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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045804
UUCD1 version UUC-HoS-00543
Ensembl Protein ID ENSP00000363313.3
UniProt Accession O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4; PRP4_HUMAN
Genbank Protein ID AAB87640.1; AAC51925.1; AAC02261.1; CAI10968.1; EAW87362.1; AAH01588.1; AAH07424.1
Protein Name U4/U6 small nuclear ribonucleoprotein Prp4; PRP4 homolog; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4
Genbank Nucleotide ID AF001687; AF016369; U82756; AL449305; CH471090; BC001588; BC007424
Gene Name PRPF4; PRP4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000136875.12 ENST00000374199.8 ENSP00000363315.3
ENSG00000136875.12 ENST00000374198.4 ENSP00000363313.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.00e-38 129.4 405 443
UBD/Beta-Prp 3.50e-93 313.7 230 477
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH  ++++++f ++  ++++Gs+D+t+kvWDlr+ +++ 
   Q: 405  GHLKEIYGINFsPNgYHIATGSGDNTCKVWDLRQRRCVY 443
           7999********77799*****************99985 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk........ilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +i+  +fsp++++lat++++g  k+w+v + +ll++l gh+  v a+ f+p++          l++++ D+ +k+w+l++ ++v  ++g
   Q: 230  DDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTvsldpkdvNLASCAADGSVKLWSLDSDEPVADIEG 321
           67899999**************************************99999999988888899999************************** PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
           h+ +v  + ++psg +l ++  dr  r+wdle ++++   ++gh+  v  +++h+dg+l  +G+lD + r+Wdl+tg+++  l+g h + +y
   Q: 322  HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL-HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEG-HLKEIY 411
           **************************************.********************************************99.****** PP
   S: 185  slsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriW 249
            ++f++ng ++++gs d+t k+wdl++ +cv+t  +h++ v+ v+f   ++++l++g+ D++ +iW
   Q: 412  GINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEpIHGNFLLTGAYDNTAKIW 477
           ***********************************************88***************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
 Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
Protein Sequence
(Fasta)
MASSRASSTQ ATKTKAPDDL VAPVVKKPHI YYGSLEEKER ERLAKGESGI LGKDGLKAGI 60
EAGNINITSG EVFEIEEHIS ERQAEVLAEF ERRKRARQIN VSTDDSEVKA CLRALGEPIT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045804|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGAGTTCAG CCCCGAGCCG CGCGAGTCGA CTCACCTACC TCTTTTCAAG CCGGCCTAGC 60
CCCTTCCCGG AACCTCGGCT CCCCCCCAAC GAAACTACTG CTAAGCCAAC TGGACTACAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045804|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0682--Retinitis pigmentosa
KW-0747--Spliceosome
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR014906--PRP4-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08799--PRP4
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00500--SFM
SM00320--WD40
Gene Ontology

GO:0015030--C:Cajal body
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0097525--C:spliceosomal snRNP complex
GO:0071001--C:U4/U6 snRNP
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0030621--F:U4 snRNA binding
GO:0017070--F:U6 snRNA binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006396--P:RNA processing
GO:0008380--P:RNA splicing
GO:0000375--P:RNA splicing, via transesterification reactions
KEGG hsa:9128
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000771 Aegilops tauschii 44.63 2.00e-100 359.00
IUUC-Aml-001737 Ailuropoda melanoleuca 99.60 0.00e+00 1012.00
IUUC-Atr-002828 Amborella trichopoda 43.33 2.00e-103 369.00
IUUC-Apl-003723 Anas platyrhynchos 90.25 0.00e+00 949.00
IUUC-Aca-004972 Anolis carolinensis 89.89 0.00e+00 897.00
IUUC-Aly-006531 Arabidopsis lyrata 43.15 1.00e-94 340.00
IUUC-Ath-007367 Arabidopsis thaliana 44.03 2.00e-108 386.00
IUUC-Ago-007893 Ashbya gossypii 32.89 4.00e-55 209.00
IUUC-Acl-008236 Aspergillus clavatus 38.45 7.00e-90 324.00
IUUC-Afl-008522 Aspergillus flavus 40.21 2.00e-98 353.00
IUUC-Afu-008904 Aspergillus fumigatus 38.92 6.00e-95 341.00
IUUC-Ani-009198 Aspergillus nidulans 39.58 6.00e-98 351.00
IUUC-Ang-009662 Aspergillus niger 42.51 3.00e-99 355.00
IUUC-Aor-009881 Aspergillus oryzae 40.21 1.00e-98 353.00
IUUC-Ate-010333 Aspergillus terreus 38.02 6.00e-88 318.00
IUUC-Ame-011697 Astyanax mexicanus 80.59 0.00e+00 817.00
IUUC-Bgr-012254 Blumeria graminis 38.76 3.00e-97 349.00
IUUC-Bta-012615 Bos taurus 98.47 0.00e+00 992.00
IUUC-Bci-013720 Botrytis cinerea 38.84 4.00e-99 355.00
IUUC-Bdi-014302 Brachypodium distachyon 45.43 6.00e-109 387.00
IUUC-Bol-015594 Brassica oleracea 43.10 2.00e-98 353.00
IUUC-Bra-017465 Brassica rapa 42.89 1.00e-98 353.00
IUUC-Cel-018632 Caenorhabditis elegans 45.25 6.00e-108 384.00
IUUC-Cja-019747 Callithrix jacchus 99.62 0.00e+00 1045.00
IUUC-Cfa-020288 Canis familiaris 99.60 0.00e+00 1014.00
IUUC-Cpo-021440 Cavia porcellus 97.44 0.00e+00 995.00
IUUC-Cre-022716 Chlamydomonas reinhardtii 48.03 3.00e-87 315.00
IUUC-Csa-023139 Chlorocebus sabaeus 99.70 0.00e+00 705.00
IUUC-Cho-024481 Choloepus hoffmanni 95.80 0.00e+00 865.00
IUUC-Cin-025106 Ciona intestinalis 59.11 3.00e-176 611.00
IUUC-Csv-026087 Ciona savignyi 57.34 2.00e-174 605.00
IUUC-Cgl-026538 Colletotrichum gloeosporioides 37.93 3.00e-93 337.00
IUUC-Cne-026793 Cryptococcus neoformans 41.29 4.00e-105 375.00
IUUC-Dre-028723 Danio rerio 80.00 0.00e+00 793.00
IUUC-Dno-029299 Dasypus novemcinctus 99.01 0.00e+00 1010.00
IUUC-Dor-030345 Dipodomys ordii 76.30 1.00e-101 363.00
IUUC-Dse-031562 Dothistroma septosporum 37.16 3.00e-89 322.00
IUUC-Dme-031783 Drosophila melanogaster 56.89 1.00e-140 493.00
IUUC-Ete-032669 Echinops telfairi 97.32 0.00e+00 1021.00
IUUC-Eca-033566 Equus caballus 99.60 0.00e+00 1010.00
IUUC-Eeu-034524 Erinaceus europaeus 98.74 6.00e-146 510.00
IUUC-Fca-036215 Felis catus 99.60 0.00e+00 1014.00
IUUC-Fal-037018 Ficedula albicollis 90.21 0.00e+00 795.00
IUUC-Fox-037936 Fusarium oxysporum 37.42 2.00e-86 313.00
IUUC-Fso-038366 Fusarium solani 38.43 4.00e-92 332.00
IUUC-Gmo-038966 Gadus morhua 66.95 2.00e-140 491.00
IUUC-Ggr-039942 Gaeumannomyces graminis 37.16 3.00e-85 309.00
IUUC-Gga-040797 Gallus gallus 91.22 0.00e+00 936.00
IUUC-Gac-042598 Gasterosteus aculeatus 69.18 0.00e+00 665.00
IUUC-Gma-044220 Glycine max 44.75 3.00e-103 369.00
IUUC-Ggo-044682 Gorilla gorilla 99.80 0.00e+00 1009.00
IUUC-Hvu-047567 Hordeum vulgare 44.42 1.00e-94 340.00
IUUC-Itr-047882 Ictidomys tridecemlineatus 98.85 0.00e+00 1032.00
IUUC-Kpa-049369 Komagataella pastoris 33.24 2.00e-61 229.00
IUUC-Lch-050074 Latimeria chalumnae 81.25 0.00e+00 825.00
IUUC-Lpe-051333 Leersia perrieri 44.26 2.00e-99 355.00
IUUC-Loc-052164 Lepisosteus oculatus 81.58 0.00e+00 838.00
IUUC-Lma-053088 Leptosphaeria maculans 37.17 7.00e-85 308.00
IUUC-Laf-053460 Loxodonta africana 98.08 0.00e+00 1028.00
IUUC-Mcc-055859 Macaca mulatta 99.60 0.00e+00 1014.00
IUUC-Meu-056134 Macropus eugenii 95.33 0.00e+00 989.00
IUUC-Mor-057251 Magnaporthe oryzae 37.23 1.00e-85 310.00
IUUC-Mpo-057375 Magnaporthe poae 40.40 6.00e-54 204.00
IUUC-Mtr-057656 Medicago truncatula 44.19 2.00e-93 336.00
IUUC-Mla-059145 Melampsora laricipopulina 40.44 2.00e-101 363.00
IUUC-Mga-059855 Meleagris gallopavo 88.29 0.00e+00 932.00
IUUC-Mvi-060372 Microbotryum violaceum 41.98 1.00e-93 337.00
IUUC-Mmr-060826 Microcebus murinus 98.81 0.00e+00 1009.00
IUUC-Mdo-062748 Monodelphis domestica 95.64 0.00e+00 983.00
IUUC-Mmu-063351 Mus musculus 99.21 0.00e+00 1010.00
IUUC-Mac-064846 Musa acuminata 44.70 8.00e-96 343.00
IUUC-Mpu-066006 Mustela putorius furo 99.60 0.00e+00 1014.00
IUUC-Mlu-067398 Myotis lucifugus 99.21 0.00e+00 1009.00
IUUC-Nfi-068399 Neosartorya fischeri 38.72 3.00e-100 358.00
IUUC-Ncr-068711 Neurospora crassa 37.92 2.00e-93 336.00
IUUC-Nle-069982 Nomascus leucogenys 99.62 0.00e+00 1045.00
IUUC-Opr-070596 Ochotona princeps 98.85 0.00e+00 1039.00
IUUC-Ont-072374 Oreochromis niloticus 75.10 0.00e+00 758.00
IUUC-Oan-073166 Ornithorhynchus anatinus 94.37 0.00e+00 749.00
IUUC-Ocu-074371 Oryctolagus cuniculus 99.41 0.00e+00 1013.00
IUUC-Oba-075083 Oryza barthii 44.06 1.00e-102 366.00
IUUC-Obr-076405 Oryza brachyantha 44.03 5.00e-99 354.00
IUUC-Ogl-077683 Oryza glaberrima 43.86 2.00e-102 366.00
IUUC-Ogu-078486 Oryza glumaepatula 44.09 3.00e-102 365.00
IUUC-Oin-079679 Oryza indica 44.06 3.00e-105 376.00
IUUC-Olo-080243 Oryza longistaminata 46.22 2.00e-90 326.00
IUUC-Ome-081230 Oryza meridionalis 43.86 4.00e-105 375.00
IUUC-Oni-082961 Oryza nivara 43.86 4.00e-105 375.00
IUUC-Opu-083189 Oryza punctata 42.98 8.00e-102 364.00
IUUC-Oru-084353 Oryza rufipogon 44.16 6.00e-103 367.00
IUUC-Osa-085458 Oryza sativa 43.86 4.00e-105 375.00
IUUC-Ola-086940 Oryzias latipes 74.90 0.00e+00 752.00
IUUC-Olu-087580 Ostreococcus lucimarinus 35.68 4.00e-64 238.00
IUUC-Oga-088703 Otolemur garnettii 94.25 0.00e+00 980.00
IUUC-Oar-089829 Ovis aries 98.85 0.00e+00 995.00
IUUC-Ptr-090838 Pan troglodytes 100.00 0.00e+00 1049.00
IUUC-Pan-092261 Papio anubis 98.85 0.00e+00 1035.00
IUUC-Psi-093020 Pelodiscus sinensis 90.86 0.00e+00 954.00
IUUC-Pno-094858 Phaeosphaeria nodorum 38.15 1.00e-80 293.00
IUUC-Ppa-095531 Physcomitrella patens 45.14 1.00e-117 417.00
IUUC-Pfo-096812 Poecilia formosa 70.22 0.00e+00 669.00
IUUC-Pab-097805 Pongo abelii 89.26 0.00e+00 889.00
IUUC-Pop-100051 Populus trichocarpa 44.37 5.00e-105 375.00
IUUC-Pca-100152 Procavia capensis 99.03 0.00e+00 1021.00
IUUC-Ppe-101244 Prunus persica 46.00 5.00e-106 377.00
IUUC-Pva-102529 Pteropus vampyrus 95.59 0.00e+00 992.00
IUUC-Pgr-103550 Puccinia graminis 36.88 2.00e-102 366.00
IUUC-Ptt-103951 Puccinia triticina 33.33 2.00e-81 296.00
IUUC-Pte-104151 Pyrenophora teres 37.58 3.00e-80 292.00
IUUC-Pyt-104571 Pyrenophora triticirepentis 38.23 1.00e-81 297.00
IUUC-Rno-105747 Rattus norvegicus 99.01 0.00e+00 1008.00
IUUC-Sce-106418 Saccharomyces cerevisiae 33.63 1.00e-67 250.00
IUUC-Sha-107334 Sarcophilus harrisii 96.24 0.00e+00 986.00
IUUC-Sja-107794 Schizosaccharomyces japonicus 35.25 3.00e-71 262.00
IUUC-Spo-108189 Schizosaccharomyces pombe 38.12 2.00e-81 296.00
IUUC-Ssl-108550 Sclerotinia sclerotiorum 37.98 5.00e-97 348.00
IUUC-Smo-109578 Selaginella moellendorffii 46.57 9.00e-111 394.00
IUUC-Sit-110102 Setaria italica 44.34 2.00e-103 369.00
IUUC-Sly-111668 Solanum lycopersicum 46.05 5.00e-107 381.00
IUUC-Stu-111928 Solanum tuberosum 45.60 2.00e-106 380.00
IUUC-Sar-113266 Sorex araneus 86.36 0.00e+00 825.00
IUUC-Sbi-114134 Sorghum bicolor 44.12 9.00e-104 370.00
IUUC-Sre-115114 Sporisorium reilianum 41.31 2.00e-104 372.00
IUUC-Ssc-115443 Sus scrofa 99.60 0.00e+00 1013.00
IUUC-Tgu-117157 Taeniopygia guttata 90.26 0.00e+00 888.00
IUUC-Tru-118587 Takifugu rubripes 74.46 0.00e+00 732.00
IUUC-Tsy-119157 Tarsius syrichta 99.49 0.00e+00 782.00
IUUC-Tni-120427 Tetraodon nigroviridis 75.05 0.00e+00 745.00
IUUC-Tca-121368 Theobroma cacao 44.35 1.00e-106 380.00
IUUC-Tre-122074 Trichoderma reesei 37.66 8.00e-89 321.00
IUUC-Tvi-122349 Trichoderma virens 36.86 2.00e-87 316.00
IUUC-Tae-125651 Triticum aestivum 44.32 8.00e-103 367.00
IUUC-Tur-126532 Triticum urartu 43.86 1.00e-88 320.00
IUUC-Tme-126951 Tuber melanosporum 41.05 1.00e-102 366.00
IUUC-Tbe-128136 Tupaia belangeri 90.61 0.00e+00 929.00
IUUC-Ttr-129169 Tursiops truncatus 98.99 2.00e-166 578.00
IUUC-Uma-129399 Ustilago maydis 42.39 1.00e-102 366.00
IUUC-Vda-129842 Verticillium dahliae 37.98 2.00e-94 339.00
IUUC-Vpa-130440 Vicugna pacos 99.23 0.00e+00 1041.00
IUUC-Vvi-131075 Vitis vinifera 47.17 2.00e-107 383.00
IUUC-Xtr-132713 Xenopus tropicalis 49.12 8.00e-109 387.00
IUUC-Xma-133002 Xiphophorus maculatus 79.67 1.00e-171 595.00
IUUC-Yli-134569 Yarrowia lipolytica 36.04 2.00e-76 279.00
IUUC-Zma-135799 Zea mays 42.40 8.00e-101 360.00
Created Date 25-Jun-2017

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