iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	73.66	0.00e+00	659.00	IUUC-Hsa-046081
UBD/Alpha-Helix/UBA	74.82	0.00e+00	657.00	IUUC-Mmu-063504

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Drosophila melanogaster

Functional Description
(View)

Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Inhibits nuclear localization of Yki. Regulates salivary gland degradation in a PI3K-dependent manner and Yki- and Sd-independent, mechanism.

Protein Sequence
(Fasta)

MHPAGEKRGG RPNDKYTAEA LESIKQDLTR FEVQNNHRNN QNYTPLRYTA TNGRNDALTP 60
DYHHAKQPME PPPSASPAPD VVIPPPPAIV GQPGAGSISV SGVGVGVVGV ANGRVPKMMT 120

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Nucleotide Sequence
(Fasta)

GTCTATCGAT ATCGGTCTAT CGATATGTGA ACATATCTAG CACGACGGCA GCAACAAAAC 60
CACGAATTAA TTTTACTAAA TTTAAGCCAA ACGCGCATCG GAAATGCCTG AAAAATGCGA 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0043--Tumor suppressor

Interpro

IPR000961--AGC-kinase_C
IPR011989--ARM-like
IPR011009--Kinase-like_dom
IPR028741--LATS1/Warts
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0005912--C:adherens junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005815--C:microtubule organizing center
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0007298--P:border follicle cell migration
GO:0001708--P:cell fate specification
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0007446--P:imaginal disc growth
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0060253--P:negative regulation of glial cell proliferation
GO:0046621--P:negative regulation of organ growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0018105--P:peptidyl-serine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0006468--P:protein phosphorylation
GO:0045464--P:R8 cell fate specification
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0048814--P:regulation of dendrite morphogenesis
GO:0010906--P:regulation of glucose metabolic process
GO:0045570--P:regulation of imaginal disc growth
GO:0010212--P:response to ionizing radiation
GO:0072089--P:stem cell proliferation
GO:0060439--P:trachea morphogenesis

KEGG

dme:Dmel_CG12072

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001895	Ailuropoda melanoleuca	73.44	0.00e+00	665.00
IUUC-Apl-003278	Anas platyrhynchos	72.29	0.00e+00	659.00
IUUC-Aca-005319	Anolis carolinensis	72.35	0.00e+00	663.00
IUUC-Ame-011324	Astyanax mexicanus	71.24	0.00e+00	656.00
IUUC-Bta-013438	Bos taurus	73.44	0.00e+00	664.00
IUUC-Cel-018517	Caenorhabditis elegans	52.29	2.00e-126	446.00
IUUC-Cja-019072	Callithrix jacchus	73.67	0.00e+00	665.00
IUUC-Cfa-021267	Canis familiaris	73.44	0.00e+00	665.00
IUUC-Cpo-021985	Cavia porcellus	72.26	0.00e+00	634.00
IUUC-Csa-023255	Chlorocebus sabaeus	73.44	0.00e+00	664.00
IUUC-Cho-024461	Choloepus hoffmanni	77.84	2.00e-156	546.00
IUUC-Cin-025264	Ciona intestinalis	66.30	4.00e-141	493.00
IUUC-Dre-028034	Danio rerio	71.20	0.00e+00	644.00
IUUC-Dno-029888	Dasypus novemcinctus	73.44	0.00e+00	664.00
IUUC-Dor-030172	Dipodomys ordii	71.79	0.00e+00	634.00
IUUC-Ete-032813	Echinops telfairi	73.67	0.00e+00	660.00
IUUC-Eca-033781	Equus caballus	73.44	0.00e+00	663.00
IUUC-Eeu-035007	Erinaceus europaeus	74.59	0.00e+00	662.00
IUUC-Fca-036142	Felis catus	73.44	0.00e+00	664.00
IUUC-Fal-036626	Ficedula albicollis	72.52	0.00e+00	660.00
IUUC-Gmo-038688	Gadus morhua	72.68	2.00e-165	575.00
IUUC-Gga-040553	Gallus gallus	72.29	0.00e+00	658.00
IUUC-Gac-042031	Gasterosteus aculeatus	71.79	0.00e+00	650.00
IUUC-Ggo-045242	Gorilla gorilla	73.44	0.00e+00	665.00
IUUC-Hsa-046081	Homo sapiens	73.44	0.00e+00	665.00
IUUC-Itr-048668	Ictidomys tridecemlineatus	73.44	0.00e+00	660.00
IUUC-Lch-049425	Latimeria chalumnae	72.52	0.00e+00	660.00
IUUC-Loc-052418	Lepisosteus oculatus	73.65	0.00e+00	650.00
IUUC-Laf-053710	Loxodonta africana	72.40	0.00e+00	662.00
IUUC-Mcc-055079	Macaca mulatta	73.44	0.00e+00	664.00
IUUC-Meu-056509	Macropus eugenii	64.43	9.00e-141	493.00
IUUC-Mga-059713	Meleagris gallopavo	72.29	0.00e+00	659.00
IUUC-Mmr-061728	Microcebus murinus	73.44	0.00e+00	664.00
IUUC-Mdo-061942	Monodelphis domestica	72.98	0.00e+00	660.00
IUUC-Mmu-063504	Mus musculus	74.59	0.00e+00	662.00
IUUC-Mpu-066034	Mustela putorius furo	73.44	0.00e+00	665.00
IUUC-Mlu-067986	Myotis lucifugus	73.67	0.00e+00	667.00
IUUC-Nle-069202	Nomascus leucogenys	73.44	0.00e+00	664.00
IUUC-Opr-070801	Ochotona princeps	74.59	0.00e+00	657.00
IUUC-Ont-072487	Oreochromis niloticus	71.49	0.00e+00	654.00
IUUC-Oan-073128	Ornithorhynchus anatinus	74.23	0.00e+00	658.00
IUUC-Ocu-073998	Oryctolagus cuniculus	73.44	0.00e+00	664.00
IUUC-Ola-086858	Oryzias latipes	71.59	0.00e+00	652.00
IUUC-Oga-088874	Otolemur garnettii	72.75	0.00e+00	652.00
IUUC-Oar-089236	Ovis aries	73.27	0.00e+00	660.00
IUUC-Ptr-091425	Pan troglodytes	73.44	0.00e+00	665.00
IUUC-Pan-091851	Papio anubis	73.44	0.00e+00	664.00
IUUC-Psi-093920	Pelodiscus sinensis	72.25	0.00e+00	636.00
IUUC-Pfo-096326	Poecilia formosa	71.33	0.00e+00	648.00
IUUC-Pab-097815	Pongo abelii	73.44	0.00e+00	665.00
IUUC-Pca-101081	Procavia capensis	72.49	0.00e+00	632.00
IUUC-Pva-102836	Pteropus vampyrus	72.96	0.00e+00	646.00
IUUC-Ptt-103762	Puccinia triticina	38.94	3.00e-89	322.00
IUUC-Rno-106053	Rattus norvegicus	73.21	0.00e+00	660.00
IUUC-Sha-106843	Sarcophilus harrisii	73.21	0.00e+00	660.00
IUUC-Sar-113649	Sorex araneus	72.29	0.00e+00	642.00
IUUC-Ssc-115486	Sus scrofa	77.01	6.00e-156	542.00
IUUC-Tgu-116903	Taeniopygia guttata	72.29	0.00e+00	654.00
IUUC-Tru-118760	Takifugu rubripes	71.95	0.00e+00	650.00
IUUC-Tsy-119361	Tarsius syrichta	73.44	0.00e+00	663.00
IUUC-Tni-120058	Tetraodon nigroviridis	71.49	0.00e+00	649.00
IUUC-Tbe-127681	Tupaia belangeri	73.44	0.00e+00	663.00
IUUC-Ttr-129256	Tursiops truncatus	71.56	0.00e+00	632.00
IUUC-Vpa-130538	Vicugna pacos	72.52	0.00e+00	655.00
IUUC-Xtr-132593	Xenopus tropicalis	69.70	5.00e-180	624.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence