH
   Q: 397  PETLEGDNKYDAGV-HGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAESENT---LADYVLHAVLVHSGDNHGGH 490
           *********99886.68******************************************************7766...79****************** PP
   S: 295  Yvayvknekgk.WllfdDskVtevkeeevleetg.............staYvlfYkrr 338
           Yv++++ + ++ W++fdD+ V++++++e  e++              s+aY+l+Y r+
   Q: 491  YVVFINPKADGrWFKFDDDVVSSCRKQEAIEQNYggmddeisfhakcSNAYMLVYIRQ 548
           *****9865555************87666665556********************875 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Hydrolase that deubiquitinates target proteins.

Protein Sequence
(Fasta)

MEIETDQSIE AMDTQDTQEV EILTSDLQQT QQQRNSPPQL PKFKNLIQPQ LHAVGAVTQL 60
PSENGNMPPQ QLLADSSSTS FGDGEAMGID DESKEDQFRS ETTFSFTVEN VVQLKSQRLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCGTTTTT GACAGCTGCA CGAGCTGCGC GCTGCATGTG TATGTGTGTG TGCGAAAATA 60
TTAATTGATA CGTTAACGCT GCGATGCAGT GCCGTGTGAA ATACTTCAAA ACTGTTCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR002083--MATH/TRAF_dom
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00917--MATH
PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0043234--C:protein complex
GO:0035328--C:transcriptionally silent chromatin
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006342--P:chromatin silencing
GO:0016578--P:histone deubiquitination
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG1490

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000761	Aegilops tauschii	31.51	2.00e-128	452.00
IUUC-Aml-002408	Ailuropoda melanoleuca	48.95	0.00e+00	1024.00
IUUC-Atr-003067	Amborella trichopoda	36.34	6.00e-121	427.00
IUUC-Apl-003558	Anas platyrhynchos	48.59	0.00e+00	1038.00
IUUC-Aca-004518	Anolis carolinensis	46.65	0.00e+00	966.00
IUUC-Aly-006453	Arabidopsis lyrata	34.95	1.00e-149	523.00
IUUC-Ath-006591	Arabidopsis thaliana	34.62	1.00e-147	516.00
IUUC-Ago-007849	Ashbya gossypii	29.76	1.00e-122	433.00
IUUC-Acl-008327	Aspergillus clavatus	32.34	3.00e-152	532.00
IUUC-Afl-008491	Aspergillus flavus	32.81	2.00e-148	519.00
IUUC-Afu-008804	Aspergillus fumigatus	32.74	1.00e-142	500.00
IUUC-Ang-009776	Aspergillus niger	32.59	5.00e-144	504.00
IUUC-Aor-009998	Aspergillus oryzae	31.97	9.00e-140	490.00
IUUC-Ate-010428	Aspergillus terreus	32.72	7.00e-145	507.00
IUUC-Ame-010903	Astyanax mexicanus	48.08	0.00e+00	1032.00
IUUC-Bgr-012132	Blumeria graminis	31.26	5.00e-134	471.00
IUUC-Bta-013192	Bos taurus	48.77	0.00e+00	1026.00
IUUC-Bci-013924	Botrytis cinerea	30.67	1.00e-126	447.00
IUUC-Bdi-015069	Brachypodium distachyon	34.15	4.00e-145	508.00
IUUC-Bol-015224	Brassica oleracea	34.17	4.00e-149	521.00
IUUC-Bra-017448	Brassica rapa	34.85	9.00e-148	517.00
IUUC-Cel-018219	Caenorhabditis elegans	32.60	4.00e-140	491.00
IUUC-Cja-019006	Callithrix jacchus	48.59	0.00e+00	1021.00
IUUC-Cfa-020361	Canis familiaris	48.58	0.00e+00	1022.00
IUUC-Cpo-022320	Cavia porcellus	48.68	0.00e+00	1025.00
IUUC-Cre-022708	Chlamydomonas reinhardtii	41.75	2.00e-87	315.00
IUUC-Csa-024050	Chlorocebus sabaeus	48.58	0.00e+00	1023.00
IUUC-Cho-024434	Choloepus hoffmanni	40.38	4.00e-167	581.00
IUUC-Cin-025689	Ciona intestinalis	43.50	0.00e+00	923.00
IUUC-Csv-025963	Ciona savignyi	42.77	0.00e+00	883.00
IUUC-Cgl-026650	Colletotrichum gloeosporioides	31.32	1.00e-135	476.00
IUUC-Cne-026968	Cryptococcus neoformans	34.71	5.00e-157	548.00
IUUC-Cme-027103	Cyanidioschyzon merolae	40.85	4.00e-97	349.00
IUUC-Dre-028510	Danio rerio	48.09	0.00e+00	1034.00
IUUC-Dno-029696	Dasypus novemcinctus	48.68	0.00e+00	1023.00
IUUC-Dor-030611	Dipodomys ordii	66.77	9.00e-128	450.00
IUUC-Dse-031433	Dothistroma septosporum	30.77	2.00e-128	452.00
IUUC-Ete-033191	Echinops telfairi	47.85	0.00e+00	1000.00
IUUC-Eca-034122	Equus caballus	48.86	0.00e+00	1021.00
IUUC-Eeu-035292	Erinaceus europaeus	54.72	5.00e-120	424.00
IUUC-Fca-036377	Felis catus	48.49	0.00e+00	1021.00
IUUC-Fal-036964	Ficedula albicollis	49.39	0.00e+00	1040.00
IUUC-Fox-037695	Fusarium oxysporum	31.18	1.00e-137	483.00
IUUC-Fso-038084	Fusarium solani	31.02	4.00e-137	482.00
IUUC-Gmo-038644	Gadus morhua	48.23	0.00e+00	1028.00
IUUC-Ggr-040029	Gaeumannomyces graminis	31.32	3.00e-132	465.00
IUUC-Gga-040944	Gallus gallus	48.68	0.00e+00	1042.00
IUUC-Gac-041740	Gasterosteus aculeatus	48.51	0.00e+00	1033.00
IUUC-Gma-043300	Glycine max	34.78	4.00e-157	548.00
IUUC-Ggo-044947	Gorilla gorilla	48.58	0.00e+00	1025.00
IUUC-Hsa-046278	Homo sapiens	48.58	0.00e+00	1025.00
IUUC-Hvu-047749	Hordeum vulgare	34.91	6.00e-123	434.00
IUUC-Itr-047904	Ictidomys tridecemlineatus	49.52	0.00e+00	906.00
IUUC-Kpa-049121	Komagataella pastoris	29.31	2.00e-115	410.00
IUUC-Lch-049847	Latimeria chalumnae	48.88	0.00e+00	1040.00
IUUC-Lpe-051505	Leersia perrieri	34.36	2.00e-135	476.00
IUUC-Loc-052234	Lepisosteus oculatus	52.91	0.00e+00	762.00
IUUC-Lma-053169	Leptosphaeria maculans	33.43	4.00e-144	505.00
IUUC-Laf-053566	Loxodonta africana	48.68	0.00e+00	1025.00
IUUC-Mcc-055549	Macaca mulatta	48.58	0.00e+00	1022.00
IUUC-Meu-056887	Macropus eugenii	38.67	4.00e-143	501.00
IUUC-Mor-057149	Magnaporthe oryzae	30.86	1.00e-137	483.00
IUUC-Mpo-057536	Magnaporthe poae	30.78	1.00e-132	467.00
IUUC-Mtr-058583	Medicago truncatula	34.69	2.00e-147	516.00
IUUC-Mla-058899	Melampsora laricipopulina	33.51	3.00e-154	538.00
IUUC-Mga-060148	Meleagris gallopavo	48.68	0.00e+00	1041.00
IUUC-Mvi-060207	Microbotryum violaceum	34.84	8.00e-157	547.00
IUUC-Mmr-060946	Microcebus murinus	48.77	0.00e+00	1024.00
IUUC-Mdo-062079	Monodelphis domestica	46.60	0.00e+00	890.00
IUUC-Mmu-063678	Mus musculus	48.49	0.00e+00	1019.00
IUUC-Mac-064786	Musa acuminata	35.29	1.00e-144	506.00
IUUC-Mpu-066744	Mustela putorius furo	49.02	0.00e+00	1018.00
IUUC-Mlu-067949	Myotis lucifugus	48.50	0.00e+00	1010.00
IUUC-Nfi-068342	Neosartorya fischeri	32.56	9.00e-142	497.00
IUUC-Ncr-068818	Neurospora crassa	31.79	5.00e-139	488.00
IUUC-Nle-070064	Nomascus leucogenys	48.58	0.00e+00	1024.00
IUUC-Opr-071001	Ochotona princeps	49.52	0.00e+00	883.00
IUUC-Ont-072095	Oreochromis niloticus	48.29	0.00e+00	1032.00
IUUC-Oan-073483	Ornithorhynchus anatinus	49.11	0.00e+00	1018.00
IUUC-Ocu-073967	Oryctolagus cuniculus	49.09	0.00e+00	1003.00
IUUC-Oba-075811	Oryza barthii	32.88	3.00e-130	459.00
IUUC-Obr-076857	Oryza brachyantha	34.97	2.00e-142	499.00
IUUC-Ogl-077038	Oryza glaberrima	34.88	3.00e-138	485.00
IUUC-Ogu-078265	Oryza glumaepatula	32.90	8.00e-123	434.00
IUUC-Oin-079513	Oryza indica	34.07	6.00e-134	471.00
IUUC-Olo-081067	Oryza longistaminata	32.87	8.00e-129	454.00
IUUC-Ome-081879	Oryza meridionalis	34.31	8.00e-138	484.00
IUUC-Oni-082461	Oryza nivara	32.72	3.00e-133	469.00
IUUC-Opu-083199	Oryza punctata	34.63	7.00e-138	484.00
IUUC-Oru-085109	Oryza rufipogon	33.94	5.00e-133	468.00
IUUC-Osa-085418	Oryza sativa	34.68	1.00e-118	420.00
IUUC-Ola-086640	Oryzias latipes	48.70	0.00e+00	1045.00
IUUC-Olu-087874	Ostreococcus lucimarinus	32.37	3.00e-120	425.00
IUUC-Oga-089059	Otolemur garnettii	44.87	0.00e+00	896.00
IUUC-Oar-089710	Ovis aries	48.77	0.00e+00	1028.00
IUUC-Ptr-091334	Pan troglodytes	48.58	0.00e+00	1025.00
IUUC-Pan-091717	Papio anubis	49.62	0.00e+00	1018.00
IUUC-Psi-093933	Pelodiscus sinensis	48.45	0.00e+00	1036.00
IUUC-Pma-094648	Petromyzon marinus	51.00	0.00e+00	979.00
IUUC-Pno-095020	Phaeosphaeria nodorum	45.91	1.00e-99	357.00
IUUC-Ppa-096020	Physcomitrella patens	34.39	7.00e-153	534.00
IUUC-Pfo-096181	Poecilia formosa	48.57	0.00e+00	1037.00
IUUC-Pab-098231	Pongo abelii	46.58	0.00e+00	965.00
IUUC-Pop-099680	Populus trichocarpa	35.32	2.00e-145	509.00
IUUC-Pca-100543	Procavia capensis	48.11	3.00e-155	541.00
IUUC-Ppe-101847	Prunus persica	34.46	3.00e-142	498.00
IUUC-Pva-102472	Pteropus vampyrus	48.04	0.00e+00	988.00
IUUC-Pgr-103463	Puccinia graminis	34.55	4.00e-153	535.00
IUUC-Ptt-103716	Puccinia triticina	34.96	3.00e-152	532.00
IUUC-Pte-104360	Pyrenophora teres	33.67	6.00e-133	468.00
IUUC-Pyt-104581	Pyrenophora triticirepentis	33.55	5.00e-134	471.00
IUUC-Rno-105816	Rattus norvegicus	48.58	0.00e+00	1025.00
IUUC-Sce-106230	Saccharomyces cerevisiae	39.03	9.00e-99	354.00
IUUC-Sha-107439	Sarcophilus harrisii	48.58	0.00e+00	1024.00
IUUC-Sja-107690	Schizosaccharomyces japonicus	31.83	1.00e-117	417.00
IUUC-Spo-108019	Schizosaccharomyces pombe	33.18	4.00e-120	425.00
IUUC-Smo-109308	Selaginella moellendorffii	35.25	3.00e-144	505.00
IUUC-Sit-110367	Setaria italica	34.38	6.00e-147	514.00
IUUC-Sly-111774	Solanum lycopersicum	34.79	3.00e-156	545.00
IUUC-Stu-112387	Solanum tuberosum	34.70	2.00e-155	542.00
IUUC-Sar-113685	Sorex araneus	47.95	0.00e+00	1001.00
IUUC-Sbi-114424	Sorghum bicolor	33.57	2.00e-138	486.00
IUUC-Sre-115156	Sporisorium reilianum	34.88	2.00e-150	526.00
IUUC-Ssc-116297	Sus scrofa	48.77	0.00e+00	1025.00
IUUC-Tgu-116767	Taeniopygia guttata	48.77	0.00e+00	1040.00
IUUC-Tru-118208	Takifugu rubripes	48.42	0.00e+00	1016.00
IUUC-Tsy-119277	Tarsius syrichta	57.14	2.00e-120	426.00
IUUC-Tni-119890	Tetraodon nigroviridis	48.33	0.00e+00	1016.00
IUUC-Tca-121630	Theobroma cacao	34.89	3.00e-144	505.00
IUUC-Tre-122169	Trichoderma reesei	31.96	2.00e-131	463.00
IUUC-Tvi-122600	Trichoderma virens	32.49	6.00e-138	484.00
IUUC-Tae-123032	Triticum aestivum	34.12	8.00e-142	497.00
IUUC-Tur-126287	Triticum urartu	32.08	1.00e-132	466.00
IUUC-Tme-127045	Tuber melanosporum	33.86	3.00e-146	512.00
IUUC-Tbe-127696	Tupaia belangeri	53.01	5.00e-100	358.00
IUUC-Ttr-129161	Tursiops truncatus	48.77	0.00e+00	1021.00
IUUC-Uma-129535	Ustilago maydis	35.59	9.00e-156	543.00
IUUC-Vda-129708	Verticillium dahliae	31.11	1.00e-140	493.00
IUUC-Vvi-130882	Vitis vinifera	35.08	3.00e-144	505.00
IUUC-Xtr-132073	Xenopus tropicalis	48.29	0.00e+00	1009.00
IUUC-Xma-133949	Xiphophorus maculatus	48.48	0.00e+00	1033.00
IUUC-Yli-134527	Yarrowia lipolytica	30.49	3.00e-119	422.00
IUUC-Zma-135550	Zea mays	34.25	6.00e-137	481.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence