iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	11862484

Classification

Family	E-value	Score	Start	End
E2/UBC	2.60e-40	137.4	8	141
UBD/Alpha-Helix/UBA	3.90e-09	36.4	163	199

Active Site

Position(s)	Description	Evidence
92	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdpp...egisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWsp 94
           R+k+e+ke+++++     +i++++v++   te++ +i Gp+dtpYegg+F lei++pe+YPf+PPkv+f+t+i+hPn+++  G++Cl+ilk  ++W +
   Q: 8    RIKREFKEVMRSEEivqCSIKIELVND-SWTELRGEIAGPPDTPYEGGKFVLEIKVPETYPFNPPKVRFITRIWHPNISSVtGAICLDILK--DNWAA 102
           899999998776655447788888888.5***************************************************99********9..***** PP
   S: 95   alsvesvllsiqsllaepnpesplneeaaellkknreey 133
           a+++++vlls+q+lla ++p++p+++ +a ++k++   +
   Q: 103  AMTLRTVLLSLQALLAAAEPDDPQDAVVAYQFKDKYDLF 141
           ***************************999998876655 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLld 40
            +k++ l++MG+d++ea+  L  +n+nle A+e L++
   Q: 163  DSKIQRLRDMGIDEHEARAVLSKENWNLEKATEGLFS 199
           589********************************95 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins.

Protein Sequence
(Fasta)

MANMAVSRIK REFKEVMRSE EIVQCSIKIE LVNDSWTELR GEIAGPPDTP YEGGKFVLEI 60
KVPETYPFNP PKVRFITRIW HPNISSVTGA ICLDILKDNW AAAMTLRTVL LSLQALLAAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAAAAAA GAAATAGCGC TGGCAAAATA GACGTGCTGA GCGCTGTAAA AAGTCAGATT 60
CGTGTTGAAA TTGGAATAAT AAGTTTTTTA TTTTCCGTGC GCTGGTCGAG CTCGTTGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0070628--F:proteasome binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle

KEGG

dme:Dmel_CG8284

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	38.94	6.00e-31	126.00
IUUC-Aml-001286	Ailuropoda melanoleuca	68.34	1.00e-71	261.00
IUUC-Atr-003063	Amborella trichopoda	48.19	6.00e-40	155.00
IUUC-Apl-004122	Anas platyrhynchos	61.81	2.00e-62	231.00
IUUC-Aca-004565	Anolis carolinensis	62.96	4.00e-62	229.00
IUUC-Aly-006390	Arabidopsis lyrata	45.36	2.00e-42	164.00
IUUC-Ath-006637	Arabidopsis thaliana	43.78	1.00e-39	154.00
IUUC-Acl-008189	Aspergillus clavatus	41.27	4.00e-22	97.40
IUUC-Afl-008489	Aspergillus flavus	48.39	5.00e-24	103.00
IUUC-Afu-008850	Aspergillus fumigatus	41.58	1.00e-23	102.00
IUUC-Ang-009548	Aspergillus niger	45.16	6.00e-23	100.00
IUUC-Aor-010105	Aspergillus oryzae	48.39	5.00e-24	103.00
IUUC-Ame-011454	Astyanax mexicanus	67.84	2.00e-71	260.00
IUUC-Bta-012992	Bos taurus	68.34	1.00e-71	261.00
IUUC-Bci-013806	Botrytis cinerea	46.15	2.00e-31	128.00
IUUC-Bdi-015024	Brachypodium distachyon	50.52	3.00e-41	160.00
IUUC-Bol-015985	Brassica oleracea	44.62	2.00e-42	164.00
IUUC-Bra-016805	Brassica rapa	44.62	1.00e-42	164.00
IUUC-Cel-018353	Caenorhabditis elegans	53.27	1.00e-57	214.00
IUUC-Cja-019051	Callithrix jacchus	68.84	2.00e-72	263.00
IUUC-Cfa-020016	Canis familiaris	68.34	1.00e-71	261.00
IUUC-Cpo-022026	Cavia porcellus	68.34	1.00e-71	261.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	46.39	2.00e-37	147.00
IUUC-Csa-023059	Chlorocebus sabaeus	68.34	1.00e-71	261.00
IUUC-Cho-024276	Choloepus hoffmanni	64.38	7.00e-44	168.00
IUUC-Cin-025598	Ciona intestinalis	59.60	3.00e-53	200.00
IUUC-Csv-025831	Ciona savignyi	57.58	2.00e-49	187.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	40.38	1.00e-28	118.00
IUUC-Cne-027068	Cryptococcus neoformans	41.15	1.00e-37	148.00
IUUC-Dre-028139	Danio rerio	68.34	6.00e-72	262.00
IUUC-Dno-029169	Dasypus novemcinctus	63.92	6.00e-64	235.00
IUUC-Dor-030382	Dipodomys ordii	55.28	4.00e-51	193.00
IUUC-Dse-031335	Dothistroma septosporum	46.75	1.00e-32	132.00
IUUC-Ete-032868	Echinops telfairi	62.81	2.00e-53	201.00
IUUC-Eca-033428	Equus caballus	68.34	1.00e-71	261.00
IUUC-Fca-035366	Felis catus	68.34	1.00e-71	261.00
IUUC-Fal-037016	Ficedula albicollis	68.34	1.00e-71	261.00
IUUC-Gmo-039135	Gadus morhua	67.34	1.00e-70	258.00
IUUC-Gga-041018	Gallus gallus	68.34	1.00e-71	261.00
IUUC-Gac-041503	Gasterosteus aculeatus	67.34	5.00e-71	259.00
IUUC-Gma-042779	Glycine max	47.12	3.00e-42	163.00
IUUC-Ggo-045032	Gorilla gorilla	68.34	1.00e-71	261.00
IUUC-Hsa-046490	Homo sapiens	68.34	1.00e-71	261.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	68.34	1.00e-71	261.00
IUUC-Lch-050588	Latimeria chalumnae	55.88	2.00e-53	201.00
IUUC-Lpe-051070	Leersia perrieri	51.28	2.00e-35	140.00
IUUC-Loc-052549	Lepisosteus oculatus	68.34	9.00e-72	261.00
IUUC-Laf-053688	Loxodonta africana	62.56	6.00e-63	232.00
IUUC-Mcc-055606	Macaca mulatta	68.34	1.00e-71	261.00
IUUC-Mor-056946	Magnaporthe oryzae	40.24	1.00e-21	95.50
IUUC-Mtr-058002	Medicago truncatula	46.32	7.00e-42	162.00
IUUC-Mla-059007	Melampsora laricipopulina	42.79	3.00e-37	147.00
IUUC-Mga-059254	Meleagris gallopavo	68.79	2.00e-61	226.00
IUUC-Mvi-060346	Microbotryum violaceum	38.57	3.00e-32	130.00
IUUC-Mmr-061211	Microcebus murinus	68.34	1.00e-71	261.00
IUUC-Mdo-062458	Monodelphis domestica	68.34	7.00e-70	255.00
IUUC-Mmu-063648	Mus musculus	68.34	1.00e-71	261.00
IUUC-Mac-065447	Musa acuminata	47.96	5.00e-41	159.00
IUUC-Mpu-066407	Mustela putorius furo	68.34	7.00e-71	259.00
IUUC-Mlu-067682	Myotis lucifugus	62.94	1.00e-63	234.00
IUUC-Nfi-068517	Neosartorya fischeri	46.10	1.00e-23	102.00
IUUC-Ncr-068749	Neurospora crassa	42.04	6.00e-32	129.00
IUUC-Nle-069712	Nomascus leucogenys	68.79	3.00e-61	226.00
IUUC-Opr-070651	Ochotona princeps	68.34	1.00e-71	261.00
IUUC-Ont-071433	Oreochromis niloticus	69.35	7.00e-73	265.00
IUUC-Oan-073058	Ornithorhynchus anatinus	67.35	2.00e-48	183.00
IUUC-Ocu-074939	Oryctolagus cuniculus	68.34	1.00e-71	261.00
IUUC-Oba-075530	Oryza barthii	51.28	1.00e-34	138.00
IUUC-Obr-076838	Oryza brachyantha	51.28	4.00e-34	136.00
IUUC-Ogl-077606	Oryza glaberrima	51.28	1.00e-34	138.00
IUUC-Ogu-078238	Oryza glumaepatula	51.28	1.00e-34	138.00
IUUC-Oin-079643	Oryza indica	51.28	2.00e-34	137.00
IUUC-Ome-081274	Oryza meridionalis	51.28	1.00e-34	138.00
IUUC-Oni-082651	Oryza nivara	51.28	1.00e-34	138.00
IUUC-Opu-083933	Oryza punctata	50.77	3.00e-34	137.00
IUUC-Oru-085054	Oryza rufipogon	51.28	2.00e-34	137.00
IUUC-Osa-085716	Oryza sativa	51.28	2.00e-34	137.00
IUUC-Ola-087278	Oryzias latipes	69.85	2.00e-73	267.00
IUUC-Olu-087846	Ostreococcus lucimarinus	44.85	7.00e-40	155.00
IUUC-Oga-088897	Otolemur garnettii	64.74	7.00e-63	232.00
IUUC-Oar-089673	Ovis aries	61.93	3.00e-63	233.00
IUUC-Ptr-091295	Pan troglodytes	68.34	1.00e-71	261.00
IUUC-Pan-092034	Papio anubis	68.79	3.00e-61	227.00
IUUC-Psi-093498	Pelodiscus sinensis	68.34	1.00e-71	261.00
IUUC-Pma-094115	Petromyzon marinus	65.82	2.00e-67	246.00
IUUC-Ppa-095326	Physcomitrella patens	48.22	1.00e-41	161.00
IUUC-Pfo-096940	Poecilia formosa	69.35	7.00e-73	265.00
IUUC-Pab-098279	Pongo abelii	68.34	1.00e-71	261.00
IUUC-Pop-099543	Populus trichocarpa	47.42	3.00e-42	163.00
IUUC-Pca-100782	Procavia capensis	67.84	1.00e-69	254.00
IUUC-Ppe-101789	Prunus persica	48.21	3.00e-38	150.00
IUUC-Pva-102147	Pteropus vampyrus	52.00	6.00e-36	142.00
IUUC-Rno-104984	Rattus norvegicus	68.34	1.00e-71	261.00
IUUC-Sce-106394	Saccharomyces cerevisiae	52.35	6.00e-34	136.00
IUUC-Sha-106624	Sarcophilus harrisii	65.83	9.00e-69	251.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	43.59	9.00e-32	129.00
IUUC-Smo-109656	Selaginella moellendorffii	47.15	9.00e-40	155.00
IUUC-Sit-110639	Setaria italica	49.23	2.00e-40	157.00
IUUC-Sly-110978	Solanum lycopersicum	47.94	6.00e-45	172.00
IUUC-Stu-112088	Solanum tuberosum	47.94	9.00e-45	172.00
IUUC-Sar-113285	Sorex araneus	53.76	7.00e-41	159.00
IUUC-Sbi-113986	Sorghum bicolor	49.74	7.00e-41	159.00
IUUC-Sre-115046	Sporisorium reilianum	47.74	1.00e-35	142.00
IUUC-Ssc-116314	Sus scrofa	68.34	1.00e-71	261.00
IUUC-Tgu-117427	Taeniopygia guttata	68.79	2.00e-61	227.00
IUUC-Tru-118618	Takifugu rubripes	70.35	4.00e-73	266.00
IUUC-Tsy-119208	Tarsius syrichta	65.99	2.00e-68	250.00
IUUC-Tni-119667	Tetraodon nigroviridis	67.84	2.00e-71	260.00
IUUC-Tca-121446	Theobroma cacao	47.89	3.00e-43	167.00
IUUC-Tvi-122533	Trichoderma virens	44.30	4.00e-31	126.00
IUUC-Tae-125119	Triticum aestivum	51.28	7.00e-35	139.00
IUUC-Tme-127024	Tuber melanosporum	56.67	2.00e-34	138.00
IUUC-Tbe-127752	Tupaia belangeri	65.83	2.00e-67	247.00
IUUC-Ttr-128287	Tursiops truncatus	68.79	2.00e-61	227.00
IUUC-Vda-129947	Verticillium dahliae	44.52	1.00e-30	125.00
IUUC-Vpa-130481	Vicugna pacos	67.86	9.00e-70	254.00
IUUC-Vvi-131429	Vitis vinifera	45.64	8.00e-42	162.00
IUUC-Xtr-132710	Xenopus tropicalis	54.23	2.00e-58	217.00
IUUC-Xma-134308	Xiphophorus maculatus	68.84	2.00e-72	263.00
IUUC-Yli-134523	Yarrowia lipolytica	51.68	1.00e-34	138.00
IUUC-Zma-135733	Zea mays	47.83	2.00e-39	154.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence