iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/Other	E3 adaptor/Cullin RING/Other	21098278

Organism

Homo sapiens

Functional Description
(View)

Belongs to the Antp homeobox family. Deformed subfamily.

Protein Sequence
(Fasta)

MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC 60
TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG ALLPEPGQRC EAVSSSPPPP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAATTGAA AACCTTGTAA TCCCAAGAAC AGACTCGCAC TGCCTTTTTC TGTTCCCAGA 60
GCTCAAAACT AGAACAAAAC GAAATAAAAC CAAAGCACTC AAACCACACC CCAAACGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR009057--Homeobox-like
IPR017995--Homeobox_antennapedia
IPR001827--Homeobox_Antennapedia_CS
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR020479--Homeobox_metazoa

PROSITE

PS00032--ANTENNAPEDIA
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2

Pfam

PF00046--Homeobox

PRINTS

PR00025--ANTENNAPEDIA
PR00024--HOMEOBOX

SMART

SM00389--HOX

Gene Ontology

GO:0005813--C:centrosome
GO:0005634--C:nucleus
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0009952--P:anterior/posterior pattern specification
GO:0048539--P:bone marrow development
GO:0008283--P:cell proliferation
GO:0060216--P:definitive hemopoiesis
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0060218--P:hematopoietic stem cell differentiation
GO:0002011--P:morphogenesis of an epithelial sheet
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:2000738--P:positive regulation of stem cell differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0048103--P:somatic stem cell division
GO:0048536--P:spleen development
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:3214

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002156	Ailuropoda melanoleuca	65.94	4.00e-74	270.00
IUUC-Aca-004281	Anolis carolinensis	69.74	3.00e-76	278.00
IUUC-Ame-011424	Astyanax mexicanus	65.07	2.00e-70	258.00
IUUC-Bta-013580	Bos taurus	95.63	1.00e-102	365.00
IUUC-Bdi-014316	Brachypodium distachyon	47.54	1.00e-09	57.40
IUUC-Bra-017918	Brassica rapa	49.15	1.00e-09	57.00
IUUC-Cja-019422	Callithrix jacchus	89.91	7.00e-96	343.00
IUUC-Cfa-020551	Canis familiaris	92.14	1.00e-105	375.00
IUUC-Cpo-022099	Cavia porcellus	99.18	3.00e-64	237.00
IUUC-Csa-023337	Chlorocebus sabaeus	100.00	3.00e-104	370.00
IUUC-Dre-027947	Danio rerio	65.65	7.00e-72	263.00
IUUC-Dno-029094	Dasypus novemcinctus	97.37	6.00e-102	363.00
IUUC-Dme-031651	Drosophila melanogaster	29.82	1.10e+00	30.40
IUUC-Fca-035652	Felis catus	100.00	5.00e-61	226.00
IUUC-Gac-041606	Gasterosteus aculeatus	59.67	6.00e-65	240.00
IUUC-Itr-048677	Ictidomys tridecemlineatus	97.40	2.00e-106	378.00
IUUC-Lch-050353	Latimeria chalumnae	67.10	3.00e-71	261.00
IUUC-Laf-053406	Loxodonta africana	98.25	1.00e-106	379.00
IUUC-Meu-056129	Macropus eugenii	86.90	1.00e-99	355.00
IUUC-Mdo-062656	Monodelphis domestica	86.03	5.00e-99	353.00
IUUC-Mmu-064317	Mus musculus	96.07	6.00e-104	370.00
IUUC-Mpu-066715	Mustela putorius furo	99.56	3.00e-105	374.00
IUUC-Nle-069403	Nomascus leucogenys	99.12	8.00e-104	369.00
IUUC-Ont-072022	Oreochromis niloticus	61.86	4.00e-65	241.00
IUUC-Oan-073355	Ornithorhynchus anatinus	79.04	5.00e-92	330.00
IUUC-Obr-076254	Oryza brachyantha	45.00	4.00e-08	51.60
IUUC-Oga-089067	Otolemur garnettii	98.25	7.00e-105	373.00
IUUC-Oar-089454	Ovis aries	80.35	3.00e-97	347.00
IUUC-Ptr-091405	Pan troglodytes	100.00	1.00e-103	369.00
IUUC-Pan-092634	Papio anubis	100.00	3.00e-104	370.00
IUUC-Psi-093940	Pelodiscus sinensis	70.74	1.00e-75	276.00
IUUC-Pfo-097180	Poecilia formosa	58.23	3.00e-62	231.00
IUUC-Pab-097837	Pongo abelii	100.00	9.00e-104	369.00
IUUC-Pva-102648	Pteropus vampyrus	98.69	2.00e-106	378.00
IUUC-Rno-106098	Rattus norvegicus	95.20	1.00e-103	369.00
IUUC-Sha-107548	Sarcophilus harrisii	86.46	1.00e-98	352.00
IUUC-Sly-111303	Solanum lycopersicum	44.29	1.00e-08	53.90
IUUC-Ssc-116419	Sus scrofa	99.56	2.00e-104	371.00
IUUC-Tru-118619	Takifugu rubripes	61.86	9.00e-66	243.00
IUUC-Tni-120889	Tetraodon nigroviridis	60.43	2.00e-65	242.00
IUUC-Ttr-128475	Tursiops truncatus	98.69	1.00e-104	372.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence