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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046475
UUCD1 version UUC-HoS-00184
Ensembl Protein ID ENSP00000334657.4
UniProt Accession Q7Z4K8; A0AVI6; B1AVQ4; Q5VT60; Q5VT62; Q6NT17; Q6NT41; Q6ZRL7; Q9H5P2; TRI46_HUMAN
Genbank Protein ID AAP51206.1; BAB15580.1; BAC87293.1; CAH71197.1; CAH71197.1; CAH71199.1; CAH71199.1; CAI95081.1; CAI95081.1; CAI95083.1; CAI95083.1; EAW53120.1; EAW53123.1; AAH69416.1; AAH69568.1; AAI26373.1
Protein Name Tripartite motif-containing protein 46; Gene Y protein; Tripartite, fibronectin type-III and C-terminal SPRY motif protein
Genbank Nucleotide ID AY251386; AK026882; AK096158; AL607067; AL713999; AL607067; AL713999; AL713999; AL607067; AL713999; AL607067; CH471121; CH471121; BC069416; BC069568; BC126372
Gene Name TRIM46; TRIFIC
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163462.17 ENST00000368385.8 ENSP00000357369.4
ENSG00000163462.17 ENST00000368383.7 ENSP00000357367.3
ENSG00000163462.17 ENST00000334634.8 ENSP00000334657.4
ENSG00000163462.17 ENST00000611379.1 ENSP00000478669.1
ENSG00000163462.17 ENST00000392451.6 ENSP00000376245.3
ENSG00000163462.17 ENST00000543729.5 ENSP00000442719.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
microRNATRANSFACTargetScanRepTar
miRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18248090
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.50e-06 30.3 33 133
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw................pglknssskefr................................... 41
           C++C+e++k+ plvlpC H  ++ C   +                p ++                                           
   Q: 33   CPVCQEMYKQ-PLVLPCTHNVCQACAREVlgqqgyighggdpssePTSP-------Astpstrsprlsrrtlpkpdrldrllksgfgtypgr 116
           ********99.**************877755555566644443332222.......134444556666777777777777777777777777 PP
   S: 42   .............CPlC 45
                        CP C
   Q: 117  krgalhpqvimfpCPAC 133
           77777777777777766 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MAEGEDMQTF TSIMDALVRI STSMKNMEKE LLCPVCQEMY KQPLVLPCTH NVCQACAREV 60
LGQQGYIGHG GDPSSEPTSP ASTPSTRSPR LSRRTLPKPD RLDRLLKSGF GTYPGRKRGA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046475|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGAACTATT TCCCACCCCC TACCCCGACG GGCGCTGTTC GAGGCTGGTC CCGGGAGCAT 60
GCGCAGTGAC ACCTCAACCC CCAGCCCTCC TCACACCCCC ACTGGGCTCC TGCATTAAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046475|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00336--BBOX
SM00184--RING
Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0043194--C:axon initial segment
GO:1990769--C:proximal neuron projection
GO:0008270--F:zinc ion binding
GO:0048490--P:anterograde synaptic vesicle transport
GO:0007409--P:axonogenesis
GO:0001578--P:microtubule bundle formation
GO:0001764--P:neuron migration
GO:0099612--P:protein localization to axon
KEGG hsa:80128
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001433 Ailuropoda melanoleuca 95.26 0.00e+00 1385.00
IUUC-Apl-003350 Anas platyrhynchos 67.34 0.00e+00 989.00
IUUC-Ame-011708 Astyanax mexicanus 60.08 0.00e+00 909.00
IUUC-Bta-012983 Bos taurus 98.55 0.00e+00 1425.00
IUUC-Cja-018992 Callithrix jacchus 97.76 0.00e+00 1427.00
IUUC-Cfa-020108 Canis familiaris 97.72 0.00e+00 1407.00
IUUC-Cpo-022537 Cavia porcellus 97.91 0.00e+00 805.00
IUUC-Csa-023757 Chlorocebus sabaeus 99.47 0.00e+00 1463.00
IUUC-Dre-027914 Danio rerio 59.42 0.00e+00 876.00
IUUC-Dno-029447 Dasypus novemcinctus 99.34 0.00e+00 1460.00
IUUC-Dor-030163 Dipodomys ordii 98.81 0.00e+00 1452.00
IUUC-Eca-033632 Equus caballus 98.42 0.00e+00 1452.00
IUUC-Fca-036188 Felis catus 98.45 0.00e+00 747.00
IUUC-Fal-037431 Ficedula albicollis 73.13 0.00e+00 1064.00
IUUC-Gmo-039199 Gadus morhua 55.38 0.00e+00 779.00
IUUC-Gac-041603 Gasterosteus aculeatus 58.75 0.00e+00 900.00
IUUC-Ggo-045326 Gorilla gorilla 99.87 0.00e+00 1468.00
IUUC-Itr-048505 Ictidomys tridecemlineatus 98.42 0.00e+00 1463.00
IUUC-Lch-049891 Latimeria chalumnae 65.00 0.00e+00 1006.00
IUUC-Laf-053620 Loxodonta africana 98.16 0.00e+00 1458.00
IUUC-Mcc-055666 Macaca mulatta 99.60 0.00e+00 1471.00
IUUC-Mmr-060777 Microcebus murinus 99.21 0.00e+00 1435.00
IUUC-Mdo-062526 Monodelphis domestica 93.46 0.00e+00 754.00
IUUC-Mmu-063938 Mus musculus 97.89 0.00e+00 1445.00
IUUC-Mpu-066543 Mustela putorius furo 97.12 0.00e+00 1269.00
IUUC-Mlu-067086 Myotis lucifugus 93.69 0.00e+00 1341.00
IUUC-Nle-070157 Nomascus leucogenys 99.87 0.00e+00 1464.00
IUUC-Ont-071483 Oreochromis niloticus 60.41 0.00e+00 922.00
IUUC-Ocu-073837 Oryctolagus cuniculus 98.02 0.00e+00 1441.00
IUUC-Ola-086452 Oryzias latipes 59.46 0.00e+00 896.00
IUUC-Oga-088518 Otolemur garnettii 98.88 0.00e+00 1188.00
IUUC-Oar-089791 Ovis aries 93.15 0.00e+00 1343.00
IUUC-Ptr-091585 Pan troglodytes 100.00 0.00e+00 1469.00
IUUC-Pan-092902 Papio anubis 97.76 0.00e+00 1467.00
IUUC-Pfo-096276 Poecilia formosa 59.08 0.00e+00 898.00
IUUC-Pab-098589 Pongo abelii 99.74 0.00e+00 1466.00
IUUC-Pva-103153 Pteropus vampyrus 96.18 0.00e+00 1412.00
IUUC-Rno-105322 Rattus norvegicus 97.92 0.00e+00 1013.00
IUUC-Sha-107412 Sarcophilus harrisii 93.94 0.00e+00 1395.00
IUUC-Ssc-115661 Sus scrofa 98.16 0.00e+00 1442.00
IUUC-Tru-117886 Takifugu rubripes 59.85 0.00e+00 922.00
IUUC-Tni-120625 Tetraodon nigroviridis 59.79 0.00e+00 886.00
IUUC-Ttr-129000 Tursiops truncatus 96.57 0.00e+00 1417.00
Created Date 25-Jun-2017

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