• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064363
UUCD1 version UUC-MuM-00229
Ensembl Protein ID ENSMUSP00000066210.5
UniProt Accession P62869; Q63529; Q80W20; ELOB_MOUSE
Genbank Protein ID BAB31677.1; BAB21946.1; BAB22417.1; BAB22684.1; BAB25690.1; BAB25727.1; BAB28121.1; BAB31590.1; BAB31608.1; AAH51927.2; AAH56983.1
Protein Name Elongin-B; Elongin 18 kDa subunit; RNA polymerase II transcription factor SIII subunit B; SIII p18; Transcription elongation factor B polypeptide 2
Genbank Nucleotide ID AK019358; AK002223; AK002868; AK003277; AK008477; AK008534; AK012254; AK019181; AK019218; BC051927; BC056983
Gene Name Tceb2; Elob
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000055839.5 ENSMUST00000069579.5 ENSMUSP00000066210.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UBQ/UBQ_Other 1.10e-09 39.1 18 61
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 17   vnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyg 60
            ++s+tV eLK+ +e+ l+ ppe+qrL+ ++++L+d+ktL+++g
   Q: 18   AKESSTVFELKRIVEGILKRPPEEQRLYKDDQLLDDGKTLGECG 61
           3799***************************************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
 The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Protein Sequence
(Fasta)
MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPE EQRLYKDDQL LDDGKTLGEC 60
GFTSQTARPQ APATVGLAFR ADDTFEALRI EPFSSPPELP DVMKPQDSGG SANEQAVQ 118
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064363|ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCGAGCCAG AAGCAGCCGC CGGGATGGTG AGCGGGCGCG GGGGGGAGGG GCGCGGGGCC 60
GGGGGCGGCG GGGGCTCCGG GGCCACGCCG GGGGCCGCGG GCTAGCGCTG ACGCGGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064363|ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50053--UBIQUITIN_2
Pfam

PF00240--ubiquitin
SMART

SM00213--UBQ
Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0070449--C:elongin complex
GO:0070062--C:extracellular exosome
GO:0030891--C:VCB complex
GO:0016567--P:protein ubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:67673
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001280 Ailuropoda melanoleuca 94.96 3.00e-62 229.00
IUUC-Atr-002796 Amborella trichopoda 28.70 3.00e-06 43.10
IUUC-Apl-003979 Anas platyrhynchos 87.88 2.00e-12 63.50
IUUC-Aca-004530 Anolis carolinensis 88.98 3.00e-57 213.00
IUUC-Aly-005974 Arabidopsis lyrata 29.03 1.00e-05 41.20
IUUC-Ath-007691 Arabidopsis thaliana 26.88 2.00e-05 40.40
IUUC-Ame-011292 Astyanax mexicanus 88.24 1.00e-58 217.00
IUUC-Bta-012458 Bos taurus 96.61 8.00e-64 234.00
IUUC-Bdi-014917 Brachypodium distachyon 28.57 4.00e-07 46.20
IUUC-Cel-018575 Caenorhabditis elegans 38.53 1.00e-16 77.80
IUUC-Cja-019950 Callithrix jacchus 96.58 2.00e-62 230.00
IUUC-Cfa-020172 Canis familiaris 96.15 5.00e-40 155.00
IUUC-Cpo-022344 Cavia porcellus 99.15 1.00e-64 237.00
IUUC-Csa-024213 Chlorocebus sabaeus 97.44 5.00e-63 232.00
IUUC-Csv-026001 Ciona savignyi 56.41 3.00e-35 140.00
IUUC-Dre-027429 Danio rerio 86.55 8.00e-57 211.00
IUUC-Dno-029254 Dasypus novemcinctus 96.58 5.00e-63 232.00
IUUC-Dme-031644 Drosophila melanogaster 55.08 9.00e-32 128.00
IUUC-Eeu-034507 Erinaceus europaeus 67.07 2.00e-27 113.00
IUUC-Fca-036342 Felis catus 97.44 2.00e-63 233.00
IUUC-Gmo-039577 Gadus morhua 87.39 3.00e-47 179.00
IUUC-Gac-041786 Gasterosteus aculeatus 84.03 2.00e-56 210.00
IUUC-Gma-044029 Glycine max 31.18 6.00e-07 46.20
IUUC-Ggo-044725 Gorilla gorilla 96.58 2.00e-62 231.00
IUUC-Hsa-046790 Homo sapiens 97.46 1.00e-63 234.00
IUUC-Hvu-047856 Hordeum vulgare 32.20 3.00e-06 42.70
IUUC-Lpe-051645 Leersia perrieri 30.43 1.00e-07 47.40
IUUC-Laf-054303 Loxodonta africana 97.44 1.00e-63 233.00
IUUC-Mcc-054748 Macaca mulatta 96.58 5.00e-63 232.00
IUUC-Mtr-058736 Medicago truncatula 32.26 1.00e-07 47.80
IUUC-Mmr-061528 Microcebus murinus 97.44 2.00e-63 233.00
IUUC-Mdo-062545 Monodelphis domestica 92.31 2.00e-60 223.00
IUUC-Mpu-066915 Mustela putorius furo 96.58 4.00e-63 232.00
IUUC-Mlu-067606 Myotis lucifugus 92.86 9.00e-41 157.00
IUUC-Nle-069340 Nomascus leucogenys 96.58 1.00e-62 231.00
IUUC-Ont-071550 Oreochromis niloticus 86.44 3.00e-57 213.00
IUUC-Oan-073548 Ornithorhynchus anatinus 95.80 5.00e-53 199.00
IUUC-Ocu-074024 Oryctolagus cuniculus 97.35 4.00e-61 225.00
IUUC-Obr-076724 Oryza brachyantha 28.26 2.00e-06 43.50
IUUC-Oin-080167 Oryza indica 28.26 8.00e-06 41.20
IUUC-Opu-084014 Oryza punctata 28.26 7.00e-06 41.60
IUUC-Osa-085650 Oryza sativa 28.26 8.00e-06 41.20
IUUC-Ola-086438 Oryzias latipes 85.59 7.00e-56 209.00
IUUC-Oar-090425 Ovis aries 96.58 4.00e-63 232.00
IUUC-Ptr-090487 Pan troglodytes 96.61 3.00e-63 234.00
IUUC-Pan-092779 Papio anubis 96.61 2.00e-63 234.00
IUUC-Pfo-097197 Poecilia formosa 85.71 1.00e-56 211.00
IUUC-Pab-098035 Pongo abelii 96.61 2.00e-63 234.00
IUUC-Pop-099504 Populus trichocarpa 27.47 9.00e-05 38.10
IUUC-Rno-105121 Rattus norvegicus 100.00 7.00e-66 241.00
IUUC-Sha-107566 Sarcophilus harrisii 93.22 3.00e-61 226.00
IUUC-Sar-113663 Sorex araneus 45.78 4.00e-18 82.40
IUUC-Sbi-114447 Sorghum bicolor 26.51 8.00e-06 41.60
IUUC-Ssc-115270 Sus scrofa 96.61 8.00e-64 234.00
IUUC-Tru-118420 Takifugu rubripes 84.87 1.00e-56 211.00
IUUC-Tni-120611 Tetraodon nigroviridis 84.21 6.00e-53 198.00
IUUC-Tca-121839 Theobroma cacao 27.96 8.00e-06 41.60
IUUC-Tae-125514 Triticum aestivum 31.11 3.00e-09 52.80
IUUC-Ttr-128410 Tursiops truncatus 95.76 5.00e-63 233.00
IUUC-Vvi-130839 Vitis vinifera 29.03 2.00e-05 41.60
IUUC-Xtr-132615 Xenopus tropicalis 84.75 3.00e-56 209.00
IUUC-Xma-133408 Xiphophorus maculatus 84.03 2.00e-55 207.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved