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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064003
UUCD1 version UUC-MuM-00077
Ensembl Protein ID ENSMUSP00000017290.4
UniProt Accession P48754; A2A4Q4; Q60957; Q60983; BRCA1_MOUSE
Genbank Protein ID AAB17114.1; AAB17113.1; AAA96393.1; AAC52323.1; CAM21026.1; AAA99742.1
Protein Name Breast cancer type 1 susceptibility protein homolog; RING-type E3 ubiquitin transferase BRCA1
Genbank Nucleotide ID U31625; U35641; U32446; U36475; AL590996; U33835
Gene Name Brca1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000017146.12 ENSMUST00000017290.10 ENSMUSP00000017290.4
ENSMUSG00000017146.12 ENSMUST00000191198.1 ENSMUSP00000139737.1
ENSMUSG00000017146.12 ENSMUST00000142086.2 ENSMUSP00000139813.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 5.50e-07 31.1 24 65
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQKKGPSQCPLCK 65
           ********99.**************9666...68899********7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (By similarity). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.
 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (By similarity). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.
Protein Sequence
(Fasta)
MDLSAVQIQE VQNVLHAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 60
CPLCKNEITK RSLQGSTRFS QLAEELLRIM AAFELDTGMQ LTNGFSFSKK RNNSCERLNE 120
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Protein Fasta Sequence


>IUUC-Mmu-064003|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GTTCCGAAAG GCTAGCGCTA GGCGCCAAGC GGCCGGTTTC CTTGGCGACG GAGAGCGCGG 60
GAATTTTAGA TAGATTGTAA TTGCGGCTGC GCGGCCGCTG CCCGTGCAGC CAGAGGATCC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064003|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0131--Cell cycle
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-1017--Isopeptide bond
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4
PRINTS

PR00493--BRSTCANCERI
SMART

SM00292--BRCT
SM00184--RING
Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005813--C:centrosome
GO:0005694--C:chromosome
GO:0000793--C:condensed chromosome
GO:0000794--C:condensed nuclear chromosome
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0003684--F:damaged DNA binding
GO:0019899--F:enzyme binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0051298--P:centrosome duplication
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0006302--P:double-strand break repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0006633--P:fatty acid biosynthetic process
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0010628--P:positive regulation of gene expression
GO:0035066--P:positive regulation of histone acetylation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042127--P:regulation of cell proliferation
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation
GO:0006351--P:transcription, DNA-templated
KEGG mmu:12189
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002388 Ailuropoda melanoleuca 54.21 0.00e+00 1697.00
IUUC-Apl-003252 Anas platyrhynchos 35.25 1.00e-69 259.00
IUUC-Aca-004526 Anolis carolinensis 50.47 3.00e-63 236.00
IUUC-Ame-011720 Astyanax mexicanus 43.22 4.00e-42 167.00
IUUC-Bgr-011969 Blumeria graminis 41.18 7.00e-08 52.00
IUUC-Bta-013433 Bos taurus 52.81 0.00e+00 1631.00
IUUC-Cja-019149 Callithrix jacchus 54.98 0.00e+00 1745.00
IUUC-Cfa-020322 Canis familiaris 53.30 0.00e+00 1653.00
IUUC-Cpo-021583 Cavia porcellus 40.94 0.00e+00 982.00
IUUC-Csa-024227 Chlorocebus sabaeus 70.99 1.00e-104 374.00
IUUC-Cho-024530 Choloepus hoffmanni 53.56 0.00e+00 850.00
IUUC-Cin-025364 Ciona intestinalis 34.35 1.00e-14 73.60
IUUC-Csv-026245 Ciona savignyi 37.23 1.00e-13 70.10
IUUC-Dno-029247 Dasypus novemcinctus 51.93 0.00e+00 1275.00
IUUC-Dme-032032 Drosophila melanogaster 54.35 9.00e-11 58.20
IUUC-Ete-032472 Echinops telfairi 43.16 0.00e+00 1090.00
IUUC-Eca-033446 Equus caballus 56.17 0.00e+00 1815.00
IUUC-Eeu-034858 Erinaceus europaeus 45.30 7.00e-178 619.00
IUUC-Fca-035991 Felis catus 53.62 0.00e+00 1706.00
IUUC-Fal-036803 Ficedula albicollis 28.80 1.00e-75 279.00
IUUC-Gmo-038782 Gadus morhua 38.02 6.00e-34 139.00
IUUC-Ggr-039833 Gaeumannomyces graminis 35.71 3.00e-08 53.10
IUUC-Gga-040969 Gallus gallus 53.14 2.00e-65 245.00
IUUC-Gac-042296 Gasterosteus aculeatus 40.89 6.00e-42 166.00
IUUC-Ggo-044740 Gorilla gorilla 53.76 0.00e+00 1660.00
IUUC-Hsa-046086 Homo sapiens 55.93 0.00e+00 1730.00
IUUC-Itr-048512 Ictidomys tridecemlineatus 55.74 0.00e+00 1798.00
IUUC-Lch-049789 Latimeria chalumnae 48.82 7.00e-59 223.00
IUUC-Loc-051952 Lepisosteus oculatus 45.54 5.00e-52 200.00
IUUC-Laf-053648 Loxodonta africana 53.31 0.00e+00 1560.00
IUUC-Mcc-055210 Macaca mulatta 55.15 0.00e+00 1778.00
IUUC-Meu-056342 Macropus eugenii 33.64 3.00e-70 261.00
IUUC-Mor-057034 Magnaporthe oryzae 35.71 3.00e-08 53.50
IUUC-Mga-060163 Meleagris gallopavo 53.14 1.00e-64 242.00
IUUC-Mmr-061402 Microcebus murinus 54.78 2.00e-165 575.00
IUUC-Mdo-062209 Monodelphis domestica 40.32 0.00e+00 961.00
IUUC-Mpu-065825 Mustela putorius furo 56.30 3.00e-144 505.00
IUUC-Mlu-068176 Myotis lucifugus 53.47 0.00e+00 1527.00
IUUC-Nle-069178 Nomascus leucogenys 56.09 0.00e+00 1753.00
IUUC-Opr-070574 Ochotona princeps 47.82 0.00e+00 1353.00
IUUC-Ont-072380 Oreochromis niloticus 40.98 2.00e-44 175.00
IUUC-Oan-073243 Ornithorhynchus anatinus 73.81 2.00e-33 134.00
IUUC-Ocu-074424 Oryctolagus cuniculus 53.18 0.00e+00 1621.00
IUUC-Ola-086863 Oryzias latipes 42.44 7.00e-45 176.00
IUUC-Oar-089938 Ovis aries 53.07 0.00e+00 1660.00
IUUC-Ptr-090960 Pan troglodytes 56.36 0.00e+00 1769.00
IUUC-Pan-092609 Papio anubis 54.68 0.00e+00 1529.00
IUUC-Psi-093889 Pelodiscus sinensis 28.12 2.00e-37 151.00
IUUC-Pfo-096328 Poecilia formosa 43.46 1.00e-48 189.00
IUUC-Pab-097982 Pongo abelii 56.63 0.00e+00 1789.00
IUUC-Pca-100698 Procavia capensis 53.22 1.00e-146 515.00
IUUC-Pva-102631 Pteropus vampyrus 57.60 0.00e+00 827.00
IUUC-Rno-105879 Rattus norvegicus 81.06 0.00e+00 2825.00
IUUC-Sha-106701 Sarcophilus harrisii 35.50 1.00e-132 468.00
IUUC-Spo-108335 Schizosaccharomyces pombe 34.83 3.00e-10 60.10
IUUC-Sar-113047 Sorex araneus 48.91 0.00e+00 989.00
IUUC-Ssc-115846 Sus scrofa 54.60 0.00e+00 1688.00
IUUC-Tgu-116785 Taeniopygia guttata 32.27 5.00e-63 237.00
IUUC-Tru-117895 Takifugu rubripes 40.57 2.00e-44 174.00
IUUC-Tsy-118885 Tarsius syrichta 57.14 4.00e-123 436.00
IUUC-Tni-119654 Tetraodon nigroviridis 40.39 4.00e-43 170.00
IUUC-Tbe-127421 Tupaia belangeri 48.67 2.00e-93 338.00
IUUC-Ttr-128685 Tursiops truncatus 53.87 0.00e+00 1550.00
IUUC-Vpa-130216 Vicugna pacos 67.32 2.00e-147 517.00
IUUC-Xtr-132398 Xenopus tropicalis 34.61 1.00e-49 192.00
IUUC-Xma-133651 Xiphophorus maculatus 44.69 2.00e-38 155.00
Created Date 25-Jun-2017

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