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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046184
Ensembl Protein ID ENSP00000438085.2
UniProt Accession Q9NZ52; B7Z7E2; B7Z7M9; J3KRN0; Q15017; Q6IS16; Q9UJY3; GGA3_HUMAN
Genbank Protein ID AAF42848.1; AAF05709.1; AAF42849.1; BAA09926.1; BAH13578.1; BAH13665.1; EAW89258.1; AAH70044.1
Protein Name ADP-ribosylation factor-binding protein GGA3; Golgi-localized, gamma ear-containing, ARF-binding protein 3
Genbank Nucleotide ID AF219138; AF190864; AF219139; D63876; AK301895; AK302278; AC022211; BC070044
Gene Name GGA3; KIAA0154
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000125447.16 ENST00000538886.5 ENSP00000446421.2
ENSG00000125447.16 ENST00000621870.4 ENSP00000479464.1
ENSG00000125447.16 ENST00000621217.4 ENSP00000484733.1
ENSG00000125447.16 ENST00000537686.5 ENSP00000438085.2
ENSG00000125447.16 ENST00000578348.5 ENSP00000463288.1
ENSG00000125447.16 ENST00000582486.5 ENSP00000462629.1
ENSG00000125447.16 ENST00000580646.5 ENSP00000464574.1
ENSG00000125447.16 ENST00000583282.5 ENSP00000463115.1
ENSG00000125447.16 ENST00000584550.1 ENSP00000462279.1
ENSG00000125447.16 ENST00000578773.1 ENSP00000464268.1
ENSG00000125447.16 ENST00000584243.5 ENSP00000464318.1
ENSG00000125447.16 ENST00000582376.1 ENSP00000464365.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/GAT GAT 15494413; 15701688; 15966896; 16996030; 17494868
Classification
Family E-value Score Start End
UBD/Alpha-Helix/GAT 2.70e-49 168.1 171 297
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/GAT
   S: 1    deeksklLerLlkskkPeDLreAnkLikelvkededkaekikkliseleevksnvkllnemlselspegeepednellqelyetckaarpkl 92
           deeksklL++Llksk+P+DL+eAnkLik++vkede++++k++k++++leev++nv+ll+eml ++s+e++++ d+el++el+++c+++r++l
   Q: 171  DEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTL 262
           79****************************************************************************************** PP
   S: 93   lklieeeedndellaellkanDelnqvlnkykqlk 127
           +kl++e+ednd++l+++l+a+D+l++v+n+yk+++
   Q: 263  FKLASETEDNDNSLGDILQASDNLSRVINSYKTII 297
           ********************************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
Protein Sequence
(Fasta)
MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL AHKIQSPQEW 60
EALQALTVLE ACMKNCGRRF HNEVGKFRFL NELIKVVSPK YLGDRVSEKV KTKVIELLYS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046184|UBD,GAT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACAACAATTC AGGCCCTTGT CCCAAGTAGG AGGACATTCC CCAAGCAGGC GGGTAAAGTC 60
TCCTCCTGGT CAAGTGCTAA CGGTAAGGAT GGGCTTGGCG CCTACACACC CATCCCAATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046184|UBD,GAT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR008152--Clathrin_a/b/g-adaptin_app_Ig
IPR008153--Clathrin_g-adaptin_app
IPR013041--Coatomer/clathrin_app_Ig-like
IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR027422--GGA3
IPR002014--VHS_dom
PROSITE

PS50180--GAE
PS50909--GAT
PS50179--VHS
Pfam

PF02883--Alpha_adaptinC2
PF03127--GAT
PF00790--VHS
SMART

SM00809--Alpha_adaptinC2
SM00288--VHS
Gene Ontology

GO:0030131--C:clathrin adaptor complex
GO:0031901--C:early endosome membrane
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0055038--C:recycling endosome membrane
GO:0005802--C:trans-Golgi network
GO:0030306--F:ADP-ribosylation factor binding
GO:0044267--P:cellular protein metabolic process
GO:0006886--P:intracellular protein transport
GO:0061024--P:membrane organization
GO:0045732--P:positive regulation of protein catabolic process
GO:0016192--P:vesicle-mediated transport
KEGG hsa:23163
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002322 Ailuropoda melanoleuca 86.39 0.00e+00 956.00
IUUC-Apl-003683 Anas platyrhynchos 67.59 0.00e+00 825.00
IUUC-Aca-004859 Anolis carolinensis 68.13 0.00e+00 796.00
IUUC-Ago-007767 Ashbya gossypii 27.87 2.00e-16 80.90
IUUC-Ame-010868 Astyanax mexicanus 73.27 5.00e-124 438.00
IUUC-Bta-013431 Bos taurus 75.50 0.00e+00 644.00
IUUC-Cja-019158 Callithrix jacchus 95.16 0.00e+00 1119.00
IUUC-Cfa-020509 Canis familiaris 86.07 0.00e+00 987.00
IUUC-Cpo-021520 Cavia porcellus 81.15 0.00e+00 983.00
IUUC-Csa-023292 Chlorocebus sabaeus 97.93 0.00e+00 1158.00
IUUC-Cho-025040 Choloepus hoffmanni 86.79 7.00e-73 268.00
IUUC-Cin-025211 Ciona intestinalis 56.52 8.00e-88 318.00
IUUC-Csv-026066 Ciona savignyi 56.38 3.00e-95 342.00
IUUC-Cgl-026721 Colletotrichum gloeosporioides 27.00 1.00e-18 88.20
IUUC-Dre-028244 Danio rerio 71.26 1.00e-128 453.00
IUUC-Dno-029654 Dasypus novemcinctus 84.28 0.00e+00 1005.00
IUUC-Ete-033003 Echinops telfairi 77.74 6.00e-126 444.00
IUUC-Eca-034436 Equus caballus 87.84 0.00e+00 1037.00
IUUC-Eeu-034519 Erinaceus europaeus 86.80 7.00e-167 580.00
IUUC-Fca-035372 Felis catus 84.60 0.00e+00 944.00
IUUC-Fal-037437 Ficedula albicollis 69.29 0.00e+00 808.00
IUUC-Fso-038382 Fusarium solani 26.71 1.00e-16 81.60
IUUC-Gmo-038952 Gadus morhua 72.54 1.00e-133 470.00
IUUC-Gga-041130 Gallus gallus 71.66 0.00e+00 872.00
IUUC-Gac-041460 Gasterosteus aculeatus 71.86 2.00e-133 469.00
IUUC-Ggo-044495 Gorilla gorilla 96.24 0.00e+00 1159.00
IUUC-Itr-048345 Ictidomys tridecemlineatus 86.77 0.00e+00 1036.00
IUUC-Lch-049582 Latimeria chalumnae 65.74 0.00e+00 775.00
IUUC-Loc-051903 Lepisosteus oculatus 77.45 1.00e-132 467.00
IUUC-Laf-054207 Loxodonta africana 84.15 0.00e+00 966.00
IUUC-Mcc-055642 Macaca mulatta 96.68 0.00e+00 1149.00
IUUC-Meu-056386 Macropus eugenii 73.79 2.00e-123 436.00
IUUC-Mga-060101 Meleagris gallopavo 70.49 0.00e+00 826.00
IUUC-Mmr-060937 Microcebus murinus 90.96 0.00e+00 1058.00
IUUC-Mdo-062835 Monodelphis domestica 75.58 0.00e+00 763.00
IUUC-Mmu-064008 Mus musculus 84.56 0.00e+00 966.00
IUUC-Mpu-066397 Mustela putorius furo 85.38 0.00e+00 944.00
IUUC-Mlu-067731 Myotis lucifugus 87.43 0.00e+00 1073.00
IUUC-Nle-069975 Nomascus leucogenys 96.77 9.00e-167 580.00
IUUC-Opr-070313 Ochotona princeps 82.93 0.00e+00 898.00
IUUC-Ont-071992 Oreochromis niloticus 71.30 9.00e-129 454.00
IUUC-Ocu-074749 Oryctolagus cuniculus 81.94 0.00e+00 978.00
IUUC-Ola-086409 Oryzias latipes 67.16 1.00e-123 437.00
IUUC-Oga-088203 Otolemur garnettii 88.57 0.00e+00 939.00
IUUC-Oar-089423 Ovis aries 78.33 0.00e+00 979.00
IUUC-Ptr-090623 Pan troglodytes 98.65 0.00e+00 1031.00
IUUC-Pan-092274 Papio anubis 98.20 0.00e+00 1149.00
IUUC-Psi-093397 Pelodiscus sinensis 70.05 0.00e+00 822.00
IUUC-Pfo-096335 Poecilia formosa 71.77 7.00e-128 451.00
IUUC-Pab-097977 Pongo abelii 93.66 0.00e+00 1044.00
IUUC-Pca-100991 Procavia capensis 77.35 0.00e+00 808.00
IUUC-Pva-102285 Pteropus vampyrus 85.20 0.00e+00 1058.00
IUUC-Rno-105106 Rattus norvegicus 85.66 0.00e+00 1014.00
IUUC-Sha-106548 Sarcophilus harrisii 75.38 0.00e+00 884.00
IUUC-Sja-107801 Schizosaccharomyces japonicus 25.61 6.00e-15 75.90
IUUC-Ssc-116343 Sus scrofa 79.61 0.00e+00 953.00
IUUC-Tgu-117119 Taeniopygia guttata 72.74 0.00e+00 866.00
IUUC-Tru-118049 Takifugu rubripes 74.75 2.00e-129 456.00
IUUC-Tsy-119623 Tarsius syrichta 84.34 0.00e+00 971.00
IUUC-Tni-120803 Tetraodon nigroviridis 59.64 3.00e-131 462.00
IUUC-Ttr-129167 Tursiops truncatus 82.71 0.00e+00 984.00
IUUC-Vda-129948 Verticillium dahliae 25.73 1.00e-16 81.60
IUUC-Xtr-132922 Xenopus tropicalis 77.95 7.00e-144 504.00
Created Date 25-Jun-2017

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