iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	92.09	0.00e+00	842.00	IUUC-Hsa-046893

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).

Protein Sequence
(Fasta)

MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS LGEESSGSFS FADYQYLGSC 60
PGSEGSVITD TLSPASSPSS VSCPAVPTST DESPGNALNI ECRICGDKAS GYHYGVHACE 120

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Nucleotide Sequence
(Fasta)

GAACTGTCCG CTACTTCGAG TCCCCTTGAG CGCCGTGTGC CGGCTCTGAA CATTGGCGTT 60
CGCAGCTGTT TTGTGGGCTG GAGGGTTCGT GGAGTCCTGG AACTGAAGCG ACGCTGGGTC 120

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Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003076--1Cnucl_rcpt_A
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01289--PROXISOMPAAR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0008144--F:drug binding
GO:0008289--F:lipid binding
GO:0097371--F:MDM2/MDM4 family protein binding
GO:0051525--F:NFAT protein binding
GO:0019902--F:phosphatase binding
GO:0032403--F:protein complex binding
GO:0019904--F:protein domain specific binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0001223--F:transcription coactivator binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0035095--P:behavioral response to nicotine
GO:0032922--P:circadian regulation of gene expression
GO:0070166--P:enamel mineralization
GO:0008544--P:epidermis development
GO:0006631--P:fatty acid metabolic process
GO:0007507--P:heart development
GO:0042157--P:lipoprotein metabolic process
GO:0032099--P:negative regulation of appetite
GO:0045776--P:negative regulation of blood pressure
GO:0010887--P:negative regulation of cholesterol storage
GO:0050728--P:negative regulation of inflammatory response
GO:1903038--P:negative regulation of leukocyte cell-cell adhesion
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:1901215--P:negative regulation of neuron death
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0032091--P:negative regulation of protein binding
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:2000678--P:negative regulation of transcription regulatory region DNA binding
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0045722--P:positive regulation of gluconeogenesis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0072366--P:regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752--P:regulation of circadian rhythm
GO:0019217--P:regulation of fatty acid metabolic process
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369--P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0042060--P:wound healing

KEGG

rno:25747

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002222	Ailuropoda melanoleuca	90.00	0.00e+00	868.00
IUUC-Apl-003330	Anas platyrhynchos	85.17	0.00e+00	801.00
IUUC-Aca-004598	Anolis carolinensis	82.48	0.00e+00	795.00
IUUC-Acl-008339	Aspergillus clavatus	48.48	7.10e-02	30.40
IUUC-Ame-011508	Astyanax mexicanus	71.49	0.00e+00	660.00
IUUC-Bta-012621	Bos taurus	91.88	0.00e+00	867.00
IUUC-Cja-019688	Callithrix jacchus	91.45	0.00e+00	869.00
IUUC-Cfa-020859	Canis familiaris	91.03	0.00e+00	872.00
IUUC-Cpo-021607	Cavia porcellus	87.39	0.00e+00	822.00
IUUC-Csa-023313	Chlorocebus sabaeus	91.45	0.00e+00	872.00
IUUC-Cho-024741	Choloepus hoffmanni	81.41	0.00e+00	736.00
IUUC-Dre-027446	Danio rerio	70.70	0.00e+00	652.00
IUUC-Dno-029173	Dasypus novemcinctus	90.17	0.00e+00	827.00
IUUC-Dor-030581	Dipodomys ordii	92.51	0.00e+00	820.00
IUUC-Dme-031794	Drosophila melanogaster	35.58	7.00e-55	209.00
IUUC-Ete-032330	Echinops telfairi	87.82	0.00e+00	833.00
IUUC-Eca-033712	Equus caballus	91.03	0.00e+00	856.00
IUUC-Fca-036555	Felis catus	91.06	0.00e+00	870.00
IUUC-Fal-036677	Ficedula albicollis	84.83	0.00e+00	796.00
IUUC-Gmo-039240	Gadus morhua	78.67	0.00e+00	626.00
IUUC-Gga-040473	Gallus gallus	85.47	0.00e+00	801.00
IUUC-Gac-041872	Gasterosteus aculeatus	69.56	0.00e+00	668.00
IUUC-Ggo-045226	Gorilla gorilla	92.09	0.00e+00	880.00
IUUC-Hsa-046893	Homo sapiens	92.09	0.00e+00	880.00
IUUC-Itr-048952	Ictidomys tridecemlineatus	92.95	0.00e+00	877.00
IUUC-Lch-050116	Latimeria chalumnae	76.50	0.00e+00	723.00
IUUC-Loc-052131	Lepisosteus oculatus	81.00	0.00e+00	649.00
IUUC-Laf-054323	Loxodonta africana	91.24	0.00e+00	870.00
IUUC-Mcc-054841	Macaca mulatta	92.09	0.00e+00	876.00
IUUC-Meu-056833	Macropus eugenii	80.13	0.00e+00	730.00
IUUC-Mga-059995	Meleagris gallopavo	76.48	0.00e+00	705.00
IUUC-Mdo-061954	Monodelphis domestica	85.16	0.00e+00	741.00
IUUC-Mmu-064295	Mus musculus	98.08	0.00e+00	880.00
IUUC-Mpu-066216	Mustela putorius furo	91.03	0.00e+00	871.00
IUUC-Nle-069970	Nomascus leucogenys	91.88	0.00e+00	876.00
IUUC-Ont-071594	Oreochromis niloticus	69.77	0.00e+00	653.00
IUUC-Oan-073501	Ornithorhynchus anatinus	88.24	0.00e+00	719.00
IUUC-Ocu-074634	Oryctolagus cuniculus	84.29	0.00e+00	835.00
IUUC-Oni-082926	Oryza nivara	29.41	1.00e-02	31.20
IUUC-Ola-086585	Oryzias latipes	76.46	2.00e-178	617.00
IUUC-Oga-088738	Otolemur garnettii	92.09	0.00e+00	864.00
IUUC-Oar-090453	Ovis aries	91.45	0.00e+00	865.00
IUUC-Ptr-091518	Pan troglodytes	91.88	0.00e+00	872.00
IUUC-Pan-092006	Papio anubis	91.88	0.00e+00	872.00
IUUC-Psi-093352	Pelodiscus sinensis	83.47	0.00e+00	797.00
IUUC-Pfo-096060	Poecilia formosa	70.61	0.00e+00	655.00
IUUC-Pab-098602	Pongo abelii	86.29	0.00e+00	784.00
IUUC-Pva-102175	Pteropus vampyrus	85.68	0.00e+00	811.00
IUUC-Sce-106436	Saccharomyces cerevisiae	29.03	1.00e-02	31.60
IUUC-Sha-106560	Sarcophilus harrisii	88.68	0.00e+00	817.00
IUUC-Smo-109075	Selaginella moellendorffii	30.61	1.70e-01	29.30
IUUC-Ssc-115266	Sus scrofa	90.81	0.00e+00	877.00
IUUC-Tgu-116778	Taeniopygia guttata	84.40	0.00e+00	793.00
IUUC-Tru-118436	Takifugu rubripes	69.34	0.00e+00	653.00
IUUC-Tsy-119642	Tarsius syrichta	78.63	0.00e+00	720.00
IUUC-Tni-119859	Tetraodon nigroviridis	69.13	0.00e+00	647.00
IUUC-Tbe-127464	Tupaia belangeri	90.81	0.00e+00	875.00
IUUC-Ttr-129307	Tursiops truncatus	87.85	0.00e+00	815.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence