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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045880
UUCD1 version UUC-HoS-00131
Ensembl Protein ID ENSP00000309198.8
UniProt Accession Q15386; A4D235; A6NCP3; Q8TC15; Q96CR4; Q9UDU3; UBE3C_HUMAN
Genbank Protein ID BAA02799.2; AAD51453.1; EAL23922.1; EAX04568.1; AAH14029.1; AAH26241.1
Protein Name Ubiquitin-protein ligase E3C; HECT-type ubiquitin transferase E3C; HectH2
Genbank Nucleotide ID D13635; AC004898; CH236954; CH471149; BC014029; BC026241
Gene Name UBE3C; KIAA0010; KIAA10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000009335.17 ENST00000348165.9 ENSP00000309198.8
ENSG00000009335.17 ENST00000389103.4 ENSP00000373755.4
ENSG00000009335.17 ENST00000430750.1 ENSP00000397432.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 21167755; 20008553
UBD/Other/Other UBD/Other/Other 16341092
Classification
Family E-value Score Start End
E3 activity/HECT 5.30e-105 353.2 746 1083
Active Site
Position(s) Description Evidence
1051 Glycyl thioester intermediate N/A
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrl 87
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +    ++++flGr+lgkal+++ l
   Q: 746  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD-SFARHYYFLGRMLGKALYENML 834
           689**********99**9************************************9999999999965.999******************* PP
   S: 88   ldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++lp++ +f+++llg+  ++++++l+++dpe+yk+l ++k++ e+d+eelgl++t+   ++ lge++++eLk gG++ipVt +N+ +Y++
   Q: 835  VELPFAGFFLSKLLGTsaDVDIHHLASLDPEVYKNLLFLKSY-EDDVEELGLNFTV--VNNDLGEAQVVELKFGGKDIPVTSANRIAYIH 921
           ***************9666889********************.6788887666665..5889**************************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           lv++yrl+++i++++ afr+G+ +v++le+l++F+++e+++li+G    i++edlk++t+y ggy++d+p+i+ Fw+v+e+f++ee++++
   Q: 922  LVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAqVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKL 1011
           **********************************************899***************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           L+FvT++sr Pl Gf+el p  f+i++ +sd +rlP+++TC+n+LkLPe+  ++ l++kLlyAie ++gFels
   Q: 1012 LKFVTSCSRPPLLGFKELYPA-FCIHNGGSDlERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS 1083
           *******************88.*****99999**************************************985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
 E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
Protein Sequence
(Fasta)
MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFIRGYR 60
DRKQQYSIQR SAFDRCATLS QSGGAFPIAN GPNLTLLVRQ LLFFYKQNED SKRLIWLYQN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045880|E3,HECT;UBD,UBD/Other/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCTGCAGGGC CGCGCACGCA CTGACGGCTG ACCGCCATCT TCCCTCCCGA GGCGGCAGTT 60
CCAGGTGCAA GCGCCGGGTT TGCTGCCCGC TGGGCGCCCC TGCAGCGGCC CGAGCTGTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045880|E3,HECT;UBD,UBD/Other/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS
PROSITE

PS50237--HECT
PS50096--IQ
Pfam

PF00632--HECT
SMART

SM00119--HECTc
SM00015--IQ
Gene Ontology

GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
KEGG hsa:9690
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001355 Ailuropoda melanoleuca 93.94 0.00e+00 1963.00
IUUC-Apl-003731 Anas platyrhynchos 90.78 0.00e+00 1940.00
IUUC-Aca-005248 Anolis carolinensis 89.29 0.00e+00 1926.00
IUUC-Aly-005768 Arabidopsis lyrata 35.13 9.00e-108 385.00
IUUC-Ath-006576 Arabidopsis thaliana 34.98 2.00e-107 383.00
IUUC-Ago-007748 Ashbya gossypii 41.84 1.00e-76 281.00
IUUC-Acl-008158 Aspergillus clavatus 37.95 8.00e-76 279.00
IUUC-Afl-008398 Aspergillus flavus 33.68 2.00e-77 284.00
IUUC-Afu-008937 Aspergillus fumigatus 38.43 5.00e-78 286.00
IUUC-Ani-009252 Aspergillus nidulans 37.74 1.00e-79 292.00
IUUC-Ang-009773 Aspergillus niger 33.68 8.00e-78 286.00
IUUC-Aor-009940 Aspergillus oryzae 33.68 2.00e-77 284.00
IUUC-Ate-010395 Aspergillus terreus 38.59 4.00e-76 280.00
IUUC-Ame-010769 Astyanax mexicanus 63.04 0.00e+00 1052.00
IUUC-Bgr-012269 Blumeria graminis 37.55 3.00e-74 272.00
IUUC-Bta-012841 Bos taurus 93.18 0.00e+00 1974.00
IUUC-Bci-013743 Botrytis cinerea 29.98 2.00e-85 311.00
IUUC-Bol-015390 Brassica oleracea 34.36 6.00e-100 359.00
IUUC-Bra-016853 Brassica rapa 35.12 1.00e-106 381.00
IUUC-Cel-018638 Caenorhabditis elegans 40.34 5.00e-91 329.00
IUUC-Cja-019743 Callithrix jacchus 96.84 0.00e+00 2006.00
IUUC-Cfa-021031 Canis familiaris 95.31 0.00e+00 2011.00
IUUC-Cpo-022401 Cavia porcellus 93.44 0.00e+00 1982.00
IUUC-Cre-022725 Chlamydomonas reinhardtii 43.99 3.00e-84 305.00
IUUC-Csa-024107 Chlorocebus sabaeus 99.72 0.00e+00 2085.00
IUUC-Cho-024750 Choloepus hoffmanni 82.92 0.00e+00 806.00
IUUC-Cin-025432 Ciona intestinalis 44.88 5.00e-97 348.00
IUUC-Cgl-026559 Colletotrichum gloeosporioides 34.26 5.00e-88 319.00
IUUC-Cne-026841 Cryptococcus neoformans 36.48 1.00e-93 338.00
IUUC-Cme-027265 Cyanidioschyzon merolae 46.86 1.00e-102 368.00
IUUC-Dre-028196 Danio rerio 77.10 0.00e+00 1603.00
IUUC-Dno-029024 Dasypus novemcinctus 96.22 0.00e+00 2041.00
IUUC-Dor-030483 Dipodomys ordii 91.64 0.00e+00 692.00
IUUC-Dse-031416 Dothistroma septosporum 34.08 8.00e-79 289.00
IUUC-Dme-031946 Drosophila melanogaster 36.73 0.00e+00 672.00
IUUC-Ete-032240 Echinops telfairi 82.89 3.00e-177 615.00
IUUC-Eca-033828 Equus caballus 95.57 0.00e+00 1995.00
IUUC-Eeu-034604 Erinaceus europaeus 85.77 2.00e-127 449.00
IUUC-Fca-035907 Felis catus 94.46 0.00e+00 2015.00
IUUC-Fal-037389 Ficedula albicollis 90.96 0.00e+00 1966.00
IUUC-Fox-037788 Fusarium oxysporum 37.07 4.00e-91 329.00
IUUC-Fso-038088 Fusarium solani 35.83 2.00e-88 321.00
IUUC-Gmo-039254 Gadus morhua 66.53 0.00e+00 1240.00
IUUC-Ggr-039941 Gaeumannomyces graminis 34.15 1.00e-83 305.00
IUUC-Gga-040310 Gallus gallus 90.68 0.00e+00 1958.00
IUUC-Gac-042054 Gasterosteus aculeatus 69.60 0.00e+00 1307.00
IUUC-Gma-042836 Glycine max 35.53 1.00e-101 364.00
IUUC-Ggo-045031 Gorilla gorilla 99.91 0.00e+00 2089.00
IUUC-Itr-048555 Ictidomys tridecemlineatus 90.76 0.00e+00 717.00
IUUC-Kpa-049307 Komagataella pastoris 36.75 8.00e-65 242.00
IUUC-Lch-050403 Latimeria chalumnae 82.03 0.00e+00 1692.00
IUUC-Loc-052218 Lepisosteus oculatus 81.11 0.00e+00 1708.00
IUUC-Lma-053096 Leptosphaeria maculans 38.15 2.00e-79 291.00
IUUC-Laf-054162 Loxodonta africana 91.31 0.00e+00 1714.00
IUUC-Mcc-055127 Macaca mulatta 99.63 0.00e+00 2081.00
IUUC-Meu-056187 Macropus eugenii 82.17 5.00e-105 375.00
IUUC-Mor-057021 Magnaporthe oryzae 35.37 3.00e-80 293.00
IUUC-Mpo-057570 Magnaporthe poae 36.46 3.00e-76 280.00
IUUC-Mtr-058154 Medicago truncatula 35.13 2.00e-104 374.00
IUUC-Mla-059124 Melampsora laricipopulina 48.28 3.00e-101 362.00
IUUC-Mga-059581 Meleagris gallopavo 90.72 0.00e+00 1945.00
IUUC-Mvi-060445 Microbotryum violaceum 37.87 3.00e-104 373.00
IUUC-Mmr-061360 Microcebus murinus 92.62 0.00e+00 1900.00
IUUC-Mdo-062194 Monodelphis domestica 87.68 0.00e+00 1947.00
IUUC-Mmu-064189 Mus musculus 93.35 0.00e+00 2016.00
IUUC-Mac-065275 Musa acuminata 48.90 1.00e-107 384.00
IUUC-Mpu-066439 Mustela putorius furo 93.26 0.00e+00 1940.00
IUUC-Mlu-068228 Myotis lucifugus 89.66 0.00e+00 1918.00
IUUC-Nfi-068280 Neosartorya fischeri 38.43 2.00e-78 288.00
IUUC-Ncr-068869 Neurospora crassa 35.61 3.00e-81 296.00
IUUC-Nle-069687 Nomascus leucogenys 99.34 0.00e+00 2030.00
IUUC-Opr-070592 Ochotona princeps 78.90 2.00e-128 453.00
IUUC-Ont-071836 Oreochromis niloticus 78.02 0.00e+00 1657.00
IUUC-Oan-072800 Ornithorhynchus anatinus 91.42 0.00e+00 1962.00
IUUC-Ocu-074587 Oryctolagus cuniculus 97.60 0.00e+00 2062.00
IUUC-Ola-087209 Oryzias latipes 78.12 0.00e+00 1635.00
IUUC-Olu-087699 Ostreococcus lucimarinus 42.59 3.00e-86 311.00
IUUC-Oga-088776 Otolemur garnettii 91.14 0.00e+00 1847.00
IUUC-Oar-089441 Ovis aries 92.08 0.00e+00 1949.00
IUUC-Ptr-091273 Pan troglodytes 99.91 0.00e+00 2088.00
IUUC-Pan-091981 Papio anubis 99.72 0.00e+00 2086.00
IUUC-Psi-093203 Pelodiscus sinensis 89.43 0.00e+00 1685.00
IUUC-Pma-094738 Petromyzon marinus 65.05 0.00e+00 1330.00
IUUC-Pno-095132 Phaeosphaeria nodorum 29.38 3.00e-59 224.00
IUUC-Ppa-095682 Physcomitrella patens 37.18 4.00e-111 396.00
IUUC-Pfo-097511 Poecilia formosa 77.93 0.00e+00 1668.00
IUUC-Pab-098634 Pongo abelii 96.86 0.00e+00 2006.00
IUUC-Pop-098928 Populus trichocarpa 34.53 3.00e-98 353.00
IUUC-Pca-100987 Procavia capensis 85.74 0.00e+00 863.00
IUUC-Pva-103034 Pteropus vampyrus 89.45 0.00e+00 1836.00
IUUC-Pgr-103513 Puccinia graminis 39.18 4.00e-106 379.00
IUUC-Ptt-103967 Puccinia triticina 41.32 7.00e-94 338.00
IUUC-Pte-104105 Pyrenophora teres 34.20 1.00e-80 295.00
IUUC-Pyt-104449 Pyrenophora triticirepentis 37.28 2.00e-77 285.00
IUUC-Rno-105380 Rattus norvegicus 92.72 0.00e+00 1745.00
IUUC-Sce-106446 Saccharomyces cerevisiae 40.53 3.00e-68 253.00
IUUC-Sha-107108 Sarcophilus harrisii 84.53 0.00e+00 1793.00
IUUC-Sja-107889 Schizosaccharomyces japonicus 42.49 6.00e-94 339.00
IUUC-Spo-108097 Schizosaccharomyces pombe 43.87 5.00e-93 336.00
IUUC-Ssl-108520 Sclerotinia sclerotiorum 30.75 5.00e-83 303.00
IUUC-Sar-113687 Sorex araneus 82.13 0.00e+00 912.00
IUUC-Sre-115038 Sporisorium reilianum 44.23 3.00e-97 350.00
IUUC-Ssc-116168 Sus scrofa 88.47 0.00e+00 816.00
IUUC-Tgu-116729 Taeniopygia guttata 90.69 0.00e+00 1957.00
IUUC-Tru-118068 Takifugu rubripes 76.92 0.00e+00 1617.00
IUUC-Tsy-118942 Tarsius syrichta 97.82 0.00e+00 730.00
IUUC-Tni-120732 Tetraodon nigroviridis 75.90 0.00e+00 1561.00
IUUC-Tre-121892 Trichoderma reesei 36.94 3.00e-87 317.00
IUUC-Tvi-122354 Trichoderma virens 35.51 1.00e-88 322.00
IUUC-Tme-127102 Tuber melanosporum 35.64 1.00e-90 328.00
IUUC-Tbe-127351 Tupaia belangeri 82.74 0.00e+00 1555.00
IUUC-Ttr-129061 Tursiops truncatus 91.61 0.00e+00 1915.00
IUUC-Uma-129343 Ustilago maydis 44.23 5.00e-98 353.00
IUUC-Vda-129748 Verticillium dahliae 38.60 3.00e-81 297.00
IUUC-Vvi-131234 Vitis vinifera 34.75 4.00e-102 366.00
IUUC-Xtr-132094 Xenopus tropicalis 85.91 0.00e+00 1799.00
IUUC-Xma-133923 Xiphophorus maculatus 78.21 0.00e+00 1671.00
Created Date 25-Jun-2017

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