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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063552
Ensembl Protein ID ENSMUSP00000130492.1
UniProt Accession P29595; NEDD8_MOUSE
Genbank Protein ID BAA01719.1; AAH04625.1
Protein Name NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; Ubiquitin-like protein Nedd8
Genbank Nucleotide ID D10918; BC004625
Gene Name Nedd8; Nedd-8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000010376.14 ENSMUST00000163750.7 ENSMUSP00000130492.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UBL/NEDD8 4.80e-44 149.6 1 76
ULD/UDP/UBQ/UBQ_PIM 2.90e-22 79.5 1 71
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UBL/NEDD8
   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           mlikvktLtgkeiei+ie++d++erikerveekeGiPP+qqrliy+Gkq++d+ktaady++ +gsvLhLvLaLrGG
   Q: 1    MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGG 76
           89*************************************************************************9 PP
   

   ULD/UDP/UBQ/UBQ_PIM
   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
           m ++vktl+gke+e+++++ d+ve+ Ke+++++ g+pp+qq+LIy+Gk+++D++t  +++i  gsv+hlv+
   Q: 1    MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVL 71
           789******************************************************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
 Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
Protein Sequence
(Fasta)
MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK 60
ILGGSVLHLV LALRGGGGLG Q 81
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063552|ULD,NEDD8;ULD,UBQ_PIM|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTGCCGTGG AGTGCTGGGA AGCGGCAGCG GCAGCAGCGA CCACAGCGGG AGAAGCAGCA 60
CTCTAGCCGC CTGCAACCCC AACCTGGGAA GAAGATGCTA ATTAAAGTGA AGGTGGGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063552|ULD,NEDD8;ULD,UBQ_PIM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
Pfam

PF00240--ubiquitin
PRINTS

PR00348--UBIQUITIN
SMART

SM00213--UBQ
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0031625--F:ubiquitin protein ligase binding
GO:0008104--P:protein localization
GO:0045116--P:protein neddylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0014070--P:response to organic cyclic compound
KEGG mmu:18002
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001930 Ailuropoda melanoleuca 98.33 5.00e-21 92.00
IUUC-Atr-003172 Amborella trichopoda 82.35 3.00e-28 115.00
IUUC-Ago-008002 Ashbya gossypii 61.76 5.00e-20 88.60
IUUC-Acl-008037 Aspergillus clavatus 76.47 1.00e-25 107.00
IUUC-Afu-008979 Aspergillus fumigatus 70.59 8.00e-24 101.00
IUUC-Ani-009466 Aspergillus nidulans 76.47 2.00e-25 106.00
IUUC-Ang-009839 Aspergillus niger 75.00 4.00e-25 105.00
IUUC-Ame-011045 Astyanax mexicanus 98.53 1.00e-25 107.00
IUUC-Bgr-011975 Blumeria graminis 69.12 2.00e-22 96.30
IUUC-Bta-013565 Bos taurus 95.31 2.00e-22 96.70
IUUC-Cel-018445 Caenorhabditis elegans 86.76 2.00e-20 89.70
IUUC-Cja-019714 Callithrix jacchus 100.00 4.00e-24 102.00
IUUC-Cfa-020576 Canis familiaris 98.33 5.00e-21 92.00
IUUC-Cpo-022447 Cavia porcellus 93.85 2.00e-22 96.70
IUUC-Csa-023443 Chlorocebus sabaeus 94.12 3.00e-32 129.00
IUUC-Cho-024788 Choloepus hoffmanni 100.00 3.00e-26 108.00
IUUC-Cin-025290 Ciona intestinalis 89.71 1.00e-22 97.40
IUUC-Cgl-026712 Colletotrichum gloeosporioides 69.12 5.00e-22 95.10
IUUC-Dre-028273 Danio rerio 98.53 2.00e-25 106.00
IUUC-Dno-029313 Dasypus novemcinctus 100.00 1.00e-18 86.70
IUUC-Dor-030213 Dipodomys ordii 100.00 3.00e-26 109.00
IUUC-Dse-031407 Dothistroma septosporum 75.00 1.00e-24 103.00
IUUC-Dme-031610 Drosophila melanogaster 92.65 2.00e-32 129.00
IUUC-Ete-032442 Echinops telfairi 100.00 4.00e-26 108.00
IUUC-Eca-033619 Equus caballus 100.00 4.00e-24 102.00
IUUC-Eeu-035250 Erinaceus europaeus 100.00 4.00e-24 102.00
IUUC-Fca-036565 Felis catus 96.72 2.00e-21 92.80
IUUC-Fal-036836 Ficedula albicollis 90.91 2.00e-21 93.60
IUUC-Fox-037878 Fusarium oxysporum 70.59 9.00e-23 97.80
IUUC-Fso-038359 Fusarium solani 70.59 7.00e-23 98.20
IUUC-Gmo-038699 Gadus morhua 98.46 3.00e-23 99.40
IUUC-Ggr-039872 Gaeumannomyces graminis 72.06 2.00e-23 100.00
IUUC-Gga-041132 Gallus gallus 98.53 1.00e-25 108.00
IUUC-Gac-042098 Gasterosteus aculeatus 98.53 2.00e-25 106.00
IUUC-Ggo-044777 Gorilla gorilla 100.00 6.00e-21 91.70
IUUC-Hsa-045911 Homo sapiens 100.00 4.00e-24 102.00
IUUC-Hvu-047076 Hordeum vulgare 82.09 4.00e-18 82.00
IUUC-Itr-048900 Ictidomys tridecemlineatus 100.00 2.00e-26 109.00
IUUC-Lch-050564 Latimeria chalumnae 98.53 2.00e-25 106.00
IUUC-Lma-053069 Leptosphaeria maculans 76.47 4.00e-25 105.00
IUUC-Laf-053906 Loxodonta africana 95.59 2.00e-24 103.00
IUUC-Mcc-054619 Macaca mulatta 85.25 1.00e-23 100.00
IUUC-Meu-056784 Macropus eugenii 98.46 3.00e-23 99.40
IUUC-Mor-057128 Magnaporthe oryzae 75.00 2.00e-24 102.00
IUUC-Mpo-057329 Magnaporthe poae 73.53 6.00e-24 101.00
IUUC-Mvi-060369 Microbotryum violaceum 69.12 3.00e-22 96.30
IUUC-Mmr-060807 Microcebus murinus 96.08 3.00e-14 71.20
IUUC-Mdo-062773 Monodelphis domestica 95.08 2.00e-20 90.10
IUUC-Mpu-065984 Mustela putorius furo 96.88 3.00e-23 99.40
IUUC-Nfi-068282 Neosartorya fischeri 70.59 8.00e-24 101.00
IUUC-Ncr-068922 Neurospora crassa 72.06 2.00e-23 100.00
IUUC-Nle-069841 Nomascus leucogenys 100.00 7.00e-22 97.10
IUUC-Ocu-074716 Oryctolagus cuniculus 100.00 4.00e-24 102.00
IUUC-Opu-083943 Oryza punctata 57.58 3.00e-17 79.70
IUUC-Olu-087844 Ostreococcus lucimarinus 86.57 3.00e-19 85.90
IUUC-Oga-088993 Otolemur garnettii 96.08 3.00e-14 71.20
IUUC-Oar-089805 Ovis aries 96.72 3.00e-21 92.40
IUUC-Ptr-091370 Pan troglodytes 96.08 3.00e-14 71.20
IUUC-Pan-092763 Papio anubis 100.00 4.00e-24 102.00
IUUC-Pno-095039 Phaeosphaeria nodorum 77.94 6.00e-26 108.00
IUUC-Pfo-096478 Poecilia formosa 98.53 1.00e-25 107.00
IUUC-Pab-098633 Pongo abelii 98.46 2.00e-23 99.80
IUUC-Pca-100180 Procavia capensis 100.00 4.00e-24 102.00
IUUC-Pva-102640 Pteropus vampyrus 100.00 4.00e-24 102.00
IUUC-Pgr-103621 Puccinia graminis 67.65 3.00e-22 95.90
IUUC-Pte-104313 Pyrenophora teres 76.47 1.00e-25 107.00
IUUC-Pyt-104549 Pyrenophora triticirepentis 75.00 5.00e-25 105.00
IUUC-Rno-105633 Rattus norvegicus 100.00 1.00e-24 103.00
IUUC-Sha-107504 Sarcophilus harrisii 91.18 3.00e-23 99.40
IUUC-Sja-107751 Schizosaccharomyces japonicus 79.41 3.00e-27 112.00
IUUC-Spo-108180 Schizosaccharomyces pombe 79.41 6.00e-27 111.00
IUUC-Sar-113327 Sorex araneus 100.00 4.00e-24 102.00
IUUC-Sre-114970 Sporisorium reilianum 80.88 1.00e-27 114.00
IUUC-Ssc-115698 Sus scrofa 93.75 1.00e-21 94.00
IUUC-Tru-118771 Takifugu rubripes 98.53 1.00e-25 107.00
IUUC-Tsy-118907 Tarsius syrichta 100.00 4.00e-24 102.00
IUUC-Tni-120655 Tetraodon nigroviridis 98.53 2.00e-25 106.00
IUUC-Tre-122155 Trichoderma reesei 70.59 9.00e-23 97.80
IUUC-Tvi-122440 Trichoderma virens 70.59 4.00e-23 99.00
IUUC-Tme-126933 Tuber melanosporum 73.53 1.00e-24 103.00
IUUC-Ttr-128587 Tursiops truncatus 92.65 7.00e-22 94.70
IUUC-Uma-129335 Ustilago maydis 80.88 2.00e-27 113.00
IUUC-Vda-129767 Verticillium dahliae 67.65 1.00e-21 94.40
IUUC-Vpa-130121 Vicugna pacos 96.92 6.00e-23 98.20
IUUC-Xtr-132345 Xenopus tropicalis 98.53 2.00e-25 106.00
IUUC-Xma-133886 Xiphophorus maculatus 98.39 3.00e-22 95.90
Created Date 25-Jun-2017

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