iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
AREsite	CircNet	miRTarBase	microRNA
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	8.40e-12	46.9	57	119

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv + v+g+ef+ah++vLaasS++F++   l+++ +        +   ++p++f+++l   Ytg+l++
   Q: 57   CDVSIRVQGREFRAHRAVLAASSPYFHDQVlLKGMTSI------SLPSvMDPGAFETVLASAYTGRLSM 119
           8***************************9845555544......3444578***************986 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein Sequence
(Fasta)

MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS 60
IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATAAATGC TTCGGCCGAA CCAAGTCCTG AGCTCCCAGC GGAGGAGGGG ACCTGATCTT 60
TTAAGGTGGA ATGTGGCGAT GTTTCTTTAA AGGCAAAGTG GCCGAGTCGG CCGAGTATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR000877--Prot_inh_BBI
IPR011333--SKP1/BTB/POZ
IPR029833--ZBT22
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:9278

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003846	Anas platyrhynchos	67.21	1.00e-62	231.00
IUUC-Aca-005194	Anolis carolinensis	55.58	9.00e-135	474.00
IUUC-Ame-011159	Astyanax mexicanus	43.77	3.00e-59	223.00
IUUC-Dre-028178	Danio rerio	42.38	3.00e-102	366.00
IUUC-Ete-033181	Echinops telfairi	72.52	9.00e-157	547.00
IUUC-Gmo-038995	Gadus morhua	71.08	2.00e-25	110.00
IUUC-Gac-042389	Gasterosteus aculeatus	42.86	8.00e-54	204.00
IUUC-Lch-049688	Latimeria chalumnae	50.55	6.00e-142	497.00
IUUC-Opr-070675	Ochotona princeps	67.01	3.00e-57	216.00
IUUC-Ont-072206	Oreochromis niloticus	46.05	1.00e-53	204.00
IUUC-Ola-086973	Oryzias latipes	41.72	4.00e-50	192.00
IUUC-Oga-089041	Otolemur garnettii	85.19	8.00e-86	310.00
IUUC-Psi-093312	Pelodiscus sinensis	54.40	7.00e-134	470.00
IUUC-Tgu-116464	Taeniopygia guttata	76.32	6.00e-48	182.00
IUUC-Tru-118446	Takifugu rubripes	40.96	2.00e-52	200.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence