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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046134
UUCD1 version UUC-HoS-00169
Ensembl Protein ID ENSP00000262144.6
UniProt Accession Q6PJI9; B3KRC3; Q71RE7; Q96PW5; Q9BSW6; Q9HA43; WDR59_HUMAN
Genbank Protein ID BAB14015.1; BAG52335.1; AAQ15226.1; AAH04519.1; AAH14887.2; BAB67816.1
Protein Name WD repeat-containing protein 59
Genbank Nucleotide ID AK022332; AK091316; AF370390; BC004519; BC014887; AB067510
Gene Name WDR59; KIAA1923; FP977
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000103091.14 ENST00000262144.10 ENSP00000262144.6
ENSG00000103091.14 ENST00000563797.5 ENSP00000455060.1
ENSG00000103091.14 ENST00000569229.5 ENSP00000454382.1
ENSG00000103091.14 ENST00000566924.1 ENSP00000457978.1
ENSG00000103091.14 ENST00000536050.5 ENSP00000481730.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.20e-19 70.4 190 224
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           H +++++l++ +d  ++l+++s D+++k WD+r+ 
   Q: 190  HLSKIHGLDWhPDseHILATSSQDNSVKFWDYRQP 224
           99*********6665778*************9876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:25457612, PubMed:27487210).
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:25457612, PubMed:27487210).
Protein Sequence
(Fasta)
MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPFEG HRKISRQSKW 60
DIGAVQWNPH DSFAHYFAAS SNQRVDLYKW KDGSGEVGTT LQGHTRVISD LDWAVFEPDL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046134|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAACCTTGGC ACGCACGCGA AGGCTTGGGG CGCCCCGGCG CGCCCTCCCT CCGAGGCCTC 60
CACCACCCGC GGACTCACCA CTATGCGAGC TGAACCACCT GGGTGCGATG TGCAGAGGTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046134|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50908--RWD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00591--RWD
SM00320--WD40
Gene Ontology

GO:0061700--C:GATOR2 complex
GO:0034198--P:cellular response to amino acid starvation
GO:0032008--P:positive regulation of TOR signaling
KEGG hsa:79726
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002149 Ailuropoda melanoleuca 97.13 0.00e+00 1925.00
IUUC-Apl-004021 Anas platyrhynchos 89.05 0.00e+00 1694.00
IUUC-Aca-004977 Anolis carolinensis 84.91 0.00e+00 1714.00
IUUC-Ago-007961 Ashbya gossypii 28.95 3.00e-58 221.00
IUUC-Acl-008161 Aspergillus clavatus 28.78 2.00e-56 215.00
IUUC-Afl-008686 Aspergillus flavus 28.31 3.00e-58 221.00
IUUC-Afu-008932 Aspergillus fumigatus 34.57 3.00e-52 201.00
IUUC-Ani-009493 Aspergillus nidulans 34.35 3.00e-54 207.00
IUUC-Ang-009876 Aspergillus niger 29.39 4.00e-59 224.00
IUUC-Aor-009926 Aspergillus oryzae 28.31 3.00e-58 221.00
IUUC-Ate-010274 Aspergillus terreus 33.23 1.00e-50 195.00
IUUC-Ame-011297 Astyanax mexicanus 70.64 0.00e+00 1408.00
IUUC-Bgr-012173 Blumeria graminis 31.48 3.00e-44 174.00
IUUC-Bta-013261 Bos taurus 97.33 0.00e+00 1939.00
IUUC-Bci-013971 Botrytis cinerea 33.13 1.00e-46 182.00
IUUC-Cja-019167 Callithrix jacchus 97.74 0.00e+00 1939.00
IUUC-Cfa-020287 Canis familiaris 96.82 0.00e+00 1919.00
IUUC-Cpo-022510 Cavia porcellus 94.90 0.00e+00 1829.00
IUUC-Csa-023474 Chlorocebus sabaeus 97.58 0.00e+00 1976.00
IUUC-Cho-024634 Choloepus hoffmanni 93.38 0.00e+00 791.00
IUUC-Cin-025642 Ciona intestinalis 33.43 8.00e-136 478.00
IUUC-Csv-025848 Ciona savignyi 45.15 4.00e-55 207.00
IUUC-Cgl-026531 Colletotrichum gloeosporioides 32.80 1.00e-44 176.00
IUUC-Cne-027088 Cryptococcus neoformans 32.32 2.00e-43 171.00
IUUC-Dre-028753 Danio rerio 71.60 0.00e+00 1397.00
IUUC-Dno-029733 Dasypus novemcinctus 95.58 0.00e+00 1885.00
IUUC-Dor-030781 Dipodomys ordii 97.26 0.00e+00 983.00
IUUC-Dme-031803 Drosophila melanogaster 34.21 3.00e-149 523.00
IUUC-Ete-032622 Echinops telfairi 88.09 0.00e+00 1710.00
IUUC-Eca-033344 Equus caballus 97.84 0.00e+00 1931.00
IUUC-Eeu-034523 Erinaceus europaeus 87.24 0.00e+00 1666.00
IUUC-Fca-035650 Felis catus 97.74 0.00e+00 1942.00
IUUC-Fal-037404 Ficedula albicollis 88.61 0.00e+00 1727.00
IUUC-Fox-037955 Fusarium oxysporum 33.81 4.00e-43 171.00
IUUC-Fso-038289 Fusarium solani 33.23 4.00e-47 184.00
IUUC-Gmo-038547 Gadus morhua 67.37 0.00e+00 1383.00
IUUC-Ggr-039858 Gaeumannomyces graminis 36.46 4.00e-43 171.00
IUUC-Gga-041030 Gallus gallus 88.91 0.00e+00 1742.00
IUUC-Gac-042581 Gasterosteus aculeatus 71.00 0.00e+00 1434.00
IUUC-Ggo-044641 Gorilla gorilla 99.59 0.00e+00 1975.00
IUUC-Itr-048551 Ictidomys tridecemlineatus 97.02 0.00e+00 756.00
IUUC-Kpa-049091 Komagataella pastoris 32.63 9.00e-46 179.00
IUUC-Lch-050288 Latimeria chalumnae 75.28 0.00e+00 1474.00
IUUC-Loc-052802 Lepisosteus oculatus 74.22 0.00e+00 1504.00
IUUC-Lma-053296 Leptosphaeria maculans 32.70 1.00e-48 189.00
IUUC-Laf-053997 Loxodonta africana 96.17 0.00e+00 1963.00
IUUC-Mcc-055855 Macaca mulatta 99.49 0.00e+00 1957.00
IUUC-Meu-056898 Macropus eugenii 95.96 0.00e+00 738.00
IUUC-Mor-056913 Magnaporthe oryzae 34.98 1.00e-42 169.00
IUUC-Mpo-057612 Magnaporthe poae 36.46 2.00e-43 171.00
IUUC-Mla-059097 Melampsora laricipopulina 30.67 3.00e-47 184.00
IUUC-Mga-059218 Meleagris gallopavo 88.92 0.00e+00 1707.00
IUUC-Mvi-060251 Microbotryum violaceum 31.60 1.00e-46 182.00
IUUC-Mmr-061093 Microcebus murinus 94.66 0.00e+00 1868.00
IUUC-Mdo-062757 Monodelphis domestica 93.29 0.00e+00 1831.00
IUUC-Mmu-063839 Mus musculus 94.46 0.00e+00 1930.00
IUUC-Mpu-065977 Mustela putorius furo 97.43 0.00e+00 1933.00
IUUC-Mlu-067460 Myotis lucifugus 95.57 0.00e+00 1929.00
IUUC-Nfi-068250 Neosartorya fischeri 34.57 2.00e-52 201.00
IUUC-Ncr-068710 Neurospora crassa 32.45 2.00e-45 178.00
IUUC-Nle-070011 Nomascus leucogenys 99.28 0.00e+00 1966.00
IUUC-Opr-070731 Ochotona princeps 90.04 0.00e+00 1751.00
IUUC-Ont-072165 Oreochromis niloticus 70.44 0.00e+00 1422.00
IUUC-Oan-072887 Ornithorhynchus anatinus 91.78 0.00e+00 1855.00
IUUC-Ocu-073926 Oryctolagus cuniculus 95.42 0.00e+00 1773.00
IUUC-Ola-087111 Oryzias latipes 67.07 0.00e+00 1355.00
IUUC-Oga-088850 Otolemur garnettii 97.95 0.00e+00 1942.00
IUUC-Oar-090291 Ovis aries 97.02 0.00e+00 1931.00
IUUC-Ptr-091044 Pan troglodytes 99.49 0.00e+00 1963.00
IUUC-Pan-092374 Papio anubis 97.38 0.00e+00 1971.00
IUUC-Psi-093170 Pelodiscus sinensis 55.88 0.00e+00 965.00
IUUC-Pma-094544 Petromyzon marinus 67.79 1.00e-171 596.00
IUUC-Pno-095068 Phaeosphaeria nodorum 30.56 1.00e-44 176.00
IUUC-Pfo-096480 Poecilia formosa 67.79 0.00e+00 1325.00
IUUC-Pab-098134 Pongo abelii 98.14 0.00e+00 1924.00
IUUC-Pca-100763 Procavia capensis 75.29 0.00e+00 996.00
IUUC-Pva-102544 Pteropus vampyrus 96.51 0.00e+00 1929.00
IUUC-Pgr-103257 Puccinia graminis 32.33 4.00e-50 194.00
IUUC-Ptt-103942 Puccinia triticina 31.55 1.00e-45 179.00
IUUC-Pte-104065 Pyrenophora teres 32.20 4.00e-46 181.00
IUUC-Rno-105468 Rattus norvegicus 93.03 0.00e+00 1761.00
IUUC-Sce-106356 Saccharomyces cerevisiae 28.13 8.00e-58 219.00
IUUC-Sha-106662 Sarcophilus harrisii 95.31 0.00e+00 1857.00
IUUC-Sja-107973 Schizosaccharomyces japonicus 28.08 5.00e-74 273.00
IUUC-Spo-108265 Schizosaccharomyces pombe 28.22 4.00e-61 230.00
IUUC-Ssl-108662 Sclerotinia sclerotiorum 33.43 6.00e-46 180.00
IUUC-Sar-113525 Sorex araneus 93.72 0.00e+00 1085.00
IUUC-Sre-115163 Sporisorium reilianum 37.05 2.00e-40 162.00
IUUC-Ssc-115381 Sus scrofa 96.32 0.00e+00 1048.00
IUUC-Tgu-116525 Taeniopygia guttata 85.23 0.00e+00 1663.00
IUUC-Tru-118432 Takifugu rubripes 69.23 0.00e+00 1410.00
IUUC-Tsy-119306 Tarsius syrichta 80.89 0.00e+00 1256.00
IUUC-Tni-120757 Tetraodon nigroviridis 68.87 0.00e+00 1372.00
IUUC-Tre-122187 Trichoderma reesei 35.03 5.00e-48 187.00
IUUC-Tvi-122367 Trichoderma virens 35.35 1.00e-47 186.00
IUUC-Tme-126986 Tuber melanosporum 34.70 2.00e-54 207.00
IUUC-Tbe-127800 Tupaia belangeri 82.29 0.00e+00 1381.00
IUUC-Ttr-129154 Tursiops truncatus 88.81 0.00e+00 1708.00
IUUC-Uma-129366 Ustilago maydis 35.97 1.00e-39 159.00
IUUC-Vda-129827 Verticillium dahliae 33.86 1.00e-47 186.00
IUUC-Vpa-130493 Vicugna pacos 97.18 0.00e+00 1880.00
IUUC-Xtr-131941 Xenopus tropicalis 81.33 0.00e+00 1600.00
IUUC-Xma-133903 Xiphophorus maculatus 69.40 0.00e+00 1401.00
Created Date 25-Jun-2017

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