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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046236
UUCD1 version UUC-HoS-00321
Ensembl Protein ID ENSP00000479617.1
UniProt Accession Q96T88; A0JBR2; A8K024; B2RBA9; Q2HIX7; Q8J022; Q9H6S6; Q9P115; Q9P1U7; UHRF1_HUMAN
Genbank Protein ID AAF28469.1; BAF36719.1; BAF36720.1; BAC20576.1; AAK55744.1; ABQ59043.1; BAB15177.1; BAF82078.1; BAG37156.1; AAV40831.1; AAF64067.1; EAW69187.1; AAI13876.2
Protein Name E3 ubiquitin-protein ligase UHRF1; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; RING finger protein 106; RING-type E3 ubiquitin transferase UHRF1; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 1
Genbank Nucleotide ID AF129507; AB177623; AB177624; AB075601; AF274048; EF560733; AK025578; AK289389; AK314579; AY787925; AC027319; CH471139; BC113875
Gene Name UHRF1; ICBP90; NP95; RNF106
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000276043.4 ENST00000620565.4 ENSP00000478171.1
ENSG00000276043.4 ENST00000613817.4 ENSP00000480214.1
ENSG00000276043.4 ENST00000622802.4 ENSP00000479617.1
Annotation
Cancer Mutation
TCGACGAP
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOTCGAICGCHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRecords
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 14993289; 21268065; 21045206
ULD/UDP/UBQ/UBQ_Other UBQ_Other 12084726; 19056828
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.011 17.9 737 776
ULD/UDP/UBQ/UBQ_Other 1.40e-14 55.3 14 89
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+ C+e  ++ p+++ C+H  ++dCl +      +  + f+CP Cr
   Q: 737  CICCQELVFR-PITTVCQHNVCKDCLDRS-----FRAQVFSCPACR 776
           88899999**.***************555.....6**********8 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgs.eltlk.vnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
           ++++v+++dg+ ++t+  +++ + V eL++ki++++++ p  qrL y+Gk +ed++tL dy ++ ++ti ll+++s
   Q: 14   MWIQVRTMDGRqTHTVDsLSRLTKVEELRRKIQELFHVEPGLQRLFYRGKQMEDGHTLFDYEVRLNDTIQLLVRQS 89
           789*********************************************************************9986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.
 Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.
Protein Sequence
(Fasta)
MGVFAVPPLS ADTMWIQVRT MDGRQTHTVD SLSRLTKVEE LRRKIQELFH VEPGLQRLFY 60
RGKQMEDGHT LFDYEVRLND TIQLLVRQSL VLPHSTKERD SELSDTDSGC CLGQSESDKS 120
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Protein Fasta Sequence


>IUUC-Hsa-046236|E3,RING;ULD,UBQ_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCAGGGGTGC CATCTTGGCT CACTGCAACC TCCGCCTCAT GGGTTCAAGC AATTCTCCTG 60
CCTCAGCCTC CTGAGTAGCT GGGACCACGG GTGCATGCCA GCATGCCCAG CTAATTTTTT 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046236|E3,RING;ULD,UBQ_Other|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015947--PUA-like_domain
IPR014722--Rib_L2_dom2
IPR003105--SRA_YDG
IPR021991--TTD_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50053--UBIQUITIN_2
PS51015--YDG
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00628--PHD
PF02182--SAD_SRA
PF12148--TTD
PF00240--ubiquitin
SMART

SM00249--PHD
SM00184--RING
SM00466--SRA
SM00213--UBQ
Gene Ontology

GO:0000791--C:euchromatin
GO:0000792--C:heterochromatin
GO:0000790--C:nuclear chromatin
GO:0005720--C:nuclear heterochromatin
GO:0016363--C:nuclear matrix
GO:0005634--C:nucleus
GO:0005657--C:replication fork
GO:0000987--F:core promoter proximal region sequence-specific DNA binding
GO:0044729--F:hemi-methylated DNA-binding
GO:0042393--F:histone binding
GO:0042802--F:identical protein binding
GO:0008327--F:methyl-CpG binding
GO:0035064--F:methylated histone binding
GO:0031493--F:nucleosomal histone binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0008283--P:cell proliferation
GO:0006281--P:DNA repair
GO:0010390--P:histone monoubiquitination
GO:0016574--P:histone ubiquitination
GO:0010216--P:maintenance of DNA methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032270--P:positive regulation of cellular protein metabolic process
GO:2000373--P:positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090308--P:regulation of methylation-dependent chromatin silencing
GO:0006351--P:transcription, DNA-templated
KEGG hsa:29128
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000242 Aegilops tauschii 34.62 5.00e-46 179.00
IUUC-Aml-001285 Ailuropoda melanoleuca 87.53 0.00e+00 1337.00
IUUC-Atr-002603 Amborella trichopoda 47.53 2.00e-44 173.00
IUUC-Apl-003819 Anas platyrhynchos 73.97 0.00e+00 1132.00
IUUC-Aca-004970 Anolis carolinensis 61.80 0.00e+00 957.00
IUUC-Ame-011845 Astyanax mexicanus 67.67 0.00e+00 1033.00
IUUC-Bta-012600 Bos taurus 82.75 0.00e+00 1272.00
IUUC-Bci-013703 Botrytis cinerea 30.36 1.00e-10 61.20
IUUC-Cja-018864 Callithrix jacchus 93.81 0.00e+00 1500.00
IUUC-Cfa-020558 Canis familiaris 86.83 0.00e+00 1327.00
IUUC-Cpo-022125 Cavia porcellus 83.60 0.00e+00 1337.00
IUUC-Cre-022645 Chlamydomonas reinhardtii 30.86 6.00e-22 99.40
IUUC-Csa-023649 Chlorocebus sabaeus 94.55 0.00e+00 1501.00
IUUC-Cin-025454 Ciona intestinalis 51.50 0.00e+00 747.00
IUUC-Cgl-026498 Colletotrichum gloeosporioides 34.27 1.00e-12 68.20
IUUC-Cne-026942 Cryptococcus neoformans 45.73 7.00e-29 119.00
IUUC-Dre-028200 Danio rerio 66.54 0.00e+00 1070.00
IUUC-Dno-029523 Dasypus novemcinctus 85.00 0.00e+00 983.00
IUUC-Dor-031084 Dipodomys ordii 84.56 0.00e+00 1363.00
IUUC-Eca-033266 Equus caballus 84.65 0.00e+00 1297.00
IUUC-Eeu-035077 Erinaceus europaeus 86.44 1.00e-152 532.00
IUUC-Fca-035685 Felis catus 78.78 0.00e+00 1199.00
IUUC-Fal-037550 Ficedula albicollis 72.84 0.00e+00 1058.00
IUUC-Gmo-039452 Gadus morhua 64.81 0.00e+00 1037.00
IUUC-Ggr-039874 Gaeumannomyces graminis 28.18 5.00e-09 56.20
IUUC-Gga-040484 Gallus gallus 73.72 0.00e+00 1197.00
IUUC-Gac-042196 Gasterosteus aculeatus 65.09 0.00e+00 1043.00
IUUC-Gma-042831 Glycine max 33.18 8.00e-49 188.00
IUUC-Ggo-045414 Gorilla gorilla 99.88 0.00e+00 1570.00
IUUC-Hvu-047471 Hordeum vulgare 34.89 4.00e-46 179.00
IUUC-Itr-047867 Ictidomys tridecemlineatus 83.19 0.00e+00 1286.00
IUUC-Lch-050162 Latimeria chalumnae 63.41 0.00e+00 991.00
IUUC-Loc-051806 Lepisosteus oculatus 67.75 0.00e+00 1085.00
IUUC-Lma-052953 Leptosphaeria maculans 27.03 1.00e-10 61.60
IUUC-Laf-053671 Loxodonta africana 84.96 0.00e+00 1338.00
IUUC-Mcc-055513 Macaca mulatta 98.25 0.00e+00 1559.00
IUUC-Mpo-057318 Magnaporthe poae 30.86 2.00e-09 57.40
IUUC-Mla-059148 Melampsora laricipopulina 41.62 1.00e-31 130.00
IUUC-Mga-059759 Meleagris gallopavo 73.33 0.00e+00 1100.00
IUUC-Mvi-060378 Microbotryum violaceum 44.00 4.00e-32 132.00
IUUC-Mmr-060600 Microcebus murinus 78.58 0.00e+00 1184.00
IUUC-Mdo-061911 Monodelphis domestica 77.47 0.00e+00 1215.00
IUUC-Mmu-063738 Mus musculus 72.57 0.00e+00 1172.00
IUUC-Mpu-065696 Mustela putorius furo 84.96 0.00e+00 1305.00
IUUC-Mlu-067538 Myotis lucifugus 76.95 0.00e+00 1223.00
IUUC-Opr-070813 Ochotona princeps 74.72 0.00e+00 660.00
IUUC-Ont-072292 Oreochromis niloticus 66.21 0.00e+00 1039.00
IUUC-Olo-080527 Oryza longistaminata 43.68 3.00e-35 143.00
IUUC-Oni-082510 Oryza nivara 32.46 1.00e-45 178.00
IUUC-Oru-084985 Oryza rufipogon 32.46 1.00e-45 178.00
IUUC-Ola-086416 Oryzias latipes 65.34 0.00e+00 1045.00
IUUC-Oga-088221 Otolemur garnettii 87.24 0.00e+00 1432.00
IUUC-Oar-089604 Ovis aries 78.61 0.00e+00 1170.00
IUUC-Ptr-090559 Pan troglodytes 97.64 0.00e+00 1557.00
IUUC-Pan-092855 Papio anubis 98.13 0.00e+00 1561.00
IUUC-Psi-093763 Pelodiscus sinensis 75.89 0.00e+00 870.00
IUUC-Pma-094339 Petromyzon marinus 63.65 0.00e+00 955.00
IUUC-Ppa-095940 Physcomitrella patens 36.07 7.00e-50 192.00
IUUC-Pfo-096243 Poecilia formosa 63.30 0.00e+00 1023.00
IUUC-Pab-098243 Pongo abelii 99.13 0.00e+00 1539.00
IUUC-Pop-099561 Populus trichocarpa 34.51 5.00e-51 196.00
IUUC-Pca-100503 Procavia capensis 81.55 0.00e+00 1272.00
IUUC-Pva-102240 Pteropus vampyrus 83.81 0.00e+00 1068.00
IUUC-Pgr-103644 Puccinia graminis 46.95 2.00e-31 130.00
IUUC-Ptt-103867 Puccinia triticina 44.44 2.00e-32 133.00
IUUC-Rno-105345 Rattus norvegicus 73.63 0.00e+00 1193.00
IUUC-Sha-106618 Sarcophilus harrisii 77.30 0.00e+00 1220.00
IUUC-Smo-109319 Selaginella moellendorffii 45.09 8.00e-46 178.00
IUUC-Stu-112842 Solanum tuberosum 46.19 2.00e-45 177.00
IUUC-Sar-113651 Sorex araneus 71.77 5.00e-89 322.00
IUUC-Sre-115182 Sporisorium reilianum 43.62 7.00e-34 138.00
IUUC-Ssc-116081 Sus scrofa 81.62 0.00e+00 1303.00
IUUC-Tgu-116538 Taeniopygia guttata 77.53 0.00e+00 994.00
IUUC-Tru-117599 Takifugu rubripes 64.03 0.00e+00 1020.00
IUUC-Tca-121614 Theobroma cacao 45.81 3.00e-46 180.00
IUUC-Tae-123299 Triticum aestivum 34.40 2.00e-45 177.00
IUUC-Tme-127149 Tuber melanosporum 48.55 5.00e-27 115.00
IUUC-Ttr-128522 Tursiops truncatus 84.04 0.00e+00 1345.00
IUUC-Vvi-131413 Vitis vinifera 47.20 2.00e-45 177.00
IUUC-Xtr-132432 Xenopus tropicalis 68.38 0.00e+00 1108.00
IUUC-Xma-133516 Xiphophorus maculatus 64.23 0.00e+00 1044.00
Created Date 25-Jun-2017

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