iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRecords	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/ULP	ULP	19784069

Classification

Family	E-value	Score	Start	End
DUB/ULP	7.60e-36	125.6	13	173

Active Site

Position(s)	Description	Evidence
163	Nucleophile	N/A

Domain Profile

DUB/ULP

   S: 3    vtnedlkcLeegeflnDviidfylkylvlekl..kkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpine.......aaH 85
           ++++d++ L+++++lnD+ii f ++y++++++  ++++v+ i++ +++f+k++++++  ++ ++++++dl +k+++f++in+       ++H
   Q: 13   LRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFhdCSDHVSFISPEVTQFIKCTSNPA--EIAMFLEPLDLPNKRVVFLAINDnsnqaagGTH 102
           7899****************************9999*******************99..9***************************988** PP
   S: 86   WslavvcfkkksilllDSlrgasksnvvkklreylev.evkkkskrefskeklkgsnpkvpqQkNssDCGvyvlqyves 163
           Wsl+v+ ++k+s++++DS+ + s+s  +k+++e le    +k++k +f +e       k p Q+Ns+DCG+yv++++e+
   Q: 103  WSLLVYLQDKNSFFHYDSH-SRSNSVHAKQVAEKLEAfLGRKGDKLAFVEE-------KAPAQQNSYDCGMYVICNTEA 173
           *******************.56666666666666666555699*****994.......59****************997 PP

Organism

Homo sapiens

Functional Description
(View)

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

Protein Sequence
(Fasta)

MDPVVLSYMD SLLRQSDVSL LDPPSWLNDH IIGFAFEYFA NSQFHDCSDH VSFISPEVTQ 60
FIKCTSNPAE IAMFLEPLDL PNKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTACTCCA ACAGCAGTCA AGAGAATGAA CAGGAGGGCA TGACAAGAGG CAGAAGACAG 60
AAGGCAAGAA GACCACTCAG CATTACAGAA GCCCAACAAA CAGATATTTT CAGTTAAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0019784--F:NEDD8-specific protease activity
GO:0016929--F:SUMO-specific protease activity
GO:0016926--P:protein desumoylation
GO:0016579--P:protein deubiquitination

KEGG

hsa:123228

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000648	Aegilops tauschii	36.89	5.00e-16	79.70
IUUC-Aml-001531	Ailuropoda melanoleuca	94.79	2.00e-119	421.00
IUUC-Atr-003013	Amborella trichopoda	33.33	5.00e-30	124.00
IUUC-Apl-004195	Anas platyrhynchos	76.42	6.00e-97	346.00
IUUC-Aca-004786	Anolis carolinensis	74.53	3.00e-87	314.00
IUUC-Aly-006071	Arabidopsis lyrata	32.40	3.00e-22	98.60
IUUC-Ath-006941	Arabidopsis thaliana	34.08	3.00e-24	105.00
IUUC-Acl-008184	Aspergillus clavatus	34.46	8.00e-15	73.90
IUUC-Afl-008691	Aspergillus flavus	35.29	3.00e-16	78.60
IUUC-Afu-008846	Aspergillus fumigatus	33.78	2.00e-14	72.80
IUUC-Ani-009338	Aspergillus nidulans	35.67	1.00e-15	76.60
IUUC-Ang-009621	Aspergillus niger	35.67	2.00e-17	82.80
IUUC-Aor-010058	Aspergillus oryzae	35.62	8.00e-15	74.30
IUUC-Ate-010257	Aspergillus terreus	37.27	2.00e-16	79.00
IUUC-Ame-011123	Astyanax mexicanus	63.68	7.00e-69	253.00
IUUC-Bgr-012027	Blumeria graminis	29.10	2.00e-14	73.20
IUUC-Bta-013318	Bos taurus	91.47	8.00e-109	385.00
IUUC-Bci-013780	Botrytis cinerea	38.18	3.00e-17	82.40
IUUC-Bdi-014628	Brachypodium distachyon	35.16	7.00e-18	84.00
IUUC-Bol-015265	Brassica oleracea	36.87	5.00e-29	120.00
IUUC-Bra-017473	Brassica rapa	35.75	2.00e-25	108.00
IUUC-Cel-018221	Caenorhabditis elegans	27.14	4.00e-19	87.80
IUUC-Cja-019384	Callithrix jacchus	95.75	1.00e-121	428.00
IUUC-Cfa-021012	Canis familiaris	95.73	1.00e-120	425.00
IUUC-Cpo-022076	Cavia porcellus	88.15	8.00e-113	399.00
IUUC-Cre-022914	Chlamydomonas reinhardtii	31.71	8.00e-20	90.90
IUUC-Csa-023063	Chlorocebus sabaeus	97.64	2.00e-123	434.00
IUUC-Cin-025409	Ciona intestinalis	45.20	7.00e-30	123.00
IUUC-Csv-025804	Ciona savignyi	42.86	5.00e-33	134.00
IUUC-Cgl-026720	Colletotrichum gloeosporioides	32.53	2.00e-13	69.70
IUUC-Dre-027976	Danio rerio	60.09	7.00e-70	256.00
IUUC-Dno-028918	Dasypus novemcinctus	91.94	2.00e-116	411.00
IUUC-Dor-030731	Dipodomys ordii	85.71	5.00e-106	376.00
IUUC-Dse-031309	Dothistroma septosporum	35.93	3.00e-17	82.40
IUUC-Dme-031655	Drosophila melanogaster	36.50	6.00e-34	137.00
IUUC-Eca-034335	Equus caballus	93.36	1.00e-118	418.00
IUUC-Fca-036443	Felis catus	94.79	1.00e-119	422.00
IUUC-Fal-037240	Ficedula albicollis	74.06	1.00e-93	335.00
IUUC-Fox-037732	Fusarium oxysporum	33.73	1.00e-14	73.90
IUUC-Fso-038212	Fusarium solani	33.73	1.00e-13	70.50
IUUC-Gmo-039320	Gadus morhua	61.06	1.00e-71	262.00
IUUC-Ggr-039866	Gaeumannomyces graminis	27.74	2.00e-08	52.80
IUUC-Gga-040846	Gallus gallus	76.42	1.00e-96	345.00
IUUC-Gac-041495	Gasterosteus aculeatus	60.85	3.00e-66	244.00
IUUC-Gma-043532	Glycine max	33.93	9.00e-30	123.00
IUUC-Ggo-045516	Gorilla gorilla	98.58	4.00e-125	439.00
IUUC-Hvu-047187	Hordeum vulgare	32.58	2.00e-20	92.80
IUUC-Itr-048831	Ictidomys tridecemlineatus	92.89	1.00e-116	411.00
IUUC-Kpa-049383	Komagataella pastoris	32.18	1.00e-15	77.40
IUUC-Lch-049930	Latimeria chalumnae	66.04	7.00e-84	303.00
IUUC-Lpe-051072	Leersia perrieri	35.75	2.00e-12	67.00
IUUC-Loc-052263	Lepisosteus oculatus	62.26	4.00e-75	273.00
IUUC-Lma-053175	Leptosphaeria maculans	35.83	1.00e-14	74.30
IUUC-Laf-053748	Loxodonta africana	93.40	2.00e-118	417.00
IUUC-Mcc-055121	Macaca mulatta	97.64	2.00e-123	434.00
IUUC-Mor-057015	Magnaporthe oryzae	30.12	4.00e-10	58.50
IUUC-Mpo-057551	Magnaporthe poae	29.75	1.00e-10	60.10
IUUC-Mtr-058308	Medicago truncatula	31.11	2.00e-27	115.00
IUUC-Mga-059787	Meleagris gallopavo	77.25	2.00e-90	324.00
IUUC-Mmr-061606	Microcebus murinus	92.42	4.00e-116	410.00
IUUC-Mdo-062222	Monodelphis domestica	83.96	3.00e-107	380.00
IUUC-Mmu-063494	Mus musculus	92.45	1.00e-117	415.00
IUUC-Mac-064771	Musa acuminata	34.71	2.00e-23	102.00
IUUC-Mpu-065843	Mustela putorius furo	94.79	4.00e-119	420.00
IUUC-Mlu-068110	Myotis lucifugus	94.79	8.00e-120	422.00
IUUC-Nfi-068584	Neosartorya fischeri	33.78	1.00e-14	72.80
IUUC-Ncr-068707	Neurospora crassa	32.53	3.00e-13	68.60
IUUC-Nle-069021	Nomascus leucogenys	98.11	2.00e-124	437.00
IUUC-Opr-070594	Ochotona princeps	83.89	6.00e-106	376.00
IUUC-Ont-072612	Oreochromis niloticus	64.15	4.00e-63	234.00
IUUC-Oan-073506	Ornithorhynchus anatinus	79.72	1.00e-94	338.00
IUUC-Ocu-074685	Oryctolagus cuniculus	89.10	3.00e-105	374.00
IUUC-Oba-075541	Oryza barthii	34.27	4.00e-13	69.30
IUUC-Obr-076358	Oryza brachyantha	29.41	3.00e-10	60.10
IUUC-Ogl-077166	Oryza glaberrima	32.98	2.00e-14	72.40
IUUC-Ogu-078617	Oryza glumaepatula	25.00	8.00e-06	45.80
IUUC-Oin-079763	Oryza indica	34.08	3.00e-14	72.00
IUUC-Olo-080606	Oryza longistaminata	34.64	5.00e-19	89.40
IUUC-Ome-081337	Oryza meridionalis	34.27	7.00e-13	68.90
IUUC-Oni-083102	Oryza nivara	34.27	7.00e-13	68.90
IUUC-Oru-084547	Oryza rufipogon	34.27	6.00e-14	72.40
IUUC-Osa-085591	Oryza sativa	34.08	3.00e-14	71.60
IUUC-Ola-087005	Oryzias latipes	62.26	2.00e-60	225.00
IUUC-Oga-088415	Otolemur garnettii	91.00	5.00e-116	409.00
IUUC-Oar-090151	Ovis aries	90.52	6.00e-114	402.00
IUUC-Ptr-091183	Pan troglodytes	99.06	1.00e-125	441.00
IUUC-Pan-092515	Papio anubis	97.63	6.00e-123	432.00
IUUC-Psi-093874	Pelodiscus sinensis	75.94	2.00e-97	348.00
IUUC-Pma-094504	Petromyzon marinus	46.58	6.00e-51	193.00
IUUC-Pno-094778	Phaeosphaeria nodorum	31.67	2.00e-12	65.90
IUUC-Ppa-095729	Physcomitrella patens	35.40	7.00e-30	124.00
IUUC-Pfo-097485	Poecilia formosa	65.09	2.00e-71	261.00
IUUC-Pab-098456	Pongo abelii	98.58	4.00e-125	439.00
IUUC-Pop-099754	Populus trichocarpa	33.19	9.00e-29	120.00
IUUC-Ppe-101897	Prunus persica	33.94	9.00e-31	126.00
IUUC-Pva-103087	Pteropus vampyrus	94.79	9.00e-119	419.00
IUUC-Pte-104338	Pyrenophora teres	32.94	3.00e-19	88.60
IUUC-Pyt-104743	Pyrenophora triticirepentis	30.38	2.00e-15	75.90
IUUC-Rno-105791	Rattus norvegicus	92.45	2.00e-117	414.00
IUUC-Sha-107481	Sarcophilus harrisii	83.49	6.00e-108	383.00
IUUC-Sja-107774	Schizosaccharomyces japonicus	29.95	1.00e-16	80.50
IUUC-Spo-108158	Schizosaccharomyces pombe	29.28	4.00e-13	69.30
IUUC-Sit-110301	Setaria italica	30.94	2.00e-18	85.90
IUUC-Sly-110870	Solanum lycopersicum	36.30	4.00e-18	84.00
IUUC-Stu-112872	Solanum tuberosum	34.86	3.00e-27	115.00
IUUC-Sar-113306	Sorex araneus	90.52	9.00e-115	405.00
IUUC-Sbi-113811	Sorghum bicolor	32.24	3.00e-13	70.10
IUUC-Sre-114940	Sporisorium reilianum	23.48	8.00e-10	57.40
IUUC-Ssc-116172	Sus scrofa	94.31	1.00e-118	418.00
IUUC-Tgu-117518	Taeniopygia guttata	74.53	9.00e-93	332.00
IUUC-Tru-118187	Takifugu rubripes	58.12	4.00e-59	221.00
IUUC-Tsy-119532	Tarsius syrichta	93.87	3.00e-118	417.00
IUUC-Tni-119854	Tetraodon nigroviridis	61.79	8.00e-62	229.00
IUUC-Tca-121178	Theobroma cacao	32.59	3.00e-28	118.00
IUUC-Tre-121875	Trichoderma reesei	33.13	3.00e-13	68.60
IUUC-Tvi-122665	Trichoderma virens	33.13	1.00e-14	73.20
IUUC-Tae-123260	Triticum aestivum	34.78	9.00e-21	94.00
IUUC-Tur-126065	Triticum urartu	33.68	2.00e-17	83.60
IUUC-Tme-126891	Tuber melanosporum	35.15	2.00e-18	86.30
IUUC-Tbe-127748	Tupaia belangeri	91.94	9.00e-117	412.00
IUUC-Uma-129463	Ustilago maydis	25.11	1.00e-07	50.40
IUUC-Vda-129820	Verticillium dahliae	32.19	1.00e-11	63.50
IUUC-Vpa-130744	Vicugna pacos	93.81	2.00e-117	414.00
IUUC-Vvi-131735	Vitis vinifera	34.40	4.00e-30	124.00
IUUC-Xtr-132666	Xenopus tropicalis	50.00	2.00e-58	218.00
IUUC-Xma-134199	Xiphophorus maculatus	64.15	3.00e-70	258.00
IUUC-Yli-134333	Yarrowia lipolytica	33.33	1.00e-20	95.10
IUUC-Zma-135340	Zea mays	32.97	4.00e-18	84.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence