iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	23487316

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.30e-18	64.9	157	223
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	3.50e-12	45.3	256	286

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dvilv +++e++ah+ vLa++S++Fya+f + +ees+ + +++++ v++ +++ l++++Yt +++ ne
   Q: 157  CDVILVADDVEIHAHRMVLASCSPYFYAMF-TSFEESR-QARITLQSVDARALELLIDYVYTATVEVNE 223
           8*****************************.56****9.*************************99886 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           +Nclgi+ fAd++ c +L  +a+++i++hF+
   Q: 256  SNCLGIREFADIHACVELLNYAETYIEQHFN 286
           8*****************************6 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Component of ring canals that regulates the flow of cytoplasm between cells. May be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. Binds actin.

Protein Sequence
(Fasta)

MIALSALLTK YTIGIMSNLS NGNSNNNNQQ QQQQQQGQNP QQPAQNEGGA GAEFVAPPPG 60
LGAAVGVAAM QQRNRLLQQQ QQQHHHHQNP AAEGSGLERG SCLLRYASQN SLDESSQKHV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGCTAGTGG TAACTTGCGA CCAACCCGAG GCTGGTCACA CTGCTCTGGT CGCGTCCAAA 60
AAGTGTACAA TTTTTCACCA CCTCGGTTTG TTTTTTCGGA CCAGGCGAGG CACCTTCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0880--Kelch repeat
KW-0896--Oogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0712--Selenocysteine

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0035324--C:female germline ring canal
GO:0035183--C:female germline ring canal inner rim
GO:0045172--C:germline ring canal
GO:0003779--F:actin binding
GO:0030036--P:actin cytoskeleton organization
GO:0007349--P:cellularization
GO:0007301--P:female germline ring canal formation
GO:0030717--P:karyosome formation
GO:0048477--P:oogenesis
GO:0007297--P:ovarian follicle cell migration
GO:0030723--P:ovarian fusome organization
GO:0007300--P:ovarian nurse cell to oocyte transport
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG7210

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002378	Ailuropoda melanoleuca	61.90	0.00e+00	699.00
IUUC-Apl-003260	Anas platyrhynchos	61.54	0.00e+00	701.00
IUUC-Aca-005143	Anolis carolinensis	59.93	0.00e+00	707.00
IUUC-Ame-010670	Astyanax mexicanus	60.43	0.00e+00	670.00
IUUC-Bta-013354	Bos taurus	58.77	0.00e+00	695.00
IUUC-Bci-013669	Botrytis cinerea	39.47	1.00e-07	53.10
IUUC-Bdi-014143	Brachypodium distachyon	33.56	3.00e-43	169.00
IUUC-Cel-018136	Caenorhabditis elegans	43.44	2.00e-129	455.00
IUUC-Cja-018942	Callithrix jacchus	61.90	0.00e+00	699.00
IUUC-Cfa-020886	Canis familiaris	62.08	0.00e+00	701.00
IUUC-Cpo-022543	Cavia porcellus	62.08	0.00e+00	701.00
IUUC-Csa-023088	Chlorocebus sabaeus	62.08	0.00e+00	701.00
IUUC-Csv-026032	Ciona savignyi	54.25	5.00e-170	590.00
IUUC-Dre-028082	Danio rerio	60.47	0.00e+00	689.00
IUUC-Dno-029873	Dasypus novemcinctus	61.10	0.00e+00	689.00
IUUC-Dor-030156	Dipodomys ordii	49.37	1.00e-155	542.00
IUUC-Dse-031229	Dothistroma septosporum	29.25	3.00e-08	50.80
IUUC-Ete-033064	Echinops telfairi	51.59	3.00e-140	491.00
IUUC-Eca-033798	Equus caballus	61.72	0.00e+00	697.00
IUUC-Eeu-034824	Erinaceus europaeus	58.75	8.00e-179	619.00
IUUC-Fca-036455	Felis catus	62.08	0.00e+00	701.00
IUUC-Fal-037293	Ficedula albicollis	61.12	0.00e+00	692.00
IUUC-Gmo-038811	Gadus morhua	59.03	0.00e+00	627.00
IUUC-Gga-040805	Gallus gallus	61.72	0.00e+00	701.00
IUUC-Gac-041979	Gasterosteus aculeatus	61.00	0.00e+00	632.00
IUUC-Ggo-045485	Gorilla gorilla	58.60	0.00e+00	688.00
IUUC-Hsa-046265	Homo sapiens	62.08	0.00e+00	701.00
IUUC-Itr-048605	Ictidomys tridecemlineatus	60.47	0.00e+00	695.00
IUUC-Lch-050246	Latimeria chalumnae	56.29	0.00e+00	655.00
IUUC-Loc-052780	Lepisosteus oculatus	62.08	0.00e+00	704.00
IUUC-Laf-053800	Loxodonta africana	59.60	0.00e+00	699.00
IUUC-Mcc-055732	Macaca mulatta	61.47	0.00e+00	689.00
IUUC-Meu-056011	Macropus eugenii	62.92	0.00e+00	683.00
IUUC-Mga-059994	Meleagris gallopavo	58.71	7.00e-176	609.00
IUUC-Mmr-061067	Microcebus murinus	61.71	0.00e+00	687.00
IUUC-Mdo-062977	Monodelphis domestica	62.25	0.00e+00	699.00
IUUC-Mmu-064035	Mus musculus	61.71	0.00e+00	687.00
IUUC-Mpu-066726	Mustela putorius furo	62.08	0.00e+00	700.00
IUUC-Mlu-067020	Myotis lucifugus	62.08	0.00e+00	701.00
IUUC-Nle-069456	Nomascus leucogenys	62.08	0.00e+00	701.00
IUUC-Opr-071130	Ochotona princeps	55.46	9.00e-174	602.00
IUUC-Ont-072219	Oreochromis niloticus	61.36	0.00e+00	669.00
IUUC-Oan-073699	Ornithorhynchus anatinus	61.66	6.00e-180	622.00
IUUC-Ocu-074045	Oryctolagus cuniculus	60.51	0.00e+00	702.00
IUUC-Ogl-077595	Oryza glaberrima	32.88	4.00e-36	145.00
IUUC-Oin-079973	Oryza indica	32.53	1.00e-35	144.00
IUUC-Olo-080536	Oryza longistaminata	33.20	1.00e-33	138.00
IUUC-Osa-085891	Oryza sativa	32.88	1.00e-36	147.00
IUUC-Ola-086853	Oryzias latipes	59.08	0.00e+00	658.00
IUUC-Oga-088494	Otolemur garnettii	62.08	0.00e+00	701.00
IUUC-Oar-089645	Ovis aries	61.72	0.00e+00	697.00
IUUC-Ptr-091063	Pan troglodytes	62.08	0.00e+00	700.00
IUUC-Pan-091705	Papio anubis	58.90	0.00e+00	697.00
IUUC-Psi-093946	Pelodiscus sinensis	60.25	0.00e+00	697.00
IUUC-Pma-094177	Petromyzon marinus	61.46	0.00e+00	646.00
IUUC-Pno-095143	Phaeosphaeria nodorum	23.86	1.00e-13	70.10
IUUC-Ppa-095249	Physcomitrella patens	31.31	4.00e-16	78.60
IUUC-Pfo-096817	Poecilia formosa	60.47	0.00e+00	679.00
IUUC-Pab-097768	Pongo abelii	62.08	0.00e+00	701.00
IUUC-Pca-100607	Procavia capensis	54.93	4.00e-130	457.00
IUUC-Pva-102218	Pteropus vampyrus	58.68	0.00e+00	649.00
IUUC-Pgr-103359	Puccinia graminis	26.44	1.70e-02	33.50
IUUC-Pyt-104553	Pyrenophora triticirepentis	29.89	4.00e-06	45.40
IUUC-Rno-105250	Rattus norvegicus	61.90	0.00e+00	698.00
IUUC-Ssl-108429	Sclerotinia sclerotiorum	27.81	7.00e-06	43.90
IUUC-Sar-113249	Sorex araneus	61.45	0.00e+00	681.00
IUUC-Ssc-115423	Sus scrofa	61.72	0.00e+00	697.00
IUUC-Tgu-117050	Taeniopygia guttata	60.36	0.00e+00	687.00
IUUC-Tru-118239	Takifugu rubripes	60.66	0.00e+00	702.00
IUUC-Tsy-119377	Tarsius syrichta	52.42	5.00e-172	596.00
IUUC-Tni-120122	Tetraodon nigroviridis	61.41	0.00e+00	640.00
IUUC-Tae-124075	Triticum aestivum	29.82	1.00e-39	157.00
IUUC-Vpa-130707	Vicugna pacos	59.66	3.00e-161	560.00
IUUC-Xtr-132035	Xenopus tropicalis	61.32	0.00e+00	718.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence