iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000206500.9	ENST00000376750.6	ENSP00000365941.2
ENSG00000206500.9	ENST00000383611.2	ENSP00000373106.2

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	RepTar	miRcode	RAID2
Protein-protein Interaction
Mentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.10e-07	31.1	88	134

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkw..pglknssskefrCPlC 45
           C++C  +f+d p++l C H f++ Cl  +w  p     +     CP C
   Q: 88   CPLCGGSFED-PVLLACEHSFCRACLaRRWgtPPATGTEASPTACPCC 134
           **********.999****************88555556666667**99 PP

Organism

Homo sapiens

Functional Description
(View)

May play a role in prolonged long term-potentiation (LTP) maintenance.

Protein Sequence
(Fasta)

MWWRDLTRLR LWLKREAIPG EGRKAAKVNA GVGEKGIYTA SSRGGPPSAR SKAVTVVAEG 60
AASRSWLSMD APELGPGLVE RLEQLATCPL CGGSFEDPVL LACEHSFCRA CLARRWGTPP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGTTACGC AAGGCCTGGT GTTTACCTCC CGTGGGAGCC TCCTCCCTCC CTATAAAGCC 60
TGATGTGGTG GAGAGATTTG ACGAGACTGA GACTCTGGTT GAAGAGAGAG GCAATCCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0008270--F:zinc ion binding

KEGG

hsa:80352

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-018750	Callithrix jacchus	93.10	0.00e+00	655.00
IUUC-Cfa-020026	Canis familiaris	85.88	1.00e-143	502.00
IUUC-Csa-024011	Chlorocebus sabaeus	96.67	0.00e+00	719.00
IUUC-Dor-030883	Dipodomys ordii	83.77	1.00e-179	622.00
IUUC-Ete-033195	Echinops telfairi	73.28	1.00e-120	426.00
IUUC-Eca-034051	Equus caballus	74.79	6.00e-118	417.00
IUUC-Itr-047886	Ictidomys tridecemlineatus	89.46	3.00e-165	574.00
IUUC-Laf-053446	Loxodonta africana	87.46	2.00e-134	472.00
IUUC-Mcc-055579	Macaca mulatta	95.01	0.00e+00	699.00
IUUC-Mmu-063921	Mus musculus	83.81	1.00e-150	525.00
IUUC-Oga-088846	Otolemur garnettii	85.92	2.00e-164	572.00
IUUC-Ptr-091464	Pan troglodytes	99.43	2.00e-87	315.00
IUUC-Pan-092055	Papio anubis	96.43	0.00e+00	718.00
IUUC-Pab-098409	Pongo abelii	97.11	2.00e-141	494.00
IUUC-Pca-100434	Procavia capensis	73.27	1.00e-139	489.00
IUUC-Pva-102973	Pteropus vampyrus	81.82	2.00e-172	598.00
IUUC-Rno-105103	Rattus norvegicus	82.39	6.00e-160	556.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence