iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	UniProt
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	1.00e-28	100.1	5	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
           ++vk l g ++ ++v  s+tV+eLK++i +k g+p+ qqrL  +  +L+d+ tL+++gl + st++l++++ 
   Q: 5    LKVKMLGGNDFLVSVTNSMTVSELKKQIAQKIGVPAFQQRLAHQTAVLQDGLTLSSLGLGPSSTVMLVVQNC 76
           79******************************************************************9975 PP

Organism

Mus musculus

Functional Description
(View)

Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, TRIM25, STAT5A, MAPK1/ERK2 and globin. Can also isgylate: DDX58/RIG-I which inhibits its function in antiviral signaling response and EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A and B virus, sindbis virus (SV) and herpes simplex type-1 (HHV-1). Plays a significant role in the control of neonatal Chikungunya virus (CHIKV) infection by acting as a putative immunomodulator of proinflammatory cytokines. Protects mice against the consequences of Chikungunya virus infection by downregulating the pathogenic cytokine response, often denoted as the cytokine storm. Plays a role in erythroid differentiation. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity.

Protein Sequence
(Fasta)

MAWDLKVKML GGNDFLVSVT NSMTVSELKK QIAQKIGVPA FQQRLAHQTA VLQDGLTLSS 60
LGLGPSSTVM LVVQNCSEPL SILVRNERGH SNIYEVFLTQ TVDTLKKKVS QREQVHEDQF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCGACCCA GTCTCTGACT CTGAGAGTCG ATCCAGTCTC TGACTGTGAG AGCAAGCAGC 60
CAGAAGCAGA CTCCTTAATT CCAGGGGACC TAGAGCTAGA GCCTGCAGCA ATGGTGAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0051--Antiviral defense
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0677--Repeat
KW-0702--S-nitrosylation
KW-0964--Secreted
KW-0833--Ubl conjugation pathway

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005576--C:extracellular region
GO:0031386--F:protein tag
GO:0042742--P:defense response to bacterium
GO:0051607--P:defense response to virus
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0045071--P:negative regulation of viral genome replication
GO:0030501--P:positive regulation of bone mineralization
GO:0045648--P:positive regulation of erythrocyte differentiation
GO:0032649--P:regulation of interferon-gamma production
GO:0034340--P:response to type I interferon

KEGG

mmu:100038882

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001878	Ailuropoda melanoleuca	64.71	8.00e-51	192.00
IUUC-Aca-004519	Anolis carolinensis	36.08	2.00e-24	105.00
IUUC-Bta-013171	Bos taurus	62.42	5.00e-47	179.00
IUUC-Cja-019835	Callithrix jacchus	63.12	5.00e-52	196.00
IUUC-Cfa-020065	Canis familiaris	65.16	2.00e-52	197.00
IUUC-Cpo-021861	Cavia porcellus	60.65	9.00e-49	185.00
IUUC-Csa-023867	Chlorocebus sabaeus	65.82	2.00e-49	187.00
IUUC-Dno-029882	Dasypus novemcinctus	64.38	6.00e-53	199.00
IUUC-Dor-030951	Dipodomys ordii	63.27	2.00e-45	174.00
IUUC-Eca-034085	Equus caballus	65.58	3.00e-49	187.00
IUUC-Fca-035436	Felis catus	64.33	4.00e-53	199.00
IUUC-Ggo-045637	Gorilla gorilla	64.38	2.00e-53	201.00
IUUC-Hsa-046999	Homo sapiens	65.82	4.00e-48	183.00
IUUC-Itr-048270	Ictidomys tridecemlineatus	60.90	2.00e-50	191.00
IUUC-Laf-053813	Loxodonta africana	57.42	3.00e-46	177.00
IUUC-Mcc-055557	Macaca mulatta	66.46	9.00e-55	205.00
IUUC-Mmr-060685	Microcebus murinus	63.69	2.00e-50	191.00
IUUC-Mdo-062517	Monodelphis domestica	45.81	1.00e-24	105.00
IUUC-Mpu-066848	Mustela putorius furo	64.42	4.00e-53	200.00
IUUC-Ocu-074687	Oryctolagus cuniculus	61.04	6.00e-48	182.00
IUUC-Oga-089098	Otolemur garnettii	62.59	1.00e-46	179.00
IUUC-Oar-089908	Ovis aries	62.42	5.00e-50	189.00
IUUC-Ptr-090653	Pan troglodytes	66.46	5.00e-54	202.00
IUUC-Pan-092485	Papio anubis	67.09	3.00e-55	207.00
IUUC-Pab-098308	Pongo abelii	66.46	2.00e-54	204.00
IUUC-Rno-106108	Rattus norvegicus	73.89	3.00e-64	236.00
IUUC-Sha-107193	Sarcophilus harrisii	43.54	7.00e-29	119.00
IUUC-Ssc-115784	Sus scrofa	64.29	1.00e-52	198.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence