iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Cel-018448

UUCD1 version

UUC-CaE-00689

Ensembl Protein ID

F29B9.6

UniProt Accession

Q95017; Q9GYI5; UBC9_CAEEL

Genbank Protein ID

AAC97374.1; CCD70229.1

Protein Name

SUMO-conjugating enzyme UBC9; RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin-conjugating enzyme E2 9; Ubiquitin-protein ligase 9

Genbank Nucleotide ID

AF106565; FO081255

Gene Name

ubc-9; F29B9.6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00006706	F29B9.6	F29B9.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	5.00e-46	156.2	8	149

Active Site

Position(s)	Description	Evidence
93	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvdesd....ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           Rl++e k+++kd+p g+ akpv+++d    l++we++i G +dt++egg++++++ f++d+P++PPk+kf+ ++fhPnvy++G+vCls+l+e+++W+p +s+
   Q: 8    RLAEERKHWRKDHPFGFIAKPVKNADgtlnLFNWECAIPGRKDTIWEGGLYRIRMLFKDDFPSTPPKCKFEPPLFHPNVYPSGTVCLSLLDENKDWKPSISI 109
           89**********************989988************************************************************************ PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++ l++iq ll++pn+e+p+++ea++++++nr+ey+k+v+
   Q: 110  KQLLIGIQDLLNHPNIEDPAQAEAYQIYCQNRAEYEKRVK 149
           **************************************98 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates.

Protein Sequence
(Fasta)

MSGIAAGRLA EERKHWRKDH PFGFIAKPVK NADGTLNLFN WECAIPGRKD TIWEGGLYRI 60
RMLFKDDFPS TPPKCKFEPP LFHPNVYPSG TVCLSLLDEN KDWKPSISIK QLLIGIQDLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTAACCGAA CAAAAATGTC GGGAATTGCT GCAGGACGCC TCGCGGAAGA AAGGAAACAC 60
TGGCGAAAGG TGAGAATTTT ATCATTACAT GGCAAGTCGG GGCGATTTGT ATTACAAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR027230--Ubc9
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005635--C:nuclear envelope
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0032093--F:SAM domain binding
GO:0061656--F:SUMO conjugating enzyme activity
GO:0019789--F:SUMO transferase activity
GO:0009952--P:anterior/posterior pattern specification
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0002119--P:nematode larval development
GO:0043282--P:pharyngeal muscle development
GO:0016925--P:protein sumoylation
GO:1903827--P:regulation of cellular protein localization

KEGG

cel:CELE_F29B9.6

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000510	Aegilops tauschii	55.14	9.00e-36	141.00
IUUC-Aml-002383	Ailuropoda melanoleuca	76.92	3.00e-75	272.00
IUUC-Atr-002982	Amborella trichopoda	58.44	6.00e-46	174.00
IUUC-Apl-003840	Anas platyrhynchos	76.92	2.00e-75	272.00
IUUC-Aca-004772	Anolis carolinensis	76.92	3.00e-75	272.00
IUUC-Aly-005652	Arabidopsis lyrata	59.62	4.00e-57	212.00
IUUC-Ath-007084	Arabidopsis thaliana	59.62	4.00e-57	212.00
IUUC-Ago-007998	Ashbya gossypii	55.77	1.00e-52	196.00
IUUC-Acl-008040	Aspergillus clavatus	59.46	1.00e-48	184.00
IUUC-Afl-008563	Aspergillus flavus	58.78	2.00e-48	182.00
IUUC-Afu-008873	Aspergillus fumigatus	61.31	2.00e-46	176.00
IUUC-Ani-009222	Aspergillus nidulans	63.51	1.00e-50	190.00
IUUC-Ang-009740	Aspergillus niger	63.04	1.00e-47	180.00
IUUC-Aor-010170	Aspergillus oryzae	59.46	1.00e-48	184.00
IUUC-Ate-010410	Aspergillus terreus	60.81	1.00e-49	187.00
IUUC-Ame-011711	Astyanax mexicanus	75.00	8.00e-75	271.00
IUUC-Bgr-012012	Blumeria graminis	53.38	8.00e-49	184.00
IUUC-Bta-013269	Bos taurus	76.92	3.00e-75	272.00
IUUC-Bci-013748	Botrytis cinerea	56.08	3.00e-45	172.00
IUUC-Bdi-014883	Brachypodium distachyon	58.33	6.00e-56	207.00
IUUC-Bol-015738	Brassica oleracea	59.09	1.00e-46	177.00
IUUC-Bra-017235	Brassica rapa	59.09	2.00e-46	176.00
IUUC-Cja-019349	Callithrix jacchus	76.92	3.00e-75	272.00
IUUC-Cfa-021008	Canis familiaris	77.68	4.00e-54	202.00
IUUC-Cpo-021324	Cavia porcellus	76.92	3.00e-75	272.00
IUUC-Cre-022836	Chlamydomonas reinhardtii	56.77	2.00e-54	202.00
IUUC-Csa-024207	Chlorocebus sabaeus	76.92	3.00e-75	272.00
IUUC-Cin-025734	Ciona intestinalis	73.89	7.00e-73	264.00
IUUC-Csv-026049	Ciona savignyi	75.16	3.00e-74	268.00
IUUC-Cgl-026699	Colletotrichum gloeosporioides	61.22	2.00e-55	206.00
IUUC-Cne-027034	Cryptococcus neoformans	62.99	6.00e-62	228.00
IUUC-Cme-027203	Cyanidioschyzon merolae	55.84	1.00e-47	181.00
IUUC-Dre-028839	Danio rerio	76.28	5.00e-75	271.00
IUUC-Dno-030037	Dasypus novemcinctus	76.92	3.00e-75	272.00
IUUC-Dor-031037	Dipodomys ordii	76.64	2.00e-65	239.00
IUUC-Dse-031366	Dothistroma septosporum	60.81	2.00e-56	209.00
IUUC-Dme-031818	Drosophila melanogaster	77.71	4.00e-75	271.00
IUUC-Ete-032517	Echinops telfairi	78.10	1.00e-66	243.00
IUUC-Eca-033789	Equus caballus	76.92	3.00e-75	272.00
IUUC-Fca-035851	Felis catus	76.92	3.00e-75	272.00
IUUC-Fal-037177	Ficedula albicollis	76.92	2.00e-75	272.00
IUUC-Fox-037789	Fusarium oxysporum	62.16	3.00e-58	216.00
IUUC-Fso-038166	Fusarium solani	62.16	8.00e-58	214.00
IUUC-Gmo-039401	Gadus morhua	75.64	3.00e-75	272.00
IUUC-Ggr-039892	Gaeumannomyces graminis	64.44	2.00e-54	203.00
IUUC-Gga-041199	Gallus gallus	76.92	3.00e-75	272.00
IUUC-Gac-041458	Gasterosteus aculeatus	75.64	3.00e-75	272.00
IUUC-Gma-043827	Glycine max	59.35	4.00e-57	212.00
IUUC-Ggo-045530	Gorilla gorilla	76.92	3.00e-75	272.00
IUUC-Hsa-046248	Homo sapiens	76.92	3.00e-75	272.00
IUUC-Hvu-047363	Hordeum vulgare	57.05	4.00e-55	205.00
IUUC-Itr-048429	Ictidomys tridecemlineatus	76.92	3.00e-75	272.00
IUUC-Kpa-049362	Komagataella pastoris	55.13	2.00e-53	199.00
IUUC-Lch-050202	Latimeria chalumnae	76.92	3.00e-75	272.00
IUUC-Lpe-051643	Leersia perrieri	57.14	1.00e-54	204.00
IUUC-Loc-052357	Lepisosteus oculatus	76.28	6.00e-75	271.00
IUUC-Lma-053142	Leptosphaeria maculans	56.16	5.00e-54	201.00
IUUC-Laf-053577	Loxodonta africana	76.92	3.00e-75	272.00
IUUC-Mcc-054925	Macaca mulatta	76.92	3.00e-75	272.00
IUUC-Meu-056094	Macropus eugenii	64.23	1.00e-49	187.00
IUUC-Mor-057141	Magnaporthe oryzae	62.16	5.00e-58	214.00
IUUC-Mpo-057613	Magnaporthe poae	62.96	2.00e-52	196.00
IUUC-Mtr-058465	Medicago truncatula	60.51	2.00e-59	219.00
IUUC-Mla-059115	Melampsora laricipopulina	61.18	8.00e-59	217.00
IUUC-Mga-059384	Meleagris gallopavo	76.92	3.00e-75	272.00
IUUC-Mvi-060328	Microbotryum violaceum	57.62	3.00e-45	172.00
IUUC-Mmr-061541	Microcebus murinus	76.92	3.00e-75	272.00
IUUC-Mdo-062540	Monodelphis domestica	76.92	3.00e-75	272.00
IUUC-Mmu-063818	Mus musculus	76.92	3.00e-75	272.00
IUUC-Mac-065518	Musa acuminata	57.69	8.00e-56	207.00
IUUC-Mpu-065734	Mustela putorius furo	76.92	3.00e-75	272.00
IUUC-Mlu-067619	Myotis lucifugus	76.92	3.00e-75	272.00
IUUC-Nfi-068567	Neosartorya fischeri	60.14	2.00e-49	186.00
IUUC-Ncr-068897	Neurospora crassa	61.29	4.00e-58	215.00
IUUC-Nle-069541	Nomascus leucogenys	76.77	1.00e-74	270.00
IUUC-Ont-071438	Oreochromis niloticus	75.64	3.00e-75	272.00
IUUC-Oan-073178	Ornithorhynchus anatinus	76.32	4.00e-34	134.00
IUUC-Ocu-074588	Oryctolagus cuniculus	71.15	6.00e-67	244.00
IUUC-Oba-075803	Oryza barthii	58.23	3.00e-56	209.00
IUUC-Obr-076591	Oryza brachyantha	58.86	2.00e-57	213.00
IUUC-Ogl-077864	Oryza glaberrima	58.23	3.00e-56	209.00
IUUC-Ogu-077979	Oryza glumaepatula	58.94	4.00e-55	205.00
IUUC-Oin-080163	Oryza indica	58.23	3.00e-56	209.00
IUUC-Olo-080940	Oryza longistaminata	51.27	8.00e-46	174.00
IUUC-Ome-081909	Oryza meridionalis	58.94	4.00e-55	205.00
IUUC-Oni-082410	Oryza nivara	58.23	3.00e-56	209.00
IUUC-Opu-083206	Oryza punctata	58.44	1.00e-55	207.00
IUUC-Oru-084706	Oryza rufipogon	58.23	3.00e-56	209.00
IUUC-Osa-086079	Oryza sativa	58.23	3.00e-56	209.00
IUUC-Ola-086314	Oryzias latipes	75.64	3.00e-75	272.00
IUUC-Olu-087715	Ostreococcus lucimarinus	54.09	5.00e-48	182.00
IUUC-Oga-088729	Otolemur garnettii	78.10	1.00e-66	243.00
IUUC-Oar-090221	Ovis aries	76.92	4.00e-75	272.00
IUUC-Ptr-090528	Pan troglodytes	76.92	3.00e-75	272.00
IUUC-Pan-092834	Papio anubis	76.92	3.00e-75	272.00
IUUC-Psi-093001	Pelodiscus sinensis	76.92	3.00e-75	272.00
IUUC-Pma-094539	Petromyzon marinus	76.92	3.00e-75	272.00
IUUC-Pno-094954	Phaeosphaeria nodorum	58.67	2.00e-55	206.00
IUUC-Ppa-095314	Physcomitrella patens	58.44	3.00e-56	209.00
IUUC-Pfo-097457	Poecilia formosa	76.92	2.00e-75	273.00
IUUC-Pab-098205	Pongo abelii	76.92	3.00e-75	272.00
IUUC-Pop-099063	Populus trichocarpa	58.33	3.00e-56	209.00
IUUC-Pca-100603	Procavia capensis	78.10	2.00e-66	243.00
IUUC-Ppe-101501	Prunus persica	59.09	5.00e-47	178.00
IUUC-Pva-103251	Pteropus vampyrus	62.77	3.00e-47	178.00
IUUC-Pte-104067	Pyrenophora teres	54.73	5.00e-54	201.00
IUUC-Pyt-104436	Pyrenophora triticirepentis	54.73	8.00e-54	201.00
IUUC-Rno-105794	Rattus norvegicus	76.92	3.00e-75	272.00
IUUC-Sce-106308	Saccharomyces cerevisiae	53.21	3.00e-51	192.00
IUUC-Sha-106997	Sarcophilus harrisii	71.52	1.00e-67	246.00
IUUC-Sja-108000	Schizosaccharomyces japonicus	61.78	6.00e-53	197.00
IUUC-Spo-108311	Schizosaccharomyces pombe	60.26	5.00e-52	195.00
IUUC-Smo-108685	Selaginella moellendorffii	57.79	4.00e-46	175.00
IUUC-Sit-110037	Setaria italica	57.69	2.00e-55	207.00
IUUC-Sly-111392	Solanum lycopersicum	61.15	2.00e-59	219.00
IUUC-Stu-111975	Solanum tuberosum	62.66	3.00e-53	199.00
IUUC-Sbi-114521	Sorghum bicolor	57.05	9.00e-55	204.00
IUUC-Sre-114957	Sporisorium reilianum	62.26	6.00e-62	228.00
IUUC-Ssc-116173	Sus scrofa	76.92	3.00e-75	272.00
IUUC-Tgu-116668	Taeniopygia guttata	76.92	3.00e-75	272.00
IUUC-Tru-118365	Takifugu rubripes	76.28	4.00e-75	271.00
IUUC-Tni-120455	Tetraodon nigroviridis	76.28	5.00e-76	275.00
IUUC-Tca-120956	Theobroma cacao	57.79	8.00e-55	204.00
IUUC-Tre-121927	Trichoderma reesei	60.81	2.00e-57	213.00
IUUC-Tvi-122363	Trichoderma virens	61.49	3.00e-58	216.00
IUUC-Tae-124409	Triticum aestivum	57.69	1.00e-55	207.00
IUUC-Tur-126625	Triticum urartu	57.69	1.00e-55	207.00
IUUC-Tme-126981	Tuber melanosporum	55.03	1.00e-37	147.00
IUUC-Ttr-128280	Tursiops truncatus	79.31	1.00e-41	160.00
IUUC-Uma-129582	Ustilago maydis	63.69	1.00e-62	230.00
IUUC-Vda-129845	Verticillium dahliae	58.78	8.00e-56	207.00
IUUC-Vpa-130242	Vicugna pacos	78.10	2.00e-66	243.00
IUUC-Vvi-130948	Vitis vinifera	57.14	1.00e-54	204.00
IUUC-Xtr-132540	Xenopus tropicalis	76.92	4.00e-75	271.00
IUUC-Xma-133010	Xiphophorus maculatus	76.92	2.00e-75	273.00
IUUC-Yli-134673	Yarrowia lipolytica	52.00	9.00e-50	187.00
IUUC-Zma-135004	Zea mays	57.69	8.00e-56	207.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence