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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045874
Ensembl Protein ID ENSP00000332791.8
UniProt Accession Q96M94; Q32MN3; Q8NDA3; Q96BM6; Q9C0I6; KLH15_HUMAN
Genbank Protein ID BAB71415.1; AAH15415.1; AAI09059.1; AAI09060.1; BAB21768.1; CAD38983.1
Protein Name Kelch-like protein 15
Genbank Nucleotide ID AK057298; BC015415; BC109058; BC109059; AB051464; AL834313
Gene Name KLHL15; KIAA1677
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000174010.9 ENST00000328046.8 ENSP00000332791.8
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 4.70e-18 67.0 32 96
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+lv+++ +f+ahk+ La++S++F+ +f+ +++e++ ++++++k++ ++ f+++l+F+Y g++++
   Q: 32   DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERD-QDKIHLKGLTATGFSHVLQFMYYGTIEL 96
           9***********************************9.************************9876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354).
 Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354).
Protein Sequence
(Fasta)
MAGDVEGFCS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA TQSDYFRIMF 60
TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT VHEILQAAMY VQLIEVVKFC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045874|E3,BTB_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
GTTTCAACTC TTGCTTGAAT CAAGAACAGA AGCCTCTCTT TAGACAGGTC AGTGCCACAT 60
AGTAATGTAT AGCTTAAAAT GTTAGTTAAT GTACAAAAAT CCAAACTCAG CGTTTAGATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045874|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0880--Kelch repeat
KW-0991--Mental retardation
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030597--KLHL15
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005634--C:nucleus
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
KEGG hsa:80311
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001418 Ailuropoda melanoleuca 98.84 0.00e+00 1160.00
IUUC-Apl-003970 Anas platyrhynchos 94.37 0.00e+00 1117.00
IUUC-Aca-005217 Anolis carolinensis 93.38 0.00e+00 1105.00
IUUC-Ame-011065 Astyanax mexicanus 86.42 0.00e+00 1071.00
IUUC-Bta-012443 Bos taurus 98.51 0.00e+00 1160.00
IUUC-Cja-019831 Callithrix jacchus 99.83 0.00e+00 1170.00
IUUC-Cfa-020941 Canis familiaris 99.01 0.00e+00 1163.00
IUUC-Cpo-021730 Cavia porcellus 99.17 0.00e+00 1165.00
IUUC-Csa-023247 Chlorocebus sabaeus 99.83 0.00e+00 1170.00
IUUC-Dre-028474 Danio rerio 85.26 0.00e+00 1067.00
IUUC-Dno-029411 Dasypus novemcinctus 98.18 0.00e+00 1155.00
IUUC-Dor-030576 Dipodomys ordii 99.17 0.00e+00 1165.00
IUUC-Ete-032327 Echinops telfairi 95.36 0.00e+00 1112.00
IUUC-Eca-033477 Equus caballus 98.51 0.00e+00 1158.00
IUUC-Fca-035546 Felis catus 98.84 0.00e+00 1162.00
IUUC-Fal-037370 Ficedula albicollis 94.37 0.00e+00 1117.00
IUUC-Gmo-038961 Gadus morhua 83.25 0.00e+00 986.00
IUUC-Gga-041049 Gallus gallus 94.21 0.00e+00 1116.00
IUUC-Gac-042003 Gasterosteus aculeatus 82.27 0.00e+00 989.00
IUUC-Ggo-044451 Gorilla gorilla 99.83 0.00e+00 1170.00
IUUC-Itr-048357 Ictidomys tridecemlineatus 99.34 0.00e+00 1166.00
IUUC-Lch-049603 Latimeria chalumnae 89.17 2.00e-127 448.00
IUUC-Loc-052300 Lepisosteus oculatus 89.40 0.00e+00 1099.00
IUUC-Laf-054459 Loxodonta africana 98.01 0.00e+00 1154.00
IUUC-Mcc-054846 Macaca mulatta 99.83 0.00e+00 1170.00
IUUC-Meu-056797 Macropus eugenii 98.21 3.00e-115 409.00
IUUC-Mga-059446 Meleagris gallopavo 94.37 0.00e+00 1117.00
IUUC-Mmr-061125 Microcebus murinus 98.34 0.00e+00 1157.00
IUUC-Mdo-062947 Monodelphis domestica 92.72 0.00e+00 1080.00
IUUC-Mmu-063708 Mus musculus 99.34 0.00e+00 1165.00
IUUC-Mpu-066447 Mustela putorius furo 98.83 0.00e+00 1153.00
IUUC-Mlu-066999 Myotis lucifugus 94.32 0.00e+00 975.00
IUUC-Nle-069918 Nomascus leucogenys 99.83 0.00e+00 1170.00
IUUC-Ont-071446 Oreochromis niloticus 83.81 0.00e+00 979.00
IUUC-Oan-072872 Ornithorhynchus anatinus 90.23 0.00e+00 1105.00
IUUC-Ocu-073969 Oryctolagus cuniculus 98.16 0.00e+00 907.00
IUUC-Ola-087557 Oryzias latipes 83.23 1.00e-151 528.00
IUUC-Oga-088567 Otolemur garnettii 99.00 0.00e+00 1159.00
IUUC-Oar-089882 Ovis aries 98.34 0.00e+00 1159.00
IUUC-Ptr-091229 Pan troglodytes 99.83 0.00e+00 1138.00
IUUC-Pan-091977 Papio anubis 99.83 0.00e+00 1170.00
IUUC-Psi-093496 Pelodiscus sinensis 94.90 4.00e-156 544.00
IUUC-Pfo-096759 Poecilia formosa 82.90 0.00e+00 997.00
IUUC-Pab-098480 Pongo abelii 99.83 0.00e+00 1170.00
IUUC-Rno-105500 Rattus norvegicus 99.34 0.00e+00 1165.00
IUUC-Sha-106521 Sarcophilus harrisii 92.71 0.00e+00 1053.00
IUUC-Ssc-116372 Sus scrofa 98.84 0.00e+00 1162.00
IUUC-Tgu-116481 Taeniopygia guttata 94.37 0.00e+00 1117.00
IUUC-Tru-118542 Takifugu rubripes 81.13 0.00e+00 985.00
IUUC-Tsy-118848 Tarsius syrichta 100.00 1.00e-128 453.00
IUUC-Tni-119989 Tetraodon nigroviridis 81.73 0.00e+00 926.00
IUUC-Tbe-127485 Tupaia belangeri 99.50 0.00e+00 1167.00
IUUC-Ttr-129214 Tursiops truncatus 98.51 0.00e+00 1156.00
IUUC-Vpa-130261 Vicugna pacos 95.86 0.00e+00 1118.00
IUUC-Xtr-132092 Xenopus tropicalis 89.17 0.00e+00 1017.00
Created Date 25-Jun-2017

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