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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045740
Ensembl Protein ID ENSP00000320543.5
UniProt Accession O95208; A8MTV8; B3KRX8; E9PBC2; O95207; Q52LD0; Q9H7Z2; Q9UPT7; EPN2_HUMAN
Genbank Protein ID AAC78608.1; AAC78609.1; BAA83017.2; BAG51000.1; BAB14831.1; BAG52540.1; EAW50876.1; AAH93972.1; AAH93974.1
Protein Name Epsin-2; EPS-15-interacting protein 2
Genbank Nucleotide ID AF062084; AF062085; AB028988; AK001996; AK024115; AK092366; AC106017; BC093972; BC093974
Gene Name EPN2; KIAA1065
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000072134.15 ENST00000314728.9 ENSP00000320543.5
ENSG00000072134.15 ENST00000580579.5 ENSP00000463769.1
ENSG00000072134.15 ENST00000494192.6 ENSP00000460193.1
ENSG00000072134.15 ENST00000395620.6 ENSP00000378982.2
ENSG00000072134.15 ENST00000395626.5 ENSP00000378988.1
ENSG00000072134.15 ENST00000571254.1 ENSP00000459542.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 17244534
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UIM 0.0014 20.1 275 293
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+++LqlAla+S++++e+
   Q: 275  EEELQLQLALAMSREVAEQ 293
           79***************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in the formation of clathrin-coated invaginations and endocytosis.
 Plays a role in the formation of clathrin-coated invaginations and endocytosis.
Protein Sequence
(Fasta)
MTTSSIRRQM KNIVNNYSEA EIKVREATSN DPWGPSSSLM TEIADLTYNV VAFSEIMSMV 60
WKRLNDHGKN WRHVYKALTL LDYLIKTGSE RVAQQCRENI FAIQTLKDFQ YIDRDGKDQG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045740|UBD,UIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCCTTCCGGC CGGCCCCCTG CTCGCATCTT GGCTTGCTGA GGCTGCGGGT CTTGGCCGGG 60
CCTTCGAGAA TCCCCCGCCG CCTCCCCTTC TGGATGTATC TGCGCCGCCT CCTTTCTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045740|UBD,UIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
IPR027319--Epsin-2_metazoa
IPR003903--UIM_dom
PROSITE

PS50942--ENTH
PS50330--UIM
Pfam

PF01417--ENTH
SMART

SM00273--ENTH
SM00726--UIM
Gene Ontology

GO:0030128--C:clathrin coat of endocytic vesicle
GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0045296--F:cadherin binding
GO:0008289--F:lipid binding
GO:0006897--P:endocytosis
GO:0061024--P:membrane organization
KEGG hsa:22905
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000113 Aegilops tauschii 49.32 8.00e-42 166.00
IUUC-Aml-001209 Ailuropoda melanoleuca 89.12 8.00e-154 537.00
IUUC-Atr-002956 Amborella trichopoda 47.20 5.00e-42 166.00
IUUC-Apl-003474 Anas platyrhynchos 71.47 0.00e+00 842.00
IUUC-Aca-005348 Anolis carolinensis 95.98 4.00e-115 409.00
IUUC-Aly-006457 Arabidopsis lyrata 47.17 8.00e-42 166.00
IUUC-Ath-007675 Arabidopsis thaliana 47.17 4.00e-42 166.00
IUUC-Ago-007986 Ashbya gossypii 47.40 9.00e-40 157.00
IUUC-Ame-011423 Astyanax mexicanus 86.50 5.00e-87 315.00
IUUC-Bta-013258 Bos taurus 85.51 0.00e+00 911.00
IUUC-Bdi-014129 Brachypodium distachyon 48.37 2.00e-42 168.00
IUUC-Bol-016058 Brassica oleracea 47.17 3.00e-42 167.00
IUUC-Bra-017893 Brassica rapa 47.17 5.00e-42 166.00
IUUC-Cja-019818 Callithrix jacchus 83.00 0.00e+00 894.00
IUUC-Cfa-020229 Canis familiaris 86.79 7.00e-147 514.00
IUUC-Cpo-022174 Cavia porcellus 86.56 1.00e-139 489.00
IUUC-Csa-023789 Chlorocebus sabaeus 84.40 0.00e+00 920.00
IUUC-Cho-024649 Choloepus hoffmanni 61.29 1.00e-56 214.00
IUUC-Cin-025755 Ciona intestinalis 56.34 7.00e-81 293.00
IUUC-Csv-025907 Ciona savignyi 43.20 3.00e-103 369.00
IUUC-Cgl-026614 Colletotrichum gloeosporioides 55.92 2.00e-47 183.00
IUUC-Cne-027047 Cryptococcus neoformans 57.81 6.00e-42 165.00
IUUC-Dno-029660 Dasypus novemcinctus 85.07 0.00e+00 826.00
IUUC-Dor-030230 Dipodomys ordii 82.09 0.00e+00 935.00
IUUC-Ete-032944 Echinops telfairi 74.92 0.00e+00 880.00
IUUC-Eca-033636 Equus caballus 91.73 0.00e+00 1025.00
IUUC-Eeu-034601 Erinaceus europaeus 81.90 1.00e-163 569.00
IUUC-Fca-036004 Felis catus 85.47 0.00e+00 867.00
IUUC-Fal-036640 Ficedula albicollis 95.98 2.00e-115 409.00
IUUC-Fox-037900 Fusarium oxysporum 54.31 3.00e-33 136.00
IUUC-Fso-038083 Fusarium solani 50.66 1.00e-41 164.00
IUUC-Gmo-038468 Gadus morhua 83.92 6.00e-94 337.00
IUUC-Ggr-039910 Gaeumannomyces graminis 55.26 6.00e-47 182.00
IUUC-Gga-040781 Gallus gallus 67.00 3.00e-122 432.00
IUUC-Gac-042432 Gasterosteus aculeatus 50.59 2.00e-121 429.00
IUUC-Gma-042967 Glycine max 49.06 9.00e-44 172.00
IUUC-Ggo-044421 Gorilla gorilla 99.38 0.00e+00 1171.00
IUUC-Hvu-047135 Hordeum vulgare 48.37 3.00e-42 167.00
IUUC-Itr-048090 Ictidomys tridecemlineatus 88.11 5.00e-143 501.00
IUUC-Lch-049618 Latimeria chalumnae 58.25 2.00e-178 619.00
IUUC-Lpe-051296 Leersia perrieri 49.02 1.00e-43 172.00
IUUC-Loc-051728 Lepisosteus oculatus 57.76 1.00e-150 526.00
IUUC-Laf-053389 Loxodonta africana 99.50 1.00e-117 417.00
IUUC-Mcc-055565 Macaca mulatta 90.48 0.00e+00 1026.00
IUUC-Mor-057254 Magnaporthe oryzae 55.26 1.00e-46 181.00
IUUC-Mpo-057426 Magnaporthe poae 55.92 1.00e-46 181.00
IUUC-Mtr-058328 Medicago truncatula 49.67 9.00e-43 169.00
IUUC-Mga-060111 Meleagris gallopavo 67.34 3.00e-118 419.00
IUUC-Mvi-060293 Microbotryum violaceum 54.84 1.00e-48 187.00
IUUC-Mmr-060793 Microcebus murinus 88.16 0.00e+00 982.00
IUUC-Mdo-061941 Monodelphis domestica 65.75 0.00e+00 684.00
IUUC-Mmu-064004 Mus musculus 87.68 0.00e+00 1003.00
IUUC-Mpu-066625 Mustela putorius furo 91.42 0.00e+00 946.00
IUUC-Mlu-068085 Myotis lucifugus 80.15 0.00e+00 875.00
IUUC-Ncr-068627 Neurospora crassa 54.76 1.00e-38 154.00
IUUC-Nle-069825 Nomascus leucogenys 97.82 0.00e+00 1153.00
IUUC-Opr-070492 Ochotona princeps 82.28 1.00e-150 526.00
IUUC-Oan-073743 Ornithorhynchus anatinus 70.95 2.00e-130 459.00
IUUC-Ocu-074139 Oryctolagus cuniculus 98.99 5.00e-118 417.00
IUUC-Oba-075922 Oryza barthii 49.02 7.00e-44 172.00
IUUC-Obr-076552 Oryza brachyantha 48.37 4.00e-43 170.00
IUUC-Ogl-077885 Oryza glaberrima 49.02 7.00e-44 172.00
IUUC-Ogu-078795 Oryza glumaepatula 49.02 6.00e-44 172.00
IUUC-Oin-080196 Oryza indica 49.02 7.00e-44 172.00
IUUC-Olo-080509 Oryza longistaminata 49.02 6.00e-44 172.00
IUUC-Ome-081531 Oryza meridionalis 49.02 6.00e-44 172.00
IUUC-Oni-083003 Oryza nivara 49.02 7.00e-44 172.00
IUUC-Opu-083829 Oryza punctata 49.02 1.00e-43 172.00
IUUC-Oru-084248 Oryza rufipogon 49.02 7.00e-44 172.00
IUUC-Osa-085910 Oryza sativa 49.02 7.00e-44 172.00
IUUC-Ola-087087 Oryzias latipes 58.61 8.00e-141 494.00
IUUC-Oga-088870 Otolemur garnettii 89.64 2.00e-170 592.00
IUUC-Oar-090233 Ovis aries 86.14 0.00e+00 935.00
IUUC-Ptr-091026 Pan troglodytes 99.69 0.00e+00 1175.00
IUUC-Pan-092050 Papio anubis 84.56 0.00e+00 891.00
IUUC-Psi-093688 Pelodiscus sinensis 68.66 4.00e-127 448.00
IUUC-Pma-094335 Petromyzon marinus 48.60 3.00e-125 442.00
IUUC-Pfo-096650 Poecilia formosa 60.34 2.00e-138 486.00
IUUC-Pab-098209 Pongo abelii 98.28 0.00e+00 1191.00
IUUC-Pop-098881 Populus trichocarpa 48.12 3.00e-43 171.00
IUUC-Pca-100479 Procavia capensis 82.09 0.00e+00 941.00
IUUC-Ppe-101157 Prunus persica 49.02 3.00e-42 167.00
IUUC-Pva-102177 Pteropus vampyrus 80.37 0.00e+00 889.00
IUUC-Rno-105746 Rattus norvegicus 80.36 9.00e-133 467.00
IUUC-Sce-106344 Saccharomyces cerevisiae 52.67 7.00e-37 148.00
IUUC-Sha-107254 Sarcophilus harrisii 58.06 0.00e+00 668.00
IUUC-Smo-109370 Selaginella moellendorffii 50.00 2.00e-40 158.00
IUUC-Sit-109784 Setaria italica 49.02 3.00e-43 170.00
IUUC-Sly-111438 Solanum lycopersicum 47.80 2.00e-43 171.00
IUUC-Stu-112874 Solanum tuberosum 47.80 2.00e-43 171.00
IUUC-Sar-113696 Sorex araneus 89.79 0.00e+00 783.00
IUUC-Sbi-114540 Sorghum bicolor 47.71 2.00e-42 168.00
IUUC-Sre-114959 Sporisorium reilianum 55.97 6.00e-43 168.00
IUUC-Tgu-117391 Taeniopygia guttata 95.98 1.00e-115 410.00
IUUC-Tsy-119034 Tarsius syrichta 62.82 1.00e-60 228.00
IUUC-Tni-120827 Tetraodon nigroviridis 86.93 8.00e-101 361.00
IUUC-Tca-121377 Theobroma cacao 48.10 5.00e-43 170.00
IUUC-Tre-122134 Trichoderma reesei 50.00 2.00e-44 173.00
IUUC-Tvi-122308 Trichoderma virens 50.00 1.00e-44 174.00
IUUC-Tae-122690 Triticum aestivum 48.37 2.00e-42 167.00
IUUC-Tur-126042 Triticum urartu 48.37 2.00e-42 167.00
IUUC-Tbe-127405 Tupaia belangeri 97.25 3.00e-152 531.00
IUUC-Ttr-128595 Tursiops truncatus 78.94 1.00e-171 596.00
IUUC-Uma-129605 Ustilago maydis 58.40 6.00e-43 168.00
IUUC-Vda-129905 Verticillium dahliae 54.61 3.00e-45 176.00
IUUC-Vpa-130825 Vicugna pacos 61.68 5.00e-61 229.00
IUUC-Vvi-131209 Vitis vinifera 50.00 1.00e-41 164.00
IUUC-Xtr-132334 Xenopus tropicalis 55.24 2.00e-167 582.00
IUUC-Xma-134173 Xiphophorus maculatus 60.38 2.00e-149 523.00
IUUC-Yli-134375 Yarrowia lipolytica 50.00 2.00e-39 157.00
Created Date 25-Jun-2017

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