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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046769
Ensembl Protein ID ENSP00000314080.3
UniProt Accession Q14526; D3DTI4; HIC1_HUMAN
Genbank Protein ID AAD09201.1; EAW90562.1; EAW90563.1
Protein Name Hypermethylated in cancer 1 protein; Zinc finger and BTB domain-containing protein 29
Genbank Nucleotide ID L41919; AC090617; CH471108
Gene Name HIC1; ZBTB29
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000177374.12 ENST00000322941.3 ENSP00000314080.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.70e-12 48.1 47 106
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgkl 65
           +Dvi+vv++  f+ahk vLaasS ++++l  +        +  +++ d v+p vfr +l+F+Ytg+l
   Q: 47   CDVIIVVQNALFRAHKNVLAASSAYLKSLVVH-------DNLLNLDhDmVSPAVFRLVLDFIYTGRL 106
           9*****************************77.......4566677678****************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
 Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
Protein Sequence
(Fasta)
MTFPEADILL KSGECAGQTM LDTMEAPGHS RQLLLQLNNQ RTKGFLCDVI IVVQNALFRA 60
HKNVLAASSA YLKSLVVHDN LLNLDHDMVS PAVFRLVLDF IYTGRLADGA EAAAAAAVAP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046769|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCGAGCAGC GGCGCGACAG TGCGGGGTCC CCTTTCTCCC AGAAGAGACG TCACCCACAC 60
AAACCTGACC TTCACGTGGG GCGCGGGACC TTGCGGGGTC CCAGCCGCAG GCGCCCCTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046769|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR028424--HIC1
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0042826--F:histone deacetylase binding
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0007275--P:multicellular organism development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0043517--P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG hsa:3090
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001347 Ailuropoda melanoleuca 92.38 4.00e-153 535.00
IUUC-Aca-004680 Anolis carolinensis 57.10 2.00e-68 253.00
IUUC-Ame-010967 Astyanax mexicanus 60.24 1.00e-93 337.00
IUUC-Bta-013567 Bos taurus 97.86 2.00e-165 575.00
IUUC-Cja-019621 Callithrix jacchus 98.94 7.00e-47 179.00
IUUC-Cfa-020731 Canis familiaris 96.73 0.00e+00 903.00
IUUC-Cpo-021326 Cavia porcellus 93.62 0.00e+00 906.00
IUUC-Csa-023645 Chlorocebus sabaeus 99.32 0.00e+00 906.00
IUUC-Dre-028027 Danio rerio 57.64 2.00e-91 330.00
IUUC-Dno-028900 Dasypus novemcinctus 95.56 0.00e+00 881.00
IUUC-Fal-036980 Ficedula albicollis 56.19 3.00e-167 582.00
IUUC-Gga-040708 Gallus gallus 70.61 3.00e-105 375.00
IUUC-Ggo-044591 Gorilla gorilla 100.00 5.00e-140 491.00
IUUC-Itr-048627 Ictidomys tridecemlineatus 96.27 0.00e+00 899.00
IUUC-Lch-049412 Latimeria chalumnae 54.34 0.00e+00 631.00
IUUC-Loc-051883 Lepisosteus oculatus 63.47 4.00e-93 335.00
IUUC-Laf-053358 Loxodonta africana 94.29 2.00e-169 588.00
IUUC-Mcc-054981 Macaca mulatta 99.30 0.00e+00 867.00
IUUC-Meu-056181 Macropus eugenii 71.93 4.00e-113 401.00
IUUC-Mga-059592 Meleagris gallopavo 73.54 2.00e-102 365.00
IUUC-Mmr-061560 Microcebus murinus 96.22 0.00e+00 855.00
IUUC-Mdo-062511 Monodelphis domestica 81.45 6.00e-91 328.00
IUUC-Mmu-064258 Mus musculus 95.42 0.00e+00 860.00
IUUC-Mpu-065911 Mustela putorius furo 96.78 0.00e+00 865.00
IUUC-Mlu-067575 Myotis lucifugus 80.36 2.00e-127 449.00
IUUC-Ont-072493 Oreochromis niloticus 65.97 2.00e-80 293.00
IUUC-Ola-086584 Oryzias latipes 61.66 3.00e-89 322.00
IUUC-Oga-088774 Otolemur garnettii 96.18 0.00e+00 942.00
IUUC-Ptr-090491 Pan troglodytes 100.00 5.00e-122 431.00
IUUC-Pma-094179 Petromyzon marinus 70.51 4.00e-31 125.00
IUUC-Pfo-096282 Poecilia formosa 58.86 7.00e-87 315.00
IUUC-Pab-098488 Pongo abelii 99.17 8.00e-178 617.00
IUUC-Pca-100667 Procavia capensis 96.89 8.00e-143 501.00
IUUC-Pva-102421 Pteropus vampyrus 96.32 0.00e+00 885.00
IUUC-Rno-105528 Rattus norvegicus 92.03 0.00e+00 845.00
IUUC-Sar-113478 Sorex araneus 99.17 9.00e-120 424.00
IUUC-Ssc-115420 Sus scrofa 94.27 0.00e+00 862.00
IUUC-Tgu-116642 Taeniopygia guttata 71.88 1.00e-106 380.00
IUUC-Tru-118583 Takifugu rubripes 60.44 4.00e-85 309.00
IUUC-Xtr-132210 Xenopus tropicalis 59.06 0.00e+00 664.00
Created Date 25-Jun-2017

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