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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-031791
UUCD1 version UUC-DrM-00115
Ensembl Protein ID FBpp0080048
UniProt Accession O62621; Q3KN33; Q8MRM3; Q9VJZ0; COPB2_DROME
Genbank Protein ID CAA07084.1; CAA07085.1; AAF53294.2; ABA81840.1; AAM50181.1
Protein Name Coatomer subunit beta'; Beta'-coat protein
Genbank Nucleotide ID AJ006523; AJ006524; AE014134; BT023906; AY119527
Gene Name beta'COP; CG6699
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0025724 FBtr0080469 FBpp0080048
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINA
Post-translational Modifications (PTMs)
CPLMdbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-31 107.6 183 224
UBD/Beta-Prp 2.40e-65 220.7 13 289
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+ +v+c+++    d ++l+sG+dD  +k+WD+   +++++
   Q: 183  GHEKGVNCVDYyhgGDkPYLISGADDRLVKIWDYQNKTCVQT 224
           8*********99*9778****************999988875 PP
   

   UBD/Beta-Prp
   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsps 105
           +++++++cv+ +p +++++ + ++g + + +++++++++ ++ ++ +v++ +f  ++++++tgs+D+ i+v++++t + vh++++h+d++++++++p+
   Q: 13   SRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFVARKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPT 110
           56899********************************************************************************************* PP
   S: 106  gdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng..kelvsgsl 200
           +  +++ s+d  i++w++e+ +  + +++gh++ v+ +v++p++ n ++s+slDrtv++W+l +++   tl+g h++ v+++++ + g  ++l+sg++
   Q: 111  QPLVLTSSDDMLIKLWNWEKMWACQRVFEGHTHYVMQIVFNPKDnNTFASASLDRTVKVWQLGSNFANFTLEG-HEKGVNCVDYYHGGdkPYLISGAD 207
           ************************99**********************************************9.*********9988888******** PP
   S: 201  dgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvl 282
           d+ vk+wd+q+++cv+tl+gh +n++ v f+p+  ++++gs+Dg++riW + +  l ++l++  ++v+ ++ ++ ++nv + 
   Q: 208  DRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGTYRLETCLNYGFERVWTISSMRGTNNVALG 289
           ***********************************************************************97777776543 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Protein Sequence
(Fasta)
MPLKLDIKRR LTSRSDRVKC VDLHPAEPWM LCALYNGHVH IMNYENQQMV KDFEVCDVPV 60
RSARFVARKN WILTGSDDMQ IRVFNYNTLE KVHSFEAHSD YLRCIAVHPT QPLVLTSSDD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031791|E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTGACACA TTAACGAAGC GAAGAAGAAG AGCAGCGGAG GCAGCAAAAG AGTTTTTTTG 60
GTCTCGCCGC AATTAATTAG TGTTTTCGCA GACAGCCATA GTTGGCCCAA ACCGTGGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031791|E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04053--Coatomer_WDAD
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005795--C:Golgi stack
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0010883--P:regulation of lipid storage
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
KEGG dme:Dmel_CG6699
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000222 Aegilops tauschii 57.59 0.00e+00 736.00
IUUC-Aml-002154 Ailuropoda melanoleuca 67.40 0.00e+00 1320.00
IUUC-Atr-003090 Amborella trichopoda 53.68 0.00e+00 976.00
IUUC-Apl-003976 Anas platyrhynchos 69.08 0.00e+00 1309.00
IUUC-Aca-004301 Anolis carolinensis 70.71 0.00e+00 1308.00
IUUC-Aly-005853 Arabidopsis lyrata 55.70 0.00e+00 1008.00
IUUC-Ath-007635 Arabidopsis thaliana 56.31 0.00e+00 997.00
IUUC-Ago-007914 Ashbya gossypii 45.66 0.00e+00 731.00
IUUC-Acl-008237 Aspergillus clavatus 52.93 0.00e+00 917.00
IUUC-Afl-008535 Aspergillus flavus 54.03 0.00e+00 877.00
IUUC-Afu-008845 Aspergillus fumigatus 53.06 0.00e+00 903.00
IUUC-Ani-009135 Aspergillus nidulans 54.24 0.00e+00 896.00
IUUC-Ang-009654 Aspergillus niger 55.96 0.00e+00 825.00
IUUC-Aor-009939 Aspergillus oryzae 53.17 0.00e+00 927.00
IUUC-Ate-010355 Aspergillus terreus 52.98 0.00e+00 889.00
IUUC-Ame-010922 Astyanax mexicanus 64.14 0.00e+00 1133.00
IUUC-Bgr-012249 Blumeria graminis 53.62 0.00e+00 907.00
IUUC-Bta-013579 Bos taurus 72.31 0.00e+00 1142.00
IUUC-Bci-013866 Botrytis cinerea 53.66 0.00e+00 893.00
IUUC-Bdi-015046 Brachypodium distachyon 56.99 0.00e+00 1023.00
IUUC-Bol-015731 Brassica oleracea 56.05 0.00e+00 1020.00
IUUC-Bra-017758 Brassica rapa 56.17 0.00e+00 1017.00
IUUC-Cel-018387 Caenorhabditis elegans 60.92 0.00e+00 1115.00
IUUC-Cja-019145 Callithrix jacchus 67.98 0.00e+00 1319.00
IUUC-Cfa-020564 Canis familiaris 69.61 0.00e+00 1312.00
IUUC-Cpo-022201 Cavia porcellus 69.35 0.00e+00 1308.00
IUUC-Cre-022938 Chlamydomonas reinhardtii 54.92 0.00e+00 936.00
IUUC-Csa-023383 Chlorocebus sabaeus 75.04 0.00e+00 954.00
IUUC-Cho-024454 Choloepus hoffmanni 67.66 0.00e+00 1083.00
IUUC-Cin-025681 Ciona intestinalis 65.86 0.00e+00 1200.00
IUUC-Csv-026012 Ciona savignyi 65.42 0.00e+00 1181.00
IUUC-Cgl-026649 Colletotrichum gloeosporioides 49.63 0.00e+00 792.00
IUUC-Cne-026986 Cryptococcus neoformans 50.42 0.00e+00 883.00
IUUC-Cme-027219 Cyanidioschyzon merolae 45.55 0.00e+00 834.00
IUUC-Dre-027846 Danio rerio 70.70 0.00e+00 1301.00
IUUC-Dor-030462 Dipodomys ordii 69.72 0.00e+00 1008.00
IUUC-Dse-031268 Dothistroma septosporum 52.75 0.00e+00 908.00
IUUC-Ete-033166 Echinops telfairi 67.50 0.00e+00 816.00
IUUC-Eca-034180 Equus caballus 68.12 0.00e+00 1265.00
IUUC-Eeu-035086 Erinaceus europaeus 52.92 2.00e-163 569.00
IUUC-Fca-036265 Felis catus 67.98 0.00e+00 1324.00
IUUC-Fal-037202 Ficedula albicollis 68.85 0.00e+00 1262.00
IUUC-Fox-037711 Fusarium oxysporum 54.23 0.00e+00 848.00
IUUC-Fso-038268 Fusarium solani 53.27 0.00e+00 842.00
IUUC-Gmo-039046 Gadus morhua 69.99 0.00e+00 1286.00
IUUC-Ggr-039863 Gaeumannomyces graminis 54.79 0.00e+00 886.00
IUUC-Gga-041112 Gallus gallus 69.09 0.00e+00 1317.00
IUUC-Gac-041733 Gasterosteus aculeatus 70.87 0.00e+00 1266.00
IUUC-Gma-042910 Glycine max 57.28 0.00e+00 1030.00
IUUC-Ggo-044984 Gorilla gorilla 67.43 0.00e+00 1317.00
IUUC-Hsa-046698 Homo sapiens 68.09 0.00e+00 1317.00
IUUC-Hvu-047669 Hordeum vulgare 67.32 5.00e-160 555.00
IUUC-Itr-048212 Ictidomys tridecemlineatus 67.03 0.00e+00 1306.00
IUUC-Kpa-049265 Komagataella pastoris 46.97 0.00e+00 828.00
IUUC-Lch-050473 Latimeria chalumnae 67.21 0.00e+00 1324.00
IUUC-Lpe-051579 Leersia perrieri 57.11 0.00e+00 1012.00
IUUC-Loc-052675 Lepisosteus oculatus 71.11 0.00e+00 1310.00
IUUC-Lma-053218 Leptosphaeria maculans 51.59 0.00e+00 879.00
IUUC-Laf-053757 Loxodonta africana 67.58 0.00e+00 1308.00
IUUC-Mcc-054859 Macaca mulatta 67.54 0.00e+00 1318.00
IUUC-Meu-056174 Macropus eugenii 61.73 3.00e-139 488.00
IUUC-Mor-057264 Magnaporthe oryzae 56.00 0.00e+00 861.00
IUUC-Mpo-057538 Magnaporthe poae 54.42 0.00e+00 893.00
IUUC-Mtr-058310 Medicago truncatula 57.28 0.00e+00 1029.00
IUUC-Mla-058937 Melampsora laricipopulina 50.88 0.00e+00 855.00
IUUC-Mga-059875 Meleagris gallopavo 68.82 0.00e+00 1311.00
IUUC-Mvi-060240 Microbotryum violaceum 52.55 0.00e+00 889.00
IUUC-Mmr-061261 Microcebus murinus 67.87 0.00e+00 1322.00
IUUC-Mdo-062076 Monodelphis domestica 68.90 0.00e+00 1313.00
IUUC-Mmu-063324 Mus musculus 67.80 0.00e+00 1324.00
IUUC-Mac-064636 Musa acuminata 56.30 0.00e+00 1003.00
IUUC-Mpu-065961 Mustela putorius furo 67.76 0.00e+00 1321.00
IUUC-Mlu-067059 Myotis lucifugus 68.74 0.00e+00 1276.00
IUUC-Nfi-068277 Neosartorya fischeri 53.01 0.00e+00 894.00
IUUC-Ncr-068659 Neurospora crassa 53.00 0.00e+00 904.00
IUUC-Nle-069034 Nomascus leucogenys 67.54 0.00e+00 1317.00
IUUC-Opr-070334 Ochotona princeps 72.69 0.00e+00 1176.00
IUUC-Ont-071563 Oreochromis niloticus 70.94 0.00e+00 1298.00
IUUC-Oan-073416 Ornithorhynchus anatinus 70.65 0.00e+00 1243.00
IUUC-Ocu-074522 Oryctolagus cuniculus 67.32 0.00e+00 1313.00
IUUC-Oba-075760 Oryza barthii 56.07 0.00e+00 1006.00
IUUC-Obr-076201 Oryza brachyantha 56.33 0.00e+00 1018.00
IUUC-Ogl-077450 Oryza glaberrima 56.92 0.00e+00 1030.00
IUUC-Ogu-078994 Oryza glumaepatula 56.07 0.00e+00 1005.00
IUUC-Oin-079856 Oryza indica 56.67 0.00e+00 998.00
IUUC-Olo-080731 Oryza longistaminata 55.58 0.00e+00 990.00
IUUC-Ome-081762 Oryza meridionalis 52.31 0.00e+00 926.00
IUUC-Oni-082324 Oryza nivara 56.07 0.00e+00 1004.00
IUUC-Opu-083400 Oryza punctata 53.79 0.00e+00 989.00
IUUC-Oru-084829 Oryza rufipogon 56.07 0.00e+00 1005.00
IUUC-Osa-086026 Oryza sativa 57.04 0.00e+00 1033.00
IUUC-Ola-087245 Oryzias latipes 70.19 0.00e+00 1290.00
IUUC-Olu-087655 Ostreococcus lucimarinus 55.20 0.00e+00 999.00
IUUC-Oga-088163 Otolemur garnettii 65.14 0.00e+00 1258.00
IUUC-Oar-089842 Ovis aries 69.61 0.00e+00 1313.00
IUUC-Ptr-090501 Pan troglodytes 67.54 0.00e+00 1318.00
IUUC-Pan-092011 Papio anubis 67.36 0.00e+00 1320.00
IUUC-Psi-093308 Pelodiscus sinensis 71.67 0.00e+00 1317.00
IUUC-Pma-094695 Petromyzon marinus 66.04 0.00e+00 1174.00
IUUC-Pno-094785 Phaeosphaeria nodorum 56.51 1.00e-103 369.00
IUUC-Ppa-095911 Physcomitrella patens 58.43 0.00e+00 1050.00
IUUC-Pfo-096587 Poecilia formosa 70.82 0.00e+00 1301.00
IUUC-Pab-097926 Pongo abelii 66.52 0.00e+00 1240.00
IUUC-Pop-099634 Populus trichocarpa 57.16 0.00e+00 1026.00
IUUC-Pca-100965 Procavia capensis 66.78 0.00e+00 1276.00
IUUC-Ppe-101470 Prunus persica 56.57 0.00e+00 1019.00
IUUC-Pva-102451 Pteropus vampyrus 70.01 0.00e+00 1015.00
IUUC-Pgr-103453 Puccinia graminis 51.41 0.00e+00 884.00
IUUC-Ptt-103868 Puccinia triticina 51.02 0.00e+00 884.00
IUUC-Pte-104274 Pyrenophora teres 52.01 0.00e+00 906.00
IUUC-Pyt-104794 Pyrenophora triticirepentis 51.85 0.00e+00 862.00
IUUC-Rno-105979 Rattus norvegicus 63.33 0.00e+00 976.00
IUUC-Sce-106269 Saccharomyces cerevisiae 45.09 0.00e+00 744.00
IUUC-Sha-106905 Sarcophilus harrisii 71.07 0.00e+00 1311.00
IUUC-Sja-107838 Schizosaccharomyces japonicus 46.09 0.00e+00 786.00
IUUC-Spo-108299 Schizosaccharomyces pombe 43.99 0.00e+00 778.00
IUUC-Smo-108695 Selaginella moellendorffii 56.11 0.00e+00 1004.00
IUUC-Sit-110239 Setaria italica 57.40 0.00e+00 1034.00
IUUC-Sly-111525 Solanum lycopersicum 57.11 0.00e+00 1030.00
IUUC-Stu-112906 Solanum tuberosum 56.44 0.00e+00 920.00
IUUC-Sar-113472 Sorex araneus 69.47 0.00e+00 931.00
IUUC-Sbi-114052 Sorghum bicolor 57.90 0.00e+00 1026.00
IUUC-Sre-115040 Sporisorium reilianum 51.06 0.00e+00 877.00
IUUC-Ssc-115593 Sus scrofa 67.65 0.00e+00 1314.00
IUUC-Tgu-117239 Taeniopygia guttata 69.28 0.00e+00 1315.00
IUUC-Tru-118025 Takifugu rubripes 70.90 0.00e+00 1299.00
IUUC-Tsy-118824 Tarsius syrichta 69.52 0.00e+00 945.00
IUUC-Tni-120142 Tetraodon nigroviridis 70.95 0.00e+00 1293.00
IUUC-Tca-121613 Theobroma cacao 57.04 0.00e+00 1026.00
IUUC-Tre-122072 Trichoderma reesei 53.38 0.00e+00 897.00
IUUC-Tvi-122546 Trichoderma virens 53.14 0.00e+00 879.00
IUUC-Tae-125395 Triticum aestivum 56.80 0.00e+00 1020.00
IUUC-Tur-126283 Triticum urartu 49.71 0.00e+00 866.00
IUUC-Tme-127041 Tuber melanosporum 52.70 0.00e+00 922.00
IUUC-Tbe-127770 Tupaia belangeri 71.62 0.00e+00 1031.00
IUUC-Ttr-129294 Tursiops truncatus 67.65 0.00e+00 1313.00
IUUC-Uma-129351 Ustilago maydis 49.45 0.00e+00 880.00
IUUC-Vda-129716 Verticillium dahliae 52.62 0.00e+00 910.00
IUUC-Vpa-130037 Vicugna pacos 54.81 6.00e-172 597.00
IUUC-Vvi-131689 Vitis vinifera 56.62 0.00e+00 1013.00
IUUC-Xtr-132633 Xenopus tropicalis 68.82 0.00e+00 1308.00
IUUC-Xma-133347 Xiphophorus maculatus 70.82 0.00e+00 1301.00
IUUC-Yli-134455 Yarrowia lipolytica 48.35 0.00e+00 789.00
IUUC-Zma-135789 Zea mays 57.04 0.00e+00 1029.00
Created Date 25-Jun-2017

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