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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047014
UUCD1 version UUC-HoS-00428
Ensembl Protein ID ENSP00000261819.3
UniProt Accession Q9UJX4; E9PFB2; Q8N4H7; Q9BQD4; APC5_HUMAN
Genbank Protein ID AAF05753.1; CAD97812.1; AAH01081.1; AAH01950.1; AAH06301.1; AAH34243.1
Protein Name Anaphase-promoting complex subunit 5; Cyclosome subunit 5
Genbank Nucleotide ID AF191339; AK025614; AC048337; BC001950; BC006301; BC034243
Gene Name ANAPC5; APC5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000089053.12 ENST00000539079.5 ENSP00000437857.1
ENSG00000089053.12 ENST00000541887.5 ENSP00000439875.1
ENSG00000089053.12 ENST00000261819.7 ENSP00000261819.3
ENSG00000089053.12 ENST00000535482.1 ENSP00000438754.1
ENSG00000089053.12 ENST00000539871.1 ENSP00000445191.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
circBaseCircNetmiRTarBasemicroRNA
TRANSFACmiRWalkRepTarmiRNAMap
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C APC_C 21107322; 16763193
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 29.63 4.30e-02 35.00 IUUC-Sce-106345
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKIAVLVL LNEMSRTGEG AVSLMERRRL 60
NQLLLPLLQG PDITLSKLYK LIEESCPQLA NSVQIRIKLM AEGELKDMEQ FFDDLSDSFS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047014|E3,APC_C|Homo sapiens
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Nucleotide Sequence
(Fasta)
AAGACCTGCG GACCTGGGCG TGGCGGAAGG CGCGCTGCGG CGCTGCTTTC TCGGTTGGGT 60
GTTTGAAATG GGAGATAGCG TCCCTGAGGA AGCTGCTGCG GCTTTCTGGG CTAGGTGGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047014|E3,APC_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR026000--Apc5_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
Pfam

PF12862--ANAPC5
SMART

SM00028--TPR
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019903--F:protein phosphatase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
KEGG hsa:51433
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000646 Aegilops tauschii 26.49 9.00e-13 69.30
IUUC-Aml-001228 Ailuropoda melanoleuca 96.96 0.00e+00 1425.00
IUUC-Atr-003077 Amborella trichopoda 35.71 5.00e-04 36.20
IUUC-Apl-003267 Anas platyrhynchos 86.02 0.00e+00 1308.00
IUUC-Aly-005908 Arabidopsis lyrata 26.16 1.00e-12 69.30
IUUC-Ath-007298 Arabidopsis thaliana 26.67 7.00e-13 69.70
IUUC-Acl-008249 Aspergillus clavatus 25.91 4.00e-15 77.00
IUUC-Afl-008627 Aspergillus flavus 22.87 6.00e-17 82.80
IUUC-Afu-008849 Aspergillus fumigatus 27.34 1.00e-15 79.00
IUUC-Ani-009400 Aspergillus nidulans 22.89 2.00e-11 64.70
IUUC-Ang-009751 Aspergillus niger 27.41 5.00e-16 80.10
IUUC-Aor-010070 Aspergillus oryzae 29.54 7.00e-16 78.60
IUUC-Ate-010499 Aspergillus terreus 26.94 6.00e-18 86.30
IUUC-Ame-011897 Astyanax mexicanus 63.61 0.00e+00 906.00
IUUC-Bgr-012227 Blumeria graminis 26.64 1.00e-12 68.60
IUUC-Bta-013451 Bos taurus 97.22 0.00e+00 1416.00
IUUC-Bci-013682 Botrytis cinerea 22.20 4.00e-15 77.00
IUUC-Bdi-014911 Brachypodium distachyon 26.32 2.00e-14 75.10
IUUC-Bol-015869 Brassica oleracea 26.09 1.00e-12 69.30
IUUC-Bra-017532 Brassica rapa 25.87 6.00e-12 66.60
IUUC-Cel-018109 Caenorhabditis elegans 21.04 9.00e-06 45.80
IUUC-Cja-019568 Callithrix jacchus 98.94 0.00e+00 1467.00
IUUC-Cfa-020050 Canis familiaris 97.88 0.00e+00 1432.00
IUUC-Cpo-021705 Cavia porcellus 92.61 0.00e+00 1354.00
IUUC-Csa-023099 Chlorocebus sabaeus 98.28 0.00e+00 1451.00
IUUC-Cho-024968 Choloepus hoffmanni 83.21 0.00e+00 665.00
IUUC-Cin-025286 Ciona intestinalis 28.43 3.00e-28 119.00
IUUC-Cgl-026397 Colletotrichum gloeosporioides 27.53 1.00e-13 72.00
IUUC-Dre-028446 Danio rerio 65.62 0.00e+00 949.00
IUUC-Dno-029248 Dasypus novemcinctus 96.29 0.00e+00 1405.00
IUUC-Dor-030713 Dipodomys ordii 90.23 0.00e+00 1177.00
IUUC-Dse-031480 Dothistroma septosporum 28.87 1.00e-05 45.10
IUUC-Dme-031636 Drosophila melanogaster 27.61 6.00e-38 152.00
IUUC-Ete-032483 Echinops telfairi 95.36 0.00e+00 1405.00
IUUC-Eca-033381 Equus caballus 98.15 0.00e+00 1436.00
IUUC-Eeu-034557 Erinaceus europaeus 70.98 0.00e+00 684.00
IUUC-Fca-035995 Felis catus 99.27 0.00e+00 1068.00
IUUC-Fal-037344 Ficedula albicollis 85.92 0.00e+00 1273.00
IUUC-Fox-038064 Fusarium oxysporum 20.82 2.00e-10 61.60
IUUC-Fso-038085 Fusarium solani 23.54 1.00e-12 68.90
IUUC-Ggr-040022 Gaeumannomyces graminis 23.83 2.00e-09 58.20
IUUC-Gga-040306 Gallus gallus 85.41 0.00e+00 1295.00
IUUC-Gac-042229 Gasterosteus aculeatus 66.23 0.00e+00 951.00
IUUC-Gma-042708 Glycine max 29.72 2.00e-14 75.10
IUUC-Ggo-045040 Gorilla gorilla 99.87 0.00e+00 1483.00
IUUC-Hvu-047209 Hordeum vulgare 25.92 6.00e-15 76.60
IUUC-Itr-047936 Ictidomys tridecemlineatus 97.49 0.00e+00 841.00
IUUC-Lch-049595 Latimeria chalumnae 77.48 0.00e+00 1143.00
IUUC-Lpe-051682 Leersia perrieri 25.72 1.00e-14 75.50
IUUC-Loc-052640 Lepisosteus oculatus 72.89 0.00e+00 1086.00
IUUC-Lma-052954 Leptosphaeria maculans 24.32 2.00e-04 41.20
IUUC-Laf-054391 Loxodonta africana 97.04 0.00e+00 1380.00
IUUC-Mcc-055384 Macaca mulatta 100.00 0.00e+00 1485.00
IUUC-Meu-056410 Macropus eugenii 82.74 0.00e+00 766.00
IUUC-Mor-057156 Magnaporthe oryzae 20.81 3.00e-10 61.20
IUUC-Mpo-057453 Magnaporthe poae 34.31 8.00e-10 58.90
IUUC-Mtr-058102 Medicago truncatula 27.27 2.00e-12 68.60
IUUC-Mla-059063 Melampsora laricipopulina 35.29 1.00e-03 38.90
IUUC-Mga-059991 Meleagris gallopavo 86.96 0.00e+00 1207.00
IUUC-Mmr-060939 Microcebus murinus 95.76 0.00e+00 1381.00
IUUC-Mdo-062775 Monodelphis domestica 89.68 0.00e+00 1339.00
IUUC-Mmu-063110 Mus musculus 94.35 0.00e+00 1405.00
IUUC-Mac-065555 Musa acuminata 29.11 5.00e-15 77.00
IUUC-Mpu-066382 Mustela putorius furo 97.96 0.00e+00 1322.00
IUUC-Mlu-067724 Myotis lucifugus 91.52 0.00e+00 1315.00
IUUC-Nfi-068251 Neosartorya fischeri 27.54 1.00e-15 79.00
IUUC-Ncr-068757 Neurospora crassa 21.87 7.00e-13 69.70
IUUC-Nle-069022 Nomascus leucogenys 100.00 0.00e+00 1485.00
IUUC-Opr-070727 Ochotona princeps 94.80 0.00e+00 1051.00
IUUC-Ont-071409 Oreochromis niloticus 65.67 0.00e+00 967.00
IUUC-Oan-073732 Ornithorhynchus anatinus 91.32 0.00e+00 806.00
IUUC-Oba-075329 Oryza barthii 24.36 4.00e-12 67.40
IUUC-Obr-076176 Oryza brachyantha 25.00 3.00e-15 77.80
IUUC-Ogl-076949 Oryza glaberrima 25.66 4.00e-15 77.40
IUUC-Ogu-078835 Oryza glumaepatula 24.36 4.00e-12 67.40
IUUC-Oin-079783 Oryza indica 25.34 2.00e-12 68.60
IUUC-Olo-080921 Oryza longistaminata 24.36 1.00e-11 66.20
IUUC-Ome-081983 Oryza meridionalis 24.80 1.00e-14 76.30
IUUC-Oni-082649 Oryza nivara 24.36 4.00e-12 67.40
IUUC-Opu-083962 Oryza punctata 25.88 2.00e-15 78.20
IUUC-Oru-085221 Oryza rufipogon 24.36 4.00e-12 67.40
IUUC-Osa-086035 Oryza sativa 25.61 5.00e-15 77.00
IUUC-Ola-087386 Oryzias latipes 65.58 0.00e+00 957.00
IUUC-Olu-087848 Ostreococcus lucimarinus 24.09 1.00e-04 42.40
IUUC-Oga-089166 Otolemur garnettii 96.56 0.00e+00 1384.00
IUUC-Oar-090437 Ovis aries 96.96 0.00e+00 1409.00
IUUC-Ptr-090917 Pan troglodytes 100.00 0.00e+00 1485.00
IUUC-Pan-091739 Papio anubis 99.34 0.00e+00 1451.00
IUUC-Psi-093776 Pelodiscus sinensis 86.42 0.00e+00 1212.00
IUUC-Pma-094696 Petromyzon marinus 35.09 1.00e-43 170.00
IUUC-Pno-094995 Phaeosphaeria nodorum 23.35 9.00e-04 38.50
IUUC-Ppa-095754 Physcomitrella patens 35.66 9.00e-13 69.30
IUUC-Pfo-096997 Poecilia formosa 63.84 0.00e+00 930.00
IUUC-Pab-098518 Pongo abelii 100.00 0.00e+00 1485.00
IUUC-Pop-099568 Populus trichocarpa 24.28 4.00e-11 63.90
IUUC-Pca-100400 Procavia capensis 87.55 0.00e+00 1214.00
IUUC-Ppe-101627 Prunus persica 26.25 3.00e-16 80.90
IUUC-Pva-103252 Pteropus vampyrus 92.19 0.00e+00 1359.00
IUUC-Pte-104302 Pyrenophora teres 23.44 3.00e-04 40.80
IUUC-Pyt-104585 Pyrenophora triticirepentis 23.37 1.00e-04 42.40
IUUC-Rno-104876 Rattus norvegicus 94.75 0.00e+00 1408.00
IUUC-Sce-106345 Saccharomyces cerevisiae 28.57 2.10e-02 34.70
IUUC-Sha-107267 Sarcophilus harrisii 88.08 0.00e+00 1092.00
IUUC-Sja-107719 Schizosaccharomyces japonicus 26.50 8.00e-11 62.80
IUUC-Spo-108363 Schizosaccharomyces pombe 25.88 6.00e-09 56.60
IUUC-Ssl-108557 Sclerotinia sclerotiorum 23.36 2.00e-10 61.20
IUUC-Smo-109037 Selaginella moellendorffii 25.22 1.00e-13 72.40
IUUC-Sit-110705 Setaria italica 26.19 4.00e-15 77.40
IUUC-Sly-111864 Solanum lycopersicum 32.37 1.00e-11 65.90
IUUC-Sar-113485 Sorex araneus 87.42 0.00e+00 1315.00
IUUC-Sbi-114673 Sorghum bicolor 25.72 2.00e-15 77.80
IUUC-Sre-115155 Sporisorium reilianum 40.38 4.00e-03 37.00
IUUC-Ssc-115301 Sus scrofa 97.09 0.00e+00 1453.00
IUUC-Tgu-116928 Taeniopygia guttata 86.21 0.00e+00 1282.00
IUUC-Tru-117756 Takifugu rubripes 63.98 0.00e+00 897.00
IUUC-Tsy-119155 Tarsius syrichta 82.12 0.00e+00 1197.00
IUUC-Tni-120285 Tetraodon nigroviridis 63.85 0.00e+00 884.00
IUUC-Tca-121305 Theobroma cacao 24.92 2.00e-12 68.60
IUUC-Tre-122123 Trichoderma reesei 25.34 1.00e-12 68.90
IUUC-Tvi-122313 Trichoderma virens 24.49 1.00e-12 68.90
IUUC-Tae-125147 Triticum aestivum 26.70 1.00e-15 78.60
IUUC-Tur-126507 Triticum urartu 26.68 1.00e-15 79.30
IUUC-Tme-127132 Tuber melanosporum 21.88 3.00e-17 84.00
IUUC-Tbe-127653 Tupaia belangeri 83.12 0.00e+00 759.00
IUUC-Ttr-129200 Tursiops truncatus 96.29 0.00e+00 1419.00
IUUC-Uma-129658 Ustilago maydis 25.81 8.00e-04 39.30
IUUC-Vda-129916 Verticillium dahliae 21.65 9.00e-10 59.30
IUUC-Vpa-130494 Vicugna pacos 89.57 0.00e+00 1147.00
IUUC-Vvi-131317 Vitis vinifera 31.21 7.00e-10 58.90
IUUC-Xtr-132765 Xenopus tropicalis 81.24 0.00e+00 1219.00
IUUC-Xma-133195 Xiphophorus maculatus 66.26 0.00e+00 807.00
IUUC-Yli-134672 Yarrowia lipolytica 45.28 6.00e-06 46.60
IUUC-Zma-135338 Zea mays 27.56 3.00e-16 80.90
Created Date 25-Jun-2017

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