iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000090686.15	ENST00000308271.13	ENSP00000309262.9
ENSG00000090686.15	ENST00000374732.7	ENSP00000363864.3
ENSG00000090686.15	ENST00000529637.5	ENSP00000431949.1
ENSG00000090686.15	ENST00000534705.5	ENSP00000435604.1
ENSG00000090686.15	ENST00000421625.6	ENSP00000406256.2
ENSG00000090686.15	ENST00000374730.2	ENSP00000363862.2
ENSG00000090686.15	ENST00000400301.5	ENSP00000383157.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRecords	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
ClinVar	GWASdb	GWAS Central
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	16214042; 19615732
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	15354349

Classification

Family	E-value	Score	Start	End
DUB/USP	1.40e-72	246.4	89	419
ULD/UDP/UBQ/UBQ_Other	3.10e-10	41.5	945	1007

Active Site

Position(s)	Description	Evidence
98	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10093}
353	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +Gl+Nlg+tCY+N  LQ+ +   elr++l               ++ee ++ + ++++++lq lf+ l++s++++++p+ ++kal+     +
   Q: 89   VGLTNLGATCYVNTFLQVWFLNLELRQALYLcpstcsdyMLGDGIQEE-KDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALG-----L 174
           6*****************************955555544333333333.367888******************************9.....7 PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           ++ +qqDaqEf + +++ le++l                       +++k+   ++++++ F g++   ++c++c+++s+  ++f++l+l++
   Q: 175  DTGQQQDAQEFSKLFMSLLEDTL-----------------------SKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNI 243
           8899*******************.......................457889999************************************* PP
   S: 177  pgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctsp 268
           +g++     +l+dc+++f kee+leg+n+y+ce+c++kq+a++k++l +lP +L l+L+Rf f++++++++k+n+++ f + Ld++p+++++
   Q: 244  QGHK-----QLTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSEILDMEPYVEHK 330
           ****.....9*******************************************************************************995 PP
   S: 269  eekqkekkkYeLiavvvHsG.slssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......................staYvlfY 335
                 ++ YeL+av++H G s+ sGHY+a+vk+ ++g+W++f+D+ +++++ ++ +   +                       ++aY+l+Y
   Q: 331  GG----SYVYELSAVLIHRGvSAYSGHYIAHVKDpQSGEWYKFNDEDIEKMEGKKLQLGIEedlaepsksqtrkpkcgkgthcsRNAYMLVY 418
           54....79**************************44555************9999998665999**************************** PP
   S: 336  k 336
           +
   Q: 419  R 419
           8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 16   k...vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdgstihllekks 74
           k   v+   t +eLK +i +++++ p +q+L ++GkiL +d+ tL+ +g+ ++s+i+l  +++
   Q: 945  KallVSANQTLKELKIQIMHAFSVAPFDQNLSIDGKILsDDCATLGTLGVIPESVILLKADEP 1007
           344489999************************************************988775 PP

Organism

Homo sapiens

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.

Protein Sequence
(Fasta)

MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCKG NPNCLVGIGE 60
HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV NTFLQVWFLN LELRQALYLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCGGGAAA GGGGTTCGGA ACCGGTCTAG GCTCAAGTTA AATCTCCCTC TAAAGAGCCA 60
ACACTGGTTT CTTTGGCGAC TCGGTTTCTA CTCTAAACAG GTCCCGCTCC ACAGTCTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR033841--USP48
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS50053--UBIQUITIN_2
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:84196

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000130	Aegilops tauschii	32.66	1.00e-81	298.00
IUUC-Aml-001357	Ailuropoda melanoleuca	97.59	0.00e+00	2058.00
IUUC-Atr-002976	Amborella trichopoda	31.75	1.00e-77	285.00
IUUC-Apl-003773	Anas platyrhynchos	87.75	0.00e+00	1687.00
IUUC-Aca-004466	Anolis carolinensis	81.26	0.00e+00	869.00
IUUC-Aly-006249	Arabidopsis lyrata	29.71	2.00e-71	264.00
IUUC-Ath-006700	Arabidopsis thaliana	30.62	3.00e-80	293.00
IUUC-Ame-011554	Astyanax mexicanus	68.52	0.00e+00	1449.00
IUUC-Bta-012573	Bos taurus	96.53	0.00e+00	2063.00
IUUC-Bdi-014149	Brachypodium distachyon	32.64	1.00e-82	301.00
IUUC-Bol-016289	Brassica oleracea	27.86	6.00e-81	296.00
IUUC-Bra-017205	Brassica rapa	28.98	1.00e-70	261.00
IUUC-Cel-018662	Caenorhabditis elegans	27.65	2.00e-28	122.00
IUUC-Cja-019991	Callithrix jacchus	96.86	0.00e+00	2080.00
IUUC-Cfa-020294	Canis familiaris	97.78	0.00e+00	2102.00
IUUC-Cpo-021706	Cavia porcellus	94.76	0.00e+00	1948.00
IUUC-Cre-022636	Chlamydomonas reinhardtii	31.33	2.00e-43	172.00
IUUC-Csa-023931	Chlorocebus sabaeus	99.61	0.00e+00	2106.00
IUUC-Cho-024566	Choloepus hoffmanni	98.19	2.00e-161	563.00
IUUC-Cin-025307	Ciona intestinalis	47.49	6.00e-76	277.00
IUUC-Csv-026006	Ciona savignyi	36.79	2.00e-151	530.00
IUUC-Cne-027065	Cryptococcus neoformans	28.52	3.00e-68	254.00
IUUC-Dre-027624	Danio rerio	69.01	0.00e+00	1495.00
IUUC-Dno-029633	Dasypus novemcinctus	96.86	0.00e+00	1323.00
IUUC-Dor-030809	Dipodomys ordii	75.85	0.00e+00	1214.00
IUUC-Ete-032818	Echinops telfairi	91.70	0.00e+00	957.00
IUUC-Eca-033692	Equus caballus	97.78	0.00e+00	2088.00
IUUC-Eeu-035185	Erinaceus europaeus	75.32	0.00e+00	806.00
IUUC-Fca-035676	Felis catus	97.39	0.00e+00	2094.00
IUUC-Fal-036913	Ficedula albicollis	86.79	0.00e+00	1832.00
IUUC-Gmo-038532	Gadus morhua	65.28	0.00e+00	1389.00
IUUC-Gga-041041	Gallus gallus	87.08	0.00e+00	1829.00
IUUC-Gac-042570	Gasterosteus aculeatus	66.14	0.00e+00	1425.00
IUUC-Gma-044136	Glycine max	30.01	3.00e-91	330.00
IUUC-Ggo-045367	Gorilla gorilla	94.70	0.00e+00	1966.00
IUUC-Hvu-047303	Hordeum vulgare	33.58	2.00e-65	243.00
IUUC-Itr-048319	Ictidomys tridecemlineatus	94.98	0.00e+00	2060.00
IUUC-Lch-049989	Latimeria chalumnae	76.31	0.00e+00	1642.00
IUUC-Lpe-051612	Leersia perrieri	32.91	1.00e-80	295.00
IUUC-Loc-052756	Lepisosteus oculatus	70.81	0.00e+00	1545.00
IUUC-Laf-054043	Loxodonta africana	96.20	0.00e+00	2076.00
IUUC-Mcc-054986	Macaca mulatta	98.00	0.00e+00	2087.00
IUUC-Meu-056228	Macropus eugenii	77.26	0.00e+00	860.00
IUUC-Mtr-058610	Medicago truncatula	30.33	3.00e-81	297.00
IUUC-Mga-059896	Meleagris gallopavo	86.51	0.00e+00	1728.00
IUUC-Mvi-060269	Microbotryum violaceum	37.04	5.00e-62	233.00
IUUC-Mmr-060887	Microcebus murinus	97.88	0.00e+00	2089.00
IUUC-Mdo-062506	Monodelphis domestica	93.15	0.00e+00	1993.00
IUUC-Mmu-063642	Mus musculus	92.13	0.00e+00	2003.00
IUUC-Mac-064896	Musa acuminata	31.64	1.00e-77	285.00
IUUC-Mpu-066194	Mustela putorius furo	97.39	0.00e+00	2077.00
IUUC-Mlu-067233	Myotis lucifugus	96.46	0.00e+00	2063.00
IUUC-Nle-069052	Nomascus leucogenys	98.57	0.00e+00	2094.00
IUUC-Opr-070890	Ochotona princeps	95.24	0.00e+00	1258.00
IUUC-Ont-071450	Oreochromis niloticus	65.24	0.00e+00	1376.00
IUUC-Oan-073252	Ornithorhynchus anatinus	88.72	0.00e+00	1055.00
IUUC-Ocu-073796	Oryctolagus cuniculus	96.37	0.00e+00	1772.00
IUUC-Oba-075563	Oryza barthii	32.19	3.00e-81	297.00
IUUC-Obr-076394	Oryza brachyantha	32.28	1.00e-81	298.00
IUUC-Ogl-077339	Oryza glaberrima	38.91	6.00e-41	161.00
IUUC-Ogu-079007	Oryza glumaepatula	32.87	3.00e-74	273.00
IUUC-Oin-079997	Oryza indica	32.19	1.00e-81	298.00
IUUC-Olo-080364	Oryza longistaminata	32.19	2.00e-81	298.00
IUUC-Ome-081165	Oryza meridionalis	32.87	1.00e-74	275.00
IUUC-Oni-083026	Oryza nivara	32.19	1.00e-81	298.00
IUUC-Opu-083284	Oryza punctata	34.04	1.00e-74	275.00
IUUC-Oru-084797	Oryza rufipogon	32.19	2.00e-81	298.00
IUUC-Osa-086221	Oryza sativa	38.91	6.00e-41	161.00
IUUC-Ola-086568	Oryzias latipes	66.36	0.00e+00	1434.00
IUUC-Oga-088687	Otolemur garnettii	95.90	0.00e+00	2061.00
IUUC-Oar-090345	Ovis aries	96.68	0.00e+00	1968.00
IUUC-Ptr-090734	Pan troglodytes	99.81	0.00e+00	2109.00
IUUC-Pan-091704	Papio anubis	95.77	0.00e+00	2006.00
IUUC-Psi-092937	Pelodiscus sinensis	87.12	0.00e+00	1605.00
IUUC-Ppa-095808	Physcomitrella patens	27.92	2.00e-68	254.00
IUUC-Pab-098129	Pongo abelii	99.90	0.00e+00	2113.00
IUUC-Pop-099738	Populus trichocarpa	26.55	3.00e-77	283.00
IUUC-Pca-100647	Procavia capensis	98.48	0.00e+00	691.00
IUUC-Ppe-102091	Prunus persica	31.52	3.00e-85	310.00
IUUC-Pva-102719	Pteropus vampyrus	97.01	0.00e+00	2066.00
IUUC-Rno-105363	Rattus norvegicus	94.21	0.00e+00	2031.00
IUUC-Sha-107620	Sarcophilus harrisii	89.57	0.00e+00	1852.00
IUUC-Smo-109487	Selaginella moellendorffii	28.23	4.00e-84	306.00
IUUC-Sit-110683	Setaria italica	32.97	7.00e-82	299.00
IUUC-Sly-111377	Solanum lycopersicum	29.62	9.00e-81	295.00
IUUC-Stu-111969	Solanum tuberosum	31.61	5.00e-70	258.00
IUUC-Sar-113099	Sorex araneus	95.55	0.00e+00	1736.00
IUUC-Sbi-113833	Sorghum bicolor	42.14	1.00e-56	213.00
IUUC-Ssc-115279	Sus scrofa	90.73	0.00e+00	1372.00
IUUC-Tgu-117519	Taeniopygia guttata	84.31	0.00e+00	1682.00
IUUC-Tru-117651	Takifugu rubripes	65.68	0.00e+00	1419.00
IUUC-Tsy-119201	Tarsius syrichta	93.44	0.00e+00	1821.00
IUUC-Tni-120840	Tetraodon nigroviridis	66.92	0.00e+00	1443.00
IUUC-Tca-121674	Theobroma cacao	29.05	7.00e-85	309.00
IUUC-Tae-125247	Triticum aestivum	26.56	2.00e-84	308.00
IUUC-Tur-126599	Triticum urartu	33.02	7.00e-81	295.00
IUUC-Tbe-127782	Tupaia belangeri	85.91	0.00e+00	1762.00
IUUC-Ttr-128312	Tursiops truncatus	96.14	0.00e+00	2044.00
IUUC-Vpa-130348	Vicugna pacos	97.38	0.00e+00	1981.00
IUUC-Vvi-131353	Vitis vinifera	32.52	9.00e-84	305.00
IUUC-Xtr-132172	Xenopus tropicalis	70.46	0.00e+00	1359.00
IUUC-Xma-133263	Xiphophorus maculatus	67.74	0.00e+00	1404.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence