iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000020738.16	ENSMUST00000118155.7	ENSMUSP00000113108.1
ENSMUSG00000020738.16	ENSMUST00000021084.9	ENSMUSP00000021084.9
ENSMUSG00000020738.16	ENSMUST00000153892.1	ENSMUSP00000115044.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/SUMO	7.10e-33	114.3	14	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 5    fkapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           +  +++lkvagqdGs v+fk+k++++l+klm+a Y++r++l+++++rf+f+gq+i+e++tp++le+eded+i++++q++GG
   Q: 14   NNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKA-YCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG 93
           789******************************.**********************************************9 PP

Organism

Mus musculus

Functional Description
(View)

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity).

Protein Sequence
(Fasta)

MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLSMRQIRF 60
RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGVY 95

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGCGGGGG GAGGGAAGCG CACGACGTGC GCGCGCCCTC TGCCTCGTCC ACCGCTGCCG 60
CCTCCTCCTG CCGCTCCTGG TGCTGCTTGT GCGCTCCCTC AGTGCGGACC CGGTGCCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR027218--SUMO_2/3
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0031386--F:protein tag
GO:0003723--F:RNA binding
GO:0019789--F:SUMO transferase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016925--P:protein sumoylation

KEGG

mmu:170930

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001918	Ailuropoda melanoleuca	100.00	2.00e-53	199.00
IUUC-Apl-003372	Anas platyrhynchos	98.88	3.00e-49	186.00
IUUC-Aca-005284	Anolis carolinensis	100.00	2.00e-53	199.00
IUUC-Afl-008650	Aspergillus flavus	47.31	6.00e-18	81.60
IUUC-Afu-008969	Aspergillus fumigatus	46.81	8.00e-18	81.30
IUUC-Ang-009651	Aspergillus niger	51.28	4.00e-17	79.00
IUUC-Ame-011427	Astyanax mexicanus	96.81	2.00e-51	192.00
IUUC-Bgr-012250	Blumeria graminis	46.51	4.00e-17	79.30
IUUC-Bta-013208	Bos taurus	95.79	5.00e-51	191.00
IUUC-Bra-017377	Brassica rapa	53.26	2.00e-21	93.20
IUUC-Cja-019875	Callithrix jacchus	96.70	1.00e-47	180.00
IUUC-Cfa-020546	Canis familiaris	100.00	2.00e-53	199.00
IUUC-Cpo-021498	Cavia porcellus	100.00	2.00e-53	199.00
IUUC-Csa-023133	Chlorocebus sabaeus	100.00	2.00e-53	199.00
IUUC-Cin-025314	Ciona intestinalis	76.04	3.00e-38	149.00
IUUC-Csv-026212	Ciona savignyi	76.04	8.00e-39	150.00
IUUC-Dre-027994	Danio rerio	98.92	1.00e-51	193.00
IUUC-Dno-029390	Dasypus novemcinctus	100.00	6.00e-54	202.00
IUUC-Dor-030760	Dipodomys ordii	32.47	3.00e-06	45.80
IUUC-Dme-031967	Drosophila melanogaster	70.21	1.00e-33	133.00
IUUC-Ete-032934	Echinops telfairi	81.05	3.00e-42	162.00
IUUC-Eca-033260	Equus caballus	100.00	2.00e-53	199.00
IUUC-Fca-036393	Felis catus	93.68	1.00e-49	187.00
IUUC-Fal-037226	Ficedula albicollis	98.89	7.00e-50	188.00
IUUC-Gmo-038535	Gadus morhua	92.55	1.00e-49	186.00
IUUC-Gga-040145	Gallus gallus	100.00	2.00e-53	199.00
IUUC-Gac-041723	Gasterosteus aculeatus	92.55	2.00e-49	186.00
IUUC-Gma-043216	Glycine max	53.85	2.00e-21	93.60
IUUC-Ggo-045467	Gorilla gorilla	100.00	2.00e-53	199.00
IUUC-Hsa-046419	Homo sapiens	100.00	2.00e-53	199.00
IUUC-Itr-048667	Ictidomys tridecemlineatus	95.70	7.00e-50	187.00
IUUC-Lch-050572	Latimeria chalumnae	89.69	3.00e-46	175.00
IUUC-Loc-052560	Lepisosteus oculatus	97.89	9.00e-53	197.00
IUUC-Laf-054343	Loxodonta africana	98.95	5.00e-53	198.00
IUUC-Mcc-054832	Macaca mulatta	100.00	4.00e-52	196.00
IUUC-Mga-059768	Meleagris gallopavo	98.88	3.00e-49	186.00
IUUC-Mmr-061593	Microcebus murinus	100.00	4.00e-52	196.00
IUUC-Mdo-062678	Monodelphis domestica	98.95	3.00e-53	199.00
IUUC-Mpu-065909	Mustela putorius furo	98.89	4.00e-50	188.00
IUUC-Mlu-067634	Myotis lucifugus	93.68	2.00e-49	186.00
IUUC-Ncr-068663	Neurospora crassa	51.28	7.00e-19	85.10
IUUC-Nle-069631	Nomascus leucogenys	96.84	1.00e-51	194.00
IUUC-Ont-071512	Oreochromis niloticus	96.77	3.00e-50	189.00
IUUC-Ocu-074239	Oryctolagus cuniculus	98.95	3.00e-53	198.00
IUUC-Ola-086710	Oryzias latipes	97.85	8.00e-51	191.00
IUUC-Oar-089624	Ovis aries	94.74	1.00e-50	190.00
IUUC-Ptr-091082	Pan troglodytes	100.00	2.00e-53	199.00
IUUC-Pan-091949	Papio anubis	100.00	3.00e-52	196.00
IUUC-Psi-094000	Pelodiscus sinensis	100.00	2.00e-53	199.00
IUUC-Pno-094884	Phaeosphaeria nodorum	46.67	1.00e-18	84.30
IUUC-Pfo-097304	Poecilia formosa	97.85	2.00e-51	192.00
IUUC-Pab-098572	Pongo abelii	100.00	2.00e-53	199.00
IUUC-Ppe-101648	Prunus persica	51.61	9.00e-22	94.40
IUUC-Pte-104358	Pyrenophora teres	47.25	1.00e-19	87.40
IUUC-Pyt-104485	Pyrenophora triticirepentis	47.25	1.00e-19	87.40
IUUC-Rno-105391	Rattus norvegicus	98.94	3.00e-52	195.00
IUUC-Sar-113337	Sorex araneus	84.04	5.00e-43	165.00
IUUC-Ssc-115915	Sus scrofa	100.00	2.00e-53	199.00
IUUC-Tgu-116815	Taeniopygia guttata	98.89	4.00e-50	188.00
IUUC-Tca-120927	Theobroma cacao	52.17	5.00e-21	93.20
IUUC-Tre-121926	Trichoderma reesei	49.45	2.00e-21	93.20
IUUC-Tvi-122514	Trichoderma virens	53.75	6.00e-20	88.60
IUUC-Tbe-127363	Tupaia belangeri	92.55	6.00e-48	181.00
IUUC-Vvi-131092	Vitis vinifera	53.26	1.00e-21	94.70
IUUC-Xtr-132691	Xenopus tropicalis	95.79	2.00e-51	193.00
IUUC-Xma-133892	Xiphophorus maculatus	97.85	8.00e-52	194.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence