iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000074570.13	ENSMUST00000099061.8	ENSMUSP00000096660.2
ENSMUSG00000074570.13	ENSMUST00000103073.8	ENSMUSP00000099362.2
ENSMUSG00000074570.13	ENSMUST00000109136.2	ENSMUSP00000104764.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.60e-11	42.6	16	69

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPenFve 60
            ++lyd  a  +deL + +Gd+++++ ++  ++egW+++   l+g++Gl P+n  +
   Q: 16   ARALYDNHADCSDELAFSRGDILTIVeQNVPESEGWWRC--LLHGRQGLAPANRLQ 69
           579***********************6667899******..9**********9655 PP

Organism

Mus musculus

Functional Description
(View)

Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity).

Protein Sequence
(Fasta)

MRGTSIREGA PKTLLARALY DNHADCSDEL AFSRGDILTI VEQNVPESEG WWRCLLHGRQ 60
GLAPANRLQV LRETPADRPC PLLPRGPDTD LTSSGAPYQV QDLISPPPQG PVYEPMRSWV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTGACTCT CTTTACTTGA AAGAATCATC TCGACTGTTT CCATGTGTTG GCAAACAGTT 60
CCATAGAATC CAGCTCCTGG GAACCAGCCA GCAGCATGCA GTGATATTGC ATCATTGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR021901--CAS_DUF3513
IPR014928--Serine_rich
IPR001452--SH3_domain
IPR015224--Talin_cent

PROSITE

PS50002--SH3

Pfam

PF12026--DUF3513
PF08824--Serine_rich
PF14604--SH3_9

SMART

SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005925--C:focal adhesion
GO:0007155--P:cell adhesion

KEGG

mmu:320664

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003663	Anas platyrhynchos	35.80	7.00e-81	295.00
IUUC-Ame-010839	Astyanax mexicanus	37.43	1.00e-56	214.00
IUUC-Bta-013513	Bos taurus	56.28	0.00e+00	793.00
IUUC-Cja-018847	Callithrix jacchus	60.96	0.00e+00	831.00
IUUC-Dre-028447	Danio rerio	37.01	6.00e-57	216.00
IUUC-Dno-029953	Dasypus novemcinctus	58.99	0.00e+00	793.00
IUUC-Gga-040742	Gallus gallus	40.19	1.00e-124	441.00
IUUC-Gac-041754	Gasterosteus aculeatus	48.82	3.00e-27	117.00
IUUC-Hsa-045661	Homo sapiens	69.77	1.00e-79	290.00
IUUC-Itr-049018	Ictidomys tridecemlineatus	62.53	0.00e+00	840.00
IUUC-Lch-050612	Latimeria chalumnae	35.75	2.00e-121	429.00
IUUC-Loc-052714	Lepisosteus oculatus	30.96	1.00e-56	214.00
IUUC-Mcc-054708	Macaca mulatta	68.84	4.00e-80	291.00
IUUC-Meu-056005	Macropus eugenii	47.64	9.00e-57	215.00
IUUC-Mga-059247	Meleagris gallopavo	36.65	2.00e-112	400.00
IUUC-Mmr-061129	Microcebus murinus	63.97	0.00e+00	724.00
IUUC-Mdo-062756	Monodelphis domestica	46.09	2.00e-176	613.00
IUUC-Ont-072595	Oreochromis niloticus	35.38	7.00e-52	199.00
IUUC-Oan-073556	Ornithorhynchus anatinus	47.66	2.00e-170	592.00
IUUC-Ocu-074645	Oryctolagus cuniculus	59.32	0.00e+00	785.00
IUUC-Psi-094075	Pelodiscus sinensis	41.44	6.00e-153	535.00
IUUC-Pfo-097206	Poecilia formosa	30.74	2.00e-77	284.00
IUUC-Rno-105677	Rattus norvegicus	83.66	0.00e+00	1263.00
IUUC-Sha-106989	Sarcophilus harrisii	48.85	0.00e+00	658.00
IUUC-Ssc-115527	Sus scrofa	58.33	6.00e-68	251.00
IUUC-Tgu-116510	Taeniopygia guttata	38.15	3.00e-127	449.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence