iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.30e-19	68.9	1422	1481

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek...slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrs 53
           ++C++C+++++d++   +++eC +C +w+H +C +ls       ++lp+s ++iC+kC +
   Q: 1422 NFCPICQRCYDDNDfdlKMMECGDCGQWVHSKCEGLSdeqynLLSTLPESIEFICKKCAR 1481
           79***********9999************************99***************86 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo.

Protein Sequence
(Fasta)

MGRSKFPGKP SKSINRKRIS VLQLEDDAAN PAEPQQPAPE SQQPSGSGSG SSAAREKGNN 60
CDNDEDDNAP GGASISGNTA SSSAGSGNSG NGSSSGSSTG SGSSGSGSTN GGSVNGGTHH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTATAGTTA TCGGCGCGGT CACACTGTCC GGTCGTTTTG CTTTGCTATT TCCATTTCGC 60
TCGTCGAAAA AACGCAGAAA ATGTGGAAAA TAATTGATAA ACTGTGCTAA ATAGTGTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001628--Znf_hrmn_rcpt
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS51030--NUCLEAR_REC_DBD_2
PS50868--POST_SET
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0035097--C:histone methyltransferase complex
GO:0005875--C:microtubule associated complex
GO:0044665--C:MLL1/2 complex
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0008023--C:transcription elongation factor complex
GO:0003682--F:chromatin binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0008157--F:protein phosphatase 1 binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0001654--P:eye development
GO:0008354--P:germ cell migration
GO:0007482--P:haltere development
GO:0016573--P:histone acetylation
GO:0043966--P:histone H3 acetylation
GO:0051568--P:histone H3-K4 methylation
GO:0016571--P:histone methylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0019233--P:sensory perception of pain
GO:0006351--P:transcription, DNA-templated

KEGG

dme:Dmel_CG8651

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000310	Aegilops tauschii	32.24	7.00e-14	71.60
IUUC-Aml-002367	Ailuropoda melanoleuca	47.28	4.00e-93	337.00
IUUC-Atr-002455	Amborella trichopoda	50.00	9.00e-41	161.00
IUUC-Apl-003478	Anas platyrhynchos	46.55	4.00e-89	323.00
IUUC-Aca-004718	Anolis carolinensis	49.00	6.00e-96	346.00
IUUC-Aly-006448	Arabidopsis lyrata	50.60	1.00e-41	164.00
IUUC-Ath-006690	Arabidopsis thaliana	43.51	1.00e-32	134.00
IUUC-Ame-010705	Astyanax mexicanus	47.54	6.00e-93	337.00
IUUC-Bta-013578	Bos taurus	47.28	9.00e-93	335.00
IUUC-Bol-016540	Brassica oleracea	42.86	2.00e-32	134.00
IUUC-Cja-019138	Callithrix jacchus	47.43	3.00e-94	340.00
IUUC-Cfa-020020	Canis familiaris	47.28	4.00e-93	337.00
IUUC-Cpo-021552	Cavia porcellus	47.28	3.00e-93	337.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	53.91	1.00e-39	159.00
IUUC-Csa-024216	Chlorocebus sabaeus	47.56	9.00e-94	338.00
IUUC-Cho-024652	Choloepus hoffmanni	44.22	8.00e-82	300.00
IUUC-Cin-025724	Ciona intestinalis	56.28	4.00e-74	272.00
IUUC-Csv-026268	Ciona savignyi	29.73	5.00e-87	315.00
IUUC-Cme-027224	Cyanidioschyzon merolae	41.98	5.00e-13	69.30
IUUC-Dre-027440	Danio rerio	48.99	2.00e-94	341.00
IUUC-Dno-029583	Dasypus novemcinctus	47.28	2.00e-93	338.00
IUUC-Dor-030903	Dipodomys ordii	47.28	4.00e-93	337.00
IUUC-Ete-032834	Echinops telfairi	48.99	1.00e-83	305.00
IUUC-Eca-034026	Equus caballus	47.28	2.00e-92	333.00
IUUC-Eeu-034687	Erinaceus europaeus	47.28	7.00e-93	336.00
IUUC-Fca-036311	Felis catus	47.28	3.00e-93	337.00
IUUC-Fal-037256	Ficedula albicollis	46.82	6.00e-91	330.00
IUUC-Gmo-039265	Gadus morhua	47.25	1.00e-91	332.00
IUUC-Gga-040828	Gallus gallus	47.11	4.00e-90	327.00
IUUC-Gac-042202	Gasterosteus aculeatus	47.83	8.00e-93	335.00
IUUC-Gma-043554	Glycine max	46.00	1.00e-34	141.00
IUUC-Ggo-044791	Gorilla gorilla	47.56	2.00e-93	337.00
IUUC-Hsa-046988	Homo sapiens	47.56	1.00e-93	338.00
IUUC-Itr-048907	Ictidomys tridecemlineatus	47.28	4.00e-93	337.00
IUUC-Lch-049704	Latimeria chalumnae	46.82	1.00e-91	332.00
IUUC-Lpe-051661	Leersia perrieri	30.67	2.00e-14	73.90
IUUC-Loc-052181	Lepisosteus oculatus	47.97	3.00e-91	331.00
IUUC-Laf-053946	Loxodonta africana	47.11	7.00e-91	330.00
IUUC-Mcc-054782	Macaca mulatta	47.56	6.00e-94	339.00
IUUC-Meu-056485	Macropus eugenii	45.95	5.00e-89	323.00
IUUC-Mtr-058327	Medicago truncatula	46.31	6.00e-33	135.00
IUUC-Mga-059943	Meleagris gallopavo	46.82	2.00e-90	328.00
IUUC-Mmr-061178	Microcebus murinus	47.11	7.00e-91	330.00
IUUC-Mdo-062648	Monodelphis domestica	47.85	2.00e-94	341.00
IUUC-Mmu-063579	Mus musculus	46.99	6.00e-93	336.00
IUUC-Mpu-066710	Mustela putorius furo	47.28	5.00e-93	336.00
IUUC-Mlu-067559	Myotis lucifugus	47.28	9.00e-93	335.00
IUUC-Nle-070085	Nomascus leucogenys	47.56	2.00e-93	337.00
IUUC-Opr-071148	Ochotona princeps	47.28	3.00e-93	337.00
IUUC-Ont-071626	Oreochromis niloticus	29.41	1.00e-96	348.00
IUUC-Oan-073324	Ornithorhynchus anatinus	33.14	4.00e-56	213.00
IUUC-Ocu-074475	Oryctolagus cuniculus	47.28	2.00e-93	337.00
IUUC-Oba-075647	Oryza barthii	45.86	1.00e-41	164.00
IUUC-Olo-080577	Oryza longistaminata	44.16	4.00e-34	139.00
IUUC-Ome-081214	Oryza meridionalis	46.41	5.00e-42	165.00
IUUC-Oni-083000	Oryza nivara	45.86	1.00e-41	164.00
IUUC-Opu-083842	Oryza punctata	43.20	7.00e-42	165.00
IUUC-Oru-084361	Oryza rufipogon	45.86	1.00e-41	164.00
IUUC-Ola-086609	Oryzias latipes	48.76	7.00e-86	312.00
IUUC-Olu-087718	Ostreococcus lucimarinus	44.91	6.00e-39	156.00
IUUC-Oga-088140	Otolemur garnettii	47.85	4.00e-94	340.00
IUUC-Oar-089447	Ovis aries	47.28	5.00e-93	336.00
IUUC-Ptr-090902	Pan troglodytes	47.56	1.00e-93	338.00
IUUC-Pan-091930	Papio anubis	47.56	1.00e-93	338.00
IUUC-Psi-094059	Pelodiscus sinensis	46.97	6.00e-90	327.00
IUUC-Pma-094258	Petromyzon marinus	38.98	2.00e-41	162.00
IUUC-Pfo-096360	Poecilia formosa	47.58	8.00e-95	342.00
IUUC-Pab-098404	Pongo abelii	47.28	3.00e-93	337.00
IUUC-Pca-100949	Procavia capensis	47.85	3.00e-94	340.00
IUUC-Pva-102634	Pteropus vampyrus	47.28	3.00e-93	337.00
IUUC-Rno-105870	Rattus norvegicus	46.99	1.00e-92	335.00
IUUC-Sha-107174	Sarcophilus harrisii	46.53	2.00e-90	328.00
IUUC-Smo-109164	Selaginella moellendorffii	37.28	6.00e-38	152.00
IUUC-Sly-111176	Solanum lycopersicum	42.68	1.00e-34	141.00
IUUC-Stu-112529	Solanum tuberosum	41.88	2.00e-34	140.00
IUUC-Sar-113289	Sorex araneus	47.28	2.00e-92	334.00
IUUC-Ssc-115509	Sus scrofa	47.14	4.00e-93	337.00
IUUC-Tgu-117047	Taeniopygia guttata	46.55	2.00e-89	325.00
IUUC-Tru-118413	Takifugu rubripes	49.00	7.00e-94	339.00
IUUC-Tsy-118953	Tarsius syrichta	43.53	8.00e-74	273.00
IUUC-Tni-119794	Tetraodon nigroviridis	48.99	2.00e-93	337.00
IUUC-Tur-126725	Triticum urartu	31.93	8.00e-12	65.50
IUUC-Tbe-127825	Tupaia belangeri	47.28	3.00e-93	337.00
IUUC-Ttr-128643	Tursiops truncatus	47.11	6.00e-91	330.00
IUUC-Vpa-130660	Vicugna pacos	35.83	5.00e-49	191.00
IUUC-Vvi-131476	Vitis vinifera	50.00	2.00e-41	163.00
IUUC-Xtr-132869	Xenopus tropicalis	47.11	1.00e-91	332.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence