iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.70e-11	44.2	779	810

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCek.CrewfHpaClklsv 36
           +C+ C ++g+d   lv+C++ C++w+H++Cl+++v
   Q: 779  ICKYCYQAGSD---LVRCSRtCSSWLHADCLERKV 810
           68888888884...******************984 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity).

Protein Sequence
(Fasta)

MKLSTDAHSE IEGDAAHGNV LCNSASDSLT ATDEVAAGND ESVATEGDDV EIPRDTNNST 60
PVRLLDKPGQ NPVQNGAQPA AEESELESQR QTPVQKQQQQ RVSMVNRKRD LINLQSALSP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGCAGTCGA AGTTTTGGCG CAAGCGAAGC CTCTGTGTTC TTAGAAATTG TCGAATTAAC 60
GGTAGTGTTT AATTGACGAG AGCGCGATTA AACTGGACCG CAGAATGAAG CTGAGCACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0000228--C:nuclear chromosome
GO:0005721--C:pericentric heterochromatin
GO:0005700--C:polytene chromosome
GO:0031490--F:chromatin DNA binding
GO:0042054--F:histone methyltransferase activity
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0018992--P:germ-line sex determination
GO:0010452--P:histone H3-K36 methylation

KEGG

dme:Dmel_CG4976

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001795	Ailuropoda melanoleuca	36.70	1.00e-122	434.00
IUUC-Apl-003953	Anas platyrhynchos	37.02	2.00e-116	414.00
IUUC-Aca-005339	Anolis carolinensis	35.78	5.00e-121	429.00
IUUC-Ame-011932	Astyanax mexicanus	36.01	8.00e-113	401.00
IUUC-Bta-012966	Bos taurus	36.87	3.00e-123	437.00
IUUC-Cja-018780	Callithrix jacchus	36.87	6.00e-123	436.00
IUUC-Cfa-020975	Canis familiaris	36.70	1.00e-122	435.00
IUUC-Cpo-021331	Cavia porcellus	35.76	3.00e-118	420.00
IUUC-Csa-024226	Chlorocebus sabaeus	36.87	1.00e-122	435.00
IUUC-Cho-025058	Choloepus hoffmanni	38.06	3.00e-52	200.00
IUUC-Csv-026298	Ciona savignyi	28.79	3.00e-33	135.00
IUUC-Dre-028152	Danio rerio	36.45	1.00e-119	424.00
IUUC-Dno-029230	Dasypus novemcinctus	41.72	6.00e-122	432.00
IUUC-Dor-031103	Dipodomys ordii	37.30	2.00e-95	343.00
IUUC-Ete-032488	Echinops telfairi	38.70	9.00e-103	367.00
IUUC-Eca-033591	Equus caballus	35.88	2.00e-122	434.00
IUUC-Eeu-035199	Erinaceus europaeus	37.10	8.00e-46	179.00
IUUC-Fca-035791	Felis catus	36.70	1.00e-122	435.00
IUUC-Fal-037378	Ficedula albicollis	36.69	3.00e-117	416.00
IUUC-Gmo-039686	Gadus morhua	36.82	5.00e-115	408.00
IUUC-Gga-040881	Gallus gallus	36.22	1.00e-118	421.00
IUUC-Gac-042123	Gasterosteus aculeatus	37.09	3.00e-121	429.00
IUUC-Ggo-044643	Gorilla gorilla	42.18	1.00e-118	421.00
IUUC-Hsa-046436	Homo sapiens	36.87	4.00e-123	436.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	36.87	5.00e-123	436.00
IUUC-Lch-050217	Latimeria chalumnae	36.19	3.00e-121	429.00
IUUC-Loc-052766	Lepisosteus oculatus	40.15	3.00e-118	419.00
IUUC-Laf-054046	Loxodonta africana	36.87	1.00e-122	434.00
IUUC-Mcc-055593	Macaca mulatta	36.87	4.00e-123	436.00
IUUC-Meu-056051	Macropus eugenii	42.94	1.00e-85	311.00
IUUC-Mga-059756	Meleagris gallopavo	36.22	4.00e-118	419.00
IUUC-Mmr-061182	Microcebus murinus	36.70	6.00e-123	436.00
IUUC-Mdo-062576	Monodelphis domestica	36.13	2.00e-118	419.00
IUUC-Mmu-063605	Mus musculus	36.80	9.00e-126	445.00
IUUC-Mpu-066446	Mustela putorius furo	36.70	7.00e-123	436.00
IUUC-Mlu-067261	Myotis lucifugus	36.70	8.00e-123	435.00
IUUC-Nle-069818	Nomascus leucogenys	36.87	8.00e-123	435.00
IUUC-Opr-070842	Ochotona princeps	39.84	2.00e-113	404.00
IUUC-Ont-072197	Oreochromis niloticus	36.76	7.00e-117	414.00
IUUC-Oan-073496	Ornithorhynchus anatinus	40.80	3.00e-120	426.00
IUUC-Ocu-074918	Oryctolagus cuniculus	36.87	4.00e-123	436.00
IUUC-Obr-076178	Oryza brachyantha	29.74	2.00e-13	70.50
IUUC-Olo-080702	Oryza longistaminata	38.18	5.00e-37	149.00
IUUC-Opu-083371	Oryza punctata	39.45	4.00e-39	155.00
IUUC-Ola-087518	Oryzias latipes	40.20	3.00e-111	394.00
IUUC-Oga-088743	Otolemur garnettii	36.70	2.00e-123	437.00
IUUC-Oar-090265	Ovis aries	36.87	4.00e-123	436.00
IUUC-Ptr-090521	Pan troglodytes	36.87	4.00e-123	436.00
IUUC-Pan-092752	Papio anubis	42.07	5.00e-116	411.00
IUUC-Psi-093620	Pelodiscus sinensis	35.35	3.00e-118	419.00
IUUC-Pma-094747	Petromyzon marinus	43.37	5.00e-87	315.00
IUUC-Pfo-096416	Poecilia formosa	35.57	6.00e-117	415.00
IUUC-Pab-098644	Pongo abelii	36.87	2.00e-122	434.00
IUUC-Pop-099927	Populus trichocarpa	27.03	8.00e-13	68.60
IUUC-Pca-100273	Procavia capensis	36.25	4.00e-116	412.00
IUUC-Pva-103094	Pteropus vampyrus	43.12	1.00e-113	405.00
IUUC-Rno-105803	Rattus norvegicus	36.70	2.00e-124	440.00
IUUC-Sha-107278	Sarcophilus harrisii	36.39	1.00e-120	428.00
IUUC-Sit-110333	Setaria italica	30.65	3.00e-13	69.30
IUUC-Sar-113310	Sorex araneus	35.34	5.00e-118	418.00
IUUC-Sbi-114254	Sorghum bicolor	28.43	6.00e-14	72.00
IUUC-Ssc-116193	Sus scrofa	36.87	2.00e-122	434.00
IUUC-Tgu-116786	Taeniopygia guttata	36.50	3.00e-119	422.00
IUUC-Tru-117638	Takifugu rubripes	36.89	5.00e-120	425.00
IUUC-Tsy-118830	Tarsius syrichta	36.87	1.00e-122	435.00
IUUC-Tni-120452	Tetraodon nigroviridis	36.54	3.00e-115	409.00
IUUC-Tca-121456	Theobroma cacao	33.69	3.00e-22	99.80
IUUC-Tbe-127291	Tupaia belangeri	39.23	1.00e-106	380.00
IUUC-Ttr-128240	Tursiops truncatus	33.92	3.00e-110	393.00
IUUC-Vpa-130666	Vicugna pacos	33.04	3.00e-103	369.00
IUUC-Xtr-132673	Xenopus tropicalis	31.09	2.00e-134	473.00
IUUC-Xma-133695	Xiphophorus maculatus	36.93	4.00e-116	412.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence