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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-136376
Ensembl Protein ID ENSP00000321330.6
UniProt Accession P50876; D6W4Y6; Q585H5; R144A_HUMAN
Genbank Protein ID D79983; AC068481; CH471053; CH471053; BC050373
Protein Name E3 ubiquitin-protein ligase RNF144A;RING finger protein 144A;UbcM4-interacting protein 4;Ubiquitin-conjugating enzyme 7-interacting protein 4
Genbank Nucleotide ID BAA11478.2; AAX82010.1; EAX01030.1; EAX01031.1; AAH50373.1
Gene Name RNF144A;KIAA0161;RNF144;UBCE7IP4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000151692.14 ENST00000320892.10 ENSP00000321330.6
ENSG00000151692.14 ENST00000416587.5 ENSP00000414420.1
ENSG00000151692.14 ENST00000433456.1 ENSP00000402645.1
ENSG00000151692.14 ENST00000432850.1 ENSP00000411616.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpressTCGAICGCCOSMIC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RBR RBR 24979766; 26216882
Classification
Family E-value Score Start End
E3 activity/RBR 1.20e-54 185.8 20 214
Active Site
Position(s) Description Evidence
198 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpek..leeseikellveeelykryekllleevveadaal 88
           Ck+Cl e++ve++t++++C+++fC+ Clkqy+el ikeg +t+iscp+a+cp++  l+e+ei++ +v +e+++ry+kl++e++v  d+++
   Q: 20   CKLCLGEYPVEQMTTIAQCQCIFCTLCLKQYVELLIKEGLETAISCPDAACPKQghLQENEIEC-MVAAEIMQRYKKLQFEREVLFDPCR 108
           ****************************************************98889*******.89*********************** PP
   S: 89   kwcpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyiekneg 176
           +wcpa++C++v++l++ +  + + v+c++c++efC++Ck++wH+g+ C e++  +     e+++a ++e  +a +k+CpkCkvyie++eg
   Q: 109  TWCPASTCQAVCQLQDVGlqTPQPVQCKACRMEFCSTCKASWHPGQGCPETMPITFLPG-ETSAAFKMEEDDAPIKRCPKCKVYIERDEG 197
           ****************8777889999*******************************99.5599999*********************** PP
   S: 177  CnhmtCakCkaefCwlC 193
           C++m+C++Ck++fCw+C
   Q: 198  CAQMMCKNCKHAFCWYC 214
           ***************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.
 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.
Protein Sequence
(Fasta)
MTTTRYRPTW DLALDPLVSC KLCLGEYPVE QMTTIAQCQC IFCTLCLKQY VELLIKEGLE 60
TAISCPDAAC PKQGHLQENE IECMVAAEIM QRYKKLQFER EVLFDPCRTW CPASTCQAVC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-136376|E3,RBR|Homo sapiens
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Nucleotide Sequence
(Fasta)
GAGCCTCCCG CGTGCCCGGC CTCTGTGCGC GCTCGCGCCC CGCCCGCGCA GCCGCTTCTC 60
CCCGCGCGGG CTCTCGGCAG GCGGGAGGCG GCAGGGCTGG CATTGCAGTG CGGGCCGTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-136376|E3,RBR|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF01485--IBR
SMART

SM00647--IBR
Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:9781
Orthology
iUUCD ID Species Identity E-value Score
Created Date 25-Jun-2017

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