iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Dme-031668

UUCD1 version

UUC-DrM-00591

Ensembl Protein ID

FBpp0078664

UniProt Accession

Q9V3H2; Q9NIU3; PSDE_DROME

Genbank Protein ID

AAF08394.1; AAF52215.1; AAL48599.1; AAF27818.1

Protein Name

26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory complex subunit p37B; 26S proteasome regulatory subunit rpn11; Yippee-interacting protein 5

Genbank Nucleotide ID

AF145313; AE014134; AY070977; AF195189

Gene Name

Rpn11; yip5; CG18174

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0028694	FBtr0079027	FBpp0078664

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/JAMM	5.20e-08	32.7	111	124

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/JAMM

   S: 1    HSHPgftcwlSsVD 14
           HSHPgf+cwlS+VD
   Q: 111  HSHPGFGCWLSGVD 124
           *************9 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).

Protein Sequence
(Fasta)

MDRLLRLGGA MPQAAPPTDA PVVDTAEQVY ISSLALLKML KHGRAGVPME VMGLMLGEFV 60
DDYTVQVIDV FAMPQTGTGV SVEAVDPVFQ AKMLDMLKQT GRPEMVVGWY HSHPGFGCWL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATACAACCCT GTTGCGAGTA TTACTTGCAA TTCTGCAAAA TCAAACGAGA CGGCTTTGTG 60
TTTTTTGTTG CTGCTTTCGA CGAGGAACGT AAATTACACG TAAAACAGTA GGAAATAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0005875--C:microtubule associated complex
GO:0000502--C:proteasome complex
GO:0005838--C:proteasome regulatory particle
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination

KEGG

dme:Dmel_CG18174

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000544	Aegilops tauschii	75.97	6.00e-133	465.00
IUUC-Aml-001416	Ailuropoda melanoleuca	89.69	4.00e-159	552.00
IUUC-Atr-002629	Amborella trichopoda	77.27	1.00e-129	454.00
IUUC-Apl-004046	Anas platyrhynchos	89.46	1.00e-160	558.00
IUUC-Aca-005228	Anolis carolinensis	89.69	1.00e-159	554.00
IUUC-Aly-005457	Arabidopsis lyrata	76.77	3.00e-134	470.00
IUUC-Ath-007290	Arabidopsis thaliana	76.77	2.00e-134	470.00
IUUC-Ago-007866	Ashbya gossypii	63.58	7.00e-114	402.00
IUUC-Acl-008338	Aspergillus clavatus	67.45	3.00e-106	377.00
IUUC-Afl-008431	Aspergillus flavus	68.53	4.00e-120	423.00
IUUC-Afu-008909	Aspergillus fumigatus	68.18	9.00e-115	405.00
IUUC-Ani-009174	Aspergillus nidulans	66.34	4.00e-123	433.00
IUUC-Ang-009854	Aspergillus niger	65.15	2.00e-119	421.00
IUUC-Aor-009942	Aspergillus oryzae	68.53	9.00e-120	422.00
IUUC-Ate-010377	Aspergillus terreus	65.18	1.00e-119	422.00
IUUC-Ame-011628	Astyanax mexicanus	90.46	1.00e-143	501.00
IUUC-Bgr-012263	Blumeria graminis	64.19	1.00e-108	385.00
IUUC-Bta-012375	Bos taurus	89.69	4.00e-159	552.00
IUUC-Bci-013850	Botrytis cinerea	70.28	2.00e-112	397.00
IUUC-Bdi-014488	Brachypodium distachyon	76.87	7.00e-130	455.00
IUUC-Bol-016172	Brassica oleracea	76.77	2.00e-134	470.00
IUUC-Bra-017926	Brassica rapa	76.77	2.00e-134	470.00
IUUC-Cel-018247	Caenorhabditis elegans	77.24	4.00e-134	469.00
IUUC-Cja-019210	Callithrix jacchus	89.46	3.00e-160	556.00
IUUC-Cfa-020926	Canis familiaris	88.28	2.00e-154	537.00
IUUC-Cpo-021572	Cavia porcellus	89.69	4.00e-159	552.00
IUUC-Cre-022925	Chlamydomonas reinhardtii	74.49	9.00e-130	455.00
IUUC-Csa-023496	Chlorocebus sabaeus	89.69	4.00e-159	552.00
IUUC-Cho-024525	Choloepus hoffmanni	83.67	3.00e-147	513.00
IUUC-Cin-025492	Ciona intestinalis	89.12	3.00e-160	556.00
IUUC-Cgl-026493	Colletotrichum gloeosporioides	66.44	6.00e-102	362.00
IUUC-Cne-026785	Cryptococcus neoformans	69.06	1.00e-118	418.00
IUUC-Cme-027105	Cyanidioschyzon merolae	58.78	1.00e-99	355.00
IUUC-Dre-028788	Danio rerio	89.42	2.00e-160	556.00
IUUC-Dno-029058	Dasypus novemcinctus	89.46	2.00e-160	556.00
IUUC-Dor-031015	Dipodomys ordii	80.61	6.00e-139	485.00
IUUC-Dse-031242	Dothistroma septosporum	69.82	1.00e-121	428.00
IUUC-Ete-033146	Echinops telfairi	81.68	3.00e-127	446.00
IUUC-Eca-033734	Equus caballus	89.69	4.00e-159	552.00
IUUC-Eeu-035168	Erinaceus europaeus	67.23	6.00e-87	312.00
IUUC-Fca-036426	Felis catus	89.69	4.00e-159	552.00
IUUC-Fal-036954	Ficedula albicollis	89.69	1.00e-159	554.00
IUUC-Fox-037838	Fusarium oxysporum	68.38	4.00e-120	423.00
IUUC-Fso-038374	Fusarium solani	68.38	4.00e-121	426.00
IUUC-Gmo-038918	Gadus morhua	89.35	1.00e-159	554.00
IUUC-Ggr-039954	Gaeumannomyces graminis	67.57	5.00e-121	426.00
IUUC-Gga-040377	Gallus gallus	89.69	1.00e-159	554.00
IUUC-Gac-042386	Gasterosteus aculeatus	87.74	8.00e-165	571.00
IUUC-Gma-042811	Glycine max	79.45	4.00e-133	466.00
IUUC-Ggo-044916	Gorilla gorilla	88.04	5.00e-161	559.00
IUUC-Hsa-045865	Homo sapiens	89.69	4.00e-159	552.00
IUUC-Hvu-047188	Hordeum vulgare	76.30	6.00e-134	469.00
IUUC-Itr-048154	Ictidomys tridecemlineatus	93.75	3.00e-97	346.00
IUUC-Kpa-049128	Komagataella pastoris	72.08	5.00e-114	402.00
IUUC-Lch-050167	Latimeria chalumnae	83.45	7.00e-148	515.00
IUUC-Lpe-051086	Leersia perrieri	77.20	1.00e-135	474.00
IUUC-Loc-052888	Lepisosteus oculatus	89.35	4.00e-159	553.00
IUUC-Lma-052962	Leptosphaeria maculans	64.29	1.00e-119	421.00
IUUC-Laf-053949	Loxodonta africana	89.69	4.00e-159	552.00
IUUC-Mcc-055279	Macaca mulatta	88.11	1.00e-152	531.00
IUUC-Meu-055956	Macropus eugenii	81.29	3.00e-142	496.00
IUUC-Mor-057166	Magnaporthe oryzae	67.79	1.00e-112	398.00
IUUC-Mpo-057344	Magnaporthe poae	67.10	8.00e-122	429.00
IUUC-Mtr-057857	Medicago truncatula	79.79	5.00e-134	469.00
IUUC-Mla-058938	Melampsora laricipopulina	72.88	1.00e-132	464.00
IUUC-Mga-060093	Meleagris gallopavo	89.69	1.00e-159	554.00
IUUC-Mvi-060565	Microbotryum violaceum	71.03	3.00e-127	447.00
IUUC-Mmr-060899	Microcebus murinus	89.64	2.00e-152	530.00
IUUC-Mdo-062175	Monodelphis domestica	89.69	8.00e-160	555.00
IUUC-Mmu-063416	Mus musculus	89.69	4.00e-159	552.00
IUUC-Mac-065642	Musa acuminata	76.95	1.00e-133	468.00
IUUC-Mpu-065946	Mustela putorius furo	89.69	4.00e-159	552.00
IUUC-Mlu-067835	Myotis lucifugus	88.04	8.00e-161	558.00
IUUC-Nfi-068279	Neosartorya fischeri	68.18	8.00e-115	405.00
IUUC-Ncr-068821	Neurospora crassa	68.79	5.00e-110	389.00
IUUC-Nle-069212	Nomascus leucogenys	89.69	4.00e-159	552.00
IUUC-Opr-070928	Ochotona princeps	58.92	4.00e-74	270.00
IUUC-Ont-072135	Oreochromis niloticus	89.35	4.00e-159	553.00
IUUC-Oan-072755	Ornithorhynchus anatinus	89.69	8.00e-160	555.00
IUUC-Ocu-074433	Oryctolagus cuniculus	91.32	6.00e-147	512.00
IUUC-Oba-075678	Oryza barthii	77.20	5.00e-136	476.00
IUUC-Obr-076756	Oryza brachyantha	77.20	1.00e-135	474.00
IUUC-Ogl-077831	Oryza glaberrima	76.87	2.00e-129	454.00
IUUC-Ogu-078941	Oryza glumaepatula	77.20	5.00e-136	476.00
IUUC-Oin-080184	Oryza indica	77.20	5.00e-136	476.00
IUUC-Olo-080580	Oryza longistaminata	80.07	1.00e-127	448.00
IUUC-Ome-081739	Oryza meridionalis	74.68	5.00e-127	446.00
IUUC-Oni-082063	Oryza nivara	77.20	5.00e-136	476.00
IUUC-Opu-083207	Oryza punctata	77.20	1.00e-135	474.00
IUUC-Oru-085034	Oryza rufipogon	77.20	5.00e-136	476.00
IUUC-Osa-085486	Oryza sativa	77.20	5.00e-136	476.00
IUUC-Ola-087317	Oryzias latipes	89.35	4.00e-159	553.00
IUUC-Olu-087889	Ostreococcus lucimarinus	71.34	7.00e-131	459.00
IUUC-Oga-088032	Otolemur garnettii	89.46	2.00e-160	556.00
IUUC-Oar-090237	Ovis aries	86.97	9.00e-161	558.00
IUUC-Ptr-090881	Pan troglodytes	89.69	4.00e-159	552.00
IUUC-Pan-092658	Papio anubis	88.04	1.00e-160	557.00
IUUC-Psi-093672	Pelodiscus sinensis	89.69	8.00e-160	555.00
IUUC-Pma-094213	Petromyzon marinus	90.78	2.00e-162	563.00
IUUC-Pno-095038	Phaeosphaeria nodorum	64.61	1.00e-119	421.00
IUUC-Ppa-095467	Physcomitrella patens	80.82	1.00e-135	474.00
IUUC-Pfo-096322	Poecilia formosa	89.35	4.00e-159	553.00
IUUC-Pab-098484	Pongo abelii	89.69	4.00e-159	552.00
IUUC-Pop-099564	Populus trichocarpa	79.45	5.00e-133	466.00
IUUC-Pca-100785	Procavia capensis	84.35	9.00e-131	458.00
IUUC-Ppe-101727	Prunus persica	76.05	1.00e-132	464.00
IUUC-Pva-102569	Pteropus vampyrus	89.15	2.00e-160	557.00
IUUC-Pgr-103351	Puccinia graminis	70.86	1.00e-130	458.00
IUUC-Ptt-103763	Puccinia triticina	66.56	6.00e-118	416.00
IUUC-Pte-104088	Pyrenophora teres	64.94	6.00e-120	422.00
IUUC-Pyt-104597	Pyrenophora triticirepentis	67.92	2.00e-110	390.00
IUUC-Rno-105115	Rattus norvegicus	89.69	4.00e-159	552.00
IUUC-Sce-106353	Saccharomyces cerevisiae	64.29	9.00e-113	398.00
IUUC-Sha-107476	Sarcophilus harrisii	89.69	8.00e-160	555.00
IUUC-Sja-107807	Schizosaccharomyces japonicus	67.74	4.00e-125	439.00
IUUC-Spo-108255	Schizosaccharomyces pombe	67.86	2.00e-116	410.00
IUUC-Ssl-108392	Sclerotinia sclerotiorum	67.10	4.00e-113	400.00
IUUC-Smo-108824	Selaginella moellendorffii	79.11	4.00e-144	503.00
IUUC-Sit-110287	Setaria italica	77.20	9.00e-136	475.00
IUUC-Sly-111656	Solanum lycopersicum	78.77	1.00e-132	464.00
IUUC-Stu-112827	Solanum tuberosum	78.77	2.00e-132	464.00
IUUC-Sar-112979	Sorex araneus	76.53	2.00e-130	457.00
IUUC-Sbi-113841	Sorghum bicolor	77.20	1.00e-135	474.00
IUUC-Sre-114930	Sporisorium reilianum	76.34	8.00e-131	458.00
IUUC-Ssc-116058	Sus scrofa	86.13	6.00e-161	558.00
IUUC-Tgu-116499	Taeniopygia guttata	89.69	1.00e-159	554.00
IUUC-Tru-117576	Takifugu rubripes	89.35	4.00e-159	553.00
IUUC-Tsy-119371	Tarsius syrichta	81.63	1.00e-141	494.00
IUUC-Tni-120868	Tetraodon nigroviridis	89.00	7.00e-157	545.00
IUUC-Tca-121292	Theobroma cacao	76.38	5.00e-133	466.00
IUUC-Tre-122183	Trichoderma reesei	68.28	5.00e-116	409.00
IUUC-Tvi-122566	Trichoderma virens	68.28	4.00e-116	409.00
IUUC-Tae-125156	Triticum aestivum	76.30	1.00e-133	468.00
IUUC-Tur-126034	Triticum urartu	80.07	3.00e-128	449.00
IUUC-Tme-126903	Tuber melanosporum	68.51	3.00e-124	437.00
IUUC-Tbe-127525	Tupaia belangeri	80.37	6.00e-130	455.00
IUUC-Ttr-129072	Tursiops truncatus	89.46	1.00e-160	557.00
IUUC-Uma-129471	Ustilago maydis	76.34	3.00e-131	459.00
IUUC-Vda-129956	Verticillium dahliae	69.12	1.00e-111	395.00
IUUC-Vpa-130490	Vicugna pacos	89.46	1.00e-160	557.00
IUUC-Vvi-131302	Vitis vinifera	76.38	5.00e-133	466.00
IUUC-Xtr-132059	Xenopus tropicalis	89.35	4.00e-159	552.00
IUUC-Xma-133101	Xiphophorus maculatus	89.35	4.00e-159	553.00
IUUC-Yli-134638	Yarrowia lipolytica	68.55	4.00e-118	416.00
IUUC-Zma-135910	Zea mays	77.20	1.00e-135	474.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence