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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045706
UUCD1 version UUC-HoS-01097
Ensembl Protein ID ENSP00000261601.6
UniProt Accession P54578; B7Z4N8; J3QRZ5; Q53XY5; UBP14_HUMAN
Genbank Protein ID AAB60365.1; AAP35847.1; BAH12624.1; AAH03556.1; ENSP00000261601
Protein Name Ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14
Genbank Nucleotide ID U30888; BT007183; AK297605; AP000845; CR976282
Gene Name USP14; TGT
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000101557.14 ENST00000582707.5 ENSP00000464447.1
ENSG00000101557.14 ENST00000400266.7 ENSP00000383125.3
ENSG00000101557.14 ENST00000383589.6 ENSP00000373083.2
ENSG00000101557.14 ENST00000261601.7 ENSP00000261601.6
ENSG00000101557.14 ENST00000583119.5 ENSP00000473563.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
GRACPDTDManually
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 16211010; 19615732
UBD/Other/Other UBD/Other/Other 16211010
ULD/UDP/UBQ/UBQ_Other UBQ_Other 16211010
Classification
Family E-value Score Start End
DUB/USP 1.80e-65 223.1 105 480
ULD/UDP/UBQ/UBQ_Other 4.00e-09 37.9 5 74
Active Site
Position(s) Description Evidence
114 Nucleophile {ECO:0000305|PubMed:16211010}
435 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs......g 86
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f       +
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekgeqgQ 194
           7******************************.****************************.99999******************999*9999 PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           y qqDa+E++ +++  l+++l+  ++ +++e+        s++a+  +++k+ksli++ F++++++++kc e +++ +++ + ++l+l+   
   Q: 195  YLQQDANECWIQMMRVLQQKLEAIEDDSVKETD-------SSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFI 279
           *********************664444444443.......33478899**************************999999888888888887 PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts... 267
           ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+ + ct    
   Q: 280  NQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPelq 364
           7754..58999999999999998.....58899999999**************************************************666 PP
   S: 268  .....................peekqke...........................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfd 310
                                p     +                           +  Y+L av+ H+G s+ssGHYv++vk ++++W++fd
   Q: 365  ekmvsfrskfkdledkkvnqqP-----NtsdkksspqkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSWVKRKQDEWIKFD 451
           6666666666666665555551.....0555556666677777777777777777************************************* PP
   S: 311  DskVtevkeeevleetg....staYvlfY 335
           D+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 452  DDKVSIVTPEDILRLSGggdwHIAYVLLY 480
           **************988************ PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd ++++ ++k+g+t++++ +
   Q: 5    SVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNIKIKNGMTLLMMGS 74
           69********99*************************************999.9**************965 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
 Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Protein Sequence
(Fasta)
MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045706|DUB,USP;UBD,UBD/Other/Other;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCTCACTTG CTCCCTCCTT CCTTCCCGCC ACCCCTCCAC CGCCTTCCCC CTCCTCCCTC 60
CTCTCGCCAC CTCTAGGCCC CGCCCCGGTC CTGCCGCCCA GTCTCCTCGC TGCAGTCGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045706|DUB,USP;UBD,UBD/Other/Other;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
SMART

SM00213--UBQ
Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0045202--C:synapse
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004866--F:endopeptidase inhibitor activity
GO:0070628--F:proteasome binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008193--F:tRNA guanylyltransferase activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:9097
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000893 Aegilops tauschii 43.96 2.00e-38 153.00
IUUC-Aml-002053 Ailuropoda melanoleuca 98.98 0.00e+00 935.00
IUUC-Atr-002725 Amborella trichopoda 42.03 1.00e-102 367.00
IUUC-Apl-004031 Anas platyrhynchos 91.26 0.00e+00 892.00
IUUC-Aca-004361 Anolis carolinensis 89.29 0.00e+00 913.00
IUUC-Aly-006078 Arabidopsis lyrata 42.20 3.00e-112 399.00
IUUC-Ath-007623 Arabidopsis thaliana 42.18 1.00e-112 400.00
IUUC-Ago-007796 Ashbya gossypii 32.22 2.00e-58 220.00
IUUC-Acl-008258 Aspergillus clavatus 36.52 8.00e-65 241.00
IUUC-Afl-008732 Aspergillus flavus 33.33 5.00e-72 265.00
IUUC-Afu-008755 Aspergillus fumigatus 34.83 1.00e-79 290.00
IUUC-Ani-009148 Aspergillus nidulans 37.90 3.00e-70 259.00
IUUC-Ang-009878 Aspergillus niger 37.32 3.00e-65 243.00
IUUC-Aor-010239 Aspergillus oryzae 33.33 6.00e-72 265.00
IUUC-Ate-010243 Aspergillus terreus 33.74 1.00e-70 261.00
IUUC-Ame-011327 Astyanax mexicanus 51.00 3.00e-127 448.00
IUUC-Bgr-012231 Blumeria graminis 34.15 3.00e-79 289.00
IUUC-Bta-012553 Bos taurus 97.57 0.00e+00 949.00
IUUC-Bci-013606 Botrytis cinerea 39.95 7.00e-70 258.00
IUUC-Bdi-014567 Brachypodium distachyon 42.91 4.00e-112 398.00
IUUC-Bol-016127 Brassica oleracea 42.60 3.00e-114 405.00
IUUC-Bra-017501 Brassica rapa 42.40 2.00e-113 402.00
IUUC-Cel-018140 Caenorhabditis elegans 41.55 3.00e-100 358.00
IUUC-Cja-019516 Callithrix jacchus 98.99 0.00e+00 965.00
IUUC-Cfa-020808 Canis familiaris 99.19 0.00e+00 961.00
IUUC-Cpo-021688 Cavia porcellus 96.96 0.00e+00 941.00
IUUC-Cre-022663 Chlamydomonas reinhardtii 37.78 8.00e-83 301.00
IUUC-Csa-023429 Chlorocebus sabaeus 99.80 0.00e+00 946.00
IUUC-Cho-024347 Choloepus hoffmanni 97.77 0.00e+00 954.00
IUUC-Cin-025198 Ciona intestinalis 54.38 6.00e-151 527.00
IUUC-Csv-026007 Ciona savignyi 53.01 4.00e-153 534.00
IUUC-Cgl-026757 Colletotrichum gloeosporioides 38.44 1.00e-63 237.00
IUUC-Cne-026963 Cryptococcus neoformans 34.68 2.00e-76 279.00
IUUC-Cme-027240 Cyanidioschyzon merolae 30.62 7.00e-60 224.00
IUUC-Dre-027647 Danio rerio 82.45 0.00e+00 831.00
IUUC-Dno-029967 Dasypus novemcinctus 97.98 0.00e+00 936.00
IUUC-Dor-030886 Dipodomys ordii 92.27 0.00e+00 765.00
IUUC-Dse-031466 Dothistroma septosporum 35.03 8.00e-57 214.00
IUUC-Dme-032079 Drosophila melanogaster 55.35 4.00e-159 554.00
IUUC-Ete-032351 Echinops telfairi 86.23 0.00e+00 860.00
IUUC-Eca-033461 Equus caballus 97.98 0.00e+00 994.00
IUUC-Eeu-035220 Erinaceus europaeus 74.18 0.00e+00 689.00
IUUC-Fca-036210 Felis catus 99.39 0.00e+00 963.00
IUUC-Fal-037528 Ficedula albicollis 90.67 0.00e+00 875.00
IUUC-Fox-037805 Fusarium oxysporum 39.90 1.00e-70 260.00
IUUC-Fso-038177 Fusarium solani 37.82 1.00e-67 250.00
IUUC-Gmo-038953 Gadus morhua 78.21 0.00e+00 767.00
IUUC-Ggr-039972 Gaeumannomyces graminis 34.48 7.00e-75 275.00
IUUC-Gga-040462 Gallus gallus 90.28 0.00e+00 886.00
IUUC-Gac-041312 Gasterosteus aculeatus 81.72 0.00e+00 802.00
IUUC-Gma-043255 Glycine max 42.43 6.00e-109 387.00
IUUC-Ggo-045458 Gorilla gorilla 82.63 0.00e+00 788.00
IUUC-Hvu-047821 Hordeum vulgare 46.76 1.00e-57 216.00
IUUC-Itr-048654 Ictidomys tridecemlineatus 97.98 0.00e+00 961.00
IUUC-Lch-050464 Latimeria chalumnae 82.45 0.00e+00 822.00
IUUC-Lpe-051419 Leersia perrieri 42.71 4.00e-108 384.00
IUUC-Loc-052732 Lepisosteus oculatus 80.85 0.00e+00 841.00
IUUC-Lma-053177 Leptosphaeria maculans 40.51 1.00e-70 260.00
IUUC-Laf-053822 Loxodonta africana 97.97 0.00e+00 949.00
IUUC-Mcc-055893 Macaca mulatta 100.00 0.00e+00 947.00
IUUC-Meu-056307 Macropus eugenii 82.45 0.00e+00 795.00
IUUC-Mor-057171 Magnaporthe oryzae 38.42 8.00e-68 251.00
IUUC-Mpo-057415 Magnaporthe poae 38.83 1.00e-69 257.00
IUUC-Mtr-057901 Medicago truncatula 43.00 1.00e-111 397.00
IUUC-Mla-058897 Melampsora laricipopulina 39.63 1.00e-75 277.00
IUUC-Mga-060016 Meleagris gallopavo 90.85 0.00e+00 890.00
IUUC-Mvi-060562 Microbotryum violaceum 38.77 4.00e-67 249.00
IUUC-Mmr-060624 Microcebus murinus 97.98 0.00e+00 999.00
IUUC-Mdo-061809 Monodelphis domestica 93.15 0.00e+00 902.00
IUUC-Mmu-063869 Mus musculus 96.76 0.00e+00 941.00
IUUC-Mac-064876 Musa acuminata 39.68 1.00e-96 347.00
IUUC-Mpu-066480 Mustela putorius furo 98.79 0.00e+00 958.00
IUUC-Mlu-067866 Myotis lucifugus 97.37 0.00e+00 957.00
IUUC-Nfi-068393 Neosartorya fischeri 36.38 4.00e-65 242.00
IUUC-Ncr-068815 Neurospora crassa 35.66 8.00e-82 298.00
IUUC-Nle-070121 Nomascus leucogenys 100.00 5.00e-141 493.00
IUUC-Opr-070712 Ochotona princeps 77.39 9.00e-174 603.00
IUUC-Ont-071544 Oreochromis niloticus 81.87 0.00e+00 769.00
IUUC-Oan-073635 Ornithorhynchus anatinus 91.59 0.00e+00 746.00
IUUC-Ocu-074926 Oryctolagus cuniculus 97.17 0.00e+00 932.00
IUUC-Oba-075633 Oryza barthii 42.18 2.00e-108 385.00
IUUC-Obr-076423 Oryza brachyantha 42.86 3.00e-110 392.00
IUUC-Ogl-077913 Oryza glaberrima 42.02 6.00e-111 394.00
IUUC-Ogu-078435 Oryza glumaepatula 42.18 2.00e-108 385.00
IUUC-Oin-080072 Oryza indica 42.15 2.00e-108 386.00
IUUC-Olo-080535 Oryza longistaminata 39.00 6.00e-93 334.00
IUUC-Ome-081309 Oryza meridionalis 42.18 2.00e-108 385.00
IUUC-Oni-083113 Oryza nivara 42.18 2.00e-108 385.00
IUUC-Opu-083168 Oryza punctata 41.24 1.00e-102 366.00
IUUC-Oru-084253 Oryza rufipogon 42.18 2.00e-108 385.00
IUUC-Osa-085554 Oryza sativa 42.02 5.00e-111 394.00
IUUC-Ola-086998 Oryzias latipes 81.14 0.00e+00 794.00
IUUC-Olu-087818 Ostreococcus lucimarinus 36.09 6.00e-71 261.00
IUUC-Oga-088571 Otolemur garnettii 97.98 0.00e+00 949.00
IUUC-Oar-089526 Ovis aries 97.36 0.00e+00 942.00
IUUC-Ptr-091433 Pan troglodytes 100.00 0.00e+00 947.00
IUUC-Pan-091966 Papio anubis 99.80 0.00e+00 946.00
IUUC-Psi-093458 Pelodiscus sinensis 89.22 0.00e+00 851.00
IUUC-Pma-094343 Petromyzon marinus 68.86 5.00e-121 427.00
IUUC-Pno-095109 Phaeosphaeria nodorum 39.65 1.00e-65 244.00
IUUC-Ppa-095756 Physcomitrella patens 43.90 3.00e-111 395.00
IUUC-Pfo-096514 Poecilia formosa 82.28 0.00e+00 785.00
IUUC-Pab-098477 Pongo abelii 87.45 0.00e+00 748.00
IUUC-Pop-099221 Populus trichocarpa 41.16 4.00e-103 368.00
IUUC-Pca-100791 Procavia capensis 81.59 7.00e-180 623.00
IUUC-Ppe-101812 Prunus persica 41.77 1.00e-107 383.00
IUUC-Pva-102462 Pteropus vampyrus 93.24 0.00e+00 768.00
IUUC-Pgr-103623 Puccinia graminis 40.69 6.00e-75 275.00
IUUC-Ptt-103767 Puccinia triticina 39.40 4.00e-68 252.00
IUUC-Pte-104109 Pyrenophora teres 38.94 1.00e-69 257.00
IUUC-Pyt-104766 Pyrenophora triticirepentis 40.56 4.00e-70 259.00
IUUC-Rno-105351 Rattus norvegicus 96.56 0.00e+00 904.00
IUUC-Sce-106168 Saccharomyces cerevisiae 32.41 1.00e-62 234.00
IUUC-Sha-107491 Sarcophilus harrisii 92.93 0.00e+00 914.00
IUUC-Sja-107769 Schizosaccharomyces japonicus 33.92 3.00e-78 285.00
IUUC-Spo-108174 Schizosaccharomyces pombe 37.63 8.00e-81 294.00
IUUC-Ssl-108659 Sclerotinia sclerotiorum 34.74 4.00e-84 305.00
IUUC-Smo-108805 Selaginella moellendorffii 43.27 7.00e-110 390.00
IUUC-Sit-110361 Setaria italica 42.34 5.00e-113 401.00
IUUC-Sly-110965 Solanum lycopersicum 40.35 2.00e-108 386.00
IUUC-Sar-113355 Sorex araneus 84.62 0.00e+00 663.00
IUUC-Sbi-114778 Sorghum bicolor 43.03 3.00e-112 398.00
IUUC-Sre-115011 Sporisorium reilianum 36.06 1.00e-61 231.00
IUUC-Ssc-116273 Sus scrofa 97.56 0.00e+00 934.00
IUUC-Tgu-117063 Taeniopygia guttata 90.04 0.00e+00 873.00
IUUC-Tru-118381 Takifugu rubripes 78.86 0.00e+00 790.00
IUUC-Tsy-119076 Tarsius syrichta 82.61 5.00e-120 424.00
IUUC-Tni-119941 Tetraodon nigroviridis 81.02 0.00e+00 781.00
IUUC-Tca-121246 Theobroma cacao 41.49 2.00e-109 389.00
IUUC-Tre-121969 Trichoderma reesei 34.49 2.00e-75 276.00
IUUC-Tvi-122543 Trichoderma virens 34.87 2.00e-77 283.00
IUUC-Tae-125484 Triticum aestivum 41.88 6.00e-109 387.00
IUUC-Tur-126128 Triticum urartu 41.87 2.00e-39 156.00
IUUC-Tbe-128030 Tupaia belangeri 91.19 0.00e+00 853.00
IUUC-Ttr-128701 Tursiops truncatus 96.70 0.00e+00 769.00
IUUC-Uma-129657 Ustilago maydis 36.80 7.00e-65 241.00
IUUC-Vda-129723 Verticillium dahliae 32.31 3.00e-71 263.00
IUUC-Vpa-130284 Vicugna pacos 70.70 0.00e+00 633.00
IUUC-Vvi-131037 Vitis vinifera 42.55 2.00e-108 385.00
IUUC-Xtr-132235 Xenopus tropicalis 86.09 0.00e+00 878.00
IUUC-Xma-133840 Xiphophorus maculatus 82.28 0.00e+00 810.00
IUUC-Yli-134453 Yarrowia lipolytica 36.78 2.00e-82 299.00
IUUC-Zma-135669 Zea mays 36.27 8.00e-94 337.00
Created Date 25-Jun-2017

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