iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000165192.13	ENST00000380470.7	ENSP00000369837.3
ENSG00000165192.13	ENST00000344384.8	ENSP00000343408.4
ENSG00000165192.13	ENST00000480796.5	ENSP00000417914.1
ENSG00000165192.13	ENST00000485437.2	ENSP00000419385.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	miRTarBase	TRANSFAC
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	24337577

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.00e-12	49.4	276	323

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           ++ llr+ p+ L +LCRl++r+clg+ +++ai+kL+LP+ L ++Lly+
   Q: 276  QALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 323
           677899*****************************************8 PP

Organism

Homo sapiens

Functional Description
(View)

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR IAEEIYGGIS 60
DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS SLHEACLGGH VACAKALLEN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTCAGTGA AATTTTACAG TCCTAGGACC CTATACAGAG CATAAGCCAA AATGGAAGAT 60
GGTCCTGTTT TCTATGGCTT TAAAAACATT TTTATTACAA TGTTTGCTAC GTTTTTTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS

Pfam

PF12796--Ank_2
PF07525--SOCS_box

SMART

SM00248--ANK
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

hsa:140456

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001489	Ailuropoda melanoleuca	94.16	4.00e-159	553.00
IUUC-Apl-003530	Anas platyrhynchos	74.61	3.00e-138	484.00
IUUC-Ame-010976	Astyanax mexicanus	34.86	2.00e-40	159.00
IUUC-Bta-012746	Bos taurus	92.26	4.00e-161	560.00
IUUC-Cja-019292	Callithrix jacchus	98.14	3.00e-172	597.00
IUUC-Cfa-020069	Canis familiaris	95.45	2.00e-162	564.00
IUUC-Cpo-022164	Cavia porcellus	95.67	4.00e-168	583.00
IUUC-Csa-023539	Chlorocebus sabaeus	99.03	4.00e-165	573.00
IUUC-Cho-024465	Choloepus hoffmanni	75.57	2.00e-113	402.00
IUUC-Dre-028590	Danio rerio	49.39	2.00e-85	309.00
IUUC-Dno-028948	Dasypus novemcinctus	94.43	5.00e-165	573.00
IUUC-Dor-030607	Dipodomys ordii	74.92	9.00e-119	419.00
IUUC-Ete-032897	Echinops telfairi	92.86	2.00e-153	534.00
IUUC-Eca-034213	Equus caballus	97.83	1.00e-170	592.00
IUUC-Eeu-034684	Erinaceus europaeus	81.21	6.00e-112	396.00
IUUC-Fca-036195	Felis catus	88.60	3.00e-155	540.00
IUUC-Fal-037341	Ficedula albicollis	54.15	2.00e-99	355.00
IUUC-Gga-040371	Gallus gallus	74.30	2.00e-137	481.00
IUUC-Ggo-045195	Gorilla gorilla	99.38	4.00e-174	603.00
IUUC-Itr-048473	Ictidomys tridecemlineatus	97.39	1.00e-165	575.00
IUUC-Lch-049957	Latimeria chalumnae	75.18	9.00e-122	429.00
IUUC-Loc-051897	Lepisosteus oculatus	68.11	6.00e-130	456.00
IUUC-Laf-053995	Loxodonta africana	92.57	6.00e-162	563.00
IUUC-Mcc-055105	Macaca mulatta	98.71	7.00e-164	569.00
IUUC-Mga-060110	Meleagris gallopavo	73.70	2.00e-133	468.00
IUUC-Mmr-060790	Microcebus murinus	91.30	3.00e-153	534.00
IUUC-Mdo-063038	Monodelphis domestica	81.73	4.00e-147	514.00
IUUC-Mmu-063999	Mus musculus	90.71	4.00e-158	550.00
IUUC-Mpu-065750	Mustela putorius furo	93.18	3.00e-157	547.00
IUUC-Mlu-067133	Myotis lucifugus	93.50	2.00e-169	588.00
IUUC-Nle-069508	Nomascus leucogenys	99.68	6.00e-166	576.00
IUUC-Opr-070897	Ochotona princeps	69.47	2.00e-99	354.00
IUUC-Ocu-074144	Oryctolagus cuniculus	96.76	2.00e-161	561.00
IUUC-Ola-086779	Oryzias latipes	51.10	4.00e-86	311.00
IUUC-Oga-088306	Otolemur garnettii	94.46	2.00e-163	567.00
IUUC-Oar-089814	Ovis aries	92.88	1.00e-161	562.00
IUUC-Ptr-091557	Pan troglodytes	91.18	4.00e-87	314.00
IUUC-Pan-092867	Papio anubis	99.35	2.00e-165	575.00
IUUC-Psi-094054	Pelodiscus sinensis	75.23	3.00e-140	491.00
IUUC-Pma-094342	Petromyzon marinus	49.44	2.00e-63	235.00
IUUC-Pfo-097132	Poecilia formosa	50.92	3.00e-90	325.00
IUUC-Pab-097685	Pongo abelii	99.38	2.00e-173	601.00
IUUC-Pva-102949	Pteropus vampyrus	93.81	6.00e-162	563.00
IUUC-Sha-107348	Sarcophilus harrisii	83.28	4.00e-149	520.00
IUUC-Sar-113203	Sorex araneus	64.09	4.00e-99	354.00
IUUC-Ssc-116245	Sus scrofa	93.19	3.00e-162	564.00
IUUC-Tgu-117317	Taeniopygia guttata	73.68	5.00e-137	480.00
IUUC-Tsy-118847	Tarsius syrichta	72.76	2.00e-111	395.00
IUUC-Tni-120408	Tetraodon nigroviridis	54.58	4.00e-81	294.00
IUUC-Tme-127223	Tuber melanosporum	23.60	2.00e-06	47.00
IUUC-Tbe-127290	Tupaia belangeri	82.04	2.00e-137	481.00
IUUC-Ttr-128755	Tursiops truncatus	92.88	1.00e-162	565.00
IUUC-Vpa-130064	Vicugna pacos	85.76	8.00e-146	509.00
IUUC-Xtr-132081	Xenopus tropicalis	66.56	1.00e-121	429.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence