iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	12529323

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	0.00071	18.0	190	207

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 2    EdeeLqlAlalSlqEeee 19
           +de+ + Al+lS++Eee 
   Q: 190  QDEDYETALQLSKEEEEL 207
           7***************95 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. Negatively regulated via phosphorylation.

Protein Sequence
(Fasta)

MSKQFVRSAK NLVKGYSSTQ VLVRNATSND NHQVSKDSLI ELAEKSYDSA DFFEIMDMLD 60
KRLNDKGKYW RHIAKALTVI DYLIRFGSEN CVLWCRENLY IIKTLKEFRH EDDEGIDQGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAAAC AATTTGTTAG ATCTGCGAAG AATTTGGTGA AAGGGTACTC TTCTACCCAG 60
GTCCTGGTAA GAAATGCAAC GTCAAACGAC AATCATCAAG TGTCCAAGGA CTCGTTAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-1017--Isopeptide bond
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
IPR003903--UIM_dom

PROSITE

PS50942--ENTH
PS50330--UIM

Pfam

PF01417--ENTH

SMART

SM00273--ENTH
SM00726--UIM

Gene Ontology

GO:0005769--C:early endosome
GO:0016020--C:membrane
GO:0030276--F:clathrin binding
GO:0008289--F:lipid binding
GO:0043130--F:ubiquitin binding
GO:0000147--P:actin cortical patch assembly
GO:0007015--P:actin filament organization
GO:0006897--P:endocytosis

KEGG

sce:YDL161W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Acl-008167	Aspergillus clavatus	59.70	4.00e-41	160.00
IUUC-Afl-008626	Aspergillus flavus	58.68	4.00e-36	143.00
IUUC-Afu-009110	Aspergillus fumigatus	59.70	2.00e-41	161.00
IUUC-Ani-009183	Aspergillus nidulans	58.96	8.00e-41	159.00
IUUC-Ang-009835	Aspergillus niger	59.70	3.00e-41	161.00
IUUC-Aor-009899	Aspergillus oryzae	59.70	5.00e-41	160.00
IUUC-Ate-010292	Aspergillus terreus	60.45	7.00e-42	162.00
IUUC-Bgr-012103	Blumeria graminis	46.88	2.00e-46	178.00
IUUC-Bci-013887	Botrytis cinerea	58.21	8.00e-41	159.00
IUUC-Cel-018350	Caenorhabditis elegans	48.18	9.00e-33	132.00
IUUC-Csa-023789	Chlorocebus sabaeus	50.70	1.00e-37	149.00
IUUC-Fso-038083	Fusarium solani	40.95	4.00e-39	153.00
IUUC-Ggr-039910	Gaeumannomyces graminis	43.78	3.00e-44	171.00
IUUC-Kpa-049233	Komagataella pastoris	45.88	6.00e-55	206.00
IUUC-Mla-058947	Melampsora laricipopulina	46.09	6.00e-46	176.00
IUUC-Nfi-068548	Neosartorya fischeri	59.70	2.00e-41	162.00
IUUC-Ncr-068627	Neurospora crassa	44.44	3.00e-40	157.00
IUUC-Pgr-103451	Puccinia graminis	45.13	1.00e-42	164.00
IUUC-Ptt-103708	Puccinia triticina	44.60	2.00e-40	157.00
IUUC-Pyt-104596	Pyrenophora triticirepentis	55.22	3.00e-39	155.00
IUUC-Sja-107671	Schizosaccharomyces japonicus	56.74	5.00e-45	173.00
IUUC-Spo-108319	Schizosaccharomyces pombe	53.24	6.00e-43	167.00
IUUC-Ssl-108625	Sclerotinia sclerotiorum	45.58	3.00e-42	164.00
IUUC-Tre-122134	Trichoderma reesei	45.61	3.00e-44	170.00
IUUC-Tvi-122308	Trichoderma virens	44.49	3.00e-44	171.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence