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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Rno-105050
UUCD1 version UUC-RaN-00887
Ensembl Protein ID ENSRNOP00000013727.1
UniProt Accession Q64259; Q64197; Q80WY8; VHL_RAT
Genbank Protein ID AAA86874.1; AAB35675.1; AAP32238.1
Protein Name Von Hippel-Lindau disease tumor suppressor; pVHL
Genbank Nucleotide ID U14746; S80345; S81658
Gene Name Vhl
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000010258.3 ENSRNOT00000013727.3 ENSRNOP00000013727.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 26.72 3.00e-04 42.00 IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 93.04 3.00e-84 308.00 IUUC-Hsa-046547
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description



     Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).
Protein Sequence
(Fasta)
MPRKAASPEE AERMPGSEEI EAGRPRPVLR SVNSREPSQV IFCNRSPRVV LPLWLNFDGE 60
PQPYPTLPPG TGRRIHSYRG HLWLFRDAGT HDGLLVNQTE LFVPSLNVDG QPIFANITLP 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Rno-105050|E3,SOCS|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGCCCACCA CCTGGGACCC TGGCTCTGTG CCGCCCCGCC CCCCAACTTG AGGGCTCTAG 60
GCGGCCATTT CCGCGTTAAA GCCGGACGGA GTACTTCTAT TGCTGGCAGA CCTGCCCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Rno-105050|E3,SOCS|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0833--Ubl conjugation pathway

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0030891--C:VCB complex
GO:0032403--F:protein complex binding
GO:0008134--F:transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030182--P:neuron differentiation
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:0051291--P:protein heterooligomerization
GO:0016567--P:protein ubiquitination
GO:2001233--P:regulation of apoptotic signaling pathway
GO:0042069--P:regulation of catecholamine metabolic process
GO:1903827--P:regulation of cellular protein localization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0045471--P:response to ethanol
GO:0001666--P:response to hypoxia
GO:0003309--P:type B pancreatic cell differentiation

KEGG rno:24874
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002327 Ailuropoda melanoleuca 81.48 1.00e-69 255.00
IUUC-Apl-003580 Anas platyrhynchos 66.28 4.00e-26 108.00
IUUC-Aca-004492 Anolis carolinensis 77.95 1.00e-56 212.00
IUUC-Ang-009806 Aspergillus niger 40.62 1.70e-01 26.90
IUUC-Ame-011818 Astyanax mexicanus 52.63 7.00e-44 170.00
IUUC-Bta-013459 Bos taurus 89.76 2.00e-85 307.00
IUUC-Cel-018173 Caenorhabditis elegans 31.87 6.00e-05 40.40
IUUC-Cja-019826 Callithrix jacchus 91.36 2.00e-85 307.00
IUUC-Cfa-021280 Canis familiaris 90.12 3.00e-83 300.00
IUUC-Cpo-022544 Cavia porcellus 90.91 2.00e-85 307.00
IUUC-Cre-022809 Chlamydomonas reinhardtii 43.33 2.00e-08 53.50
IUUC-Csa-023644 Chlorocebus sabaeus 94.30 5.00e-86 310.00
IUUC-Cho-024479 Choloepus hoffmanni 62.88 3.00e-41 160.00
IUUC-Cin-025505 Ciona intestinalis 27.05 8.00e-06 43.10
IUUC-Cme-027232 Cyanidioschyzon merolae 32.43 2.00e-05 42.70
IUUC-Dre-028350 Danio rerio 49.40 5.00e-33 133.00
IUUC-Dno-029207 Dasypus novemcinctus 83.62 1.00e-53 202.00
IUUC-Dor-030912 Dipodomys ordii 66.45 5.00e-51 193.00
IUUC-Dme-031988 Drosophila melanogaster 26.72 2.00e-05 42.00
IUUC-Eca-034007 Equus caballus 97.50 6.00e-19 85.10
IUUC-Fca-036350 Felis catus 92.95 4.00e-82 296.00
IUUC-Fal-037192 Ficedula albicollis 64.02 2.00e-55 207.00
IUUC-Gmo-038921 Gadus morhua 56.02 3.00e-45 174.00
IUUC-Gga-041016 Gallus gallus 67.11 3.00e-55 207.00
IUUC-Gac-042560 Gasterosteus aculeatus 47.88 2.00e-36 145.00
IUUC-Ggo-045419 Gorilla gorilla 92.95 1.00e-83 302.00
IUUC-Hsa-046547 Homo sapiens 92.95 1.00e-83 302.00
IUUC-Itr-048225 Ictidomys tridecemlineatus 95.00 1.00e-87 315.00
IUUC-Lch-050463 Latimeria chalumnae 61.45 2.00e-55 207.00
IUUC-Loc-052053 Lepisosteus oculatus 55.48 7.00e-48 182.00
IUUC-Laf-053893 Loxodonta africana 89.16 9.00e-86 308.00
IUUC-Mcc-055347 Macaca mulatta 74.13 1.00e-56 212.00
IUUC-Mtr-058490 Medicago truncatula 48.48 9.00e-03 33.90
IUUC-Mdo-062169 Monodelphis domestica 75.53 3.00e-38 149.00
IUUC-Mmu-064366 Mus musculus 97.84 3.00e-77 280.00
IUUC-Mpu-066593 Mustela putorius furo 91.02 2.00e-86 311.00
IUUC-Mlu-066926 Myotis lucifugus 93.71 1.00e-86 312.00
IUUC-Nle-069724 Nomascus leucogenys 93.59 1.00e-84 305.00
IUUC-Opr-070679 Ochotona princeps 78.86 3.00e-77 280.00
IUUC-Ont-071332 Oreochromis niloticus 52.87 3.00e-43 167.00
IUUC-Ola-086869 Oryzias latipes 47.02 2.00e-40 158.00
IUUC-Oga-089124 Otolemur garnettii 88.69 3.00e-85 307.00
IUUC-Oar-089799 Ovis aries 90.91 3.00e-50 189.00
IUUC-Ptr-091186 Pan troglodytes 89.11 1.00e-49 187.00
IUUC-Pan-092150 Papio anubis 93.59 4.00e-84 303.00
IUUC-Psi-094039 Pelodiscus sinensis 67.14 1.00e-51 195.00
IUUC-Pma-094129 Petromyzon marinus 43.97 3.00e-27 114.00
IUUC-Pfo-096892 Poecilia formosa 49.04 3.00e-37 147.00
IUUC-Pab-097822 Pongo abelii 93.59 1.00e-84 305.00
IUUC-Pca-101058 Procavia capensis 87.65 3.00e-78 283.00
IUUC-Pva-102932 Pteropus vampyrus 94.38 9.00e-88 315.00
IUUC-Sha-106738 Sarcophilus harrisii 79.00 4.00e-44 168.00
IUUC-Ssc-115973 Sus scrofa 89.22 2.00e-86 310.00
IUUC-Tgu-116663 Taeniopygia guttata 69.39 1.00e-33 134.00
IUUC-Tru-118654 Takifugu rubripes 51.25 9.00e-43 165.00
IUUC-Tca-121306 Theobroma cacao 38.89 3.70e-02 29.60
IUUC-Ttr-128418 Tursiops truncatus 84.66 6.00e-87 313.00
IUUC-Vpa-130268 Vicugna pacos 91.09 3.00e-49 187.00
IUUC-Xtr-132506 Xenopus tropicalis 62.18 7.00e-55 206.00
Created Date 25-Jun-2017

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