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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-063857
UUCD1 version UUC-MuM-00926
Ensembl Protein ID ENSMUSP00000125403.1
UniProt Accession Q9D4H8; Q3TUR8; CUL2_MOUSE
Genbank Protein ID BAB30283.1; BAE35903.1; AAH26779.1; AAH27428.1; AAH25902.1
Protein Name Cullin-2
Genbank Nucleotide ID AK016520; AK160597; BC026779; BC027428; BC025902
Gene Name Cul2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024231.14 ENSMUST00000162301.7 ENSMUSP00000125403.1
ENSMUSG00000024231.14 ENSMUST00000025073.11 ENSMUSP00000025073.5
ENSMUSG00000024231.14 ENSMUST00000080089.10 ENSMUSP00000078988.4
ENSMUSG00000024231.14 ENSMUST00000161317.1 ENSMUSP00000123903.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtBioGRIDmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 3.20e-208 694.5 17 644
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk...vgaklYkklkevleefikqvkkkveesedeqlLktynreWekfreqlkvlrki 86
    l +++k++++ e+v +++++++++++y+lc+++ +g++lY ++k +le++++++ k+v es +eq+L +y+r+We++++++++++++
   Q: 17 LLTTIKAVVMLEYVeRATWNDRFSDIYALCVAYpepLGERLYAETKIFLESHVRHLYKRVLES-EEQVLVMYHRYWEEYSKGADYMDCL 104
    6689***********************************************************.566********************** PP
   S: 87 fayldrtyvkk.................skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLsl 158
    ++yl+++y+kk ++ ++e+ +Lald+wrk +ve++++ l+++ll+ i+++R ge ++++++gv++s+v++++
   Q: 105 YRYLNTQYIKKnklteadiqygyggvdmNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQ 193
    ***********999998888888888877778********************************************************9 PP
   S: 159 nk....laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllael 243
    +k l++y+ F ++fl++t e+yk+e++++lqe+++++Y++kv rl++ee r+++yl++s++tk++++++++++a+hl++l++e+
   Q: 194 YKkkfpLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHSEC 282
    999************************************************************************************** PP
   S: 244 vallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldka 332
    ++++++++++d+++my Ll+ v+ gl ++++el++hi+++g++a+++ ++e++p+ +Ve++le++ k+ +l+++++n d++F++aldka
   Q: 283 HSIIQQERKNDMANMYVLLRAVSSGLPHMIEELQKHIHDEGLRATSNLTQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKA 371
    ***************************************************************************************** PP
   S: 333 fetfvnknsvlkaakspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviek 421
    ++++vn ++ ++++k+pEllA+y+D+lL+ks+kg+te+e+e++l+++++vfkyi++kdvF+k+Y+++LakRL++g+s+s+++Ee++i+k
   Q: 372 LTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINK 460
    ***************************************************************************************** PP
   S: 422 LkeecgaeftskLerMfqdlkvSedlnrqFk..eekenteesesvelsvlvLsagaWpta.setekvsLPaelektiekfeefYlekhs 507
    Lk++cg+eftskL+rM++d++vS dln++F+ ++++t ++ +++++++vL+agaWp + + +++++P+elek++++fe fY++++s
   Q: 461 LKQACGYEFTSKLHRMYTDMSVSADLNNKFNnfIRNQDTVIDLGISFQIYVLQAGAWPLTqAPSSTFAIPQELEKSVQMFELFYSQHFS 549
    *******************************77799**********************99666689*********************** PP
   S: 508 gRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeed 596
    gRkL+W+h+l+++e+k+++ ++y +V+t+QmavLLafnnse+vs++el+++t+++e+eL++t++sL+++k ++++++e+++i++e+
   Q: 550 GRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVK--MINHDSEKEDIDAES 636
    *******************999*************************************************9..*************** PP
   S: 597 lfsvNqef 604
    +fs+N++f
   Q: 637 SFSLNMSF 644
    *****998 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity).
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity).
Protein Sequence
(Fasta)
MSLKPRVVDF DETWNKLLTT IKAVVMLEYV ERATWNDRFS DIYALCVAYP EPLGERLYAE 60
TKIFLESHVR HLYKRVLESE EQVLVMYHRY WEEYSKGADY MDCLYRYLNT QYIKKNKLTE 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063857|E3,Cullin|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTGCATCCT GCGGGTGTGT GAGTGCAAGA GGCTGAGAGA GCGGAGCCGA GGGTGTGTGT 60
CCCGCAAAGC CCAGAGCTCC GGAGGACGAC AGCCTCCCCG AGCCAGCTAC CTGCCCGTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063857|E3,Cullin|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030891--C:VCB complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0030163--P:protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG mmu:71745
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001969 Ailuropoda melanoleuca 97.45 0.00e+00 1526.00
IUUC-Apl-004067 Anas platyrhynchos 94.65 0.00e+00 1488.00
IUUC-Aca-004534 Anolis carolinensis 90.96 0.00e+00 1453.00
IUUC-Ame-011695 Astyanax mexicanus 91.68 0.00e+00 1456.00
IUUC-Bta-013074 Bos taurus 97.18 0.00e+00 1521.00
IUUC-Cel-018431 Caenorhabditis elegans 42.84 2.00e-177 616.00
IUUC-Cja-019371 Callithrix jacchus 97.32 0.00e+00 1523.00
IUUC-Cfa-020508 Canis familiaris 97.18 0.00e+00 1523.00
IUUC-Cpo-021851 Cavia porcellus 96.24 0.00e+00 1507.00
IUUC-Csa-023583 Chlorocebus sabaeus 97.32 0.00e+00 1517.00
IUUC-Cho-024308 Choloepus hoffmanni 87.43 0.00e+00 649.00
IUUC-Cin-025350 Ciona intestinalis 46.52 0.00e+00 711.00
IUUC-Csv-026096 Ciona savignyi 41.62 0.00e+00 642.00
IUUC-Dre-028828 Danio rerio 91.14 0.00e+00 1439.00
IUUC-Dno-029709 Dasypus novemcinctus 96.78 0.00e+00 1517.00
IUUC-Dor-030319 Dipodomys ordii 82.50 0.00e+00 958.00
IUUC-Dme-031938 Drosophila melanogaster 50.39 0.00e+00 753.00
IUUC-Ete-032756 Echinops telfairi 85.26 0.00e+00 842.00
IUUC-Eca-034019 Equus caballus 97.18 0.00e+00 1522.00
IUUC-Eeu-034914 Erinaceus europaeus 91.09 0.00e+00 1040.00
IUUC-Fca-035926 Felis catus 97.32 0.00e+00 1524.00
IUUC-Fal-037627 Ficedula albicollis 94.36 0.00e+00 1483.00
IUUC-Gmo-038728 Gadus morhua 90.88 0.00e+00 1436.00
IUUC-Gga-040820 Gallus gallus 91.34 0.00e+00 1477.00
IUUC-Gac-041293 Gasterosteus aculeatus 90.62 0.00e+00 1440.00
IUUC-Ggo-045235 Gorilla gorilla 94.51 0.00e+00 1476.00
IUUC-Hsa-046819 Homo sapiens 97.32 0.00e+00 1524.00
IUUC-Itr-048063 Ictidomys tridecemlineatus 97.00 0.00e+00 824.00
IUUC-Lch-049443 Latimeria chalumnae 93.69 0.00e+00 1474.00
IUUC-Loc-052798 Lepisosteus oculatus 92.09 0.00e+00 1455.00
IUUC-Laf-053379 Loxodonta africana 96.78 0.00e+00 1519.00
IUUC-Mcc-055702 Macaca mulatta 97.32 0.00e+00 1523.00
IUUC-Meu-056223 Macropus eugenii 69.93 0.00e+00 971.00
IUUC-Mga-060034 Meleagris gallopavo 94.24 0.00e+00 1482.00
IUUC-Mmr-061090 Microcebus murinus 96.38 0.00e+00 1514.00
IUUC-Mdo-062530 Monodelphis domestica 94.36 0.00e+00 1483.00
IUUC-Mpu-065915 Mustela putorius furo 97.45 0.00e+00 1527.00
IUUC-Mlu-068049 Myotis lucifugus 97.32 0.00e+00 1526.00
IUUC-Nle-069102 Nomascus leucogenys 93.99 0.00e+00 1127.00
IUUC-Opr-071197 Ochotona princeps 85.39 0.00e+00 1265.00
IUUC-Ont-071902 Oreochromis niloticus 90.74 0.00e+00 1444.00
IUUC-Oan-073307 Ornithorhynchus anatinus 90.58 0.00e+00 1469.00
IUUC-Ocu-074703 Oryctolagus cuniculus 95.97 0.00e+00 1510.00
IUUC-Ola-086789 Oryzias latipes 91.03 0.00e+00 1446.00
IUUC-Oga-088480 Otolemur garnettii 96.78 0.00e+00 1513.00
IUUC-Oar-089899 Ovis aries 97.45 0.00e+00 1526.00
IUUC-Ptr-090965 Pan troglodytes 97.18 0.00e+00 1524.00
IUUC-Pan-092920 Papio anubis 93.17 0.00e+00 1447.00
IUUC-Psi-093122 Pelodiscus sinensis 94.23 0.00e+00 1478.00
IUUC-Pma-094656 Petromyzon marinus 77.48 0.00e+00 1237.00
IUUC-Pfo-096342 Poecilia formosa 90.60 0.00e+00 1443.00
IUUC-Pab-097544 Pongo abelii 97.32 0.00e+00 1526.00
IUUC-Pca-100564 Procavia capensis 97.57 0.00e+00 811.00
IUUC-Pva-102179 Pteropus vampyrus 85.14 0.00e+00 659.00
IUUC-Rno-105439 Rattus norvegicus 99.33 0.00e+00 1525.00
IUUC-Sha-106654 Sarcophilus harrisii 94.09 0.00e+00 1481.00
IUUC-Sar-113138 Sorex araneus 92.35 0.00e+00 1431.00
IUUC-Ssc-115543 Sus scrofa 97.84 0.00e+00 1045.00
IUUC-Tgu-117095 Taeniopygia guttata 94.10 0.00e+00 1480.00
IUUC-Tru-118593 Takifugu rubripes 80.19 0.00e+00 1375.00
IUUC-Tsy-119621 Tarsius syrichta 93.29 0.00e+00 968.00
IUUC-Tni-119697 Tetraodon nigroviridis 90.20 0.00e+00 1432.00
IUUC-Tbe-127831 Tupaia belangeri 89.74 0.00e+00 1235.00
IUUC-Ttr-129108 Tursiops truncatus 97.45 0.00e+00 1527.00
IUUC-Vpa-130414 Vicugna pacos 86.15 0.00e+00 702.00
IUUC-Xtr-132054 Xenopus tropicalis 90.87 0.00e+00 1428.00
Created Date 25-Jun-2017

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