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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063861
Ensembl Protein ID ENSMUSP00000110777.1
UniProt Accession O54967; Q0Z844; Q8C2U0; Q8K0K4; ACK1_MOUSE
Genbank Protein ID ABG46266.1; AAC04786.1; AAH31168.1; AAH52421.1; BAC40063.1
Protein Name Activated CDC42 kinase 1; Non-receptor protein tyrosine kinase Ack; Tyrosine kinase non-receptor protein 2
Genbank Nucleotide ID DQ666696; AF037260; BC031168; BC052421; AK087965
Gene Name Tnk2; Ack1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022791.16 ENSMUST00000115126.7 ENSMUSP00000110779.1
ENSMUSG00000022791.16 ENSMUST00000115125.7 ENSMUSP00000110778.1
ENSMUSG00000022791.16 ENSMUST00000115124.7 ENSMUSP00000110777.1
ENSMUSG00000022791.16 ENSMUST00000115123.7 ENSMUSP00000110776.1
ENSMUSG00000022791.16 ENSMUST00000152361.1 ENSMUSP00000125905.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 17182860; 20333297; 20086093
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 0.00014 23.0 975 1010
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyL 38
           d+ ++ q++  G ++ee++ aL+++++++++A+ yL
   Q: 975  DKVQMLQAMVHGVTTEECQAALQSHSWSVQRAAQYL 1010
           67778899999***********************99 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
 Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
Protein Sequence
(Fasta)
MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NITRLSHFEY VKNEDLEKIG MGRPGQRRLW 60
EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP SQHSQSTFRK PSPTPGSLPG EGTLQSLTCL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063861|UBD,UBA|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAACCCGGC TGGAGGGCCG CCGGCTCGCG GGGCCGCAGC ACCTGCGGCG CGGCGCCGGG 60
GTGGCCGAGG TCGAGTGTGG GCGGCGAGGG CGGGACGCCG GGCCCGCTTG GGGCCGAGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063861|UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0967--Endosome
KW-0418--Kinase
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR015116--Cdc42_binding_dom-like
IPR011009--Kinase-like_dom
IPR021619--Mig-6
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR009060--UBA-like
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50002--SH3
Pfam

PF09027--GTPase_binding
PF11555--Inhibitor_Mig-6
PF07714--Pkinase_Tyr
PF14604--SH3_9
PRINTS

PR00109--TYRKINASE
SMART

SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005912--C:adherens junction
GO:0030424--C:axon
GO:0005905--C:clathrin-coated pit
GO:0030136--C:clathrin-coated vesicle
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0030425--C:dendrite
GO:0005768--C:endosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0070436--C:Grb2-EGFR complex
GO:0030426--C:growth cone
GO:0016020--C:membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0005154--F:epidermal growth factor receptor binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0050699--F:WW domain binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0006897--P:endocytosis
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0016310--P:phosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0042127--P:regulation of cell proliferation
GO:2000369--P:regulation of clathrin-dependent endocytosis
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG mmu:51789
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002166 Ailuropoda melanoleuca 92.53 0.00e+00 1669.00
IUUC-Aca-004315 Anolis carolinensis 89.71 4.00e-74 270.00
IUUC-Ame-011350 Astyanax mexicanus 55.49 0.00e+00 1049.00
IUUC-Bta-012325 Bos taurus 92.89 0.00e+00 1728.00
IUUC-Cel-018130 Caenorhabditis elegans 36.48 9.00e-90 325.00
IUUC-Cja-019545 Callithrix jacchus 87.41 0.00e+00 1568.00
IUUC-Cfa-020706 Canis familiaris 92.99 0.00e+00 1739.00
IUUC-Cpo-022032 Cavia porcellus 90.32 0.00e+00 1695.00
IUUC-Csa-023936 Chlorocebus sabaeus 94.79 0.00e+00 1739.00
IUUC-Csv-026328 Ciona savignyi 58.84 2.00e-173 602.00
IUUC-Dre-028714 Danio rerio 63.26 0.00e+00 1235.00
IUUC-Dno-029525 Dasypus novemcinctus 92.52 0.00e+00 1730.00
IUUC-Dme-031778 Drosophila melanogaster 56.35 4.00e-145 509.00
IUUC-Ete-032225 Echinops telfairi 89.32 0.00e+00 844.00
IUUC-Fca-035664 Felis catus 93.28 0.00e+00 1791.00
IUUC-Gmo-039543 Gadus morhua 59.27 0.00e+00 948.00
IUUC-Gga-040241 Gallus gallus 69.24 0.00e+00 1322.00
IUUC-Gac-041457 Gasterosteus aculeatus 62.48 0.00e+00 1153.00
IUUC-Ggo-045333 Gorilla gorilla 92.32 0.00e+00 1709.00
IUUC-Hsa-046670 Homo sapiens 93.08 0.00e+00 1683.00
IUUC-Itr-048054 Ictidomys tridecemlineatus 94.97 0.00e+00 1788.00
IUUC-Lch-049670 Latimeria chalumnae 63.88 0.00e+00 1222.00
IUUC-Loc-052870 Lepisosteus oculatus 64.81 0.00e+00 1283.00
IUUC-Laf-053782 Loxodonta africana 91.65 0.00e+00 1688.00
IUUC-Mcc-055874 Macaca mulatta 94.97 0.00e+00 1732.00
IUUC-Mga-059717 Meleagris gallopavo 71.07 0.00e+00 1387.00
IUUC-Mdo-062270 Monodelphis domestica 85.92 0.00e+00 1623.00
IUUC-Mpu-066127 Mustela putorius furo 95.64 0.00e+00 1364.00
IUUC-Mlu-067937 Myotis lucifugus 90.27 0.00e+00 1321.00
IUUC-Nle-069298 Nomascus leucogenys 91.92 0.00e+00 1394.00
IUUC-Ont-072437 Oreochromis niloticus 59.00 0.00e+00 1197.00
IUUC-Oan-073708 Ornithorhynchus anatinus 75.00 2.00e-116 413.00
IUUC-Ola-087023 Oryzias latipes 62.06 0.00e+00 1155.00
IUUC-Pan-091857 Papio anubis 92.92 5.00e-94 337.00
IUUC-Psi-093401 Pelodiscus sinensis 55.15 1.00e-149 523.00
IUUC-Pfo-097455 Poecilia formosa 60.48 0.00e+00 1217.00
IUUC-Rno-105586 Rattus norvegicus 97.82 0.00e+00 1842.00
IUUC-Sha-106868 Sarcophilus harrisii 82.34 0.00e+00 1587.00
IUUC-Ssc-116250 Sus scrofa 92.14 0.00e+00 1656.00
IUUC-Tgu-116592 Taeniopygia guttata 70.43 0.00e+00 1323.00
IUUC-Tru-117852 Takifugu rubripes 69.83 0.00e+00 627.00
IUUC-Tsy-119087 Tarsius syrichta 97.77 5.00e-157 548.00
IUUC-Tni-120826 Tetraodon nigroviridis 63.46 0.00e+00 1245.00
IUUC-Xtr-132069 Xenopus tropicalis 65.95 0.00e+00 1195.00
Created Date 25-Jun-2017

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