iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000137384.12	ENST00000259930.10	ENSP00000259930.6
ENSG00000137384.12	ENST00000427952.5	ENSP00000392768.1
ENSG00000137384.12	ENST00000550969.2	ENSP00000447725.2

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.10e-06	30.7	16	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.pglknssskefrCPlCr 46
           C +C  +++d  ++ pCgH+f++ Cl ++ +   +ss k  +CPlC+
   Q: 16   CTLCAGPLED-AVTIPCGHTFCRLCLPALsQMGAQSSGKILLCPLCQ 61
           9*********.999************6663334445666668****7 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MPATPSLKVV HELPACTLCA GPLEDAVTIP CGHTFCRLCL PALSQMGAQS SGKILLCPLC 60
QEEEQAETPM APVPLGPLGE TYCEEHGEKI YFFCENDAEF LCVFCREGPT HQAHTVGFLD 120

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Nucleotide Sequence
(Fasta)

ACTTTGATGC TGTGGGCACG CCTCAGAGCC AGAAGTTTAT GGCTCCCACC TGCTCAATCT 60
GACAGGAAGC TTCTGCTCCC CAGTTCTCCC CAGCCACTGT GGTCTACAGA TTCCAGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF00097--zf-C3HC4

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0007500--P:mesodermal cell fate determination
GO:1901253--P:negative regulation of intracellular transport of viral material
GO:1902187--P:negative regulation of viral release from host cell
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1900246--P:positive regulation of RIG-I signaling pathway
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0032481--P:positive regulation of type I interferon production

KEGG

hsa:89870

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Eeu-035346	Erinaceus europaeus	79.86	2.00e-121	428.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence