iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046668

UUCD1 version

UUC-HoS-00022

Ensembl Protein ID

ENSP00000310448.5

UniProt Accession

O43290; A6NDN1; Q53GB5; SNUT1_HUMAN

Genbank Protein ID

BAA24056.1; AAK49523.1; AAP35283.1; BAD96736.1; AAH01058.1; AAD20223.1

Protein Name

U4/U6.U5 tri-snRNP-associated protein 1; SNU66 homolog; Squamous cell carcinoma antigen recognized by T-cells 1; U4/U6.U5 tri-snRNP-associated 110 kDa protein

Genbank Nucleotide ID

AB006198; AF353625; BT006637; AK223016; AP006287; AF109680

Gene Name

SART1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000175467.14	ENST00000312397.9	ENSP00000310448.5
ENSG00000175467.14	ENST00000530251.1	ENSP00000436218.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	18838541

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/Other	94.29	0.00e+00	1113.00	IUUC-Mmu-064142

Organism

Homo sapiens

Functional Description
(View)

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.

Protein Sequence
(Fasta)

MGSSKKHRGE KEAAGTTAAA GTGGATEQPP RHREHKKHKH RSGGSGGSGG ERRKRSRERG 60
GERGSGRRGA EAEARSSTHG RERSQAEPSE RRVKREKRDD GYEAAASSKT SSGDASSLSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACACGACAG CGGCTGCCGA GCGACCCGGA AGTATTCCCA TTTTGCGTTG TCTGGGCTCG 60
GCGGCAGCCG GGCTCGGAGT GGACGTGCCA CTATGGGGTC GTCCAAGAAG CATCGCGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0020--Allergen
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0747--Spliceosome
KW-0832--Ubl conjugation

Interpro

IPR005011--SNU66/SART1

Pfam

PF03343--SART-1

Gene Ontology

GO:0015030--C:Cajal body
GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0003723--F:RNA binding
GO:0007050--P:cell cycle arrest
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0000481--P:maturation of 5S rRNA
GO:0045292--P:mRNA cis splicing, via spliceosome
GO:0000398--P:mRNA splicing, via spliceosome
GO:0045585--P:positive regulation of cytotoxic T cell differentiation
GO:0000387--P:spliceosomal snRNP assembly

KEGG

hsa:9092

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000964	Aegilops tauschii	54.55	3.00e-22	100.00
IUUC-Aml-001506	Ailuropoda melanoleuca	94.91	0.00e+00	1115.00
IUUC-Atr-003123	Amborella trichopoda	36.90	3.00e-25	110.00
IUUC-Apl-004159	Anas platyrhynchos	91.11	2.00e-18	83.20
IUUC-Aca-004800	Anolis carolinensis	70.86	2.00e-101	363.00
IUUC-Aly-006240	Arabidopsis lyrata	60.44	4.00e-24	107.00
IUUC-Ath-007175	Arabidopsis thaliana	61.18	8.00e-24	105.00
IUUC-Ago-007952	Ashbya gossypii	28.92	3.00e-05	43.90
IUUC-Acl-008063	Aspergillus clavatus	34.73	2.00e-13	71.20
IUUC-Afl-008404	Aspergillus flavus	35.67	6.00e-15	76.30
IUUC-Afu-008933	Aspergillus fumigatus	35.50	5.00e-15	76.60
IUUC-Ani-009378	Aspergillus nidulans	54.55	2.00e-14	74.70
IUUC-Ang-009865	Aspergillus niger	31.82	9.00e-17	82.40
IUUC-Aor-010214	Aspergillus oryzae	35.67	6.00e-15	76.30
IUUC-Ate-010446	Aspergillus terreus	60.66	3.00e-13	70.90
IUUC-Ame-010802	Astyanax mexicanus	68.79	0.00e+00	770.00
IUUC-Bgr-012139	Blumeria graminis	32.91	3.00e-17	83.60
IUUC-Bta-012547	Bos taurus	94.17	0.00e+00	1168.00
IUUC-Bci-013790	Botrytis cinerea	29.86	1.00e-15	78.60
IUUC-Bdi-014958	Brachypodium distachyon	56.04	2.00e-22	101.00
IUUC-Bol-015305	Brassica oleracea	57.58	3.00e-24	107.00
IUUC-Bra-017189	Brassica rapa	57.58	3.00e-24	107.00
IUUC-Cel-018249	Caenorhabditis elegans	38.21	3.00e-32	134.00
IUUC-Cja-019388	Callithrix jacchus	91.32	0.00e+00	899.00
IUUC-Cfa-020033	Canis familiaris	95.16	0.00e+00	1143.00
IUUC-Cpo-021917	Cavia porcellus	90.71	0.00e+00	1033.00
IUUC-Csa-023428	Chlorocebus sabaeus	99.12	0.00e+00	1169.00
IUUC-Cho-024341	Choloepus hoffmanni	97.06	5.00e-78	285.00
IUUC-Cin-025700	Ciona intestinalis	42.66	2.00e-52	201.00
IUUC-Csv-025826	Ciona savignyi	41.61	3.00e-50	193.00
IUUC-Cgl-026437	Colletotrichum gloeosporioides	28.33	6.00e-16	79.70
IUUC-Cne-026786	Cryptococcus neoformans	51.58	4.00e-22	100.00
IUUC-Dre-027384	Danio rerio	67.03	0.00e+00	717.00
IUUC-Dno-029891	Dasypus novemcinctus	83.95	0.00e+00	832.00
IUUC-Dor-030843	Dipodomys ordii	89.75	0.00e+00	1072.00
IUUC-Dse-031367	Dothistroma septosporum	36.65	2.00e-18	87.40
IUUC-Dme-032008	Drosophila melanogaster	47.13	8.00e-59	222.00
IUUC-Eca-033761	Equus caballus	82.35	0.00e+00	936.00
IUUC-Fca-035723	Felis catus	94.79	0.00e+00	1178.00
IUUC-Fox-037689	Fusarium oxysporum	33.33	1.00e-09	58.20
IUUC-Fso-038345	Fusarium solani	64.71	3.00e-15	77.40
IUUC-Ggr-040049	Gaeumannomyces graminis	58.00	1.00e-12	68.60
IUUC-Gac-042388	Gasterosteus aculeatus	63.96	0.00e+00	741.00
IUUC-Gma-043036	Glycine max	34.52	1.00e-22	102.00
IUUC-Ggo-044803	Gorilla gorilla	99.75	0.00e+00	1139.00
IUUC-Hvu-047161	Hordeum vulgare	54.55	2.00e-22	100.00
IUUC-Itr-049078	Ictidomys tridecemlineatus	94.18	0.00e+00	1121.00
IUUC-Kpa-049385	Komagataella pastoris	51.52	3.00e-06	47.00
IUUC-Lch-049555	Latimeria chalumnae	68.04	1.00e-107	384.00
IUUC-Lpe-051037	Leersia perrieri	59.34	1.00e-23	105.00
IUUC-Loc-051839	Lepisosteus oculatus	85.83	8.00e-124	437.00
IUUC-Lma-053225	Leptosphaeria maculans	59.57	9.00e-13	68.90
IUUC-Laf-054002	Loxodonta africana	93.65	0.00e+00	1102.00
IUUC-Mcc-054874	Macaca mulatta	98.33	9.00e-168	583.00
IUUC-Meu-056111	Macropus eugenii	83.74	0.00e+00	1033.00
IUUC-Mor-056976	Magnaporthe oryzae	55.32	2.00e-11	64.30
IUUC-Mpo-057459	Magnaporthe poae	31.68	2.00e-12	67.80
IUUC-Mtr-058022	Medicago truncatula	54.00	2.00e-23	105.00
IUUC-Mla-058969	Melampsora laricipopulina	55.95	3.00e-13	70.90
IUUC-Mvi-060539	Microbotryum violaceum	38.74	3.00e-16	80.90
IUUC-Mmr-060674	Microcebus murinus	96.00	0.00e+00	1152.00
IUUC-Mdo-063085	Monodelphis domestica	77.70	0.00e+00	865.00
IUUC-Mmu-064142	Mus musculus	94.42	0.00e+00	1156.00
IUUC-Mac-065346	Musa acuminata	56.67	4.00e-23	103.00
IUUC-Mpu-065862	Mustela putorius furo	94.79	0.00e+00	1163.00
IUUC-Mlu-067452	Myotis lucifugus	93.31	0.00e+00	1091.00
IUUC-Nfi-068481	Neosartorya fischeri	34.91	3.00e-14	73.90
IUUC-Ncr-068693	Neurospora crassa	33.11	2.00e-11	64.30
IUUC-Nle-069029	Nomascus leucogenys	97.38	0.00e+00	1151.00
IUUC-Opr-070634	Ochotona princeps	96.47	3.00e-76	280.00
IUUC-Ont-071869	Oreochromis niloticus	67.97	0.00e+00	702.00
IUUC-Ocu-073829	Oryctolagus cuniculus	86.85	6.00e-40	157.00
IUUC-Oba-075629	Oryza barthii	59.34	8.00e-24	105.00
IUUC-Obr-076112	Oryza brachyantha	59.34	1.00e-23	105.00
IUUC-Ogl-077004	Oryza glaberrima	59.34	8.00e-24	105.00
IUUC-Ogu-079015	Oryza glumaepatula	59.34	9.00e-24	105.00
IUUC-Oin-079550	Oryza indica	59.34	9.00e-24	105.00
IUUC-Olo-080458	Oryza longistaminata	58.24	3.00e-23	103.00
IUUC-Ome-081108	Oryza meridionalis	59.34	7.00e-24	106.00
IUUC-Oni-082526	Oryza nivara	59.34	7.00e-24	106.00
IUUC-Opu-084013	Oryza punctata	59.34	8.00e-24	105.00
IUUC-Oru-084776	Oryza rufipogon	59.34	9.00e-24	105.00
IUUC-Osa-085489	Oryza sativa	59.34	3.00e-24	105.00
IUUC-Olu-087878	Ostreococcus lucimarinus	41.67	3.00e-14	74.30
IUUC-Oga-088247	Otolemur garnettii	97.13	0.00e+00	1108.00
IUUC-Oar-089536	Ovis aries	91.56	0.00e+00	1094.00
IUUC-Ptr-091206	Pan troglodytes	98.12	0.00e+00	1115.00
IUUC-Pan-092864	Papio anubis	98.88	0.00e+00	1169.00
IUUC-Psi-093374	Pelodiscus sinensis	76.89	0.00e+00	1000.00
IUUC-Pma-094762	Petromyzon marinus	69.53	2.00e-100	358.00
IUUC-Pno-095018	Phaeosphaeria nodorum	53.12	4.00e-13	70.10
IUUC-Ppa-095669	Physcomitrella patens	34.58	3.00e-17	84.30
IUUC-Pfo-097032	Poecilia formosa	66.99	0.00e+00	675.00
IUUC-Pab-098379	Pongo abelii	97.25	0.00e+00	1097.00
IUUC-Pop-099004	Populus trichocarpa	58.54	2.00e-22	100.00
IUUC-Pca-100431	Procavia capensis	74.39	5.00e-84	305.00
IUUC-Ppe-101183	Prunus persica	58.82	2.00e-22	101.00
IUUC-Pva-102356	Pteropus vampyrus	85.79	0.00e+00	922.00
IUUC-Pgr-103413	Puccinia graminis	31.32	6.00e-17	83.20
IUUC-Ptt-103789	Puccinia triticina	32.14	3.00e-15	77.80
IUUC-Pte-104255	Pyrenophora teres	54.24	7.00e-13	69.30
IUUC-Pyt-104629	Pyrenophora triticirepentis	54.24	6.00e-13	69.70
IUUC-Rno-105629	Rattus norvegicus	92.07	0.00e+00	1142.00
IUUC-Sce-106185	Saccharomyces cerevisiae	54.05	3.00e-07	50.40
IUUC-Sha-107543	Sarcophilus harrisii	89.76	0.00e+00	1037.00
IUUC-Sja-107921	Schizosaccharomyces japonicus	34.65	1.00e-10	61.60
IUUC-Spo-108313	Schizosaccharomyces pombe	26.50	2.00e-10	61.20
IUUC-Smo-109391	Selaginella moellendorffii	50.59	3.00e-14	73.60
IUUC-Sit-109967	Setaria italica	42.86	6.00e-24	106.00
IUUC-Sly-111069	Solanum lycopersicum	54.95	3.00e-22	100.00
IUUC-Stu-112178	Solanum tuberosum	52.13	1.00e-21	99.00
IUUC-Sbi-114103	Sorghum bicolor	42.65	2.00e-23	102.00
IUUC-Sre-115231	Sporisorium reilianum	29.79	3.00e-16	81.30
IUUC-Ssc-116400	Sus scrofa	94.04	0.00e+00	1157.00
IUUC-Tca-121799	Theobroma cacao	56.25	2.00e-16	81.30
IUUC-Tre-121898	Trichoderma reesei	62.00	5.00e-14	72.80
IUUC-Tvi-122645	Trichoderma virens	66.67	2.00e-16	80.90
IUUC-Tae-125176	Triticum aestivum	56.52	2.00e-22	99.80
IUUC-Tur-125962	Triticum urartu	54.55	2.00e-22	101.00
IUUC-Tme-127093	Tuber melanosporum	33.54	6.00e-16	79.30
IUUC-Tbe-127595	Tupaia belangeri	69.52	0.00e+00	803.00
IUUC-Ttr-128741	Tursiops truncatus	90.26	0.00e+00	1025.00
IUUC-Uma-129451	Ustilago maydis	46.43	1.00e-16	82.00
IUUC-Vda-129960	Verticillium dahliae	34.62	2.00e-16	80.90
IUUC-Vvi-131408	Vitis vinifera	34.29	8.00e-24	106.00
IUUC-Xtr-132475	Xenopus tropicalis	68.21	0.00e+00	778.00
IUUC-Xma-133174	Xiphophorus maculatus	67.45	0.00e+00	681.00
IUUC-Yli-134329	Yarrowia lipolytica	48.98	9.00e-10	58.90
IUUC-Zma-134694	Zea mays	43.38	2.00e-23	105.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence