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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-031711
UUCD1 version UUC-DrM-00057
Ensembl Protein ID FBpp0070259
UniProt Accession Q24314; Q95R67; Q9W570; VPS18_DROME
Genbank Protein ID CAA60382.1; AAF45652.1; CAA16809.1; AAL29140.1
Protein Name Vacuolar protein sorting-associated protein 18 homolog; Protein deep orange
Genbank Nucleotide ID X86683; AE014298; AL021726; AY061592
Gene Name dor; CG3093
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0000482 FBtr0070269 FBpp0070259
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 34.12 8.00e-146 516.00 IUUC-Hsa-046635
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Required for the biogenesis of eye pigment granules (PubMed:10549280). Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (PubMed:9065698, PubMed:10549280). Required to maintain normal levels of rush, which functions in endosome formation and trafficking (PubMed:22160599).
 Required for the biogenesis of eye pigment granules (PubMed:10549280). Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (PubMed:9065698, PubMed:10549280). Required to maintain normal levels of rush, which functions in endosome formation and trafficking (PubMed:22160599).
Protein Sequence
(Fasta)
MDTSMPNQPK FLPRIEHNSS GATANSYVAT ASGNPFETDD EDEIFSRHKM VLRVPSNCTG 60
DLMHLAVSRN WLVCLLGTPE RTTLLRFFLP RAIPPGEAVL EKYLSGSGYK ITRMFLDPTG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031711|E3,RING|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGCCATCA CTTCTCAGAT TGGGGCGTTT TGGTAGAACT AATTGTAAAC AGCGGAGGAA 60
AAGGCAGCAG AATGGACACG TCTATGCCTA ACCAGCCCAA GTTCCTGCCC CGCATTGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031711|E3,RING|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000547--Clathrin_H-chain/VPS_repeat
IPR007810--Pep3_Vps18
IPR011990--TPR-like_helical_dom
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50236--CHCR
Pfam

PF00637--Clathrin
PF05131--Pep3_Vps18
Gene Ontology

GO:0033263--C:CORVET complex
GO:0005768--C:endosome
GO:0030897--C:HOPS complex
GO:0031902--C:late endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0045202--C:synapse
GO:0030674--F:protein binding, bridging
GO:0008270--F:zinc ion binding
GO:0097352--P:autophagosome maturation
GO:0007298--P:border follicle cell migration
GO:0051301--P:cell division
GO:0009267--P:cellular response to starvation
GO:0048072--P:compound eye pigmentation
GO:0008340--P:determination of adult lifespan
GO:0006897--P:endocytosis
GO:0016197--P:endosomal transport
GO:0007032--P:endosome organization
GO:0008333--P:endosome to lysosome transport
GO:0006726--P:eye pigment biosynthetic process
GO:0008057--P:eye pigment granule organization
GO:0007041--P:lysosomal transport
GO:0007040--P:lysosome organization
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0007220--P:Notch receptor processing
GO:0006727--P:ommochrome biosynthetic process
GO:0006622--P:protein targeting to lysosome
GO:0006728--P:pteridine biosynthetic process
GO:0035542--P:regulation of SNARE complex assembly
GO:0006904--P:vesicle docking involved in exocytosis
KEGG dme:Dmel_CG3093
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000419 Aegilops tauschii 26.60 2.00e-71 263.00
IUUC-Aml-001240 Ailuropoda melanoleuca 34.01 2.00e-146 512.00
IUUC-Atr-003125 Amborella trichopoda 27.04 2.00e-83 303.00
IUUC-Apl-004181 Anas platyrhynchos 33.33 4.00e-148 518.00
IUUC-Aca-004437 Anolis carolinensis 33.03 4.00e-142 498.00
IUUC-Aly-006046 Arabidopsis lyrata 28.56 2.00e-88 319.00
IUUC-Ath-006932 Arabidopsis thaliana 28.21 3.00e-88 318.00
IUUC-Ago-007800 Ashbya gossypii 21.87 1.00e-38 154.00
IUUC-Acl-008035 Aspergillus clavatus 27.69 3.00e-79 289.00
IUUC-Afl-008714 Aspergillus flavus 27.67 2.00e-77 283.00
IUUC-Afu-009063 Aspergillus fumigatus 27.86 3.00e-76 279.00
IUUC-Ani-009384 Aspergillus nidulans 27.37 3.00e-78 285.00
IUUC-Ang-009507 Aspergillus niger 27.93 2.00e-75 276.00
IUUC-Aor-010094 Aspergillus oryzae 27.67 6.00e-77 281.00
IUUC-Ate-010421 Aspergillus terreus 27.42 6.00e-69 254.00
IUUC-Ame-011797 Astyanax mexicanus 32.36 6.00e-148 517.00
IUUC-Bgr-012107 Blumeria graminis 27.24 6.00e-73 268.00
IUUC-Bta-012339 Bos taurus 34.49 4.00e-152 531.00
IUUC-Bci-013895 Botrytis cinerea 27.98 5.00e-86 311.00
IUUC-Bdi-014554 Brachypodium distachyon 27.87 3.00e-87 315.00
IUUC-Bol-015270 Brassica oleracea 28.76 8.00e-89 321.00
IUUC-Bra-017424 Brassica rapa 28.30 2.00e-84 306.00
IUUC-Cel-018455 Caenorhabditis elegans 27.59 6.00e-84 305.00
IUUC-Cja-019629 Callithrix jacchus 34.30 2.00e-147 516.00
IUUC-Cfa-020425 Canis familiaris 33.91 5.00e-145 508.00
IUUC-Cpo-021349 Cavia porcellus 33.94 7.00e-146 510.00
IUUC-Cre-022799 Chlamydomonas reinhardtii 27.41 5.00e-25 109.00
IUUC-Csa-023559 Chlorocebus sabaeus 33.91 1.00e-146 513.00
IUUC-Cho-024862 Choloepus hoffmanni 28.10 9.00e-57 214.00
IUUC-Cin-025599 Ciona intestinalis 30.12 2.00e-109 389.00
IUUC-Csv-026152 Ciona savignyi 30.26 7.00e-127 447.00
IUUC-Cgl-026551 Colletotrichum gloeosporioides 27.70 3.00e-78 285.00
IUUC-Cne-026907 Cryptococcus neoformans 26.91 5.00e-68 252.00
IUUC-Dre-027747 Danio rerio 33.13 2.00e-154 538.00
IUUC-Dno-029668 Dasypus novemcinctus 33.67 5.00e-145 507.00
IUUC-Dor-030404 Dipodomys ordii 35.27 1.00e-147 516.00
IUUC-Dse-031345 Dothistroma septosporum 28.05 6.00e-79 288.00
IUUC-Ete-032308 Echinops telfairi 39.10 5.00e-95 342.00
IUUC-Eca-033637 Equus caballus 33.91 1.00e-145 509.00
IUUC-Eeu-035151 Erinaceus europaeus 36.01 2.00e-126 446.00
IUUC-Fca-035585 Felis catus 33.91 3.00e-145 508.00
IUUC-Fal-037122 Ficedula albicollis 33.33 4.00e-146 511.00
IUUC-Fox-038030 Fusarium oxysporum 28.22 2.00e-78 286.00
IUUC-Fso-038426 Fusarium solani 27.58 3.00e-79 289.00
IUUC-Gmo-038784 Gadus morhua 33.06 1.00e-146 513.00
IUUC-Ggr-039973 Gaeumannomyces graminis 28.98 5.00e-67 248.00
IUUC-Gga-040692 Gallus gallus 33.37 2.00e-147 516.00
IUUC-Gac-041868 Gasterosteus aculeatus 33.83 2.00e-155 542.00
IUUC-Gma-044274 Glycine max 28.24 9.00e-93 334.00
IUUC-Ggo-045053 Gorilla gorilla 34.12 2.00e-146 512.00
IUUC-Hsa-046635 Homo sapiens 34.12 9.00e-147 513.00
IUUC-Hvu-047361 Hordeum vulgare 28.02 2.00e-87 316.00
IUUC-Itr-048868 Ictidomys tridecemlineatus 34.11 4.00e-146 511.00
IUUC-Kpa-049270 Komagataella pastoris 25.66 8.00e-55 207.00
IUUC-Lch-050188 Latimeria chalumnae 33.99 1.00e-139 489.00
IUUC-Lpe-051026 Leersia perrieri 29.04 2.00e-93 336.00
IUUC-Loc-051821 Lepisosteus oculatus 32.93 6.00e-150 524.00
IUUC-Lma-053178 Leptosphaeria maculans 29.91 2.00e-71 263.00
IUUC-Laf-053552 Loxodonta africana 33.91 2.00e-146 512.00
IUUC-Mcc-054667 Macaca mulatta 34.01 5.00e-146 511.00
IUUC-Meu-056422 Macropus eugenii 41.01 5.00e-91 328.00
IUUC-Mor-056981 Magnaporthe oryzae 28.18 1.00e-78 286.00
IUUC-Mtr-058703 Medicago truncatula 28.57 5.00e-91 328.00
IUUC-Mla-059088 Melampsora laricipopulina 31.01 2.00e-78 285.00
IUUC-Mga-059798 Meleagris gallopavo 33.57 5.00e-148 518.00
IUUC-Mvi-060404 Microbotryum violaceum 29.08 3.00e-95 343.00
IUUC-Mmr-061630 Microcebus murinus 34.49 3.00e-147 515.00
IUUC-Mdo-062354 Monodelphis domestica 33.84 4.00e-146 511.00
IUUC-Mmu-063199 Mus musculus 34.00 3.00e-148 518.00
IUUC-Mac-065595 Musa acuminata 29.29 4.00e-80 291.00
IUUC-Mpu-066596 Mustela putorius furo 34.01 1.00e-146 513.00
IUUC-Mlu-067455 Myotis lucifugus 34.05 1.00e-146 513.00
IUUC-Nfi-068565 Neosartorya fischeri 28.24 1.00e-78 286.00
IUUC-Ncr-068748 Neurospora crassa 27.43 9.00e-80 291.00
IUUC-Nle-068979 Nomascus leucogenys 33.99 5.00e-126 444.00
IUUC-Opr-070711 Ochotona princeps 33.70 1.00e-145 510.00
IUUC-Ont-072603 Oreochromis niloticus 33.57 1.00e-155 543.00
IUUC-Oan-073136 Ornithorhynchus anatinus 37.57 9.00e-88 316.00
IUUC-Ocu-074496 Oryctolagus cuniculus 34.22 4.00e-148 518.00
IUUC-Oba-075933 Oryza barthii 26.85 6.00e-75 275.00
IUUC-Obr-076290 Oryza brachyantha 29.04 5.00e-94 338.00
IUUC-Ogu-078728 Oryza glumaepatula 26.85 6.00e-75 275.00
IUUC-Oin-079954 Oryza indica 28.09 9.00e-82 297.00
IUUC-Olo-081033 Oryza longistaminata 26.43 3.00e-67 249.00
IUUC-Ome-081797 Oryza meridionalis 27.63 4.00e-81 295.00
IUUC-Oni-082802 Oryza nivara 26.85 6.00e-75 275.00
IUUC-Opu-083595 Oryza punctata 28.56 2.00e-90 326.00
IUUC-Oru-084199 Oryza rufipogon 26.85 6.00e-75 275.00
IUUC-Osa-085349 Oryza sativa 28.78 8.00e-91 327.00
IUUC-Ola-087482 Oryzias latipes 32.71 4.00e-149 521.00
IUUC-Olu-087797 Ostreococcus lucimarinus 24.24 5.00e-52 198.00
IUUC-Oga-088817 Otolemur garnettii 34.15 2.00e-147 515.00
IUUC-Oar-090350 Ovis aries 31.95 2.00e-97 349.00
IUUC-Ptr-090999 Pan troglodytes 34.32 8.00e-147 513.00
IUUC-Pan-092704 Papio anubis 34.01 5.00e-146 511.00
IUUC-Psi-093529 Pelodiscus sinensis 33.23 6.00e-148 517.00
IUUC-Pma-094400 Petromyzon marinus 32.99 9.00e-146 510.00
IUUC-Pno-094875 Phaeosphaeria nodorum 27.42 1.00e-81 297.00
IUUC-Ppa-095231 Physcomitrella patens 28.28 3.00e-92 332.00
IUUC-Pfo-096967 Poecilia formosa 33.13 9.00e-153 533.00
IUUC-Pab-098300 Pongo abelii 34.12 9.00e-147 513.00
IUUC-Pop-098966 Populus trichocarpa 28.30 5.00e-91 328.00
IUUC-Pca-100643 Procavia capensis 33.94 2.00e-133 469.00
IUUC-Ppe-101589 Prunus persica 28.61 1.00e-91 330.00
IUUC-Pva-102766 Pteropus vampyrus 33.37 3.00e-137 481.00
IUUC-Pgr-103330 Puccinia graminis 27.78 1.00e-79 291.00
IUUC-Ptt-103809 Puccinia triticina 30.38 3.00e-71 263.00
IUUC-Pte-104319 Pyrenophora teres 27.85 5.00e-80 291.00
IUUC-Pyt-104798 Pyrenophora triticirepentis 26.37 3.00e-67 249.00
IUUC-Rno-105817 Rattus norvegicus 34.45 2.00e-146 512.00
IUUC-Sce-106255 Saccharomyces cerevisiae 21.81 5.00e-33 135.00
IUUC-Sha-107479 Sarcophilus harrisii 34.28 9.00e-148 516.00
IUUC-Sja-107976 Schizosaccharomyces japonicus 23.14 4.00e-52 199.00
IUUC-Spo-108146 Schizosaccharomyces pombe 24.41 3.00e-47 183.00
IUUC-Ssl-108663 Sclerotinia sclerotiorum 27.91 1.00e-77 283.00
IUUC-Smo-109585 Selaginella moellendorffii 29.63 1.00e-85 310.00
IUUC-Sit-110275 Setaria italica 28.56 2.00e-90 326.00
IUUC-Sly-111073 Solanum lycopersicum 29.44 3.00e-93 336.00
IUUC-Stu-112392 Solanum tuberosum 28.97 5.00e-09 53.50
IUUC-Sar-113718 Sorex araneus 33.16 7.00e-137 481.00
IUUC-Sbi-114080 Sorghum bicolor 28.81 5.00e-96 345.00
IUUC-Sre-115160 Sporisorium reilianum 26.61 3.00e-79 290.00
IUUC-Ssc-115997 Sus scrofa 34.01 1.00e-145 509.00
IUUC-Tgu-116904 Taeniopygia guttata 33.67 2.00e-140 492.00
IUUC-Tru-117946 Takifugu rubripes 34.08 3.00e-154 538.00
IUUC-Tni-119692 Tetraodon nigroviridis 33.73 1.00e-151 530.00
IUUC-Tca-121455 Theobroma cacao 28.92 2.00e-94 340.00
IUUC-Tre-122128 Trichoderma reesei 28.45 7.00e-74 271.00
IUUC-Tvi-122657 Trichoderma virens 27.52 6.00e-76 278.00
IUUC-Tae-125953 Triticum aestivum 28.06 2.00e-87 317.00
IUUC-Tur-126110 Triticum urartu 25.41 1.00e-62 233.00
IUUC-Tme-127173 Tuber melanosporum 29.29 3.00e-56 212.00
IUUC-Ttr-128420 Tursiops truncatus 35.03 3.00e-154 538.00
IUUC-Uma-129580 Ustilago maydis 26.98 1.00e-80 294.00
IUUC-Vda-129790 Verticillium dahliae 27.15 2.00e-73 270.00
IUUC-Vvi-131095 Vitis vinifera 27.66 3.00e-87 316.00
IUUC-Xtr-131906 Xenopus tropicalis 33.37 5.00e-150 524.00
IUUC-Xma-134197 Xiphophorus maculatus 32.67 9.00e-152 530.00
IUUC-Yli-134617 Yarrowia lipolytica 23.98 8.00e-54 204.00
IUUC-Zma-134979 Zea mays 26.84 2.00e-78 286.00
Created Date 25-Jun-2017

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