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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045697
Ensembl Protein ID ENSP00000368818.3
UniProt Accession Q6ZVM7; B7Z2L7; B7Z7F4; Q86V61; Q8TDE7; Q96M88; TM1L2_HUMAN
Genbank Protein ID AAL78338.1; BAB71421.1; BAC85834.1; BAH11903.1; BAH13590.1; AAH51650.1
Protein Name TOM1-like protein 2; Target of Myb-like protein 2
Genbank Nucleotide ID AF467441; AK057308; AK124331; AK294846; AK301944; AC087163
Gene Name TOM1L2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000175662.17 ENST00000581396.5 ENSP00000464297.1
ENSG00000175662.17 ENST00000379504.7 ENSP00000368818.3
ENSG00000175662.17 ENST00000318094.14 ENSP00000312860.10
ENSG00000175662.17 ENST00000535933.5 ENSP00000438621.1
ENSG00000175662.17 ENST00000540946.5 ENSP00000437655.1
ENSG00000175662.17 ENST00000542206.5 ENSP00000445188.1
ENSG00000175662.17 ENST00000468944.1 ENSP00000465677.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/VHS 1.00e-46 159.9 20 152
UBD/Alpha-Helix/GAT 3.20e-27 96.7 216 306
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/VHS
   S: 1    atselvtsedwelileicdliqetkegakdalralrkri.nnknphvalraLtlLdscvsnCgkkfhvevaskdllee..lrell.knenep 88
           at+ +++sedw+l++eicd+i+et+eg+kda+ral+kr+ +n+n  ++++aLt+L++cv+nCg++fh +va++d++++  ++ +  kn++++
   Q: 20   ATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLnGNRNYREVMLALTVLETCVKNCGHRFHILVANRDFIDSvlVKIISpKNNPPT 111
           68999**********************************779***********************************9856666699999** PP
   S: 89   kvieKlkalivsWadelknepalslivaliktlkeeGlefp 129
            v +K++ali++Wad+++++p+l+++v+++++lk++G+efp
   Q: 112  IVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGVEFP 152
           ****************************************8 PP
   

   UBD/Alpha-Helix/GAT
   S: 36   dkaekikkliseleevksnvkllnemlselspegeepednellqelyetckaarpkllklieeeedndellaellkanDelnqvlnkykqlk 127
           +++e+i +l+sel+ v++n+k+++eml+e++p++e+++d ellqel++tc+a+++++++li++ ++n+e+++ell++nD+ln+v+++y++++
   Q: 216  ANSEQIARLRSELDVVRGNTKVMSEMLTEMVPGQEDSSDLELLQELNRTCRAMQQRIVELISR-VSNEEVTEELLHVNDDLNNVFLRYERFE 306
           689************************************************************.*************************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.
 Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.
Protein Sequence
(Fasta)
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA IRALKKRLNG 60
NRNYREVMLA LTVLETCVKN CGHRFHILVA NRDFIDSVLV KIISPKNNPP TIVQDKVLAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045697|UBD,VHS;UBD,GAT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGAGTGGG GAGGGGGCAA GTGTCAGTCA GGACGGGAGT CCGGCGGGTT ACAGCGGAGG 60
CCTAGGTGGC AGACAGGGGG CCCGGGCCGC TGCGTGTTGT CCACCCAAGA TGGAGTTCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045697|UBD,VHS;UBD,GAT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR014645--TOM1
IPR027429--TOM1L2
IPR002014--VHS_dom
PROSITE

PS50909--GAT
PS50179--VHS
Pfam

PF03127--GAT
PF00790--VHS
SMART

SM00288--VHS
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005622--C:intracellular
GO:0030276--F:clathrin binding
GO:0019901--F:protein kinase binding
GO:0006886--P:intracellular protein transport
GO:0045839--P:negative regulation of mitotic nuclear division
GO:0007165--P:signal transduction
KEGG hsa:146691
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000135 Aegilops tauschii 28.24 2.00e-24 107.00
IUUC-Aml-002171 Ailuropoda melanoleuca 97.03 0.00e+00 858.00
IUUC-Atr-003138 Amborella trichopoda 31.51 1.00e-26 115.00
IUUC-Apl-003931 Anas platyrhynchos 90.14 0.00e+00 796.00
IUUC-Aca-004547 Anolis carolinensis 68.91 7.00e-166 577.00
IUUC-Aly-005656 Arabidopsis lyrata 32.58 2.00e-35 144.00
IUUC-Ath-007359 Arabidopsis thaliana 31.53 4.00e-34 139.00
IUUC-Ame-011059 Astyanax mexicanus 67.88 0.00e+00 653.00
IUUC-Bta-012995 Bos taurus 88.41 0.00e+00 794.00
IUUC-Bdi-015001 Brachypodium distachyon 30.80 4.00e-30 126.00
IUUC-Bol-015832 Brassica oleracea 32.79 5.00e-35 142.00
IUUC-Bra-017805 Brassica rapa 32.79 4.00e-35 142.00
IUUC-Cel-018158 Caenorhabditis elegans 50.29 2.00e-88 319.00
IUUC-Cja-019153 Callithrix jacchus 98.57 0.00e+00 860.00
IUUC-Cfa-020935 Canis familiaris 92.83 0.00e+00 866.00
IUUC-Cpo-021763 Cavia porcellus 91.72 0.00e+00 825.00
IUUC-Cre-022771 Chlamydomonas reinhardtii 34.97 3.00e-16 78.60
IUUC-Csa-023899 Chlorocebus sabaeus 94.03 0.00e+00 891.00
IUUC-Dre-028784 Danio rerio 69.58 0.00e+00 701.00
IUUC-Dno-029588 Dasypus novemcinctus 91.29 0.00e+00 796.00
IUUC-Dor-030371 Dipodomys ordii 77.91 0.00e+00 642.00
IUUC-Dme-032144 Drosophila melanogaster 43.27 6.00e-99 354.00
IUUC-Eca-033664 Equus caballus 97.55 0.00e+00 857.00
IUUC-Eeu-035062 Erinaceus europaeus 71.40 0.00e+00 639.00
IUUC-Fca-036096 Felis catus 97.25 0.00e+00 900.00
IUUC-Fal-036951 Ficedula albicollis 87.57 0.00e+00 801.00
IUUC-Gmo-038942 Gadus morhua 62.81 3.00e-169 588.00
IUUC-Gga-040378 Gallus gallus 92.11 0.00e+00 818.00
IUUC-Gac-042242 Gasterosteus aculeatus 71.76 0.00e+00 722.00
IUUC-Gma-043428 Glycine max 31.82 3.00e-34 140.00
IUUC-Ggo-045180 Gorilla gorilla 100.00 0.00e+00 913.00
IUUC-Hvu-047560 Hordeum vulgare 29.90 6.00e-30 125.00
IUUC-Itr-048308 Ictidomys tridecemlineatus 80.63 0.00e+00 767.00
IUUC-Lch-049647 Latimeria chalumnae 82.32 0.00e+00 758.00
IUUC-Lpe-051451 Leersia perrieri 31.85 2.00e-30 127.00
IUUC-Loc-052081 Lepisosteus oculatus 81.61 0.00e+00 808.00
IUUC-Laf-053664 Loxodonta africana 81.34 0.00e+00 741.00
IUUC-Mcc-055637 Macaca mulatta 94.22 0.00e+00 893.00
IUUC-Meu-056014 Macropus eugenii 78.30 0.00e+00 714.00
IUUC-Mtr-057784 Medicago truncatula 32.68 1.00e-33 138.00
IUUC-Mga-060056 Meleagris gallopavo 84.93 0.00e+00 698.00
IUUC-Mmr-060929 Microcebus murinus 94.08 0.00e+00 827.00
IUUC-Mdo-061814 Monodelphis domestica 89.74 0.00e+00 876.00
IUUC-Mmu-063996 Mus musculus 94.87 0.00e+00 888.00
IUUC-Mac-064731 Musa acuminata 32.53 3.00e-33 137.00
IUUC-Mpu-065820 Mustela putorius furo 94.61 0.00e+00 845.00
IUUC-Nle-069131 Nomascus leucogenys 99.58 0.00e+00 837.00
IUUC-Opr-070780 Ochotona princeps 87.44 0.00e+00 723.00
IUUC-Ont-072357 Oreochromis niloticus 70.55 0.00e+00 679.00
IUUC-Oan-072790 Ornithorhynchus anatinus 90.50 4.00e-173 600.00
IUUC-Ocu-074458 Oryctolagus cuniculus 90.58 0.00e+00 731.00
IUUC-Oba-075578 Oryza barthii 32.53 3.00e-33 137.00
IUUC-Obr-076278 Oryza brachyantha 32.29 9.00e-34 138.00
IUUC-Ogl-077232 Oryza glaberrima 32.53 3.00e-33 137.00
IUUC-Ogu-078454 Oryza glumaepatula 32.53 3.00e-33 137.00
IUUC-Oin-080097 Oryza indica 32.53 3.00e-33 137.00
IUUC-Olo-080861 Oryza longistaminata 30.72 1.00e-30 127.00
IUUC-Ome-081795 Oryza meridionalis 32.53 3.00e-33 137.00
IUUC-Oni-082061 Oryza nivara 32.53 3.00e-33 137.00
IUUC-Opu-083285 Oryza punctata 32.88 5.00e-33 136.00
IUUC-Oru-084443 Oryza rufipogon 32.53 3.00e-33 137.00
IUUC-Osa-085724 Oryza sativa 32.53 3.00e-33 137.00
IUUC-Ola-087001 Oryzias latipes 70.29 0.00e+00 656.00
IUUC-Oga-088302 Otolemur garnettii 96.65 0.00e+00 868.00
IUUC-Ptr-091081 Pan troglodytes 99.61 0.00e+00 905.00
IUUC-Pan-092566 Papio anubis 94.22 0.00e+00 893.00
IUUC-Psi-093744 Pelodiscus sinensis 91.52 0.00e+00 814.00
IUUC-Pma-094514 Petromyzon marinus 64.09 7.00e-124 436.00
IUUC-Ppa-095533 Physcomitrella patens 32.30 2.00e-31 130.00
IUUC-Pfo-096489 Poecilia formosa 71.02 0.00e+00 674.00
IUUC-Pab-098769 Pongo abelii 94.03 0.00e+00 856.00
IUUC-Pop-099695 Populus trichocarpa 31.63 1.00e-32 134.00
IUUC-Ppe-101305 Prunus persica 30.92 1.00e-33 138.00
IUUC-Pva-102889 Pteropus vampyrus 84.62 0.00e+00 739.00
IUUC-Rno-105379 Rattus norvegicus 91.67 0.00e+00 875.00
IUUC-Sce-106195 Saccharomyces cerevisiae 25.35 5.00e-17 82.80
IUUC-Smo-109609 Selaginella moellendorffii 35.06 2.00e-19 90.10
IUUC-Sit-109878 Setaria italica 32.88 8.00e-33 135.00
IUUC-Sly-111100 Solanum lycopersicum 32.90 2.00e-33 137.00
IUUC-Stu-112728 Solanum tuberosum 27.42 5.00e-14 72.00
IUUC-Sbi-114813 Sorghum bicolor 31.33 9.00e-35 141.00
IUUC-Tgu-116705 Taeniopygia guttata 91.63 0.00e+00 782.00
IUUC-Tru-117717 Takifugu rubripes 71.16 0.00e+00 681.00
IUUC-Tsy-119063 Tarsius syrichta 87.73 0.00e+00 682.00
IUUC-Tni-120164 Tetraodon nigroviridis 56.56 1.00e-137 483.00
IUUC-Tca-121503 Theobroma cacao 31.91 6.00e-32 132.00
IUUC-Tae-124026 Triticum aestivum 32.31 2.00e-28 121.00
IUUC-Tur-126378 Triticum urartu 28.16 2.00e-26 114.00
IUUC-Tbe-128123 Tupaia belangeri 83.75 3.00e-177 614.00
IUUC-Vvi-131122 Vitis vinifera 31.16 3.00e-32 133.00
IUUC-Xtr-132682 Xenopus tropicalis 82.16 0.00e+00 802.00
IUUC-Xma-134041 Xiphophorus maculatus 68.18 0.00e+00 651.00
Created Date 25-Jun-2017

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