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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063288
Ensembl Protein ID ENSMUSP00000028997.7
UniProt Accession P97477; O35624; Q8C3H8; Q91YU4; AURKA_MOUSE
Genbank Protein ID AAB62982.1; AAB63205.1; AAC12682.1; BAC39557.1; AAH05425.1; AAH14711.1
Protein Name Aurora kinase A; Aurora 2; Aurora family kinase 1; Aurora/IPL1-related kinase 1; Ipl1- and aurora-related kinase 1; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Ayk1; Serine/threonine-protein kinase aurora-A
Genbank Nucleotide ID U80932; AF007817; U69106; AK085861; BC005425; BC014711
Gene Name Aurka; Aik; Airk; Ark1; Aura; Ayk1; Btak; Iak1; Stk15; Stk6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027496.15 ENSMUST00000028997.7 ENSMUSP00000028997.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 82.18 0.00e+00 654.00 IUUC-Hsa-046968
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
 Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Protein Sequence
(Fasta)
MAVEGEPGCC KRIGKAVWRR GDMDRCKENC VSRPVKTTVP FGPKRVLVTE QIPSQNLGSA 60
SSGQAQRVLC PSNSQRVPSQ AQKLGAGQKP APKQLPAASV PRPVSRLNNP QKNEQPAASG 120
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Protein Fasta Sequence


>IUUC-Mmu-063288|E3,E3 activity/Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GAATTGTAAC GGCTGAGCTA CCGGGATCGC TTGGAGGCTT CGGTCGGGAG CAGGTTCCTG 60
CCTGTGAGTT GGAAAGGGAC ATGGCTGTTG AGGGCGAGCC TGGATGCTGC AAACGGATAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063288|E3,E3 activity/Other|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0493--Microtubule
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation
Interpro

IPR030616--Aur
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0043203--C:axon hillock
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0032133--C:chromosome passenger complex
GO:0005929--C:cilium
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005829--C:cytosol
GO:0042585--C:germinal vesicle
GO:0072687--C:meiotic spindle
GO:0015630--C:microtubule cytoskeleton
GO:0005815--C:microtubule organizing center
GO:0072686--C:mitotic spindle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0045120--C:pronucleus
GO:0005876--C:spindle microtubule
GO:0051233--C:spindle midzone
GO:0031616--C:spindle pole centrosome
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0009948--P:anterior/posterior axis specification
GO:0051301--P:cell division
GO:0051642--P:centrosome localization
GO:0051297--P:centrosome organization
GO:0097421--P:liver regeneration
GO:0007126--P:meiotic nuclear division
GO:0000212--P:meiotic spindle organization
GO:0000226--P:microtubule cytoskeleton organization
GO:0000278--P:mitotic cell cycle
GO:0007100--P:mitotic centrosome separation
GO:0007067--P:mitotic nuclear division
GO:0007052--P:mitotic spindle organization
GO:0043066--P:negative regulation of apoptotic process
GO:0032091--P:negative regulation of protein binding
GO:1990138--P:neuron projection extension
GO:1900195--P:positive regulation of oocyte maturation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071539--P:protein localization to centrosome
GO:0006468--P:protein phosphorylation
GO:0032465--P:regulation of cytokinesis
GO:0031647--P:regulation of protein stability
GO:0009611--P:response to wounding
GO:0007057--P:spindle assembly involved in female meiosis I
GO:0007051--P:spindle organization
KEGG mmu:20878
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000930 Aegilops tauschii 63.23 8.00e-107 379.00
IUUC-Aml-001426 Ailuropoda melanoleuca 84.83 0.00e+00 658.00
IUUC-Atr-002453 Amborella trichopoda 65.05 3.00e-110 391.00
IUUC-Apl-003626 Anas platyrhynchos 69.17 4.00e-149 521.00
IUUC-Aca-004602 Anolis carolinensis 65.91 8.00e-143 499.00
IUUC-Aly-005878 Arabidopsis lyrata 64.31 3.00e-107 380.00
IUUC-Ath-007117 Arabidopsis thaliana 62.67 5.00e-108 383.00
IUUC-Acl-008199 Aspergillus clavatus 56.83 6.00e-87 314.00
IUUC-Afl-008419 Aspergillus flavus 56.07 6.00e-86 311.00
IUUC-Afu-008751 Aspergillus fumigatus 54.05 1.00e-86 313.00
IUUC-Ani-009181 Aspergillus nidulans 52.61 1.00e-89 323.00
IUUC-Ang-009787 Aspergillus niger 59.61 2.00e-86 312.00
IUUC-Aor-009980 Aspergillus oryzae 56.07 6.00e-86 311.00
IUUC-Ate-010286 Aspergillus terreus 52.04 1.00e-86 313.00
IUUC-Ame-010849 Astyanax mexicanus 74.73 5.00e-128 451.00
IUUC-Bgr-012110 Blumeria graminis 49.35 8.00e-88 317.00
IUUC-Bta-013474 Bos taurus 82.22 0.00e+00 644.00
IUUC-Bci-013756 Botrytis cinerea 57.79 6.00e-94 337.00
IUUC-Bdi-014257 Brachypodium distachyon 63.23 1.00e-107 382.00
IUUC-Bol-016310 Brassica oleracea 65.68 2.00e-105 375.00
IUUC-Bra-017438 Brassica rapa 63.03 1.00e-106 379.00
IUUC-Cel-018157 Caenorhabditis elegans 61.83 7.00e-99 353.00
IUUC-Cja-019282 Callithrix jacchus 81.84 0.00e+00 636.00
IUUC-Cfa-020162 Canis familiaris 81.57 0.00e+00 653.00
IUUC-Cpo-021764 Cavia porcellus 81.14 0.00e+00 626.00
IUUC-Cre-022827 Chlamydomonas reinhardtii 69.17 2.00e-111 395.00
IUUC-Csa-023694 Chlorocebus sabaeus 78.71 1.00e-173 602.00
IUUC-Cho-024350 Choloepus hoffmanni 93.37 1.00e-107 382.00
IUUC-Cin-025542 Ciona intestinalis 69.40 6.00e-118 416.00
IUUC-Csv-025873 Ciona savignyi 70.40 1.00e-119 422.00
IUUC-Cgl-026632 Colletotrichum gloeosporioides 49.39 3.00e-82 298.00
IUUC-Cne-026928 Cryptococcus neoformans 60.85 3.00e-95 342.00
IUUC-Cme-027336 Cyanidioschyzon merolae 67.96 1.00e-117 416.00
IUUC-Dre-028198 Danio rerio 62.63 3.00e-134 471.00
IUUC-Dno-029928 Dasypus novemcinctus 81.40 9.00e-175 605.00
IUUC-Dor-030238 Dipodomys ordii 78.30 2.00e-177 614.00
IUUC-Dse-031266 Dothistroma septosporum 50.71 1.00e-95 342.00
IUUC-Dme-032007 Drosophila melanogaster 61.45 2.00e-100 359.00
IUUC-Ete-032911 Echinops telfairi 61.15 3.00e-121 428.00
IUUC-Eca-033749 Equus caballus 84.24 0.00e+00 647.00
IUUC-Eeu-035170 Erinaceus europaeus 79.61 3.00e-180 624.00
IUUC-Fca-035498 Felis catus 83.12 0.00e+00 649.00
IUUC-Fal-037397 Ficedula albicollis 66.10 3.00e-145 508.00
IUUC-Fox-037747 Fusarium oxysporum 51.45 3.00e-91 328.00
IUUC-Fso-038429 Fusarium solani 55.03 3.00e-89 322.00
IUUC-Gmo-039378 Gadus morhua 61.13 2.00e-125 442.00
IUUC-Ggr-039939 Gaeumannomyces graminis 61.45 1.00e-93 337.00
IUUC-Gga-040187 Gallus gallus 68.22 3.00e-148 518.00
IUUC-Gac-042223 Gasterosteus aculeatus 58.41 1.00e-133 469.00
IUUC-Gma-042870 Glycine max 66.67 3.00e-101 361.00
IUUC-Ggo-045617 Gorilla gorilla 82.43 0.00e+00 655.00
IUUC-Hsa-046968 Homo sapiens 82.18 0.00e+00 654.00
IUUC-Hvu-047072 Hordeum vulgare 54.10 5.00e-81 293.00
IUUC-Itr-048233 Ictidomys tridecemlineatus 74.19 4.00e-163 567.00
IUUC-Kpa-049093 Komagataella pastoris 54.79 4.00e-75 275.00
IUUC-Lch-050346 Latimeria chalumnae 70.84 4.00e-147 514.00
IUUC-Lpe-051466 Leersia perrieri 65.49 2.00e-108 384.00
IUUC-Lma-053006 Leptosphaeria maculans 58.78 1.00e-88 319.00
IUUC-Laf-053422 Loxodonta africana 80.74 0.00e+00 645.00
IUUC-Mcc-055245 Macaca mulatta 79.74 7.00e-172 596.00
IUUC-Mor-056952 Magnaporthe oryzae 59.16 4.00e-90 325.00
IUUC-Mpo-057605 Magnaporthe poae 58.61 3.00e-93 335.00
IUUC-Mtr-057726 Medicago truncatula 66.42 2.00e-107 381.00
IUUC-Mla-059174 Melampsora laricipopulina 61.39 6.00e-97 347.00
IUUC-Mga-059562 Meleagris gallopavo 60.71 9.00e-114 403.00
IUUC-Mvi-060305 Microbotryum violaceum 59.77 4.00e-92 332.00
IUUC-Mmr-061588 Microcebus murinus 81.39 0.00e+00 648.00
IUUC-Mdo-061914 Monodelphis domestica 75.71 5.00e-166 577.00
IUUC-Mac-064969 Musa acuminata 65.29 1.00e-109 389.00
IUUC-Mpu-066855 Mustela putorius furo 82.69 0.00e+00 641.00
IUUC-Mlu-068046 Myotis lucifugus 82.78 0.00e+00 637.00
IUUC-Nfi-068527 Neosartorya fischeri 60.00 5.00e-86 311.00
IUUC-Ncr-068678 Neurospora crassa 60.08 6.00e-91 327.00
IUUC-Nle-069848 Nomascus leucogenys 82.18 0.00e+00 654.00
IUUC-Opr-070589 Ochotona princeps 75.00 7.00e-168 583.00
IUUC-Ont-071733 Oreochromis niloticus 60.72 7.00e-125 440.00
IUUC-Oan-073399 Ornithorhynchus anatinus 82.26 4.00e-152 530.00
IUUC-Ocu-074063 Oryctolagus cuniculus 82.13 0.00e+00 650.00
IUUC-Oba-075264 Oryza barthii 64.26 3.00e-107 380.00
IUUC-Obr-076048 Oryza brachyantha 66.18 3.00e-106 377.00
IUUC-Ogl-077637 Oryza glaberrima 67.04 1.00e-106 379.00
IUUC-Ogu-078830 Oryza glumaepatula 64.26 3.00e-107 381.00
IUUC-Oin-079150 Oryza indica 64.26 2.00e-107 382.00
IUUC-Olo-080398 Oryza longistaminata 56.43 4.00e-81 294.00
IUUC-Ome-081544 Oryza meridionalis 53.82 1.00e-89 323.00
IUUC-Oni-082250 Oryza nivara 64.26 2.00e-107 382.00
IUUC-Opu-083638 Oryza punctata 64.26 1.00e-107 382.00
IUUC-Oru-084981 Oryza rufipogon 64.26 1.00e-107 382.00
IUUC-Osa-085961 Oryza sativa 64.26 1.00e-107 382.00
IUUC-Olu-087880 Ostreococcus lucimarinus 69.03 4.00e-113 401.00
IUUC-Oga-088891 Otolemur garnettii 82.43 0.00e+00 638.00
IUUC-Oar-090021 Ovis aries 79.61 0.00e+00 626.00
IUUC-Ptr-091458 Pan troglodytes 82.43 0.00e+00 655.00
IUUC-Pan-092546 Papio anubis 78.71 1.00e-173 602.00
IUUC-Psi-093280 Pelodiscus sinensis 75.07 5.00e-155 540.00
IUUC-Pma-094298 Petromyzon marinus 76.30 7.00e-121 426.00
IUUC-Pno-094847 Phaeosphaeria nodorum 60.31 4.00e-89 321.00
IUUC-Ppa-095855 Physcomitrella patens 62.28 1.00e-109 389.00
IUUC-Pfo-096428 Poecilia formosa 60.95 6.00e-128 450.00
IUUC-Pab-098696 Pongo abelii 81.98 0.00e+00 648.00
IUUC-Pop-099405 Populus trichocarpa 63.36 1.00e-108 386.00
IUUC-Pca-100740 Procavia capensis 77.78 5.00e-179 620.00
IUUC-Ppe-101854 Prunus persica 64.04 2.00e-109 388.00
IUUC-Pva-103212 Pteropus vampyrus 82.43 0.00e+00 629.00
IUUC-Pgr-103474 Puccinia graminis 62.12 2.00e-98 352.00
IUUC-Ptt-103933 Puccinia triticina 48.26 8.00e-62 230.00
IUUC-Pte-104089 Pyrenophora teres 51.23 3.00e-89 322.00
IUUC-Pyt-104555 Pyrenophora triticirepentis 51.23 3.00e-89 322.00
IUUC-Rno-105057 Rattus norvegicus 93.70 0.00e+00 768.00
IUUC-Sha-107137 Sarcophilus harrisii 77.38 4.00e-169 587.00
IUUC-Sja-107767 Schizosaccharomyces japonicus 59.11 1.00e-97 349.00
IUUC-Spo-108078 Schizosaccharomyces pombe 55.74 3.00e-100 358.00
IUUC-Smo-109288 Selaginella moellendorffii 66.91 4.00e-109 387.00
IUUC-Sit-110246 Setaria italica 62.54 7.00e-106 376.00
IUUC-Sly-111379 Solanum lycopersicum 65.71 2.00e-108 385.00
IUUC-Stu-112777 Solanum tuberosum 63.27 2.00e-107 381.00
IUUC-Sbi-114325 Sorghum bicolor 63.64 2.00e-106 378.00
IUUC-Sre-115203 Sporisorium reilianum 58.49 6.00e-81 295.00
IUUC-Ssc-115361 Sus scrofa 82.13 0.00e+00 646.00
IUUC-Tgu-116967 Taeniopygia guttata 70.43 2.00e-144 505.00
IUUC-Tru-117570 Takifugu rubripes 63.08 1.00e-134 472.00
IUUC-Tsy-119280 Tarsius syrichta 63.73 3.00e-131 461.00
IUUC-Tni-120721 Tetraodon nigroviridis 63.71 2.00e-135 475.00
IUUC-Tca-121494 Theobroma cacao 63.92 8.00e-108 383.00
IUUC-Tre-121869 Trichoderma reesei 56.35 1.00e-92 333.00
IUUC-Tvi-122510 Trichoderma virens 58.10 7.00e-91 327.00
IUUC-Tae-123071 Triticum aestivum 63.23 8.00e-107 379.00
IUUC-Tur-126240 Triticum urartu 63.23 2.00e-106 378.00
IUUC-Tme-126921 Tuber melanosporum 60.81 6.00e-97 347.00
IUUC-Tbe-127872 Tupaia belangeri 75.89 9.00e-162 562.00
IUUC-Ttr-129134 Tursiops truncatus 83.98 2.00e-179 621.00
IUUC-Uma-129412 Ustilago maydis 47.11 4.00e-79 288.00
IUUC-Vda-130003 Verticillium dahliae 49.00 2.00e-92 332.00
IUUC-Vvi-131272 Vitis vinifera 64.04 2.00e-108 385.00
IUUC-Xtr-132019 Xenopus tropicalis 66.91 4.00e-146 511.00
IUUC-Xma-134203 Xiphophorus maculatus 61.13 7.00e-133 466.00
IUUC-Yli-134503 Yarrowia lipolytica 53.67 8.00e-86 310.00
IUUC-Zma-135232 Zea mays 65.20 6.00e-106 376.00
Created Date 25-Jun-2017

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