iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000030707.15	ENSMUST00000106364.7	ENSMUSP00000101972.1
ENSMUSG00000030707.15	ENSMUST00000173108.7	ENSMUSP00000134123.1
ENSMUSG00000030707.15	ENSMUST00000205515.1	ENSMUSP00000146177.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	PINA	HINT
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-19	69.2	79	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvl 35
           gHt++v ++a+   +d+ ++sGs D+t++vW++ +g l
   Q: 79   GHTAPVLDIAWcphNDNVIASGSEDCTVMVWEIPDGGL 116
           8***********9877****************998865 PP

Organism

Mus musculus

Functional Description
(View)

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Protein Sequence
(Fasta)

MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFMALI CEASGGGAFL 60
VLPLGKTGRV DKNVPLVCGH TAPVLDIAWC PHNDNVIASG SEDCTVMVWE IPDGGLVLPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCACCGCC CCCGAAGGCA TGGGTTTCAC CGAGTTCTCT GTTTGAGTGT GAGTACTAGG 60
CCCCCTGGGG CTGAAGGTGG TATATGTCTA TACACTTCCT GCCAAAGCGA GTGAGAGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0009--Actin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR029508--CORO1A
IPR015505--Coronin
IPR015048--DUF1899
IPR015049--Trimer_CC
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF08954--Trimer_CC
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0005884--C:actin filament
GO:0030424--C:axon
GO:0031252--C:cell leading edge
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0030027--C:lamellipodium
GO:0016020--C:membrane
GO:0001891--C:phagocytic cup
GO:0045335--C:phagocytic vesicle
GO:0030670--C:phagocytic vesicle membrane
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0003779--F:actin binding
GO:0051015--F:actin filament binding
GO:0003785--F:actin monomer binding
GO:0008092--F:cytoskeletal protein binding
GO:0042802--F:identical protein binding
GO:0032036--F:myosin heavy chain binding
GO:0043548--F:phosphatidylinositol 3-kinase binding
GO:0008022--F:protein C-terminus binding
GO:0042803--F:protein homodimerization activity
GO:0003723--F:RNA binding
GO:0030036--P:actin cytoskeleton organization
GO:0007015--P:actin filament organization
GO:0006816--P:calcium ion transport
GO:0016477--P:cell migration
GO:0031589--P:cell-substrate adhesion
GO:0071353--P:cellular response to interleukin-4
GO:0061502--P:early endosome to recycling endosome transport
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0030595--P:leukocyte chemotaxis
GO:0043320--P:natural killer cell degranulation
GO:0051126--P:negative regulation of actin nucleation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0031339--P:negative regulation of vesicle fusion
GO:0038180--P:nerve growth factor signaling pathway
GO:0006909--P:phagocytosis
GO:0001845--P:phagolysosome assembly
GO:0050918--P:positive chemotaxis
GO:0030335--P:positive regulation of cell migration
GO:0050870--P:positive regulation of T cell activation
GO:0042102--P:positive regulation of T cell proliferation
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030833--P:regulation of actin filament polymerization
GO:0008064--P:regulation of actin polymerization or depolymerization
GO:0008360--P:regulation of cell shape
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0034097--P:response to cytokine
GO:0043029--P:T cell homeostasis
GO:0032796--P:uropod organization

KEGG

mmu:12721

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002012	Ailuropoda melanoleuca	94.36	0.00e+00	907.00
IUUC-Aca-005048	Anolis carolinensis	67.01	0.00e+00	674.00
IUUC-Ame-011101	Astyanax mexicanus	68.86	0.00e+00	682.00
IUUC-Bta-013168	Bos taurus	93.93	0.00e+00	906.00
IUUC-Cja-019660	Callithrix jacchus	94.79	0.00e+00	914.00
IUUC-Cfa-020938	Canis familiaris	94.79	0.00e+00	910.00
IUUC-Cpo-022056	Cavia porcellus	93.93	0.00e+00	909.00
IUUC-Csa-023193	Chlorocebus sabaeus	95.01	0.00e+00	911.00
IUUC-Cne-026773	Cryptococcus neoformans	39.18	1.00e-87	317.00
IUUC-Dno-029363	Dasypus novemcinctus	94.79	0.00e+00	908.00
IUUC-Dor-030426	Dipodomys ordii	95.44	0.00e+00	913.00
IUUC-Eca-034229	Equus caballus	93.28	0.00e+00	898.00
IUUC-Eeu-034499	Erinaceus europaeus	91.60	0.00e+00	770.00
IUUC-Fca-036472	Felis catus	92.62	0.00e+00	894.00
IUUC-Ggo-045162	Gorilla gorilla	94.58	0.00e+00	910.00
IUUC-Hsa-046874	Homo sapiens	94.58	0.00e+00	910.00
IUUC-Itr-048911	Ictidomys tridecemlineatus	95.44	0.00e+00	921.00
IUUC-Laf-053427	Loxodonta africana	94.79	0.00e+00	902.00
IUUC-Mcc-055750	Macaca mulatta	96.49	0.00e+00	858.00
IUUC-Meu-056083	Macropus eugenii	88.94	0.00e+00	855.00
IUUC-Mvi-060569	Microbotryum violaceum	40.00	1.00e-87	317.00
IUUC-Mmr-060858	Microcebus murinus	95.01	0.00e+00	911.00
IUUC-Mdo-062469	Monodelphis domestica	89.96	0.00e+00	855.00
IUUC-Mpu-066451	Mustela putorius furo	94.34	0.00e+00	874.00
IUUC-Mlu-066978	Myotis lucifugus	94.36	0.00e+00	904.00
IUUC-Ncr-068781	Neurospora crassa	39.15	5.00e-99	355.00
IUUC-Nle-069815	Nomascus leucogenys	94.79	0.00e+00	910.00
IUUC-Opr-070911	Ochotona princeps	92.41	0.00e+00	884.00
IUUC-Ont-072391	Oreochromis niloticus	67.97	0.00e+00	678.00
IUUC-Ocu-074429	Oryctolagus cuniculus	85.03	0.00e+00	789.00
IUUC-Oga-089072	Otolemur garnettii	93.09	0.00e+00	892.00
IUUC-Oar-089676	Ovis aries	93.71	0.00e+00	906.00
IUUC-Ptr-091647	Pan troglodytes	94.79	0.00e+00	911.00
IUUC-Pan-092672	Papio anubis	95.01	0.00e+00	911.00
IUUC-Pab-098348	Pongo abelii	89.37	0.00e+00	842.00
IUUC-Pva-102668	Pteropus vampyrus	93.71	0.00e+00	904.00
IUUC-Pgr-103354	Puccinia graminis	41.73	2.00e-91	329.00
IUUC-Ptt-103735	Puccinia triticina	34.56	6.00e-70	258.00
IUUC-Rno-105604	Rattus norvegicus	98.92	0.00e+00	940.00
IUUC-Sha-107210	Sarcophilus harrisii	89.80	0.00e+00	872.00
IUUC-Spo-108364	Schizosaccharomyces pombe	41.11	2.00e-98	353.00
IUUC-Sar-113292	Sorex araneus	94.86	0.00e+00	729.00
IUUC-Sre-114911	Sporisorium reilianum	39.61	2.00e-80	293.00
IUUC-Tre-122159	Trichoderma reesei	41.20	5.00e-94	338.00
IUUC-Tvi-122480	Trichoderma virens	42.57	7.00e-95	341.00
IUUC-Tme-126924	Tuber melanosporum	41.39	5.00e-94	338.00
IUUC-Tbe-128025	Tupaia belangeri	95.54	4.00e-152	530.00
IUUC-Ttr-128689	Tursiops truncatus	93.49	0.00e+00	902.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence