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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047025
UUCD1 version UUC-HoS-00338
Ensembl Protein ID ENSP00000291416.5
UniProt Accession Q9BVG3; B3KVH5; B4DTE4; D3DPR1; Q9NVG0; TRI62_HUMAN
Genbank Protein ID BAA91792.1; BAG53787.1; BAG61956.1; CAH70402.1; EAX07466.1; EAX07467.1; AAH01222.1; AAH07999.1; AAH11689.1; AAH12152.1
Protein Name E3 ubiquitin-protein ligase TRIM62; RING-type E3 ubiquitin transferase TRIM62; Tripartite motif-containing protein 62
Genbank Nucleotide ID AK001621; AK122896; AK300177; AL662907; CH471059; CH471059; BC001222; BC007999; BC011689; BC012152
Gene Name TRIM62
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116525.13 ENST00000291416.9 ENSP00000291416.5
ENSG00000116525.13 ENST00000543586.1 ENSP00000441173.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18248090; 23402750
Classification
Family E-value Score Start End
E3 activity/RING/U-box 2.30e-06 29.2 6 76
E3 activity/RING/RING 7.30e-08 34.5 11 54
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwl....asggktcPvtrqplteedlvPnltlrrliqawc 69
            +e+lC+I l + +dPv l + + + r++I ++     a+g + cP +r++++e  l P+l l ++++++ 
   Q: 6    KDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWvrqeAQGARDCPECRRTFAEPALAPSLKLANIVERYS 76
           689***************************9888455444444*******************999998875 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+ ++d p++l+C H f++ C+ ++w+ +   ++++  CP Cr
   Q: 11   CSICLSIYQD-PVSLGCEHYFCRRCItEHWVRQE--AQGARDCPECR 54
           **********.*******************5555..**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.
 E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.
Protein Sequence
(Fasta)
MACSLKDELL CSICLSIYQD PVSLGCEHYF CRRCITEHWV RQEAQGARDC PECRRTFAEP 60
ALAPSLKLAN IVERYSSFPL DAILNARRAA RPCQAHDKVK LFCLTDRALL CFFCDEPALH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047025|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGATTCGGCT GGTTCCGGGT TGAGAGGCTG CGCTGGACCG AAGCGGTGGC TGCTAAGCTC 60
GCGGGGGTAA GGGGTCGCGC TGGGCCAGGG TTTGGGGCCG GGATCCGGCA GCTGAGCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047025|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0032897--P:negative regulation of viral transcription
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046596--P:regulation of viral entry into host cell
GO:1902186--P:regulation of viral release from host cell
KEGG hsa:55223
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002199 Ailuropoda melanoleuca 99.37 0.00e+00 954.00
IUUC-Apl-003767 Anas platyrhynchos 87.58 0.00e+00 797.00
IUUC-Aca-004412 Anolis carolinensis 83.92 0.00e+00 816.00
IUUC-Ame-010927 Astyanax mexicanus 82.53 0.00e+00 847.00
IUUC-Bta-012927 Bos taurus 99.16 0.00e+00 953.00
IUUC-Cja-019317 Callithrix jacchus 92.84 0.00e+00 864.00
IUUC-Cfa-020292 Canis familiaris 99.41 0.00e+00 700.00
IUUC-Cpo-022274 Cavia porcellus 99.41 0.00e+00 705.00
IUUC-Csa-023042 Chlorocebus sabaeus 99.37 0.00e+00 954.00
IUUC-Dre-028493 Danio rerio 81.26 0.00e+00 839.00
IUUC-Dno-030029 Dasypus novemcinctus 94.74 0.00e+00 894.00
IUUC-Dor-031051 Dipodomys ordii 96.70 0.00e+00 904.00
IUUC-Ete-032752 Echinops telfairi 98.35 2.00e-108 386.00
IUUC-Eca-033898 Equus caballus 79.33 0.00e+00 827.00
IUUC-Eeu-034659 Erinaceus europaeus 99.36 3.00e-84 304.00
IUUC-Fca-035492 Felis catus 90.97 0.00e+00 886.00
IUUC-Fal-036867 Ficedula albicollis 87.53 0.00e+00 853.00
IUUC-Gmo-038916 Gadus morhua 81.89 0.00e+00 816.00
IUUC-Gga-040360 Gallus gallus 89.89 0.00e+00 877.00
IUUC-Gac-041871 Gasterosteus aculeatus 82.53 0.00e+00 849.00
IUUC-Ggo-044411 Gorilla gorilla 92.87 0.00e+00 880.00
IUUC-Itr-047905 Ictidomys tridecemlineatus 99.37 0.00e+00 954.00
IUUC-Loc-052114 Lepisosteus oculatus 84.00 0.00e+00 861.00
IUUC-Laf-054359 Loxodonta africana 93.63 0.00e+00 675.00
IUUC-Mcc-055563 Macaca mulatta 99.37 0.00e+00 954.00
IUUC-Meu-056027 Macropus eugenii 75.58 0.00e+00 724.00
IUUC-Mga-060146 Meleagris gallopavo 82.56 1.00e-74 271.00
IUUC-Mmr-060822 Microcebus murinus 99.16 0.00e+00 952.00
IUUC-Mdo-062117 Monodelphis domestica 77.99 0.00e+00 643.00
IUUC-Mmu-064086 Mus musculus 99.16 0.00e+00 954.00
IUUC-Mpu-066378 Mustela putorius furo 99.37 0.00e+00 954.00
IUUC-Mlu-067155 Myotis lucifugus 98.30 0.00e+00 962.00
IUUC-Nle-069464 Nomascus leucogenys 98.95 0.00e+00 951.00
IUUC-Opr-071058 Ochotona princeps 98.64 2.00e-133 468.00
IUUC-Ont-071253 Oreochromis niloticus 74.48 0.00e+00 727.00
IUUC-Oan-073614 Ornithorhynchus anatinus 93.67 1.00e-94 337.00
IUUC-Ola-086794 Oryzias latipes 82.74 0.00e+00 844.00
IUUC-Oga-088889 Otolemur garnettii 98.74 0.00e+00 951.00
IUUC-Oar-089203 Ovis aries 95.55 0.00e+00 841.00
IUUC-Ptr-090795 Pan troglodytes 99.37 0.00e+00 984.00
IUUC-Pfo-096942 Poecilia formosa 82.11 0.00e+00 838.00
IUUC-Pab-097936 Pongo abelii 85.83 0.00e+00 632.00
IUUC-Pca-100397 Procavia capensis 97.89 0.00e+00 942.00
IUUC-Ppe-101916 Prunus persica 30.97 3.00e-10 61.20
IUUC-Pva-102293 Pteropus vampyrus 99.12 0.00e+00 687.00
IUUC-Rno-105551 Rattus norvegicus 98.95 0.00e+00 949.00
IUUC-Ssc-115983 Sus scrofa 99.37 0.00e+00 954.00
IUUC-Tgu-117279 Taeniopygia guttata 74.39 0.00e+00 654.00
IUUC-Tru-118238 Takifugu rubripes 82.32 0.00e+00 843.00
IUUC-Tni-119788 Tetraodon nigroviridis 60.71 4.00e-157 547.00
IUUC-Xtr-132768 Xenopus tropicalis 74.65 0.00e+00 729.00
Created Date 25-Jun-2017

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