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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Hsa-046904
Ensembl Protein ID ENSP00000334061.5
UniProt Accession Q9UBN7; O94975; Q6NT75; Q7L3E5; Q96CY0; HDAC6_HUMAN
Genbank Protein ID AAD29048.1; BAA74924.2; CAA09893.1; EAW50748.1; AAH13737.1; AAH69243.1
Protein Name Histone deacetylase 6
Genbank Nucleotide ID AF132609; AB020708; AJ011972; AF196971; BC013737; BC069243
Gene Name HDAC6; KIAA0901; JM21
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000094631.18 ENST00000334136.9 ENSP00000334061.5
ENSG00000094631.18 ENST00000426196.5 ENSP00000402189.1
ENSG00000094631.18 ENST00000430858.1 ENSP00000397697.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWAS CentralOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/ZnF_UBP ZnF_UBP 15347674; 17512543
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Interacts with ZMYND15 (By similarity). Interacts with SIRT2 (via both phosphorylated, unphosphorylated, active or inactive forms); the interaction is necessary for the complex to interact with alpha-tubulin. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with BBIP10, CBFA2T3, CYLD, DDIT3/CHOP, F-actin and HDAC11. Interacts with FAM65B (PubMed:24687993).
Interacts with ZMYND15 (By similarity). Interacts with SIRT2 (via both phosphorylated, unphosphorylated, active or inactive forms); the interaction is necessary for the complex to interact with alpha-tubulin. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with BBIP10, CBFA2T3, CYLD, DDIT3/CHOP, F-actin and HDAC11. Interacts with FAM65B (PubMed:24687993).
Protein Sequence
(Fasta)
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV KKKGKMKKLG 60
QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL WDDSFPEGPE RLHAIKEQLI 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046904|UBD,ZnF_UBP|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGCCCGCCCG CGCTACGTCA TCACGGCGCG TCGCGCGGGA AGTCGCGGGG AAAAGGTAAG 60
ATGCCCCTTC CTAATTCCCT CGCTTCCTTG CTTGCTCTCC AGACACCGCC GACCCGAAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046904|UBD,ZnF_UBP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0966--Cell projection
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50271--ZF_UBP

Pfam

PF00850--Hist_deacetyl
PF02148--zf-UBP

PRINTS

PR01270--HDASUPER

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005901--C:caveola
GO:0031252--C:cell leading edge
GO:0005737--C:cytoplasm
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0000118--C:histone deacetylase complex
GO:0016234--C:inclusion body
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005771--C:multivesicular body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043204--C:perikaryon
GO:0048471--C:perinuclear region of cytoplasm
GO:0043014--F:alpha-tubulin binding
GO:0008013--F:beta-catenin binding
GO:0001047--F:core promoter binding
GO:0070840--F:dynein complex binding
GO:0019899--F:enzyme binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0051879--F:Hsp90 protein binding
GO:0008017--F:microtubule binding
GO:0051787--F:misfolded protein binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0031593--F:polyubiquitin binding
GO:0048156--F:tau protein binding
GO:0042903--F:tubulin deacetylase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0070842--P:aggresome assembly
GO:0006914--P:autophagy
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071218--P:cellular response to misfolded protein
GO:0035967--P:cellular response to topologically incorrect protein
GO:0060271--P:cilium assembly
GO:0048668--P:collateral sprouting
GO:0060997--P:dendritic spine morphogenesis
GO:0016575--P:histone deacetylation
GO:0070846--P:Hsp90 deacetylation
GO:0006886--P:intracellular protein transport
GO:0032418--P:lysosome localization
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0051646--P:mitochondrion localization
GO:0010727--P:negative regulation of hydrogen peroxide metabolic process
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0051354--P:negative regulation of oxidoreductase activity
GO:0043242--P:negative regulation of protein complex disassembly
GO:0045861--P:negative regulation of proteolysis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0034983--P:peptidyl-lysine deacetylation
GO:0070845--P:polyubiquitinated misfolded protein transport
GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly
GO:0010634--P:positive regulation of epithelial cell migration
GO:1901300--P:positive regulation of hydrogen peroxide-mediated programmed cell death
GO:0010870--P:positive regulation of receptor biosynthetic process
GO:0009967--P:positive regulation of signal transduction
GO:0043241--P:protein complex disassembly
GO:0006476--P:protein deacetylation
GO:0000209--P:protein polyubiquitination
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0010506--P:regulation of autophagy
GO:0070201--P:regulation of establishment of protein localization
GO:0045598--P:regulation of fat cell differentiation
GO:0040029--P:regulation of gene expression, epigenetic
GO:0016241--P:regulation of macroautophagy
GO:0060632--P:regulation of microtubule-based movement
GO:1903146--P:regulation of mitophagy
GO:0031647--P:regulation of protein stability
GO:0010469--P:regulation of receptor activity
GO:0070848--P:response to growth factor
GO:0051788--P:response to misfolded protein
GO:0010033--P:response to organic substance
GO:0009636--P:response to toxic substance
GO:0006351--P:transcription, DNA-templated
GO:0090042--P:tubulin deacetylation
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG hsa:10013
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000749 Aegilops tauschii 41.61 5.00e-71 262.00
IUUC-Aml-002087 Ailuropoda melanoleuca 80.17 0.00e+00 1853.00
IUUC-Atr-002745 Amborella trichopoda 44.38 1.00e-80 294.00
IUUC-Aca-004303 Anolis carolinensis 50.96 0.00e+00 1162.00
IUUC-Aly-006432 Arabidopsis lyrata 42.01 2.00e-80 293.00
IUUC-Ath-007355 Arabidopsis thaliana 42.78 2.00e-84 306.00
IUUC-Ago-007972 Ashbya gossypii 40.86 2.00e-77 284.00
IUUC-Acl-008187 Aspergillus clavatus 46.26 8.00e-83 301.00
IUUC-Afl-008399 Aspergillus flavus 53.95 7.00e-44 171.00
IUUC-Afu-008954 Aspergillus fumigatus 41.52 6.00e-72 265.00
IUUC-Ani-009142 Aspergillus nidulans 42.89 7.00e-75 275.00
IUUC-Ang-009522 Aspergillus niger 37.32 3.00e-44 173.00
IUUC-Aor-010069 Aspergillus oryzae 46.48 2.00e-73 270.00
IUUC-Ate-010291 Aspergillus terreus 46.36 1.00e-81 298.00
IUUC-Ame-010780 Astyanax mexicanus 50.25 0.00e+00 771.00
IUUC-Bta-013052 Bos taurus 73.52 0.00e+00 1665.00
IUUC-Bci-013789 Botrytis cinerea 40.57 6.00e-76 278.00
IUUC-Bdi-014007 Brachypodium distachyon 44.38 2.00e-81 296.00
IUUC-Bol-015468 Brassica oleracea 44.24 1.00e-83 304.00
IUUC-Bra-016680 Brassica rapa 44.24 9.00e-84 304.00
IUUC-Cel-018220 Caenorhabditis elegans 38.46 2.00e-145 509.00
IUUC-Cja-019473 Callithrix jacchus 91.92 0.00e+00 2105.00
IUUC-Cfa-020263 Canis familiaris 77.50 0.00e+00 1741.00
IUUC-Cpo-021691 Cavia porcellus 78.96 0.00e+00 1808.00
IUUC-Cre-022561 Chlamydomonas reinhardtii 55.09 8.00e-56 209.00
IUUC-Csa-024223 Chlorocebus sabaeus 98.40 0.00e+00 2276.00
IUUC-Cgl-026709 Colletotrichum gloeosporioides 42.24 2.00e-74 274.00
IUUC-Cne-026978 Cryptococcus neoformans 46.83 9.00e-85 308.00
IUUC-Dre-028820 Danio rerio 56.79 0.00e+00 893.00
IUUC-Dno-029160 Dasypus novemcinctus 69.66 0.00e+00 1581.00
IUUC-Dor-030859 Dipodomys ordii 71.50 0.00e+00 1651.00
IUUC-Dse-031186 Dothistroma septosporum 43.55 2.00e-75 277.00
IUUC-Dme-031963 Drosophila melanogaster 44.96 0.00e+00 668.00
IUUC-Ete-032279 Echinops telfairi 66.27 3.00e-151 529.00
IUUC-Eca-033842 Equus caballus 82.50 0.00e+00 1921.00
IUUC-Eeu-034487 Erinaceus europaeus 76.79 6.00e-153 535.00
IUUC-Fca-036430 Felis catus 78.92 0.00e+00 1770.00
IUUC-Fox-038067 Fusarium oxysporum 41.60 2.00e-74 273.00
IUUC-Fso-038263 Fusarium solani 41.86 1.00e-75 278.00
IUUC-Ggr-040062 Gaeumannomyces graminis 43.02 7.00e-75 275.00
IUUC-Gma-043738 Glycine max 49.53 3.00e-85 309.00
IUUC-Ggo-045022 Gorilla gorilla 99.41 0.00e+00 2311.00
IUUC-Hvu-047285 Hordeum vulgare 44.97 5.00e-82 298.00
IUUC-Itr-048484 Ictidomys tridecemlineatus 79.49 0.00e+00 1834.00
IUUC-Kpa-049281 Komagataella pastoris 40.53 9.00e-80 291.00
IUUC-Lch-050330 Latimeria chalumnae 46.24 0.00e+00 944.00
IUUC-Lpe-051214 Leersia perrieri 45.28 6.00e-83 301.00
IUUC-Lma-053263 Leptosphaeria maculans 44.76 5.00e-87 315.00
IUUC-Laf-053386 Loxodonta africana 71.89 0.00e+00 1658.00
IUUC-Mcc-055530 Macaca mulatta 98.48 0.00e+00 2278.00
IUUC-Meu-056442 Macropus eugenii 67.78 0.00e+00 957.00
IUUC-Mor-057095 Magnaporthe oryzae 39.85 6.00e-78 285.00
IUUC-Mpo-057389 Magnaporthe poae 43.02 4.00e-75 276.00
IUUC-Mtr-058463 Medicago truncatula 46.56 1.00e-85 310.00
IUUC-Mla-059143 Melampsora laricipopulina 44.57 1.00e-80 294.00
IUUC-Mmr-060637 Microcebus murinus 87.76 0.00e+00 2065.00
IUUC-Mdo-062198 Monodelphis domestica 66.71 0.00e+00 1053.00
IUUC-Mmu-063346 Mus musculus 74.57 0.00e+00 1717.00
IUUC-Mac-064630 Musa acuminata 44.79 6.00e-83 301.00
IUUC-Mpu-065884 Mustela putorius furo 78.63 0.00e+00 1819.00
IUUC-Mlu-068117 Myotis lucifugus 77.55 0.00e+00 1788.00
IUUC-Nfi-068404 Neosartorya fischeri 45.72 6.00e-83 302.00
IUUC-Ncr-068672 Neurospora crassa 43.68 1.00e-76 281.00
IUUC-Nle-069868 Nomascus leucogenys 98.69 0.00e+00 787.00
IUUC-Opr-071074 Ochotona princeps 71.68 0.00e+00 1131.00
IUUC-Ont-072246 Oreochromis niloticus 45.85 0.00e+00 947.00
IUUC-Oan-072911 Ornithorhynchus anatinus 68.92 1.00e-106 380.00
IUUC-Ocu-074627 Oryctolagus cuniculus 78.39 0.00e+00 1829.00
IUUC-Oba-075489 Oryza barthii 44.69 1.00e-81 297.00
IUUC-Obr-076150 Oryza brachyantha 44.83 3.00e-82 300.00
IUUC-Ogl-077437 Oryza glaberrima 44.69 9.00e-82 298.00
IUUC-Ogu-078370 Oryza glumaepatula 45.00 1.00e-82 301.00
IUUC-Oin-079210 Oryza indica 45.00 1.00e-82 301.00
IUUC-Olo-080971 Oryza longistaminata 45.99 4.00e-72 265.00
IUUC-Oni-082031 Oryza nivara 45.00 2.00e-82 300.00
IUUC-Opu-083471 Oryza punctata 44.27 5.00e-82 298.00
IUUC-Oru-084755 Oryza rufipogon 45.00 1.00e-82 300.00
IUUC-Osa-085447 Oryza sativa 45.00 1.00e-82 300.00
IUUC-Oga-089155 Otolemur garnettii 85.19 0.00e+00 1978.00
IUUC-Oar-089620 Ovis aries 73.36 0.00e+00 1655.00
IUUC-Ptr-090812 Pan troglodytes 99.43 0.00e+00 1396.00
IUUC-Pan-092340 Papio anubis 98.65 0.00e+00 2282.00
IUUC-Pma-094386 Petromyzon marinus 53.91 0.00e+00 808.00
IUUC-Pno-095131 Phaeosphaeria nodorum 47.70 7.00e-73 268.00
IUUC-Ppa-095550 Physcomitrella patens 49.09 3.00e-87 316.00
IUUC-Pfo-096110 Poecilia formosa 52.60 0.00e+00 713.00
IUUC-Pab-098422 Pongo abelii 97.64 0.00e+00 2247.00
IUUC-Pop-099174 Populus trichocarpa 44.69 9.00e-80 291.00
IUUC-Pca-100833 Procavia capensis 71.04 0.00e+00 1543.00
IUUC-Ppe-101644 Prunus persica 43.49 5.00e-86 311.00
IUUC-Pva-102410 Pteropus vampyrus 74.28 0.00e+00 1671.00
IUUC-Ptt-103841 Puccinia triticina 39.29 2.00e-76 280.00
IUUC-Pte-104383 Pyrenophora teres 43.85 6.00e-82 299.00
IUUC-Pyt-104427 Pyrenophora triticirepentis 44.12 5.00e-82 299.00
IUUC-Rno-105131 Rattus norvegicus 71.89 0.00e+00 1644.00
IUUC-Sce-106274 Saccharomyces cerevisiae 39.00 4.00e-78 285.00
IUUC-Sha-106661 Sarcophilus harrisii 55.65 0.00e+00 797.00
IUUC-Sja-107915 Schizosaccharomyces japonicus 42.28 2.00e-84 306.00
IUUC-Spo-108300 Schizosaccharomyces pombe 45.36 3.00e-83 303.00
IUUC-Smo-109615 Selaginella moellendorffii 44.17 3.00e-86 313.00
IUUC-Sit-110160 Setaria italica 44.65 1.00e-77 284.00
IUUC-Sly-111164 Solanum lycopersicum 41.61 1.00e-78 287.00
IUUC-Stu-112685 Solanum tuberosum 41.69 1.00e-66 248.00
IUUC-Sar-113692 Sorex araneus 66.61 0.00e+00 766.00
IUUC-Sbi-114301 Sorghum bicolor 45.03 1.00e-77 284.00
IUUC-Sre-115013 Sporisorium reilianum 43.77 8.00e-84 305.00
IUUC-Ssc-115724 Sus scrofa 75.96 0.00e+00 1655.00
IUUC-Tgu-116605 Taeniopygia guttata 47.47 0.00e+00 669.00
IUUC-Tru-117614 Takifugu rubripes 55.92 0.00e+00 850.00
IUUC-Tsy-118807 Tarsius syrichta 80.19 0.00e+00 1066.00
IUUC-Tni-119809 Tetraodon nigroviridis 54.46 0.00e+00 773.00
IUUC-Tca-121312 Theobroma cacao 45.99 9.00e-83 301.00
IUUC-Tre-121930 Trichoderma reesei 40.45 1.00e-76 281.00
IUUC-Tvi-122373 Trichoderma virens 37.61 5.00e-77 282.00
IUUC-Tae-123064 Triticum aestivum 42.39 1.00e-77 283.00
IUUC-Tme-127027 Tuber melanosporum 41.53 1.00e-69 257.00
IUUC-Tbe-127675 Tupaia belangeri 68.50 6.00e-130 458.00
IUUC-Ttr-128411 Tursiops truncatus 75.94 0.00e+00 1762.00
IUUC-Uma-129408 Ustilago maydis 47.08 2.00e-76 280.00
IUUC-Vda-129994 Verticillium dahliae 39.07 5.00e-71 262.00
IUUC-Vpa-130525 Vicugna pacos 80.85 3.00e-61 230.00
IUUC-Vvi-131038 Vitis vinifera 44.69 3.00e-84 306.00
IUUC-Xtr-132618 Xenopus tropicalis 54.12 0.00e+00 911.00
IUUC-Xma-133730 Xiphophorus maculatus 49.43 0.00e+00 698.00
IUUC-Yli-134680 Yarrowia lipolytica 42.31 2.00e-83 303.00
IUUC-Zma-135110 Zea mays 44.83 2.00e-78 286.00
Created Date 25-Jun-2017

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