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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018587
UUCD1 version UUC-CaE-00287
Ensembl Protein ID K07A1.12
UniProt Accession P90916; A2JDY3; O62411; LIN53_CAEEL
Genbank Protein ID AAD05571.1; CAB03178.1; CAB03178.1
Protein Name Probable histone-binding protein lin-53; Abnormal cell lineage protein 53; Synthetic multivulva protein p48
Genbank Nucleotide ID AF116530; Z81097; AL023833
Gene Name lin-53; rba-2; K07A1.12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003036 K07A1.12 K07A1.12
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.60e-34 114.8 264 297
UBD/Beta-Prp 9.70e-48 163.1 118 340
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           H+++v+claf   s+ +l++Gs D+t+ +WDlr 
   Q: 264  HSAEVNCLAFnpySEFILATGSADKTVALWDLRN 297
           9*********96554568*************986 PP
   

   UBD/Beta-Prp
   S: 50   gheaevtavkfspdgk.ilvtgseDrtikvwdls.........tgkcvhtlkghedsvlslsfspsg.dklvsGshdrtirvwdletgqclee......tl 133
           +he+ev+  ++ p+++ i++t s  + ++++d+          t+ +++ lkgh+++ + ls++p++   ++s+s+d+t+  wd++ +q +        ++
   Q: 118  NHEGEVNRARYMPQKSnIIATKSPHADVYIFDYLkhsavprdnTFNPLIRLKGHTKEGYGLSWNPNKeGLILSASDDQTVCHWDINANQNVAGelqakdVF 218
           79999*9999999877799999999******998899999999**********************887***********************889999**** PP
   S: 134  sghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlqtgec.vrtlnghtdnvksvrfs 231
           +gh++vv  v++h     ++ s ++D+++ +Wd++t +  +     h   v++l+f++ + + l++gs d+tv lwdl++ ++ +++++ h+d + +v+ s
   Q: 219  KGHESVVEDVAWHVLHdGVFGSVGDDKKLLIWDVRTSTPGHCIDA-HSAEVNCLAFNPYSeFILATGSADKTVALWDLRNLRMkLHSFESHRDEIFQVQWS 318
           **************999**************************98.***********99978899**************65554***************** PP
   S: 232  .pnderlvsgssDgsiriWdlr 252
             n+++l+s + D+ + +Wdl 
   Q: 319  pHNETILASSGTDKRLHVWDLS 340
           55566777888*********96 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation (PubMed:26904949). Synthetic multivulva class B (synMuvB) protein (PubMed:9875852). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:9875852, PubMed:10704416, PubMed:17075059).
 Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation (PubMed:26904949). Synthetic multivulva class B (synMuvB) protein (PubMed:9875852). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:9875852, PubMed:10704416, PubMed:17075059).
Protein Sequence
(Fasta)
MATLEDGTSE DRVANDEYKI WKKNTPFLYD LVMTHALEWP SLSVQWLPDV AKDNSDHTIH 60
RLILGTHTSD EQNHLLISKI CMPTDDAQFD ASRYDTERSE YGGFGAVNGK VEPDIRINHE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018587|E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAATGGCCA CTCTTGAAGA TGGAACCTCC GAAGATCGCG TCGCAAATGA TGAATACAAA 60
ATTTGGAAAA AGAACACCCC GTTCTTGTAC GATCTCGTAA TGACACATGC GCTTGAGTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018587|E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0070176--C:DRM complex
GO:0005634--C:nucleus
GO:0017053--C:transcriptional repressor complex
GO:0042826--F:histone deacetylase binding
GO:0001708--P:cell fate specification
GO:0016569--P:covalent chromatin modification
GO:0009790--P:embryo development
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0048557--P:embryonic digestive tract morphogenesis
GO:0040035--P:hermaphrodite genitalia development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045138--P:nematode male tail tip morphogenesis
GO:0006351--P:transcription, DNA-templated
KEGG cel:CELE_K07A1.12
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000757 Aegilops tauschii 55.86 7.00e-126 442.00
IUUC-Aml-001256 Ailuropoda melanoleuca 70.07 1.00e-180 624.00
IUUC-Atr-003075 Amborella trichopoda 60.95 2.00e-150 524.00
IUUC-Apl-003952 Anas platyrhynchos 71.88 0.00e+00 631.00
IUUC-Aca-004508 Anolis carolinensis 71.60 0.00e+00 631.00
IUUC-Aly-006342 Arabidopsis lyrata 60.60 8.00e-146 508.00
IUUC-Ath-006855 Arabidopsis thaliana 60.85 2.00e-146 510.00
IUUC-Ago-007892 Ashbya gossypii 36.34 7.00e-75 273.00
IUUC-Acl-008163 Aspergillus clavatus 47.43 6.00e-111 392.00
IUUC-Afl-008645 Aspergillus flavus 46.75 1.00e-110 392.00
IUUC-Afu-009091 Aspergillus fumigatus 47.43 1.00e-110 391.00
IUUC-Ani-009478 Aspergillus nidulans 45.12 2.00e-94 337.00
IUUC-Ang-009707 Aspergillus niger 47.32 3.00e-108 384.00
IUUC-Aor-010028 Aspergillus oryzae 46.75 1.00e-110 392.00
IUUC-Ate-010416 Aspergillus terreus 46.70 1.00e-110 391.00
IUUC-Ame-011771 Astyanax mexicanus 71.46 0.00e+00 632.00
IUUC-Bgr-012001 Blumeria graminis 44.93 6.00e-95 339.00
IUUC-Bta-012851 Bos taurus 72.51 0.00e+00 631.00
IUUC-Bci-013815 Botrytis cinerea 45.67 3.00e-111 393.00
IUUC-Bdi-014926 Brachypodium distachyon 61.08 1.00e-144 504.00
IUUC-Bol-015856 Brassica oleracea 61.23 9.00e-145 505.00
IUUC-Bra-016725 Brassica rapa 58.37 1.00e-142 498.00
IUUC-Cja-019884 Callithrix jacchus 72.51 0.00e+00 631.00
IUUC-Cfa-020343 Canis familiaris 72.51 0.00e+00 631.00
IUUC-Cpo-021591 Cavia porcellus 72.51 0.00e+00 631.00
IUUC-Cre-022563 Chlamydomonas reinhardtii 59.95 2.00e-141 494.00
IUUC-Csa-023738 Chlorocebus sabaeus 69.98 4.00e-180 622.00
IUUC-Cho-024506 Choloepus hoffmanni 72.02 2.00e-180 623.00
IUUC-Cin-025589 Ciona intestinalis 72.06 0.00e+00 629.00
IUUC-Csv-026216 Ciona savignyi 72.97 0.00e+00 630.00
IUUC-Cgl-026564 Colletotrichum gloeosporioides 45.43 9.00e-107 379.00
IUUC-Cne-026792 Cryptococcus neoformans 49.63 1.00e-120 424.00
IUUC-Cme-027307 Cyanidioschyzon merolae 47.03 9.00e-115 405.00
IUUC-Dre-028742 Danio rerio 71.84 0.00e+00 630.00
IUUC-Dno-029114 Dasypus novemcinctus 72.51 0.00e+00 631.00
IUUC-Dor-030733 Dipodomys ordii 63.25 4.00e-153 533.00
IUUC-Dse-031282 Dothistroma septosporum 43.21 9.00e-92 329.00
IUUC-Dme-032126 Drosophila melanogaster 72.22 0.00e+00 641.00
IUUC-Ete-032731 Echinops telfairi 72.51 0.00e+00 631.00
IUUC-Eca-033533 Equus caballus 72.75 0.00e+00 626.00
IUUC-Eeu-034644 Erinaceus europaeus 61.54 1.00e-79 288.00
IUUC-Fca-036202 Felis catus 72.51 0.00e+00 631.00
IUUC-Fal-037084 Ficedula albicollis 72.12 0.00e+00 632.00
IUUC-Fox-037974 Fusarium oxysporum 44.13 2.00e-103 368.00
IUUC-Fso-038246 Fusarium solani 43.99 2.00e-93 334.00
IUUC-Gmo-039214 Gadus morhua 72.33 0.00e+00 637.00
IUUC-Ggr-039741 Gaeumannomyces graminis 45.99 4.00e-107 380.00
IUUC-Gga-040396 Gallus gallus 72.51 0.00e+00 631.00
IUUC-Gac-041389 Gasterosteus aculeatus 71.36 0.00e+00 630.00
IUUC-Gma-042791 Glycine max 61.25 2.00e-143 500.00
IUUC-Ggo-045422 Gorilla gorilla 66.59 3.00e-161 559.00
IUUC-Hsa-045683 Homo sapiens 72.51 0.00e+00 631.00
IUUC-Hvu-047457 Hordeum vulgare 63.92 2.00e-71 259.00
IUUC-Itr-047950 Ictidomys tridecemlineatus 72.51 0.00e+00 631.00
IUUC-Kpa-049258 Komagataella pastoris 36.61 3.00e-69 253.00
IUUC-Lch-050545 Latimeria chalumnae 73.32 0.00e+00 645.00
IUUC-Lpe-051337 Leersia perrieri 61.58 2.00e-145 507.00
IUUC-Loc-052473 Lepisosteus oculatus 72.09 0.00e+00 632.00
IUUC-Laf-054114 Loxodonta africana 72.51 0.00e+00 631.00
IUUC-Mcc-055648 Macaca mulatta 72.51 0.00e+00 631.00
IUUC-Meu-056490 Macropus eugenii 72.51 0.00e+00 631.00
IUUC-Mor-056947 Magnaporthe oryzae 47.57 3.00e-104 370.00
IUUC-Mpo-057602 Magnaporthe poae 46.23 4.00e-108 383.00
IUUC-Mtr-057853 Medicago truncatula 61.27 2.00e-142 497.00
IUUC-Mla-058884 Melampsora laricipopulina 50.75 9.00e-118 415.00
IUUC-Mga-059452 Meleagris gallopavo 72.51 0.00e+00 631.00
IUUC-Mvi-060450 Microbotryum violaceum 52.87 1.00e-125 441.00
IUUC-Mmr-061008 Microcebus murinus 69.83 2.00e-180 624.00
IUUC-Mdo-062817 Monodelphis domestica 71.74 0.00e+00 630.00
IUUC-Mmu-063282 Mus musculus 72.51 0.00e+00 631.00
IUUC-Mac-065480 Musa acuminata 59.61 6.00e-140 489.00
IUUC-Mpu-066529 Mustela putorius furo 71.53 0.00e+00 624.00
IUUC-Mlu-068072 Myotis lucifugus 72.51 0.00e+00 631.00
IUUC-Nfi-068374 Neosartorya fischeri 47.43 4.00e-109 386.00
IUUC-Ncr-068794 Neurospora crassa 45.65 4.00e-107 380.00
IUUC-Nle-069577 Nomascus leucogenys 72.51 0.00e+00 631.00
IUUC-Opr-070245 Ochotona princeps 60.10 3.00e-139 486.00
IUUC-Ont-071809 Oreochromis niloticus 72.02 0.00e+00 631.00
IUUC-Oan-072839 Ornithorhynchus anatinus 72.33 0.00e+00 630.00
IUUC-Ocu-074778 Oryctolagus cuniculus 70.21 0.00e+00 624.00
IUUC-Oba-075719 Oryza barthii 53.24 6.00e-121 426.00
IUUC-Obr-076859 Oryza brachyantha 61.18 4.00e-144 503.00
IUUC-Ogl-077920 Oryza glaberrima 61.33 1.00e-145 508.00
IUUC-Ogu-078048 Oryza glumaepatula 52.07 9.00e-121 426.00
IUUC-Oin-079960 Oryza indica 50.86 7.00e-109 386.00
IUUC-Olo-080553 Oryza longistaminata 50.00 4.00e-117 413.00
IUUC-Ome-081835 Oryza meridionalis 61.33 4.00e-146 510.00
IUUC-Oni-082494 Oryza nivara 53.00 2.00e-119 421.00
IUUC-Opu-083913 Oryza punctata 59.55 3.00e-137 480.00
IUUC-Oru-084666 Oryza rufipogon 61.33 1.00e-145 508.00
IUUC-Osa-085884 Oryza sativa 61.33 1.00e-145 508.00
IUUC-Ola-086664 Oryzias latipes 72.02 0.00e+00 631.00
IUUC-Olu-087579 Ostreococcus lucimarinus 60.10 5.00e-133 466.00
IUUC-Oga-088364 Otolemur garnettii 66.59 7.00e-166 575.00
IUUC-Oar-089652 Ovis aries 72.51 0.00e+00 631.00
IUUC-Ptr-091598 Pan troglodytes 70.77 6.00e-180 622.00
IUUC-Pan-092412 Papio anubis 69.98 4.00e-180 622.00
IUUC-Psi-093300 Pelodiscus sinensis 72.14 1.00e-169 587.00
IUUC-Pma-094307 Petromyzon marinus 72.24 0.00e+00 630.00
IUUC-Pno-095153 Phaeosphaeria nodorum 45.23 5.00e-97 346.00
IUUC-Ppa-095800 Physcomitrella patens 61.48 7.00e-148 515.00
IUUC-Pfo-097376 Poecilia formosa 72.09 0.00e+00 633.00
IUUC-Pab-097697 Pongo abelii 72.51 0.00e+00 631.00
IUUC-Pop-099709 Populus trichocarpa 60.34 2.00e-146 510.00
IUUC-Pca-100642 Procavia capensis 63.89 7.00e-151 525.00
IUUC-Ppe-101212 Prunus persica 60.20 5.00e-144 502.00
IUUC-Pva-102253 Pteropus vampyrus 72.51 0.00e+00 631.00
IUUC-Pgr-103441 Puccinia graminis 51.28 4.00e-113 400.00
IUUC-Pte-104332 Pyrenophora teres 45.94 3.00e-99 353.00
IUUC-Pyt-104516 Pyrenophora triticirepentis 45.94 3.00e-99 353.00
IUUC-Rno-105678 Rattus norvegicus 72.51 0.00e+00 631.00
IUUC-Sce-106364 Saccharomyces cerevisiae 34.96 9.00e-64 236.00
IUUC-Sha-106663 Sarcophilus harrisii 72.51 0.00e+00 631.00
IUUC-Sja-108001 Schizosaccharomyces japonicus 45.14 2.00e-98 350.00
IUUC-Spo-108145 Schizosaccharomyces pombe 48.13 1.00e-106 378.00
IUUC-Smo-109159 Selaginella moellendorffii 60.68 1.00e-146 511.00
IUUC-Sit-110144 Setaria italica 61.35 6.00e-139 485.00
IUUC-Sly-111680 Solanum lycopersicum 60.19 1.00e-144 504.00
IUUC-Stu-111931 Solanum tuberosum 60.79 2.00e-144 503.00
IUUC-Sar-113236 Sorex araneus 63.36 2.00e-156 544.00
IUUC-Sbi-114637 Sorghum bicolor 61.10 2.00e-144 503.00
IUUC-Sre-114980 Sporisorium reilianum 50.35 1.00e-126 444.00
IUUC-Ssc-116352 Sus scrofa 70.07 0.00e+00 625.00
IUUC-Tgu-116925 Taeniopygia guttata 72.26 0.00e+00 630.00
IUUC-Tru-117549 Takifugu rubripes 71.91 0.00e+00 630.00
IUUC-Tsy-118854 Tarsius syrichta 69.83 2.00e-180 623.00
IUUC-Tni-120398 Tetraodon nigroviridis 71.67 0.00e+00 630.00
IUUC-Tca-121841 Theobroma cacao 59.85 1.00e-142 498.00
IUUC-Tre-122190 Trichoderma reesei 44.84 3.00e-97 347.00
IUUC-Tvi-122304 Trichoderma virens 44.79 9.00e-106 375.00
IUUC-Tae-124648 Triticum aestivum 60.84 1.00e-137 481.00
IUUC-Tur-126850 Triticum urartu 58.75 3.00e-104 370.00
IUUC-Tme-126949 Tuber melanosporum 47.69 5.00e-115 406.00
IUUC-Tbe-128010 Tupaia belangeri 61.28 4.00e-152 529.00
IUUC-Ttr-128558 Tursiops truncatus 63.66 2.00e-157 547.00
IUUC-Uma-129424 Ustilago maydis 50.94 4.00e-128 449.00
IUUC-Vda-129873 Verticillium dahliae 44.24 1.00e-107 382.00
IUUC-Vpa-130079 Vicugna pacos 72.02 0.00e+00 625.00
IUUC-Vvi-131585 Vitis vinifera 60.95 9.00e-145 504.00
IUUC-Xtr-132005 Xenopus tropicalis 71.74 0.00e+00 631.00
IUUC-Xma-133066 Xiphophorus maculatus 72.02 0.00e+00 631.00
IUUC-Yli-134334 Yarrowia lipolytica 38.48 9.00e-81 292.00
IUUC-Zma-135710 Zea mays 61.10 5.00e-139 486.00
Created Date 25-Jun-2017

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